Use of indicators to assess the sustainability of housing developments in Australia

Most new housing in Australia is occurring on greenfield sites on the edges of the capital cities. These housing developments are often criticised for their social and environmental unsustainability. These unsustainable suburbs are a legacy for future generations. They will create dire social and environmental problems if a serious economic downturn was to occur or a resource shortage e.g. oil was to make accessibility impossible. Coupled to these threats is that of the social ‘undesirability’ of isolated suburbs where only those on low incomes made their home. Most of those on higher incomes seek established suburbs which have ‘character’, social amenities and ease of access. Typically, these are in older suburbs close to city centres. This paper describes a methodology that has been developed to analyse past and future housing developments. The results of the analysis can provide a guide to improving the sustainability of these suburbs. The methodology uses several criteria to reflect the fact that no single criterion is adequate to describe or analyse the sustainability of a housing development. Sustainability should embrace social and environmental perspectives, so a multi-criteria analysis is appropriate. The theoretical framework for this methodology has been described elsewhere. However, in this previous work only five criteria were considered: energy use, resource use, neighbourhood character, neighbourhood connectedness and social diversity. In each case, high and low sustainability practice has been identified so that ranking is possible. This paper initially summarizes the way in which these previous five criteria are assessed but then adds a sixth criterion (social connectedness) because of a perceived gap in the previous assessment. The results of an analysis of three suburbs reported in the previous work are updated. They score poorly in terms of social connectedness underlining the need to ‘repair’ these suburbs in order to improve their overall sustainability.

The use of Integral Theory to evaluate architectural sustainability - a case study

DeKay’s concept of Integral Sustainable Design (ISD) is based on Integral Theory, a framework proposed by the American philosopher, Ken Wilber. It offers four simultaneous perspectives (represented by quadrants) which each take a different view of the problem. The ‘experiences’ quadrant focuses on individual human experiences. The ‘behaviours’ quadrant looks at environmental performance. The ‘cultures’ perspective focuses on the collective interpretation of meaning, symbolism and worldviews and the ‘systems’ quadrant investigates the response and interaction with context. Integral Theory can act as a reminder for architects of the different perspectives that a sustainable building should address. In order to evaluate ISD, the Waterfront Campus Building of Deakin University has been used as a case study. The building, its performance, impact and perception, has been evaluated using both quantitative and qualitative data. Two surveys have been conducted to gather qualitative data to: (i) determine the experience of building users (staff and students) and (ii) the perception of non-users (Geelong residents and tourists). Data from building services and a site analysis has enabled quantitative assessments to be made. These inputs have been analysed, guided by ISD, to evaluate the usefulness of ISD as a sustainability assessment tool.

Examining the feasibility and tolerability of a clinically informed multisite, repetitive transcranial magnetic stimulation protocol

BACKGROUND: Multi-site repetitive transcranial magnetic stimulation (rTMS) has been applied experimentally in the treatment of obsessive compulsive disorder (OCD). NEW METHOD: This study was conducted to systematically evaluate the safety, tolerability and neurocognitive effects of rTMS applied to three cortical regions over a period of three months. NEW METHOD: Twenty healthy participants aged 22-33 years were randomly allocated to receive one session of active or sham stimulation of low and high frequency rTMS applied sequentially to the pre-supplementary motor area, right-dorsolateral prefrontal cortex and left-orbitofrontal cortex totalling 9min. Tolerability and safety was evaluated using a standardised safety questionnaire. Neurocognitive functioning was examined using the Cambridge Neuropsychological Test Automated Battery and measures of verbal fluency from the Delis-Kaplan Executive Functioning Test™ at five time points over three months. RESULTS: The protocol was safe and tolerable. Frequencies of minor adverse effects were higher in active (17 endorsements) than sham (1 endorsement) conditions. No between group differences in neurocognitive functioning were identified over three months. COMPARISON WITH EXISTING METHOD: This study is the first to evaluate the feasibility of low and high frequency parameters applied sequentially in a single session to the three selected cortical regions whilst providing neurocognitive data. CONCLUSIONS: rTMS applied sequentially over three cortical regions was found to be safe and tolerable in healthy individuals with no major neurocognitive effects over three months. Such findings can be used to inform the development of rTMS protocols involving multi-site stimulation for OCD.

