ADESÃO AO PRÉ-NATAL NA UNIDADE ESTRATÉGIA SAÚDE DA FAMÍLIA URBANA DE JARAGUARI/MS

O pré-natal é uma ação que merece ser cuidadosamente tratado pelos profissionais da saúde materno-infantil, visto que a falta de adesão ao mesmo pode ser considerado como um grave problema de saúde pública. O objetivo deste projeto de intervenção (PI) foi aumentar a adesão ao pré-natal na unidade Estratégia Saúde da Família Urbana do município Jaraguari, estado de Mato Grosso do Sul. O PI foi desenvolvido de janeiro a junho de 2014, tendo como público alvo seis gestantes do território adscrito. Foram realizadas atividades de educação em saúde, consulta de enfermagem e visitas domiciliares. Como resultados obtivemos que a adesão ao pré-natal de Jaraguari/MS de forma geral foram alcançados, foi possível implementar o Programa de Pré-natal promovendo interação entre o conhecimento técnico e o popular através da pedagogia em forma de diálogo. Podemos concluir que frente ao papel social da atenção básica de saúde e em especial no atendimento a gestantes, a equipe deve se empenhar ao máximo para prestar uma assistência de qualidade e humanizada.

PROJETO-PILOTO JUNTO A SERVIDORES PÚBLICOS ADMINISTRATIVOS DA PREFEITURA MUNICIPAL DE JARAGUARI/MS COM PRESSÃO ARTERIAL LIMÍTROFE PARA CAPACITAÇÃO DE PROFISSIONAIS DE SAÚDE

A hipertensão arterial sistêmica (HAS) configura como um grave problema de saúde pública no Brasil e no mundo e está associada à morbimortalidade e com o aumento nos eventos de complicações cardiovasculares, encefálicas, coronarianas, renais e vasculares periféricas, com conseqüente diminuição da sobrevida e piora na qualidade de vida. Uma das medidas de prevenção dessa doença é a detecção precoce da doença, por meio da verificação da pressão arterial (PA) e a instuição de ações de prevenção e controle. Este projeto de intervenção (PI) teve como objetivo ampliar as ações de promoção a saúde do trabalhador no município de Jaraguari, estado de Mato Grosso do Sul (MS), para isso foi realizado uma sensibilização e capacitação dos profissionais de saúde do município atuantes nas unidades básicas de saúde para o desenvolvimento de ações de educação em saúde para prevenção da HAS, visando a saúde do trabalhador foi realizado junto aos servidores públicos da área administrativa da Prefeitura Municipal de Jaraguari/MS. Aplicando as diferentes etapas do planejamento de ações educativas foi desenvolvido um “Projeto-Piloto”, com o intuito de identificar os servidores com PA limítrofe, conhecer seus hábitos de vida e construir um plano de acompanhamento e orientações de educação em saúde visando mudança no estilo de vida. O foco nos servidores públicos justifica-se pelo fato da política de controle da HAS se estender para fora das unidades de saúde e devido o tipo de atividade laboral desenvolvida por esse grupo populacional, que favorece o sedentarismo. Os dados de caracterização e clínicos foram coletados por meio da aplicação de um formulário e aferição da PA e com esses foram realizados ações educativas e/ou encaminhamentos para tratamento. Espera-se que os resultados desse PI sejam a médio e a longo prazo, quando a equipe de saúde das UBS fortaleçam as ações de saúde do trabalhador ampliando suas ações, cumprindo legislações e buscando qualidade de vida.

Melhoria da Prevenção do Câncer de Colo de Útero e Controle do Câncer de Mama, na UBS Mato Castelhano/RS

