La perception subjective de l'effet des neuroleptiques chez des patients schizophrènes ambulatoires: une étude transversale [Subjective perception of the effect of neuroleptics by outpatient schizophrenic patients: a cross-sectional study].

Subjective response to neuroleptics is essential to long term observance of treatment and quality of life of patients. Numerous factors (pharmacological, relational and psychopathological) are responsible of this subjective response. Objectives of this study are: (a) to examine psychometric features of the french version of the Drug Attitude Inventory (DAI-30) [13] and (b) to explore pharmacological, relational and psychopathological factors related to this subjective response. Subjects and methods: 78 subjects were rated (self rated response rate 61% (n = 48)) for (a) subjective response to neuroleptics, (b) compliance, (c) therapeutic alliance, (d) symptoms (e) severity of disorder. RESULTS: Factor analysis yielded 2 main clinically relevant factors, similar to the original version: (I) global subjective response and (II) specific subjective response. Internal consistency is high. Correspondance analysis showed two important dimensions in the treatment of schizophrenic patients: (I) Recovery--aggravation, (II) Therapeutic ambition--positive or negative symptoms. CONCLUSION: French version of DAI-30 seems to have a similar structure and psychometric features as the original version. It shows concordance with the degree of compliance. Pharmacological factors are not the only factors implicated in subjective response, but are still to be identified. Limitations of our study are: (a) nonhomogenous indication for treatment, (b) small rate and degree of non compliance in our sample. Relationships between therapeutic ambition, type of symptoms and treatment outcome should be further studied.

Equilibrium of the simultaneous etherification ofisobutene and isoamylenes with ethanol inliquid-phase

The simultaneous etherification of isobutene and isoamylenes with ethanol has been studied using macroreticu-lar acid ion-exchange resins as catalyst. Most of the experiments were carried out over Amberlyst-35. In addition,Amberlyst-15 and Purolite CT-275 were also tested. Chemical equilibrium of four chemical reactions was studied:ethyl tert-butyl ether formation, tert-amyl ethyl ether formation from isoamylenes (2-methyl-1-butene and 2-methyl-2-butene) and isomerization reaction between both isoamylenes. Equilibrium data were obtained in a batchwisestirred tank reactor operated at 2.0 MPa and within the temperature range from 323 to 353 K. Experimental molarstandard enthalpy and entropy changes of reaction were determined for each reaction. From these data, the molarenthalpy change of formation of ethyl tert-butyl ether and tert-amyl ethyl ether were estimated. Besides, the chemical equilibrium between both diisobutene dimers, 2,4,4-trimethyl-1-pentene and 2,4,4-trimethyl-2-pentene, wasevaluated. A good agreement between thermodynamic results for the simultaneous etherification carried out in thiswork and those obtained for the isolated ethyl tert-butyl ether and tert-amyl ethyl ether systems was obtained.

Breviarium Suessionense.

F. 1 et 2 et 21-22 Oraisons du sanctoral. F. 3 Hymnaire. F. 13 Calendrier de Soissons (avec additions). F. 19 et 20 Oraisons du temporal. F. 23-68v Psautier avec cantiques et litanies (nombreuses additions). F. 69 Temporal. F. 200 Dédicace. F. 204-292 et 304-323 Sanctoral : — Translat. des reliques (304) ; — s. Drausin (315) ; — Onze mille vierges (323). F. 293 Commun des saints. F. 301v Office des morts.

Stereotypes of Age Differences in Personality Traits: Universal and Accurate?

Age trajectories for personality traits are known to be similar across cultures. To address whether stereotypes of age groups reflect these age-related changes in personality, we asked participants in 26 countries (N = 3,323) to rate typical adolescents, adults, and old persons in their own country. Raters across nations tended to share similar beliefs about different age groups; adolescents were seen as impulsive, rebellious, undisciplined, preferring excitement and novelty, whereas old people were consistently considered lower on impulsivity, activity, antagonism, and Openness. These consensual age group stereotypes correlated strongly with published age differences on the five major dimensions of personality and most of 30 specific traits, using as criteria of accuracy both self-reports and observer ratings, different survey methodologies, and data from up to 50 nations. However, personal stereotypes were considerably less accurate, and consensual stereotypes tended to exaggerate differences across age groups.

