Hormonal contraceptive use before hCG remission does not increase the risk of gestational trophoblastic neoplasia following complete hydatidiform mole: a historical database review

To re-evaluate the safety of hormonal contraceptives (HC) after uterine evacuation of complete hydatidiform mole (CHM). Historical database review. Charing Cross Hospital Gestational Trophoblastic Disease Centre, London, United Kingdom. Two thousand four hundred and twenty-three women with CHM of whom 154 commenced HC while their human chorionic gonadotropin (hCG) was still elevated, followed between 2003 and 2012. We compared time to hCG remission between HC users and nonusers. The relationship between HC use and gestational trophoblastic neoplasia (GTN) development was assessed. The relationship between HC use and a high International Federation of Gynecology and Obstetrics (FIGO) risk score was determined. Time to hCG remission, risk of developing postmolar GTN and proportion of women with high FIGO risk score. No relationship was observed between HC use with mean time to hCG remission (HC users versus non-users: 12 weeks in both, P = 0.19), GTN development (HC users versus non-users: 20.1 and 16.7%, P = 0.26) or high-risk FIGO score (HC users versus nonusers: 0% and 8%, P = 0.15). Moreover, no association between HC and GTN development was found, even when an age-adjusted model was used (OR = 1.37, 95% CI 0.91-2.08, P = 0.13). The use of current HC is not associated with development of postmolar GTN or delayed time to hCG remission. Therefore, HC can be safely used to prevent a new conception following CHM regardless of hCG level. Non-concurrent cohort study to re-evaluate the safety of low dose HCs after uterine evacuation of CHM.

Utilização de material alternativo para a obtenção e caracterização de biomodelos, por meio da técnica de impressão 3DPRINTER

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Comparação energética de tijolos comum e sem queima pela análise do ciclo de vida

This work is part of several research related to the plan of design and construction of a sustainable house. The previous researches focused on sustainable materials and it have shown that ceramic material are more interesting to improve the thermal comfort and the reduction of fees and prices of the house, making possible to construct popular home, mainly clay bricks, that have high thermal inertia and low costs, besides the fact that it is easy to find the raw materials in nature and process them. However, a major issue in using clay bricks is that it uses too many energy to be processed during the sintering (burning), a crucial part of the process that assures mechanical resistance. Alternative materials are being proposed by the researchers, as the clay bricks without the sintering mixed with Portland cement, assuring the proper resistance to the brick. Raw materials of cement, however, also need to be thermally processed in rotary kilns, in a process called clinckerization. This research was proposed for comparing the energy used by the two types of bricks and other objectives, in order to determinate which one uses less thermal energy. The intention was to compare the energy used during the sintering of regular clay bricks and the unfired bricks with 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% and 100% of Portland cement. The paper also investigated and compared the use of electrical and thermal energy of all the bricks to identify how important were the thermal stages (sintering or clinkerization) relatively to the total energy spent. At last, a resumed analysis was performed to identify the possible health damages of the many life cycles of the bricks. The conclusion was that unfired bricks with less than 40% of cement use less thermal energy to be processed. In addition, their carbon dioxides emissions were less dangerous to ... (Complete abastract click electronic access below)

Vanishing of Ext and Tor over complete intersections

Let (R,m) be a local complete intersection, that is, a local ring whose m-adic completion is the quotient of a complete regular local ring by a regular sequence. Let M and N be finitely generated R-modules. This dissertation concerns the vanishing of Tor(M, N) and Ext(M, N). In this context, M satisfies Serre's condition (S_{n}) if and only if M is an nth syzygy. The complexity of M is the least nonnegative integer r such that the nth Betti number of M is bounded by a polynomial of degree r-1 for all sufficiently large n. We use this notion of Serre's condition and complexity to study the vanishing of Tor_{i}(M, N). In particular, building on results of C. Huneke, D. Jorgensen and R. Wiegand [32], and H. Dao [21], we obtain new results showing that good depth properties on the R-modules M, N and MtensorN force the vanishing of Tor_{i}(M, N) for all i>0. We give examples showing that our results are sharp. We also show that if R is a one-dimensional domain and M and MtensorHom(M,R) are torsion-free, then M is free if and only if M has complexity at most one. If R is a hypersurface and Ext^{i}(M, N) has finite length for all i>>0, then the Herbrand difference [18] is defined as length(Ext^{2n}(M, N))-(Ext^{2n-1}(M, N)) for some (equivalently, every) sufficiently large integer n. In joint work with Hailong Dao, we generalize and study the Herbrand difference. Using the Grothendieck group of finitely generated R-modules, we also examined the number of consecutive vanishing of Ext^{i}(M, N) needed to ensure that Ext^{i}(M, N) = 0 for all i>>0. Our results recover and improve on most of the known bounds in the literature, especially when R has dimension two.

