Cohesive law estimation of adhesive joints in mode II condition

The adhesive bonding technique enables both weight and complexity reduction in structures that require some joining technique to be used on account of fabrication/component shape issues. Because of this, adhesive bonding is also one of the main repair methods for metal and composite structures by the strap and scarf configurations. The availability of strength prediction techniques for adhesive joints is essential for their generalized application and it can rely on different approaches, such as mechanics of materials, conventional fracture mechanics or damage mechanics. These two last techniques depend on the measurement of the fracture toughness (GC) of materials. Within the framework of damage mechanics, a valid option is the use of Cohesive Zone Modelling (CZM) coupled with Finite Element (FE) analyses. In this work, CZM laws for adhesive joints considering three adhesives with varying ductility were estimated. The End-Notched Flexure (ENF) test geometry was selected based on overall test simplicity and results accuracy. The adhesives Araldite® AV138, Araldite® 2015 and Sikaforce® 7752 were studied between high-strength aluminium adherends. Estimation of the CZM laws was carried out by an inverse methodology based on a curve fitting procedure, which enabled a precise estimation of the adhesive joints’ behaviour. The work allowed to conclude that a unique set of shear fracture toughness (GIIC) and shear cohesive strength (ts0) exists for each specimen that accurately reproduces the adhesive layer’ behaviour. With this information, the accurate strength prediction of adhesive joints in shear is made possible by CZM.

Leprosy control: perspectives & epidemiological and operational aspects

OBJECTIVES: As a starting point, a vast variety of 200 technical papers and documents published during the ten years 1999-2008, from Brazilian and international organizations dedicated to the control of leprosy, was taken. A study was then undertaken to investigate its future evolutive possibilities by employing resources obtained from scenario analyses. DESIGN: The methodological reconstruction in use was of a qualitative nature, based on a bibliographic review and content analysis techniques. The latter were employed in a documental, categorical, contingent, frequency-based format, in compliance with appropriate and pertinent conditions. RESULTS: Nowadays, important elements on epidemiological and operational aspects have been regained, as well as respective perspectives. CONCLUSIONS: A projection is made towards the fact that the maintenance of the disease's present incidence levels constitute economic and sanitary challenges that confront issues ranging from the neoliberal model of global societal organization to specific competences of actions taken by health teams in the field.

Otimização da operação de picking em armazéns

A Logística, vista como uma perspetiva integradora entre os parceiros de negócio, com objetivos comuns de proporcionar ao cliente mais-valias e aspetos diferenciadores perante os outros concorrentes, contribui em muito na manutenção das empresas na globalização atual, que se torna cada vez mais flexível. Através de uma boa gestão de processos críticos de negócio, boa localização dos materiais, sejam eles quais forem, produtos finais, matérias-primas ou produtos em vias de fabrico e através do transporte a logística cria utilidade temporal e diferenciadora. De facto, a logística poderá assumir um papel fundamental em proporcionar valor acrescentado ao disponibilizar, a tempo, os serviços que os clientes necessitam ou esperam. Enquadrando-se na temática de gestão dos armazéns, o presente projeto consistiu no estudo de operações de picking com a finalidade de otimização dos processos de picking no armazém do operador logístico AR – Serviços de Logística, localizado em Ribeirão, Vila Nova de Famalicão. O trabalho inicial passou pelo levantamento do funcionamento das operações do processo de picking na empresa e posteriormente confrontá-los com as tecnologias e procedimentos atuais no mercado. Com base nos resultados obtidos, foi possível definir e implementar métricas enquadradas nas finalidades estratégicas e operacionais do operador logístico. As soluções passaram também pela melhoria da aplicação de gestão de armazéns (WMS), reavaliação dos indicadores previamente estabelecidos e na aquisição de equipamentos para automatização das operações picking e localizações. Os registos e informações relacionadas com os módulos fulcrais são armazenados e tratados na base de dados de suporte à aplicação com contributo de melhoria contínua aos procedimentos logístico da empresa e sua relação com os stakeholders na estratégia global de negócio com o operador logístico. Finalmente, foi possível analisar os resultados obtidos em modo real em relação as estimativas calculadas e definidas na fase de implementação e desenvolvimento.