L'étincelle électrique (2e édition revue et augmentée) / par A. Cazin

Collection : Bibliothèque des merveilles

Langattoman Internet-puhelupalvelun tarjoaminen

Langattomalla Internetpuhelupalvelulla tarkoitetaan Internet-puheluiden (Voice over Internet Protocol, VoIP) siirtoa langattoman tiedonsiirtoverkon ylitse. Tälläisia langattomia verkkoja voivat olla esimerkiksi langattomat lähiverkot, WiMAX-verkot tai 450 megahertsin (MHz) taajuusalueella toimivat tiedonsiirtoverkot. VoIP-yhteyden toiminta voidaan jakaa kolmeen eri toiminta-alueeseen: yhteydenmuodostusprotokollaan, äänen koodaukseen sekä siirtotiehen. Yhteydenmuodostusprotokollia ovat esimerkiksi SIP (Session Initiation Protocol) sekä H.323. Yhteydenmuodostusprotokollantehtävänä on muodostaa yhteys käyttäjien välille sekä sopia yhteydessäkäytettävistä ominaisuuksista. Äänen koodauksessa ääni pakataan paketteihin, joita lähetetään siirtotietä pitkin eri käyttäjien välillä. Normaalissa Internetpuheluyhteydessä siirtotienä käytetään langallisia siirtoteitä. Tässä työssä on keskitytty langattomiin siirtoteihin ja niidentuomiin haasteisiin, kuten yhteyden luotettavuuteen ja laatuun, yhteyskapasiteetin riittävyyteen sekä siirtymiseen saman verkon eri tukiasemien sekä eri verkkojen välillä. Työssä rakennettiin yksinkertainen, mutta toimiva langaton Internetpuhelujärjestelmä sekä verrattiin sen ominaisuuksia normaaliin Internetpuhelujärjestelmään. Järjestelmää koekäytettiin oikeassa toimintatilanteessa varsinaisen puhelinjärjestelmän rinnalla tavallisessa toimistoympäristössä. Testaustulosten ja käyttäjäkokemusten perusteella on periaatteessa mahdollista rakentaa yksinkertainen langaton Internetpuhelujärjestelmä ja käyttää sitä puhelupalveluiden tarjoamiseen. Palvelun tarjoaminen vaatii kuitenkin vielä tiettyjen viestintäviraston määräysten täyttämistä ennen tuotantokäyttöön ottamista.

Transfusion practice in early trauma management

Introduction: Blood transfusions carry risks and complications. At the University Hospital of Lausanne the need for transfusion in early trauma resuscitation is based on clinical judgment and standard laboratory tests. We aimed to assess the transfusion practice for trauma patients during their early management. Method: Based on 2008 data from the Lausanne Trauma Registry of Acute Care (TRAC), we analyzed all adult trauma patients admitted to the shock room who received blood products or pro-coagulants in shock room and/or during their emergency operation. Demographics, physiological parameters and lab tests were recorded at arrival and at the end of anesthesiologic management. Coagulopathy was defined as PT <70%, PTT >60 sec, Fibrinogen <1 g/l or Thrombocytes <100 x 109 g/l. Results: In 2008, 323 trauma-patients were included in TRAC. 55 patients (17%) received blood products or pro-coagulants. 44 (83%) had an ISS >15 (med 29, IQR 10-35.5). 43 (78.2%) needed an emergency intervention. Coagulopathy was present in 25 patients (45.5%) at arrival vs. 30 (54.5%) after resuscitation (p = 0.446).

Las “nuevas guerras” del siglo XXI. Tendencias de la conflictividad armada contemporánea

El paper analiza los cambios y las continuidades en los conflictos armados de alta intensidad, las guerras, en el siglo XXI, también llamadas “nuevas guerras”. Se propone un patrón de análisis en torno a diez variables: el número de conflictos, el nivel de intensidad, las víctimas que producen, el contexto espacial en que se desarrollan, las causas que los ocasionan y los objetivos que persiguen las partes, las tácticas e instrumentos de combate utilizados, la economía de los conflictos, las pautas regionales y la relación entre conflictividad armada de alta intensidad y seguridad. Se defiende que las trasformaciones experimentadas en la pauta de conflictividad armada no han conducido a un mundo más seguro sino que, al contrario, han exacerbado la dificultad de gestión de los conflictos debido a la mayor complejidad de los mismos, tanto por la multicausalidad de las incompatibilidades y el carácter estructural de muchas de ellas, como por el mayor número de actores y sobre todo por su diversidad, vinculado al hecho de que las normas e instituciones tradicionales de gestión de conflictos están pensadas para un tipo de conflictividad –la interestatal– en clara regresión, mientras que seguimos sin disponer de instrumentos normativos vinculantes adaptados a las nuevas necesidades, y los que existen no son aceptados por todos los Estados ni siquiera por todas las grandes potencias del sistema interestatal.