VALDÉS, Yanilis Díaz. Melhoria do Programa de Prevenção do Câncer de Colo de Útero e Controle do Câncer de Mama na UBS Mato Castelhano/RS. 2015. 73f. Trabalho de Conclusão de Curso (Curso de Especialização em Saúde da Família) – Departamento de Medicina Social, Faculdade de Medicina, Universidade Federal de Pelotas, Pelotas, 2015. O câncer de colo de útero e o câncer de mamas são graves problemas de saúde pública no Brasil e no mundo. Evidências demonstram que com a realização de exame citopatológico e mamografia para a prevenção e detecção precoce destas doenças na Atenção Básica evita-se hospitalizações e mortes em muitas mulheres jovens. Nesse sentido, o objetivo desse trabalho foi melhorar o Programa de prevenção do Câncer de Colo de Útero nas mulheres entre 25 e 64 anos e Controle do Câncer de Mama nas mulheres entre 50 e 69 anos, na Unidade Básica de Saúde Mato Castelhano/RS, sendo a intervenção desenvolvida em 12 semanas, ou seja nos meses de abril, maio e junho de 2015. Para o desenvolvimento da intervenção, na coleta de dados, foram utilizados dois instrumentos: planilha de coleta de dados digital e ficha-espelho. Na análise dos dados, utilizou-se a planilha eletrônica construída pelo Curso de Especialização para fins do monitoramento. Foram traçadas e implementadas ações em quatro eixos temáticos: monitoramento e avaliação; organização e gestão do serviço; engajamento público e qualificação da prática clínica. Com a implementação do projeto de intervenção foram cadastradas 373 usuárias entre 25 e 64 anos com exames em dia para a detecção precoce de câncer de colo de útero e 264 usuárias entre 50 e 69 anos com exame em dia para detecção precoce de câncer de mamas, atingindo uma cobertura de 58,1% e 100%, respectivamente, evoluindo da seguinte maneira: Mês 1 foram cadastradas 210 (32,7%) mulheres, mês 2 270 (42,1%) e no mês 3 373 (58,1%) para o câncer de colo de útero, já para o câncer de mama foram cadastradas no mês 1 98 (37,1%), mês 2 182 (68,9%) e mês 3 264 (100%) mulheres. Além disso, a intervenção propiciou o desenvolvimento de um trabalho multidisciplinar, um maior nível de conhecimento aos profissionais mediante as atividades de qualificação da prática clínica e promoveu o trabalho integrado da equipe de saúde com a comunidade, aumentando, dessa forma, o engajamento público e a governabilidade dos profissionais na solução dos problemas que seriam de responsabilidade dos gestores. Neste momento a intervenção encontra-se completamente inserida na rotina do trabalho diário da equipe sendo o motor impulsor de outras intervenções de saúde. Palavras-chave: Saúde da Família; Atenção Primária à Saúde; Saúde da Mulher; Programas de Rastreamento; Neoplasias do colo do útero; Neoplasias da Mama.

Desorption/ionization Efficiencies Of Triacylglycerols And Phospholipids Via Easi-ms.

Knowledge of the major effects governing desorption/ionization efficiency is required for the development and application of ambient mass spectrometry. Although all triacylglycerols (TAG) have the same favorable protonation and cationization sites, their desorption/ionization efficiencies can vary dramatically during easy ambient sonic-spray ionization because of structural differences in the carbon chain. To quantify this somewhat surprising and drastic effect, we have performed a systematic investigation of desorption/ionization efficiencies as a function of unsaturation and length for TAG as well as for diacylglycerols, monoacylglycerols and several phospholipids (PL). Affinities for Na(+) as a function of unsaturation level have also been assayed via comprehensive metadynamics calculations to understand the influence of this phenomenon on the ionization efficiency. The results suggest that dipole-dipole interactions within a carbon chain tuned by unsaturation sites govern ionization efficiency of TAG and PL.

High-throughput Analysis By Sp-ldi-ms For Fast Identification Of Adulterations In Commercial Balsamic Vinegars.

Balsamic vinegar (BV) is a typical and valuable Italian product, worldwide appreciated thanks to its characteristic flavors and potential health benefits. Several studies have been conducted to assess physicochemical and microbial compositions of BV, as well as its beneficial properties. Due to highly-disseminated claims of antioxidant, antihypertensive and antiglycemic properties, BV is a known target for frauds and adulterations. For that matter, product authentication, certifying its origin (region or country) and thus the processing conditions, is becoming a growing concern. Striving for fraud reduction as well as quality and safety assurance, reliable analytical strategies to rapidly evaluate BV quality are very interesting, also from an economical point of view. This work employs silica plate laser desorption/ionization mass spectrometry (SP-LDI-MS) for fast chemical profiling of commercial BV samples with protected geographical indication (PGI) and identification of its adulterated samples with low-priced vinegars, namely apple, alcohol and red/white wines.

Chemo-, Regio- And Stereoselective Heck Arylation Of Allylated Malonates: Mechanistic Insights By Esi-ms And Synthetic Application Toward 5-arylmethyl-γ-lactones.

