Germany's stance on the TTIP. Background, interests and concerns. OSW Studies 52, March 2015

Co-operation between the United States and Germany has for many years been a subject of disputes. In addition to the differences over the US engagement in the resolution of international conflicts, bilateral relations have been strained as a consequence of the so-called Snowden scandal and the unproved allegations that Chancellor Angela Merkel’s telephone was wiretapped. The Transatlantic Trade and Investment Partnership offers a chance for improving relations between Germany and the USA for the first time in many years. Companies from the two countries may benefit from the lifting of some barriers to transatlantic economic co-operation. Furthermore, the emergence of in fact an internal EU and US market, with reduced customs tariffs and harmonised legal and economic rules, will pressure the emerging economies to make their markets more open. The TTIP may create conditions for exporting US raw materials from unconventional sources to the European Union; and this will be a benefit of geopolitical significance for Germany. The German government is aware of the fact that diversification of supplies of fossil fuels will make Europe less dependent on pressure from Moscow.

The European Union and Post-Cold War Defence Policies in South America. Jean Monnet/Robert Schuman Paper Series Vol. 14 No. 10, May 2014

None.

New insights into the pharmacokinetics and pharmacodynamics of natalizumab treatment for patients with multiple sclerosis, obtained from clinical and in vitro studies.

BACKGROUND The monoclonal antibody natalizumab (NAT) inhibits the migration of lymphocytes throughout the blood-brain barrier by blocking very late antigen (VLA)-4 interactions, thereby reducing inflammatory central nervous system (CNS) activity in patients with multiple sclerosis (MS). We evaluated the effects of different NAT treatment regimens. METHODS We developed and optimised a NAT assay to measure free NAT, cell-bound NAT and VLA-4 expression levels in blood and cerebrospinal fluid (CSF) of patients using standard and prolonged treatment intervals and after the cessation of therapy. RESULTS In paired CSF and blood samples of NAT-treated MS patients, NAT concentrations in CSF were approximately 100-fold lower than those in serum. Cell-bound NAT and mean VLA-4 expression levels in CSF were comparable with those in blood. After the cessation of therapy, the kinetics of free NAT, cell-bound NAT and VLA-4 expression levels differed. Prolonged intervals greater than 4 weeks between infusions caused a gradual reduction of free and cell-bound NAT concentrations. Sera from patients with and without NAT-neutralising antibodies could be identified in a blinded assessment. The NAT-neutralising antibodies removed NAT from the cell surface in vivo and in vitro. Intercellular NAT exchange was detected in vitro. CONCLUSIONS Incorporating assays to measure free and cell-bound NAT into clinical practice can help to determine the optimal individual NAT dosing regimen for patients with MS.

The tourist's pocket book : containing useful words and simple phrases in English, French, German, Italian, Spanish, Portuguese, Dutch, ... and Hungarian. Medical and surgical hints; cypher code for telegrams and post cards; blank forms of washing lists ... to facilitate the sayings and doings of British and American travellers /

Mode of access: Internet.

Report of pre and post road test ultrasonic inspection results on 134 passenger tires: final report.

National Highway Traffic Safety Administration, Washington, D.C.

The complexity of legal and ethical experience : studies in the method of normative subjects /

Includes bibliography.

High rate nutrient removal for combined sewer overflows : bench scale and demonstration scale studies /

Mode of access: Internet.

Understanding genetic research and population-based studies /

"P 106"--P. [4] of cover.

Understanding genetic research and population-based studies /

"P 106"--P. [4] of cover.

Los Angeles and Long Beach harbors model study : Deep-Draft Dry Bulk Export Terminal, alternative no. 6: resonant response and tidal circulation studies /

"July 1985."