Dépendances [Addiction].

The news in addiction medicine for 2011 include new knowledges coming from the neurosciences, but also new clinical concepts, as the role of hospital addiction units in an integrated network of care. The issue of cocaine vaccination is discussed from an ethical point of view. Finally, the integration of mindfulness techniques is introduced as a useful approach in the treatment of the addictions.

Reexamination of the relationship of resting metabolic rate to fat-free mass and to the metabolically active components of fat-free mass in humans.

The ratio of resting metabolic rate (RMR) to fat-free mass (FFM) is often used to compare individuals of different body sizes. Because RMR has not been well described over the full range of FFM, a literature review was conducted among groups with a wide range of FFM. It included 31 data sets comprising a total of 1111 subjects: 118 infants and preschoolers, 323 adolescents, and 670 adults; FFM ranged from 2.8 to 106 kg. The relationship of RMR to FFM was found to be nonlinear and average slopes of the regression equations of the three groups differed significantly (P less than 0.0001). For only the youngest group did the intercept approach zero. The lower slopes of RMR on FFM, at higher measures of FFM, corresponded to relatively greater proportions of less metabolically active muscle mass and to lesser proportions of more metabolically active nonmuscle organ mass. Because the contribution of FFM to RMR is not constant, an arithmetic error is introduced when the ratio of RMR to FFM is used. Hence, alternative methods should be used to compare individuals with markedly different FFM.

Conflict-based Method for Conceptual Process Synthesis

The changing business environment demands that chemical industrial processes be designed such that they enable the attainment of multi-objective requirements and the enhancement of innovativedesign activities. The requirements and key issues for conceptual process synthesis have changed and are no longer those of conventional process design; there is an increased emphasis on innovative research to develop new concepts, novel techniques and processes. A central issue, how to enhance the creativity of the design process, requires further research into methodologies. The thesis presentsa conflict-based methodology for conceptual process synthesis. The motivation of the work is to support decision-making in design and synthesis and to enhance the creativity of design activities. It deals with the multi-objective requirements and combinatorially complex nature of process synthesis. The work is carriedout based on a new concept and design paradigm adapted from Theory of InventiveProblem Solving methodology (TRIZ). TRIZ is claimed to be a `systematic creativity' framework thanks to its knowledge based and evolutionary-directed nature. The conflict concept, when applied to process synthesis, throws new lights on design problems and activities. The conflict model is proposed as a way of describing design problems and handling design information. The design tasks are represented as groups of conflicts and conflict table is built as the design tool. The general design paradigm is formulated to handle conflicts in both the early and detailed design stages. The methodology developed reflects the conflict nature of process design and synthesis. The method is implemented and verified through case studies of distillation system design, reactor/separator network design and waste minimization. Handling the various levels of conflicts evolve possible design alternatives in a systematic procedure which consists of establishing an efficient and compact solution space for the detailed design stage. The approach also provides the information to bridge the gap between the application of qualitative knowledge in the early stage and quantitative techniques in the detailed design stage. Enhancement of creativity is realized through the better understanding of the design problems gained from the conflict concept and in the improvement in engineering design practice via the systematic nature of the approach.

Las monedas con nombres de étnicos del s. II a.C. en el nordeste peninsular: ¿Reflejo de posibles circunscripciones? ¿Civitates con doble nombre?

En el s. II a.C. se emiten en el nordeste de Hispania monedas con el nombre de étnicos conocidos por las fuentes escritas. Se plantea el problema de si responden a una organización territorial en circunscripciones que, curiosamente, correponden con las regiones principales populi que cita Plinio. Por otro lado estas cecas podrían corresponder a localidades que pudieran tener otro nombre.

La repercusión del régimen constitucional en la Iglesia de Lleida durante el trienio liberal

A principios del año 1820 la revolución de Rafael de Riego instauró el régimen liberal en España. La Iglesia de Lleida se adaptó correctamente al nuevo modelo político. Pero la obra legislativa de las Cortes liberales perjudicó gravemente a todas las estructuras políticas, económicas y sociales de la institución eclesiástica. Con la radicalización del gobierno liberal se produjo la ruptura de las relaciones de los con el Ayuntamiento de Lleida, quiénes al poco tiempo sufrieron la persecución y la represión de las autoridades liberales. Por tanto, el balance del período liberal fue muy negativo y su impacto enorme.