The diagnosis of attention-deficit/hyperactivity disorder in Australian children: current paediatric practice and parent perspective

Aims In a sample of newly diagnosed children with attention-deficit/hyperactivity disorder (ADHD), the aims were to examine (1) paediatrician assessment and management practices; (2) previous assessments and interventions; (3) correspondence between parent-report and paediatrician identification of comorbidities; and (4) parent agreement with diagnosis of ADHD. Methods Design: cross-sectional, multi-site practice audit with questionnaires completed by paediatricians and parents at the point of ADHD diagnosis. Setting: private/public paediatric practices in Western Australia and Victoria, Australia. Main outcome measures: paediatricians: elements of assessment and management were indicated on a study-designed data form. Parents: ADHD symptoms and comorbidities were measured using the Conners 3 ADHD Index and Strengths and Difficulties Questionnaire, respectively. Sleep problems, previous assessments and interventions, and agreement with ADHD diagnosis were measured by questionnaire. Results Twenty-four paediatricians participated, providing data on 137 patients (77% men, mean age 8.1 years). Parent and teacher questionnaires were used in 88% and 85% of assessments, respectively. Medication was prescribed in 75% of cases. Comorbidities were commonly diagnosed (70%); however, the proportion of patients identified by paediatricians with internalising problems (18%), externalising problems (15%) and sleep problems (4%) was less than by parent report (51%, 66% and 39%). One in seven parents did not agree with the diagnosis of ADHD. Conclusions Australian paediatric practice in relation to ADHD assessment is generally consistent with best practice guidelines; however, improvements are needed in relation to the routine use of questionnaires and the identification of comorbidities. A proportion of parents do not agree with the diagnosis of ADHD made by their paediatrician.

N-acetylcysteine (NAC) in schizophrenia resistant to clozapine: a double blind randomised placebo controlled trial targeting negative symptoms

BACKGROUND: Clozapine is an effective treatment for a proportion of people with schizophrenia (SZ) who are resistant to the beneficial effects of other antipsychotic drugs. However, anything from 40-60 % of people on clozapine experience residual symptoms even on adequate doses of the medication, and thus could be considered 'clozapine resistant'. Agents that could work alongside clozapine to improve efficacy whilst not increasing the adverse effect burden are both desired and necessary to improve the lives of individuals with clozapine-resistant SZ. N-Acetylcysteine (NAC) is one such possible agent. Previous research from our research group provided promising pilot data suggesting the efficacy of NAC in this patient population. The aim of the study reported here is to expand this work by conducting a large scale clinical trial of NAC in the treatment of clozapine-resistant SZ.

METHODS: This study is an investigator initiated, multi-site, randomised, placebo-controlled trial. It aims to include 168 patients with clozapine-resistant SZ, divided into an intervention group (NAC) and a control group (placebo). Participants in the intervention group will receive 2 g daily of NAC. The primary outcome measures will be the negative symptom scores of the Positive and Negative Syndrome Scale (PANSS). Secondary outcome measures will include: changes in quality of life (QoL) as measured by the Lancashire Quality of Life Profile (LQoLP) and cognitive functioning as measured by the total score on the MATRICS. Additionally we will examine peripheral and cortical glutathione (GSH) concentrations as process outcomes.

DISCUSSION: This large scale clinical trial will investigate the efficacy of NAC as an adjunctive medication to clozapine. This trial, if successful, will establish a cheap, safe and easy-to-use agent (NAC) as a 'go to' adjunct in patients that are only partly responsive to clozapine.