Relatin Dissolved Oxygen Concentration to Fish Distribution in Jarecki Lake

Abstract Water temperature and dissolved oxygen (DO) profiles were measured once every month from mid July to mid February in a relatively deep sand-pit lake in southeast Nebraska. These profiles showed depleted DO concentrations below the thermocline during summer stratification indicating areas fish will likely avoid in summer months. Colder temperatures in fall caused complete mixing of the water column allowing fish to inhabit all depths of the lake. An inverse temperature stratification occurred directly below the ice during winter months as ice cover cooled the surface water to below 4 degrees Celsius. Ice cover also blocked air – water oxygen transfer and reduced light for photosynthesizing algae. Associated with winter ice cover, DO concentrations in the hypolimnion decreased significantly, once again reducing available fish habitat. It is likely anglers will have a higher success rate catching fishing in water above 6 meters (m) (~20 feet) in a eutrophic sandpit lake during hot summer months and below ice cover in winter. Fish can utilize all depths of the lake during fall turnover and could theoretically be caught by anglers anywhere in the lake.

COMPLETE CONTROL OF NUISANCE BIRDS IN AIRPORT HANGARS

Fogging of ReJeX-iT7 TP-40 offers a very efficient method for the control and dispersal of nuisance birds from many diverse areas. The amount of the repellent is greatly reduced over any other control method. The method is direct and is independent of the activity of the birds. The applications with any fogger, thermal or mechanical, that can deliver droplets of less than 20 microns, can be manually or fully automated and pose only minimal risks to operators or animals. All birds that became a nuisance and safety problem in the hangars of TWA and AA at LaGuardia, and TWA warehouse at Newark Airport were successfully driven out by fogging ReJeX-iT7 TP-40 with a Curtis Dyna-Fog AGolden Eagle@ thermal fogger.

Comparação energética de tijolos comum e sem queima pela análise do ciclo de vida

This work is part of several research related to the plan of design and construction of a sustainable house. The previous researches focused on sustainable materials and it have shown that ceramic material are more interesting to improve the thermal comfort and the reduction of fees and prices of the house, making possible to construct popular home, mainly clay bricks, that have high thermal inertia and low costs, besides the fact that it is easy to find the raw materials in nature and process them. However, a major issue in using clay bricks is that it uses too many energy to be processed during the sintering (burning), a crucial part of the process that assures mechanical resistance. Alternative materials are being proposed by the researchers, as the clay bricks without the sintering mixed with Portland cement, assuring the proper resistance to the brick. Raw materials of cement, however, also need to be thermally processed in rotary kilns, in a process called clinckerization. This research was proposed for comparing the energy used by the two types of bricks and other objectives, in order to determinate which one uses less thermal energy. The intention was to compare the energy used during the sintering of regular clay bricks and the unfired bricks with 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% and 100% of Portland cement. The paper also investigated and compared the use of electrical and thermal energy of all the bricks to identify how important were the thermal stages (sintering or clinkerization) relatively to the total energy spent. At last, a resumed analysis was performed to identify the possible health damages of the many life cycles of the bricks. The conclusion was that unfired bricks with less than 40% of cement use less thermal energy to be processed. In addition, their carbon dioxides emissions were less dangerous to ... (Complete abastract click electronic access below)

Changes in Complete Blood Count in Patients With Surgically Treated Facial Fractures

