A model for the modular evolution of rna addressing open questions on the origin of life

A main unsolved problem in the RNA world scenario for the origin of life is how a template-dependent RNA polymerase ribozyme emerged from short RNA oligomers generated by random polymerization of ribonucleotides (Joyce and Orgel 2006). Current estimates establish a minimum size about 165 nt long for such a ribozyme (Johnston et al. 2001), a length three to four times that of the longest RNA oligomers obtained by random polymerization on clay mineral surfaces (Huang and Ferris 2003, 2006). To overcome this gap, we have developed a stepwise model of ligation-based, modular evolution of RNA (Briones et al. 2009) whose main conceptual steps are summarized in Figure 1. This scenario has two main advantages with respect to previous hypotheses put forward for the origin of the RNA world: i) short RNA....

The effectiveness of corporate Web in small and médiumsized business: an analysis of Web Usability

Internet and the Web have changed the way that companies communicate with their publics, improving relations between them. Also providing substantial benefits for organizations. This has led to small and medium enterprises (SMEs) to develop corporate sites to establish relationships with their audiences. This paper, applying the methodology of content analysis, analyzes the main factors and tools that make the Websites usable and intuitive sites that promote better relations between SMEs and their audiences. Also, it has developed an index to measure the effectiveness of Webs from the perspective of usability. The results indicate that the Websites have, in general, appropriate levels of usability.

De controller als Businesspartner. Hoe beïnvloeden persoonskenmerken de ontwikkeling naar "Partner in Business"binnen de afdeling Financiën bij de provincie Gelderland?

Bij de provincie Gelderland is per 01-01-2009 een reorganisatie doorgevoerd waarbij o.a. de ondersteunende disciplines zoals Financiën zijn samengevoegd binnen één centrale afdeling. Binnen de afdeling Financiën is een team ‘Business control’ gevormd waarin de Financieel adviseurs zijn ondergebracht. Daarbij is vanaf 2009, in verschillende termen en bewoordingen, steeds de ambitie uitgesproken om van de “Financieel expert” naar “Partner in business” te groeien. De ervaring tot dusver laat zien dat deze ambitie in de praktijk moeizaam te realiseren is. Dit onderzoek richt zich op verschillende facetten die samenhangen met bovengenoemde ambitie. Daarbij richt het onderzoek zich vooral op de vraag wat de invloed daarbij is van de persoonskenmerken van de medewerkers. De onderzoeksvraag is: Hoe beïnvloeden de persoonskenmerken de ontwikkeling naar “Partner in Business” bij het team Business control binnen de afdeling Financiën bij de provincie Gelderland? Uit het literatuuronderzoek blijkt dat New Public Management (NPM) een belangrijke externe ontwikkelingen is voor de publieke sector. NPM heeft als doel om publieke organisaties meer resultaatgericht, meer gecoördineerd en efficiënter te laten werken. Bij NPM gaat het o.a. om begrippen als resultaatgerichtheid, output en efficiency. Aangezien de controller het management adviseert bij het efficiënt realiseren van de organisatiedoelstellingen is NPM van invloed op de (rol van) de controller. Een verandering in de rol van de controller is ook het gevolg van de veranderingen in de financiële functie. Uit diverse onderzoeken blijkt dat de controllersfunctie zich ontwikkelt van een administratieve, ten behoeve van het top-management controlerende functie, naar een beslissingsondersteunende functie voor alle geledingen van het management. Conijn et al. (2005) beschrijven de ontwikkeling in de financiële functie aan de hand van een denkmodel met daarin vier fasen met de bijbehorende archetypes Scorekeeper, Financial controller, Managementcontroller en Businesspartner. Naast deze ontwikkelingen zijn ook persoonsgerelateerde factoren van invloed op de rol van een controller binnen een organisatie. Vanuit de organisatiepsychologie worden de persoonlijke eigenschappen van mensen dikwijls in vijf verschillende dimensies gevat, ook wel ‘the big five’ genoemd. Het big five factor model gaat ervan uit dat elk persoon in meer of mindere mate de volgende vijf persoonlijke dimensies heeft: Extraversie, Meegaandheid, Zorgvuldigheid, Openheid en Emotionele stabiliteit. De situatie bij de provincie Gelderland is onderzocht aan de hand van een enquête. De enquête is uitgezet bij de 28 Financieel adviseurs met 17 representatieve respondenten. Hieruit blijkt dat de Financieel adviseurs bij de provincie Gelderland voornamelijk activiteiten verrichten die horen bij de rol van Financial controller en in mindere mate die van respectievelijk Managementcontroller, Businesspartner en Scorekeeper. Daarbij beschikken de Managementcontrollers en de Businesspartners meer over de persoonskenmerken Extraversie, Openheid en Emotionele stabiliteit dan de Scorekeepers en Financial controllers. De Scorekeepers beschikken juist het minst over deze drie persoonskenmerken ten opzichte van de andere drie typen controllers. Voor wat betreft de persoonskenmerken Zorgvuldigheid en Meegaandheid laten de resultaten van de enquête geen eenduidig beeld zien in de relatie tot de typen controllers die de Financieel adviseurs vervullen. Op basis van dit onderzoek en met inachtneming van het aantal van 17 respondenten bij de enquête, lijkt er een relatie te zijn tussen de persoonskenmerken van controllers en de rol die zij als controller vervullen. De rol van Businesspartner vraagt blijkbaar om een hoge mate van Extraversie, Openheid en Emotionele stabiliteit. Voor de provincie Gelderland betekent dit concreet dat bij de gewenste ontwikkeling van Financieel expert naar Partner in business rekening gehouden moet worden met de persoonskenmerken van de Financieel adviseurs. Hierdoor kan er een goede aansluiting tot stand worden gebracht tussen de controller als persoon en zijn/haar controllersrol binnen de organisatie. Kortom; de juiste persoon op de juiste plaats.