Real-time Biosensor for the Assessment of Nanotoxicity and Cancer Electrotherapy

Knowledge of cell electronics has led to their integration to medicine either by physically interfacing electronic devices with biological systems or by using electronics for both detection and characterization of biological materials. In this dissertation, an electrical impedance sensor (EIS) was used to measure the electrode surface impedance changes from cell samples of human and environmental toxicity of nanoscale materials in 2D and 3D cell culture models. The impedimetric response of human lung fibroblasts and rainbow trout gill epithelial cells when exposed to various nanomaterials was tested to determine their kinetic effects towards the cells and to demonstrate the biosensor’s ability to monitor nanotoxicity in real-time. Further, the EIS allowed rapid, real-time and multi-sample analysis creating a versatile, noninvasive tool that is able to provide quantitative information with respect to alteration in cellular function. We then extended the application of the unique capabilities of the EIS to do real-time analysis of cancer cell response to externally applied alternating electric fields at different intermediate frequencies and low-intensity. Decreases in the growth profiles of the ovarian and breast cancer cells were observed with the application of 200 and 100 kHz, respectively, indicating specific inhibitory effects on dividing cells in culture in contrast to the non-cancerous HUVECs and mammary epithelial cells. We then sought to enhance the effects of the electric field by altering the cancer cell’s electronegative membrane properties with HER2 antibody functionalized nanoparticles. An Annexin V/EthD-III assay and zeta potential were performed to determine the cell death mechanism indicating apoptosis and a decrease in zeta potential with the incorporation of the nanoparticles. With more negatively charged HER2-AuNPs attached to the cancer cell membrane, the decrease in membrane potential would thus leave the cells more vulnerable to the detrimental effects of the applied electric field due to the decrease in surface charge. Therefore, by altering the cell membrane potential, one could possibly control the fate of the cell. This whole cell-based biosensor will enhance our understanding of the responsiveness of cancer cells to electric field therapy and demonstrate potential therapeutic opportunities for electric field therapy in the treatment of cancer.

The Comparative Effectiveness of EEG Biomarkers in Antidepressant Response and Illness Prediction in Major Depressive Disorder

Thesis (Ph.D, Neuroscience Studies) -- Queen's University, 2016-08-27 00:55:35.782

Predictors of parental involvement activities in sport

The purpose of this research is to examine the utility of a theoretical model to predict parental involvement activities in children’s sport. Participants included 486 parents of young athletes of various sports, subdivided in two studies (n1 = 206, n2 = 280). Confirmatory factor analysis (CFA) conducted in Study 1 supported the proposed measurement model. All factors also show reliability, convergent and discriminant validity. In the Study 2, a structural equation model demonstrated that the parental role beliefs, parental self-efficacy, perceptions of child invitations, selfperceived time and energy, and knowledge and skills predicted parents’ home-based involvement. Perceptions of coach invitations were a significant negative predictor. These same constructs, with the exception of perceptions of knowledge and skills and perceptions of coach invitations, predicted parents’ club-based involvement. Multi-group analysis demonstrated the invariance of the model. Findings suggest that this model offers a useful framework to understand parents’ home and clubbased involvement.

Entrepreneurship: a long way to go

Entrepreneurship education has emerged as one popular research domain in academic fields given its aim at enhancing and developing certain entrepreneurial qualities of undergraduates that change their state of behavior, even their entrepreneurial inclination and finally may result in the formation of new businesses as well as new job opportunities. This study attempts to investigate the Colombian student´s entrepreneurial qualities and the influence of entrepreneurial education during their studies.