Design of switched-capacitor filters using low gain amplifiers

Dissertação para obtenção do Grau de Mestre em Engenharia Electrotécnica e de Computadores

Análise da Qualidade de Energia em Instalações Eléctricas com MiniProdução

Com a alteração da legislação energética em Portugal, nomeadamente a implementação da legislação de Micro e Minigeração, a produção distribuída cresceu de forma exponencial na rede elétrica nacional, diminuindo por um lado as perdas no transporte e distribuição, e por outro aumentando a complexidade na gestão do trânsito de potência ao Distribuidor. No entanto a motivação desta dissertação prende-se com o facto de que as centrais de produção distribuída, em particular as de tecnologia fotovoltaica, pela sua dimensão, serem instaladas nos pontos de consumo, em paralelo com a instalação elétrica de utilização do cliente e como tal, têm sido verificadas diversas anomalias no funcionamento e exploração das mesmas, por influência da má qualidade de energia resultante das más condições de funcionamento e exploração em que se encontram as instalações de consumo. A presente dissertação pretende apresentar uma descrição das anomalias mais frequentes verificadas nas centrais fotovoltaicas de minigeração com origem na qualidade da energia que transita das instalações elétricas de consumo ligadas ao mesmo ponto de interligação com a rede elétrica nacional. Como base de fundamento, foram demonstradas através de três casos práticos reais, algumas das mais frequentes e prejudiciais anomalias descritas na presente dissertação. Foram escolhidos 3 casos reais com diferentes tipos de instalação de consumo sendo que um deles não apresenta qualquer anomalia de forma a comprovar o bom funcionamento em condições normais de ambas as instalações. Foram encontradas e demonstradas várias soluções paras os diferentes tipos de anomalias, no entanto esta dissertação vai permitir não só a resolução deste tipo de anomalias em centrais fotovoltaicas em exploração e já com prejuízos avultados mas também introduzir em futuras instalações a análise da qualidade da energia nas instalações de consumo em fase preliminar de estudo de implementação de centrais fotovoltaicas de minigeração e de autoconsumo, precavendo futuros problemas de rentabilidade técnico-económica. Este estudo, irá certamente servir de motor de impulsão para a preocupação com a Qualidade da Energia essencialmente dentro das instalações elétricas de consumo sensibilizando os seus gestores energéticos. Poderá ainda impulsionar a reformulação do Regulamento de Qualidade de Serviço para exigências ainda mais apertadas de forma a incorporar algumas das anomalias aqui descritas, sendo por isso um elemento de alerta para todos os “Players” do Sistema Elétrico Nacional tendo como limite a melhoria continua da Segurança e da Qualidade da energia na rede elétrica beneficiando da sensibilização de todos os intervenientes.

Pipelined analog-to-digital conversion using current-mode reference shifting

Dissertação para obtenção do grau de Mestre em Engenharia Electrotécnica e de Computadores

Design and implementation of 3D buildings integration for a Webgl-Based Virtual Globe: a case study of Valencian Cadastre and Fide Building Mode

Dissertation submitted in partial fulfillment of the requirements for the Degree of Master of Science in Geospatial Technologies.

The significance of Traveler's Route Knowledge for Choice of commuting mode of transport

Dissertation submitted in partial fulfillment of the requirements for the Degree of Master of Science in Geospatial Technologies.

Crystal structure of the zinc-, cobalt-, and iron-containing adenylate kinase from Desulfovibrio gigas: a novel metal-containing adenylate kinase from Gram-negative bacteria

J Biol Inorg Chem (2011) 16:51–61 DOI 10.1007/s00775-010-0700-8

Multiple Mechanical Complications in ST-Segment Elevation Myocardial Infarction with Angiographically Normal Coronary Arteries

This case report discusses an unusual presentation of ST-segment elevation myocardial infarction (STEMI) with normal coronary arteries and severe mechanical complications successfully treated with surgery. An 82-year-old man presented STEMI with angiographically normal coronary arteries and no major echocardiographic alterations at discharge. At the first month follow-up, he complained of fatigue and dyspnea, and contrast echocardiography complemented by cardiac magnetic resonance imaging revealed a large left ventricular apical aneurysm with a thrombus communicating by two jets of a turbulent flow to an aneurysmatic formation of the right ventricular apex. The patient underwent a Dor procedure, which was successful. Ventricular septal defects and ventricular aneurysms are rare but devastating complications of STEMI, with almost all patients presenting multivessel coronary artery disease. Interestingly in this case, the angiographic pattern was normal.

