1000 resultados para Fischer, G.A. (1848-1886) -- Portraits
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Title vignette.
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Text printed in two columns.
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Cover title.
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On spine: The life and public services of James G. Blaine and of Gen. John A. Logan.
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Mode of access: Internet.
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Mode of access: Internet.
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Editor: 1886-19 , K. von Bardeleben.
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Mode of access: Internet.
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Mode of access: Internet.
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Parts II-III are taken from "American politics," by Thomas V. Cooper and Hector T. Fenton.
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Mode of access: Internet.
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protein modulation of neuronal nicotinic acetylcholine receptor ( nAChR) channels in rat intrinsic cardiac ganglia was examined using dialyzed whole-cell and excised membrane patch-recording configurations. Cell dialysis with GTP gamma S increased the agonist affinity of nAChRs, resulting in a potentiation of nicotine-evoked whole-cell currents at low concentrations. ACh- and nicotine-evoked current amplitudes were increased approximately twofold in the presence of GTP gamma S. In inside-out membrane patches, the open probability (NPo) of nAChR-mediated unitary currents was reversibly increased fourfold after bath application of 0.2mM GTP gamma S relative to control but was unchanged in the presence of GDP gamma S. The modulation of nAChR-mediated whole- cell currents was agonist specific; currents evoked by the cholinergic agonists ACh, nicotine, and 1,1-dimethyl-4-phenylpiperazinium iodide, but not cytisine or choline, were potentiated in the presence of GTP gamma S. The direct interaction between G-protein subunits and nAChRs was examined by bath application of either G(o)alpha or G beta gamma subunits to inside-out membrane patches and in glutathione S-transferase pull-down and coimmunoprecipitation experiments. Bath application of 50 nM G beta gamma increased the open probability of ACh- activated single-channel currents fivefold, whereas G(o)alpha( 50 nM) produced no significant increase in NPo. Neuronal nAChR subunits alpha 3-alpha 5 and alpha 2 exhibited a positive interaction with G(o)alpha and G beta gamma, whereas beta 4 and alpha 7 failed to interact with either of the G-protein subunits. These results provide evidence for a direct interaction between nAChR and G-protein subunits, underlying the increased open probability of ACh-activated single-channel currents and potentiation of nAChR-mediated whole-cell currents in parasympathetic neurons of rat intrinsic cardiac ganglia.
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The exponential growth of studies on the biological response to ocean acidification over the last few decades has generated a large amount of data. To facilitate data comparison, a data compilation hosted at the data publisher PANGAEA was initiated in 2008 and is updated on a regular basis (doi:10.1594/PANGAEA.149999). By January 2015, a total of 581 data sets (over 4 000 000 data points) from 539 papers had been archived. Here we present the developments of this data compilation five years since its first description by Nisumaa et al. (2010). Most of study sites from which data archived are still in the Northern Hemisphere and the number of archived data from studies from the Southern Hemisphere and polar oceans are still relatively low. Data from 60 studies that investigated the response of a mix of organisms or natural communities were all added after 2010, indicating a welcomed shift from the study of individual organisms to communities and ecosystems. The initial imbalance of considerably more data archived on calcification and primary production than on other processes has improved. There is also a clear tendency towards more data archived from multifactorial studies after 2010. For easier and more effective access to ocean acidification data, the ocean acidification community is strongly encouraged to contribute to the data archiving effort, and help develop standard vocabularies describing the variables and define best practices for archiving ocean acidification data.
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Es muy defendible afirmar que el volumen dedicado a Spinoza de la obra Historia de la filosofía moderna de Kuno Fischer es la mediación más importante –si bien no la única– para comprender la relación Spinoza-Nietzsche. A partir de la lectura de esta obra en 1881, Nietzsche reconoce a Spinoza como precursor e identifica una tendencia en común entre ambos: «hacer del conocimiento el afecto más potente». Los principales objetivos de este trabajo son destacar la exposición que Fischer lleva a cabo de algunos de los contenidos de la filosofía spinociana para poder valorar mejor su influencia en Nietzsche y resaltar la importancia que tiene tulo 22 de la edición de 1865, titulado «La voluntad humana», donde se interpreta la voluntad como deseo consciente, lo que tendrá sus consecuencias en la recepción de Nietzsche de la filosofía spinociana, además de permitir una discusión respecto del rol no siempre atendido de la voluntad en Spinoza.