ESTUDIO PILOTO SOBRE LA EVALUACIÓN CUALITATIVA DE LOS PROBLEMAS Y PROPUESTAS DE SOLUCIÓN PARA EL USO DEL RECURSO HÍDRICO EN LA SUBCUENCA DEL RÍO VIRILLA

La experiencia en la gestión de cuencas, en particular en su aspecto hídrico-social, indica que el problema surge por causalidad recíproca de distintos factores biológicos y socioeconómicos, ligados a una gestión del desarrollo, que por lo común, no atiende los riesgos que crea. La gestión efectiva de los recursos hídricos y bióticos involucrados suele ignorar el conflicto que. en términos sociales, traen consigo los usos no sustentables. Por tanto, una gestión alternativa exige un enfoque integral, que busque relacionar valores sociales (no  únicamente económicos) con criterios ecológicos y con otros parámetros diversos.La integral idad de la gestión de cuencas depende de que las decisiones estén sujetas tanto a sistemas de planificación territorial, con la perspectiva abierta sobre los ecosistemas boscosos (protección de cuencas, control de erosión, ciclo del carbono, recreación, etc.) como a sistemas interdependientes de preferencias o toma de decisiones sociales.Lo anterior no se puede evaluar eficientemente con las técnicas convencionales de valoración, ni con las herramientas de la economía ambiental y de recursos naturales para países en desarrollo. Si bien esas técnicas son útiles en la administración de algunos recursos estratégicos. no son suficientes cuando se trata de valorar ambientes donde se debe enfrentar limitaciones en términos de indeterminación, incertidumbre, indivisibilidad, racionalidades sujetas a decisiones colectivas e individuales o a cuestiones de distribución socioecológica.El diseño metodológico aquí presentado ha permitido identificar los diferentes actores involucrados, describiendo, al mismo tiempo, los problemas de gestión que enfrentan y ha pennitido delimitar los conflictos sociales y mostrar diferentes posibilidades para su solución por medio de compromisos, cooperación y diálogo entre las panes, dando oportunidad que emergieran soluciones para el manejo integral de la subcuenca del no Viruta.Abstract:The experience in the administration of basins, in particular in their social-hydric aspect, it indicates that thc problem anses for reciprocal causation of different biological and socioeconomic factors, bound toan administration of dic development thai in general doesn’t assist dic risks thai shelhe believes. The effectivc administration of the hydrics resources and involved biotic usually ignore dic conflict that, in social terms. she/he brings 1 gel the non sustainablc uses. Therefore. an alternative administration demands an integral focus thai looks for to relate social values (nol only economic) to ecological approaches and other diverse parameters.The composedly of dic basin administration depends thai the decisions are subject to systems of territorial planning. with dic open perspective on the wooded ecosystems (basin protection, erosion control. cycle of the carbon. recreation, etc.) as much as Lo intcrdcpendeni systems of preferences or taking of social decisions.The above-mentioned you can nol evaluate efficiendy with the conventional techniques of valuacion, neithcr with the tools of the environmental economy and of natural resources for countries in development. Although those techniques are useful in ihe administration of sorne strategic resources. they are fol enough when it is to value atmospheres where it should be faced limitations in indetermination terms. uncertainty, indivisibility, rationalities subject to collecuve and individual decisions. or to questions of partner-ecological distribution.The mcthodological design here prescnted it has allowcd lo ideniify. the different involved actors, describing, al the same time, dic administration problems that face and it has allowed to define the social contlicts and to show different possibilities for dic their solution through comrnitments, cooperation and dialogue arnong dic paris. giving opportunity thai solutions emerged for the integral handling of the Vinila river basin.

An interpretative phenomenological analysis of participation in a pro-anorexia Internet site and its relationship to disordered eating

Pro-anorexia Internet sites aim to promote, support and discuss anorexia nervosa. Media coverage has raised concerns that sites may increase the level of eating disorders. This research examines the meaning of participation in a pro-anorexia Internet site and its relationship with disordered eating by using an interpretative phenomenological analysis of fifteen separate message ‘threads’ followed over a six-week period. Four themes were identified: (1) tips and techniques; (2) ‘ana’ v. anorexia nervosa; (3) social support; and (4) need for anorexia. Findings suggest participation was multi-purpose, providing a coping function in relation to weight loss, and the contribution of sites to increased levels of eating disorders is not inevitable.