We describe herein a general method for the controlled Heck arylation of allylated malonates. Both electron-rich and electron-poor aryldiazonium salts were readily employed as the aryl-transfer agents in good yields and in high chemo-, regio-, and stereoselectivity without formation of decarboxylated byproducts. Reaction monitoring via ESI-MS was used to support the formation of chelated Pd species through the catalytic cycle. Additionally, some Heck adducts were successfully used in the total synthesis of pharmacologically active γ-lactones.

Esi(+)-ms And Gc-ms Study Of The Hydrolysis Of N-azobenzyl Derivatives Of Chitosan.

New N-p-chloro-, N-p-bromo-, and N-p-nitrophenylazobenzylchitosan derivatives, as well as the corresponding azophenyl and azophenyl-p-sulfonic acids, were synthesized by coupling N-benzylvchitosan with aryl diazonium salts. The synthesized molecules were analyzed by UV-Vis, FT-IR, 1H-NMR and 15N-NMR spectroscopy. The capacity of copper chelation by these materials was studied by AAS. Chitosan and the derivatives were subjected to hydrolysis and the products were analyzed by ESI(+)-MS and GC-MS, confirming the formation of N-benzyl chitosan. Furthermore, the MS results indicate that a nucleophilic aromatic substitution (SnAr) reaction occurs under hydrolysis conditions, yielding chloroaniline from N-p-bromo-, and N-p-nitrophenylazo-benzylchitosan as well as bromoaniline from N-p-chloro-, and N-p-nitrophenylazobenzyl-chitosan.

Characterization Of Anfo Explosive By High Accuracy Esi(±)-ftms With Forensic Identification On Real Samples By Easi(-)-ms.

Ammonium nitrate fuel oil (ANFO) is an explosive used in many civil applications. In Brazil, ANFO has unfortunately also been used in criminal attacks, mainly in automated teller machine (ATM) explosions. In this paper, we describe a detailed characterization of the ANFO composition and its two main constituents (diesel and a nitrate explosive) using high resolution and accuracy mass spectrometry performed on an FT-ICR-mass spectrometer with electrospray ionization (ESI(±)-FTMS) in both the positive and negative ion modes. Via ESI(-)-MS, an ion marker for ANFO was characterized. Using a direct and simple ambient desorption/ionization technique, i.e., easy ambient sonic-spray ionization mass spectrometry (EASI-MS), in a simpler, lower accuracy but robust single quadrupole mass spectrometer, the ANFO ion marker was directly detected from the surface of banknotes collected from ATM explosion theft.

Determination Of The Phenolic Composition From Brazilian Tropical Fruits By Uhplc-ms/ms.

Although Brazil is the third largest fruit producer in the world, several specimens consumed are not well studied from the chemical viewpoint, especially for quantitative analysis. For this reason and the crescent employment of mass spectrometry (MS) techniques in food science we selected twenty-two phenolic compounds with important biological activities and developed an ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method using electrospray (ESI) in negative ion mode aiming their quantification in largely consumed Brazilian fruits (açaí-do-Amazonas, acerola, cashew apple, camu-camu, pineapple and taperebá). Multiple reaction monitoring (MRM) was applied and the selection of proper product ions for each transition assured high selectivity. Linearity (0.995-333.3pg/mL), limit of quantification (96.15-1111pg/mL), inter- and intraday accuracy (>80%), precision (CV<20%) and extraction recovery rate (>80%) were satisfactory and showed that the method provides an efficient protocol to analyze phenolic compounds in fruit pulp extracts.

Serum Bdnf Levels Are Not Reliable Correlates Of Neurodegeneration In Ms Patients.

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Subclinical Mri Disease Activity Influences Cognitive Performance In Ms Patients.

The pathological mechanisms underlying cognitive dysfunction in multiple sclerosis (MS) are not yet fully understood and, in addition to demyelinating lesions and gray-matter atrophy, subclinical disease activity may play a role. To evaluate the contribution of asymptomatic gadolinium-enhancing lesions to cognitive dysfunction along with gray-matter damage and callosal atrophy in relapsing-remitting MS (RRMS) patients. Forty-two treated RRMS and 30 controls were evaluated. MRI (3T) variables of interest were brain white-matter and cortical lesion load, cortical and deep gray-matter volumes, corpus callosum volume and presence of gadolinium-enhancing lesions. Outcome variables included EDSS, MS Functional Composite (MSFC) subtests and the Brief Repeatable Battery of Neuropsychological tests. Cognitive dysfunction was classified as deficits in two or more cognitive subtests. Multivariate regression analyses assessed the contribution of MRI metrics to outcomes. Patients with cognitive impairment (45.2%) had more cortical lesions and lower gray-matter and callosal volumes. Patients with subclinical MRI activity (15%) had worse cognitive performance. Clinical disability on MSFC was mainly associated with putaminal atrophy. The main independent predictors for cognitive deficits were high burden of cortical lesions and number of gadolinium-enhancing lesions. Cognitive dysfunction was especially related to high burden of cortical lesions and subclinical disease activity. Cognitive studies in MS should look over subclinical disease activity as a potential contributor to cognitive impairment.