The effect of demand information sharing in a supply chain under demand uncertainty: a simulation study

Dissertação para obtenção do Grau de Mestre em Engenharia e Gestão Industrial

Disruption of Urate Transport in Familial Renal Glucosuria and Report on SGLT2 Expression in Normal and Pathological Kidney

Familial renal glucosuria (FRG) is a rare co -dominantly inherited benign phenotype characterized by the presence of glucose in the urine. It is caused by mutations in the SLC5A2 gene that encodes SGLT2, a Na+ -glucose co -transporter. The purpose of our current work was twofold: to characterize the molecular and phenotype findings of an FRG cohort and, in addition, to detail the SGLT2 expression in the adult human kidney. The phenotype of FRG pedigrees was evaluated using direct sequencing for the identification of sequence variations in the SLC5A2 gene. The expression of SGLT2 in the adult human kidney was studied by immunofluorescence on kidney biopsy specimens. In the absence of renal biopsies from FRG individuals, and in order to evaluate the potential disruption of SGLT2 expression in a glucosuric nephropathy, we have selected cases of nucleoside analogues induced proximal tubular toxicity. We identified six novel SLC5A2 mutations in six FRG pedigrees and described the occurrence of hyperuricosuria associated with hypouricaemia in the two probands with the most severe phenotypes. Histopathological studies proved that SGLT2 is localized to the brush -border of the proximal tubular epithelia cell and that this normal pattern was found to be disrupted in cases of nucleoside analogues induced tubulopathy. We present six novel SLC5A2 mutations, further contributing to the allelic heterogeneity in FRG, and identified hyperuricosuria and hypouricaemia as part of the FRG phenotype. SGLT2 is localized to the brush -border of the proximal tubule in the adult human normal kidney, and aberrant expression of the co -transporter may underlie the glucosuria seen with the use of nucleoside analogues.

Lack of Spontaneous Venous Pulsation: Possible Risk Indicator in Normal Tension Glaucoma?

PURPOSE: Recently, the absence of spontaneous venous pulsation (SVP) has been suggested as a vascular risk factor for primary open-angle glaucoma (POAG). As the mechanism behind this phenomenon is still unknown, the authors have studied this vascular component using colour Doppler imaging (CDI). METHODS: A total of 236 patients were divided into three diagnostic groups: healthy controls (81), POAG (86) and normal tension glaucoma (NTG; 69). All subjects were submitted to CDI studies of the retrobulbar circulation, intraocular pressure measurements and assessment of SVP existence. Mann-Whitney, chi-square contingency tables and Spearman correlations were used to explore differences and correlations between variables in the diagnostic groups. RESULTS: Eighty-two percent of healthy controls had SVP (66/81), while a smaller numbers were registered in both glaucoma groups: POAG - 50% (43/86); NTG - 51% (35/69). In NTG patients, but not in POAG patients, the prevalence of the SVP phenomenon decreases with increased glaucoma damage (p = 0.04; p = 0.55, respectively). Overall glaucoma patients from both groups had lower central retinal vein (CRV) velocities than the healthy controls (p < 0.05). NTG patients with SVP had less severe visual field defects (mean defect -6.92 versus -11.1, p < 0.05), higher [correction added after online publication 21 September 2012; the word 'higher' has been inserted to replace the word 'lower'] peak systolic and mean flow velocities in the central retinal artery (p < 0.01; p < 0.05, respectively) as well as higher [correction added after online publication 21 September 2012; the word higher has been inserted to replace the word lower] maximal velocities and RI of the CRV (p < 0.02; p < 0.05, respectively). CONCLUSIONS: Glaucoma patients have a decrease in CRV velocities. SVP is less prevalent in glaucoma patients than in healthy individuals. This phenomenon apparently reflects different hemodynamic patterns in the central retinal vessels. This variable may be of particular importance in NTG patients, where it may be associated with more advanced functional damage.

Post-Treated Prostate Cancer: Normal Findings and Signs of Local Relapse on Multiparametric Magnetic Resonance Imaging

The use of multiparametric magnetic resonance imaging (mp-MRI) for prostate cancer has increased over recent years, mainly for detection, staging, and active surveillance. However, suspicion of recurrence in the set of biochemical failure is becoming a significant reason for clinicians to request mp-MRI. Radiologists should be able to recognize the normal post-treatment MRI findings. Fibrosis and atrophic remnant seminal vesicles after prostatectomy are often found and must be differentiated from local relapse. Moreover, brachytherapy, external beam radiotherapy, cryosurgery, and hormonal therapy tend to diffusely decrease the signal intensity of the peripheral zone on T2-weighted images (T2WI) due to the loss of water content, consequently mimicking tumor and hemorrhage. The combination of T2WI and functional studies like diffusion-weighted imaging and dynamic contrast-enhanced improves the identification of local relapse. Tumor recurrence tends to restrict on diffusion images and avidly enhances after contrast administration either within or outside the gland. The authors provide a pictorial review of the normal findings and the signs of local tumor relapse after radical prostatectomy, external beam radiotherapy, brachytherapy, cryosurgery, and hormonal therapy.

Verification of analog circuits in power-down mode

Dissertação para obtenção do Grau de Mestre em Engenharia Eletrotécnica e Computadores