A two-step mechanism for epigenetic specification of centromere identity and function

The basic determinant of chromosome inheritance, the centromere, is specified in many eukaryotes by an epigenetic mark. Using gene targeting in human cells and fission yeast, chromatin containing the centromere-specific histone H3 variant CENP-A is demonstrated to be the epigenetic mark that acts through a two-step mechanism to identify, maintain and propagate centromere function indefinitely. Initially, centromere position is replicated and maintained by chromatin assembled with the centromere-targeting domain (CATD) of CENP-A substituted into H3. Subsequently, nucleation of kinetochore assembly onto CATD-containing chromatin is shown to require either the amino- or carboxy-terminal tail of CENP-A for recruitment of inner kinetochore proteins, including stabilizing CENP-B binding to human centromeres or direct recruitment of CENP-C, respectively.

The leopard's claw : a thrilling story of love and adventure from a European castle through the West African jungle, disclosing a deep insight into the quality and spiritual influence of African social institutions and conditions, and revealing a profound psyschic [sic] interpretation of African inner life, all clustered about the mysterious function and significance of the leopard's claw /

Mode of access: Internet.

Estimating costs for water treatment as a function of size and treatment efficiency /

Mode of access: Internet.

Visual function studies during exposure to a mixture of diabasic esters (DBE) in Long-Evans rats : cooperative research and development agreement with E.I. Du Pont de Nemours & Company.

Mode of access: Internet.

Mental fatigue during continuous exercise of a single function /

Also published as thesis (Ph.D.) Columbia university, 1918.

Analysis and forecast of truck traffic loads and the relative damage to pavement systems as a function of axle configurations. Final report.

Texas State Department of Highways and Public Transportation, Transportation Planning Division, Austin

Driver's visibility requirements for roadway delineation. Vol. II: color identification of yellow highway paint as a function of yellow/white pigment mixture ratio. Final report.

Federal Highway Administration, Washington, D.C.

Using an outflow meter to predict braking traction speed gradients as a function of surface tension. Technical report.

Mode of access: Internet.

Traffic controls for construction and maintenance work zones. Volume I - office function.

Federal Highway Administration, Washington, D.C.

Traffic controls for construction and maintenance work zones. Volume II - field function.

Federal Highway Administration, Washington, D.C.

Alcohol, Drug Abuse, and Mental Health Administration public advisory committees : authority, structure, function, members.

Mode of access: Internet.

Special purpose processors for radio aids and function generation in aircraft simulators /

Thesis (M. S.)--University of Illinois at Urbana-Champaign.

A linear programming code to determine whether a Boolean function is a threshold function,

Bibliography: p. 14.

Exposition of Tison's method to derive all prime implicants and all irredundant disjunctive forms for a given switching function /

"October 1979."

Three particle effects in the pair distribution function for He [superscript 4] gas,

"Supported in part by the Atomic Energy Commission."