Separation Of Glycosidic Catiomers By Twim-ms Using Co2 As A Drift Gas.

Traveling wave ion mobility mass spectrometry (TWIM-MS) is shown to be able to separate and characterize several isomeric forms of diterpene glycosides stevioside (Stv) and rebaudioside A (RebA) that are cationized by Na(+) and K(+) at different sites. Determination and characterization of these coexisting isomeric species, herein termed catiomers, arising from cationization at different and highly competitive coordinating sites, is particularly challenging for glycosides. To achieve this goal, the advantage of using CO2 as a more massive and polarizable drift gas, over N2 , was demonstrated. Post-TWIM-MS/MS experiments were used to confirm the separation. Optimization of the possible geometries and cross-sectional calculations for mobility peak assignments were also performed. Copyright © 2015 John Wiley & Sons, Ltd.

Profile Of Phenolic Compounds Of Brazilian Virgin Olive Oils By Rapid Resolution Liquid Chromatography Coupled To Electrospray Ionisation Time-of-flight Mass Spectrometry (rrlc-esi-tof-ms).

In recent years, agronomical researchers began to cultivate several olive varieties in different regions of Brazil to produce virgin olive oil (VOO). Because there has been no reported data regarding the phenolic profile of the first Brazilian VOO, the aim of this work was to determine phenolic contents of these samples using rapid-resolution liquid chromatography coupled to electrospray ionisation time-of-flight mass spectrometry. 25 VOO samples from Arbequina, Koroneiki, Arbosana, Grappolo, Manzanilla, Coratina, Frantoio and MGS Mariense varieties from three different Brazilian states and two crops were analysed. It was possible to quantify 19 phenolic compounds belonging to different classes. The results indicated that Brazilian VOOs have high total phenolic content because the values were comparable with those from high-quality VOOs produced in other countries. VOOs from Coratina, Arbosana and Grappolo presented the highest total phenolic content. These data will be useful in the development and improvement of Brazilian VOO.

Application Of Laser Microdissection Icp-ms For High Resolution Elemental Mapping In Mouse Brain Tissue: A Comparative Study With Laser Ablation Icp-ms.

Mapping of elements in biological tissue by laser induced mass spectrometry is a fast growing analytical methodology in life sciences. This method provides a multitude of useful information of metal, nonmetal, metalloid and isotopic distribution at major, minor and trace concentration ranges, usually with a lateral resolution of 12-160 µm. Selected applications in medical research require an improved lateral resolution of laser induced mass spectrometric technique at the low micrometre scale and below. The present work demonstrates the applicability of a recently developed analytical methodology - laser microdissection associated to inductively coupled plasma mass spectrometry (LMD ICP-MS) - to obtain elemental images of different solid biological samples at high lateral resolution. LMD ICP-MS images of mouse brain tissue samples stained with uranium and native are shown, and a direct comparison of LMD and laser ablation (LA) ICP-MS imaging methodologies, in terms of elemental quantification, is performed.

Avaliação de danos mecânicos causados em banana Nanicão durante as etapas de beneficiamento, transporte e embalagem

This study had as objective the evaluation of mechanical damages occurred in banana Nanicão during the improvement process, packing and distribution, identifying the probable critical points. The mechanical damages caused by transport, first cleaning; cleanness and sorting; preservation in the packing, transport, and mature were evaluated. The studied packing had been: torito wooden packing (18 kg), wood type ½ box, (13 kg) and cardboard (18 kg). The stage of preservation and transport of the fruits to the distribution center duplicated the light defects and quintupled the serious defects, causing rottenness after the acclimatization. The cardboard packing did not support the piling up and presented deformations, that resulted in the kneading the fruits of the inferior packing, causing a significant increase of the serious defects. The fruits conditioned in the involved packing of plastic bubble had presented an inferior number of serious damages when compared with the others packing, without the plastic.