The purpose of this prospective study was to verify the changes in the preoperative and postoperative complete blood counts of patients with surgically treated facial fractures. Fifty consecutive patients with a mean age of 34 years who presented facial fractures and underwent surgical treatment were included. A complete blood count was performed, comprising the red and white blood cell count (cells/mu L), hemoglobin (g/dL), and hematocrit (%) levels. These data were obtained preoperatively and postoperatively during a 6-week period. Statistical analyses were performed using the Kruskal-Wallis and Mann-Whitney tests to identify the possible differences among the groups and among the periods of observation using the Friedman and Wilcoxon matched-pairs signed-ranks tests. The most common location of the fractures was the mandible (42.3%), followed by the zygomatic-orbital (36.5%) and associated locations (21.2%). Leukocytosis was associated with neutrophilia in the immediate postoperative period in all of the groups. There were no values below the reference limits of the values of hemoglobin, hematocrit, and erythrocytes, and no values above the reference limits for the remaining white blood cells, although significant differences among periods were observed in most cells, depending on the type of fracture. The primary findings were leukocytosis associated with neutrophilia, verified in the immediate postoperative period in all of the groups, and the influence of the type of fracture on the significant alterations observed among studied periods on the values of hemoglobin, hematocrit, erythrocytes, leukocytes, neutrophils, and lymphocytes.

Pretherapeutic Expression of the hOCT1 Gene Predicts a Complete Molecular Response to Imatinib Mesylate in Chronic-Phase Chronic Myeloid Leukemia

In this retrospective study we evaluated the pretherapeutic mRNA expression of the hOCT1 (human organic cation transporter 1) gene in patients with chronic-phase (CP) chronic myeloid leukemia (CML) who varied in terms of their response to imatinib (IM). hOCT1 mRNA was quantified by real-time PCR. Patients were classified as expressing either high (n = 44) or low hOCT1 mRNA (n = 44). The complete cytogenetic response rates observed at 6, 12 and 18 months were 47.7, 84.1 and 91%, respectively, in patients with high hOCT1 mRNA and 47.5, 81.8 and 86.3%, respectively, in patients with low hOCT1 transcripts. The major molecular response rates were not significantly different between patients with high and low hOCT1 mRNA after 6 months of therapy (22.7 vs. 9.1%; p = 0.07), but they were significantly different after 12 months (54.5 vs. 31.8%; p = 0.026) and 18 months (77.2 vs. 56.8%; p = 0.034). Complete molecular responses were observed in 5 patients with low and 17 patients with high hOCT1 mRNA (p = 0.003). The 5-year event-free and overall survival analyses revealed no significant differences between the groups. These data imply that knowledge of the pretherapeutic level of hOCT1 could be a useful marker to predict IM therapy outcome in treatment-naive CP CML patients. Copyright (C) 2012 S. Karger AG, Basel

Complete Sequence of Broad-Host-Range Plasmid pRIO-5 Harboring the Extended-Spectrum-beta-Lactamase Gene bla(BES-1)

Broad-host-range plasmid pRIO-5, harboring the extended-spectrum beta-lactamase bla(BES-1) gene in Serratia marcescens, was fully sequenced. Analysis of the 12,957-bp sequence of this IncP6-type plasmid revealed that the bla(BES-1) gene was associated with two copies of the insertion sequence IS26. The promoter responsible for the bla(BES-1) expression was hybrid, made of a - 35 box located inside the inverted repeat of IS26 and a - 10 box inside a remnant of an insertion sequence.

Evaluation of Complete Denture Quality and Masticatory Efficiency in Denture Wearers

Purpose: This study aimed to investigate (1) the influence of complete denture quality and years of denture use on masticatory efficiency and (2) the relationship between complete denture quality and years of use. Materials and Methods: A cross-sectional study was conducted with 93 edentulous patients (mean age: 65.6 years) wearing both mandibular and maxillary dentures. Patients were classified into two categories according to years of denture use: <= 2 years and >= 5 years. Masticatory efficiency was evaluated via the colorimetric method with beads as the artificial test food. A reproducible method for objective evaluation of the technical quality of complete dentures was employed. The association between denture quality and years of denture use was analyzed using chi-square and Fisher exact tests. The results of masticatory efficiency testing were analyzed using two-way analysis of variance (with the Tukey post hoc test) in terms of years of denture use <= 2 years, >= 5 years) and denture quality (poor, average, good). Results: A significant relationship was found between denture quality and years of denture use (P < .05). Masticatory efficiency differed significantly (P < .05) between patients with <= 2 years of denture use (0.101 +/- 0.076 absorbance) and >= 5 years of use (0.068 +/- 0.076 absorbance). Masticatory efficiency was not influenced by denture quality. Conclusions: Complete denture quality and masticatory efficiency significantly decreased over time. However, complete denture quality did not influence masticatory efficiency. Int J Prosthodont 2012;25:625-630.