A recursive multi-scaling approach to regional flood frequency analysis

Scaling approaches are widely used by hydrologists for Regional Frequency Analysis (RFA) of floods at ungauged/sparsely gauged site(s) in river basins. This paper proposes a Recursive Multi-scaling (RMS) approach to RFA that overcomes limitations of conventional simple- and multi-scaling approaches. The approach involves identification of a separate set of attributes corresponding to each of the sites (being considered in the study area/region) in a recursive manner according to their importance, and utilizing those attributes to construct effective regional regression relationships to estimate statistical raw moments (SMs) of peak flows. The SMs are then utilized to arrive at parameters of flood frequency distribution and quantile estimate(s) corresponding to target return period(s). Effectiveness of the RMS approach in arriving at flood quantile estimates for ungauged sites is demonstrated through leave-one-out cross-validation experiment on watersheds in Indiana State, USA. Results indicate that the approach outperforms index-flood based Region-of-Influence approach, simple- and multi-scaling approaches and a multiple linear regression method. (C) 2015 Elsevier B.V. All rights reserved.

2-D and 3-D processing and interpretation of multi-fold ground penetrating radar data:a case history from an archaeological site

A 2.5-D and 3-D multi-fold GPR survey was carried out in the Archaeological Park of Aquileia (northern Italy). The primary objective of the study was the identification of targets of potential archaeological interest in an area designated by local archaeological authorities. The second geophysical objective was to test 2-D and 3-D multi-fold methods and to study localised targets of unknown shape and dimensions in hostile soil conditions. Several portions of the acquisition grid were processed in common offset (CO), common shot (CSG) and common mid point (CMP) geometry. An 8×8 m area was studied with orthogonal CMPs thus achieving a 3-D subsurface coverage with azimuthal range limited to two normal components. Coherent noise components were identified in the pre-stack domain and removed by means of FK filtering of CMP records. Stack velocities were obtained from conventional velocity analysis and azimuthal velocity analysis of 3-D pre-stack gathers. Two major discontinuities were identified in the area of study. The deeper one most probably coincides with the paleosol at the base of the layer associated with activities of man in the area in the last 2500 years. This interpretation is in agreement with the results obtained from nearby cores and excavations. The shallow discontinuity is observed in a part of the investigated area and it shows local interruptions with a linear distribution on the grid. Such interruptions may correspond to buried targets of archaeological interest. The prominent enhancement of the subsurface images obtained by means of multi-fold techniques, compared with the relatively poor quality of the conventional single-fold georadar sections, indicates that multi-fold methods are well suited for the application to high resolution studies in archaeology.

Site level cost benefit analysis of renewable energy in the near-shore environment

Senior thesis written for Oceanography 445

A zooarchaeological analysis of a late Dorset faunal assemblage from the KcFs-2 site (Nunavik, Quebec).

Ce mémoire consiste en une analyse zooarchéologique d’un assemblage faunique provenant d’un site Dorsétien des Îles Nuvuk dans l’Arctique canadien. Les données fauniques ont été analysées statistiquement en appliquant des indices d’utilité économique et des indices de densité des os. Une étude concernant le niveau de conservation de l’assemblage a révélé peu d’évidence de modification taphonomique des spécimens. Les analyses fauniques ont permis d’identifier une stratégie de subsistance de type généraliste et basée sur l’exploitation de mammifères marins, surtout des phoques annelés, pratiquée par les occupants du site de KcFs-2. Une prédominance d’individus immatures (phoques annelés) dans l’assemblage indique une abondance de ressources marines dans les régions du nord de la Baie d’Hudson et du détroit d’Hudson au moment de l’occupation, ce qui est aussi manifeste dans des études antérieures concernant les économies des peuples du Paléoesquimau tardif pour la période donnée. L’occupation du site de KcFs-2 s’est produite durant la période du Dorsétien récent au Nunavik (1500-800 B.P.), et la séquence est définie comme ayant été multi-saisonnière (de l’hiver à l’été). L’analyse des produits de l’industrie osseuse (têtes de harpons et sculptures en ivoire) a permis de confirmer l’affiliation culturelle des occupants.