Welke 'acteur' neemt de controllerrol als extraverte business partner?

Which 'actor' takes the management accountant role as an extravert business partner? Does a relation between the personal trait Extraversion and fulfilling a management accountant role as a business partner exist? Open Universiteit Nederland End thesis MSc Management, Accounting & Finance Support 1: Prof. dr. A.C.N. van de Ven RA Support 2: dr. P.C.M. Claes Examinator: dr. P. Kamminga Date of approval: September 3, 2014 student: P.R. van der Wal (studentnumber 839104017 email petervanderwal2003@yahoo.com The main question of this research is: Does a relation between the personal trait Extraversion and fulfilling a management accountant role as a business partner exist? This research is based on the dataset obtained by the controller survey 2013, executed in commission of the 'Open Universiteit' (Bork & van der Wal, 2014). From the literature review it is clear: among other management accountant roles we need business partners. And there is a relation between the personal trait Extraversion and fulfilling the role as business partner. At the same time a lack of necessary personal traits for this role has been noticed, among which is Extraversion. The factor- and cluster analyses reported by Bork & van der Wal (2014) resulted in the identification of two types of management accountant roles. In this extended research TYPE II is identified as a business partner because (s)he practices activity-combinations which are related to strategy, analyzing, supporting management in decision making, advisory, change-agency and representing the organization. 36% of the population of Dutch management accountants with a master degree (or similar) meet with the role of the business partner. Although the fulfillment of the role (TYPE II) is not purely business partnering. E.g. reporting and scorekeeping are still activities executed by TYPE II and it is not clear to what extent. Apart from that, role TYPE I executes change management and risk-management activities, which are (according to the definition) activities that belong to the business partner. The role as business partner is practiced but not that optimal as defined in theory. The logistic regression analyses on the survey-data show that Extraversion among three other triggers is significant for the prediction of the fulfillment of the management accountant role (Bork & van der Wal, 2014). A more extravert personal trait predicts a preference for TYPE II, which relates to the business partner. This 'in depth research' concentrated on the relation between the Big Five personal traits and the six activity-combinations (factors) instead of on the two clusters (I and II). The statistic analyses confirm the predicting influence of Extraversion on the business partner role. Although, except for one factor, no extra significance has been found in this additional research. The essential question can be confirmed positively: the management accountant role business partner exists in practice, some management accountants are more extravert then others, and there is a positive relation between extraversion and fulfilling the business partner role. Some formulated research limitations are related to the statistical weakness of some prediction outcomes and to interpretation differences that might occur. Further research can e.g. concentrate on the other personal traits and the significance for role-differentiation in education programs. The management accountant survey 2013 Management accountant roles in 2013 in the Netherlands Open Universiteit Nederland End thesis MSc Management, Accounting & Finance Support 1: Prof. dr. A.C.N. van de Ven RA Support 2: dr. P.C.M. Claes Examinator: dr. P. Kamminga Date of approval: September 3, 2014 student: P.R. van der Wal and H.J. Bork studentnumber: 839104017 and 838532340) email: petervanderwal2003@yahoo.com and hjbork@hotmail.com This paper describes the conceptual model and results of the 'management accountants survey 2013'. The survey is part of a longitudinal survey, earlier executed in 2004, 2007 and 2010 under responsibility of the 'Open Universiteit Nederland'. Secondly the dataset of this survey will be used by us to do our own analyses on the predicting value of the triggers 'personality factor: extraversion' and 'lever of control: interactive controls' on the management accounting role that comes close to a role defined as 'Business Partner'. Scientific research shows that there are different management accounting roles, and that these roles change and that preferences exist for certain roles (Verstegen B. , Loo, Mol, Slagter, & Geerkens, 2007). The main question that will be answered in this paper is which coherent combinations of activities are being executed by management accountants in 2013 in the Netherlands by master-graduates? And secondly which triggers of management accountants' activities predict to which cluster a management accountant belongs? The conceptual model of this research has been developed in 2004 (Verstegen B. , Loo, Mol, Slagter, & Geerkens, 2007). For this research the same 37 activities as in the former researches are included (appendix 1). In the trigger-set (appendix 1) some adaptations have been made for reasons of restricting the length of the survey and to pinpoint on particular research goals (e.g. personality and levers of control). The coherent combinations of activities were found by a factor-analysis and the groups of controllers by a cluster analysis. A regression analysis shows which trigger-items are most significant. The survey has been sent to 2.353 students that finished a controller-study on a Dutch University. There was a 9% (211) response with a completely filled survey. 137 of which indicated to work in a controller-function at the moment. These controllers have been included in the results. The factor-analysis results in six different coherent combinations of activities (factors). Shortly these factors are: advising top management on strategic level with result-effecting information (1), organizing internal reporting (2) organizing and representing the organization on external reporting (3), advising and managing changes by shortcomings in processes and control systems (4), maintaining and managing administrative organization- , information- and control systems (5) and organizing/executing risk management and internal audit (6). Factors 4, 5 and 6 are clustered in cluster TYPE I (125 controllers) and factors 1, 2 and 3 in cluster TYPE II (69 controllers). TYPE II can be associated with the management accountant role 'Business Partner', although the accountant keeps partly active in a scorekeeper role. The four most significant triggers for predicting being a TYPE II controller are 'Executing a risk-management task in order to meet compliance standards' (1), extraversion (2), company size in terms of fte (3) and gender (4).