Complete denture wear during sleep in elderly sleep apnea patients-a preliminary study

There is no consensus in the literature about the impact of complete denture wear on obstructive sleep apnea (OSA). The goal of this randomized clinical study was to assess if complete denture wear during sleep interferes with the quality of sleep. Elderly edentulous OSA patients from a complete denture clinic were enrolled and received new complete dentures. An objective sleep analysis was determined with polysomnography performed at the sleep laboratory for all patients who slept either with or without their dentures. Twenty-three patients (74% females) completed the study with a mean age of 69.6 years and a mean body mass index of 26.7 kg/m(2). The apnea and hypopnea index (AHI) was significantly higher when patients slept with dentures compared to without (25.9 +/- 14.8/h vs. 19.9 +/- 10.2/h; p > 0.005). In the mild OSA group, the AHI was significantly higher when patients slept with the dentures (16.6 +/- 6.9 vs. 8.9 +/- 2.4; p < 0.05), while in moderate to severe OSA patients, the AHI was not significantly different when sleeping with dentures (.30.8 +/- 15.6 vs. 25.7 +/- 7.5; p = 0.2). The supine AHI in mild patients was related to a higher increase in AHI while wearing dentures (12.7 +/- 8.4/h vs. 51.9 +/- 28.6/h; p < 0.001). A limitation of the study is that the mild OSA patients had a higher BMI when compared to the moderate to severe OSA patients. Ten out of 14 patients who preferred to sleep with their upper and lower dentures showed an increase in their AHI while wearing dentures to sleep. Contrary to previous studies, we found that OSA patients may experience more apneic events if they sleep with their dentures in place. Specifically, in mild OSAS patients, the use of dentures substantially increases the AHI especially when in the supine position.

Neurogenic neuroprotection: Future perspectives

Neurogenic neuroprotection elicited by deep brain stimulation is emerging as a promising approach for treating patients with ischemic brain lesions. In rats, stimulation of the fastigial nucleus, but not dentate nucleus, has been shown to reduce the volume of focal infarction. Protection of neural tissue is a rapid intervention that has a relatively long-lasting effect, rendering fastigial nucleus stimulation (FNS) a potentially valuable method for clinical application. We review some of the main findings of animal experimental research from a clinical perspective. Results: Although the complete mechanisms of neuroprotection induced by FNS remain unclear, important data has been presented in the last two decades. The acute effect of electrical stimulation of the fastigial nucleus is likely mediated by a prolonged opening of potassium channels, and the sustained effect appears to be linked to inhibition of the apoptotic cascade. A better understanding of the cellular and molecular mechanisms underlying neurogenic neuroprotection by stimulation of deep brain nuclei, with special attention to the fastigial nucleus, can contribute toward improving neurological outcomes in ischemic brain insults.

A cross-over randomised clinical trial of eccentric occlusion in complete dentures

The objective of this study is to compare the effects of canine guidance (CG) and bilateral balanced occlusion (BBO) on denture satisfaction and kinesiographic parameters of complete denture wearers, by means of a cross-over trial. Fifty edentulous patients received new maxillary and mandibular complete dentures. After the intra-oral adjustments and adaptation period, 44 participants were enrolled in the trial and randomly received a sequence of occlusal schemes: BBO followed by CG, or CG followed by BBO. Outcomes were assessed after 30 days of each occlusal scheme. Participants answered a denture satisfaction questionnaire and a kinesiograph instrument recorded mandibular physiologic movements and pattern of maxillary denture movement during chewing. Wilcoxon test and paired sample t-test were used to compare satisfaction levels and kinesiographic data for each occlusal scheme, respectively (a = 0.05). The results showed no differences between occlusal schemes on participants satisfaction and in any of the kinesiographic parameters studied, except for the vertical intrusion of the maxillary complete denture during chewing, which was lower with CG. It can be concluded that the occlusal scheme did not influence on satisfaction and kinesiographic parameters evaluated, as long as volume and resilience of residual edentulous ridges of the participants were normal. Clinical Trial Registration Identifier: NC.T01420536.

Vectorial capacity, basic reproduction number, force of infection and all that: formal notation to complete and adjust their classical concepts and equations

A dimensional analysis of the classical equations related to the dynamics of vector-borne infections is presented. It is provided a formal notation to complete the expressions for the Ross' threshold theorem, the Macdonald's basic reproduction "rate" and sporozoite "rate", Garret-Jones' vectorial capacity and Dietz-Molineaux-Thomas' force of infection. The analysis was intended to provide a formal notation that complete the classical equations proposed by these authors.