Methods, Models & Systems for Dealing with Some Business, Management & Engineering Problems

This keynote presentation will report some of our research work and experience on the development and applications of relevant methods, models, systems and simulation techniques in support of different types and various levels of decision making for business, management and engineering. In particular, the following topics will be covered. Modelling, multi-agent-based simulation and analysis of the allocation management of carbon dioxide emission permits in China (Nanfeng Liu & Shuliang Li Agent-based simulation of the dynamic evolution of enterprise carbon assets (Yin Zeng & Shuliang Li) A framework & system for extracting and representing project knowledge contexts using topic models and dynamic knowledge maps: a big data perspective (Jin Xu, Zheng Li, Shuliang Li & Yanyan Zhang) Open innovation: intelligent model, social media & complex adaptive system simulation (Shuliang Li & Jim Zheng Li) A framework, model and software prototype for modelling and simulation for deshopping behaviour and how companies respond (Shawkat Rahman & Shuliang Li) Integrating multiple agents, simulation, knowledge bases and fuzzy logic for international marketing decision making (Shuliang Li & Jim Zheng Li) A Web-based hybrid intelligent system for combined conventional, digital, mobile, social media and mobile marketing strategy formulation (Shuliang Li & Jim Zheng Li) A hybrid intelligent model for Web & social media dynamics, and evolutionary and adaptive branding (Shuliang Li) A hybrid paradigm for modelling, simulation and analysis of brand virality in social media (Shuliang Li & Jim Zheng Li) Network configuration management: attack paradigms and architectures for computer network survivability (Tero Karvinen & Shuliang Li)

A MODEL FOR EVALUATING IMPACT OF BUSINESS PROCESS MANAGEMENT IN ORGANIZATIONAL PERFORMANCE

Business Process Management (BPM) is able to organize and frame a company focusing in the improvement or assurance of performance in order to gain competitive advantage. Although it is believed that BPM improves various aspects of organizational performance, there has been a lack of empirical evidence about this. The present study has the purpose to develop a model to show the impact of business process management in organizational performance. To accomplish that, the theoretical basis required to know the elements that configurate BPM and the measures that can evaluate the BPM success on organizational performance is built through a systematic literature review (SLR). Then, a research model is proposed according to SLR results. Empirical data will be collected from a survey of  larg and mid-sized industrial and service companies headquartered in Brazil. A quantitative analysis will be performed using structural equation modeling (SEM) to show if the direct effects among BPM and organizational performance can be considered statistically significant. At the end will discuss these results and their managerial and cientific implications.Keywords: Business process management (BPM). Organizational performance. Firm performance. Business models. Structural Equation Modeling. Systematic Literature Review.

Conceptual Reference Model for Virtual Factory: Potentials for Collaborative Business

Part 11: Reference and Conceptual Models

Credit spreads and monetary policy in a small open economy: an analysis of the colombian economy

This paper estimates Bejarano and Charry (2014)’s small open economy with financial frictions model for the Colombian economy using Bayesian estimation techniques. Additionally, I compute the welfare gains of implementing an optimal response to credit spreads into an augmented Taylor rule. The main result is that a reaction to credit spreads does not imply significant welfare gains unless the economic disturbances increases its volatility, like the disruption implied by a financial crisis. Otherwise its impact over the macroeconomic variables is null.

Contemplating Open Source Enterprise Systems

Until recently, integration of enterprise systems has been supported largely by monolithic architectures. From a technical perspective, this approach has been challenged by the suggestion of component-based enterprise systems. Lately, the nature of software as proprietary item has been questioned through the increased use of open source software in business computing in general. This suggests the potential for altered technological and commercial constellations for the design of enterprise systems, which are presented in four scenarios. © Springer-Verlag 2004.