A multi-center retrospective analysis of treatment effects and quality of life in adult patients with cranial ependymomas


Autoria(s): Dützmann, Stephan; Schatlo, Bawarjan; Lobrinus, Alexander; Murek, Michael; Wostrack, Maria; Weiss, Carolin; Schaller, Karl; Raabe, Andreas; Meyer, Bernhard; Goldbrunner, Roland; Franz, Kea; Seifert, Volker; Senft, Christian
Data(s)

01/09/2013

Resumo

Long term quality of life data of adult patients harboring intracranial ependymomas have not been reported. The role of adjuvant radiation therapy in Grade II ependymomas is unclear and differs from study to study. We therefore sought to retrospectively analyze outcome and quality of life of adult patients that were operated on intracranial ependymomas at four different surgical centers in two countries. All patients were attempted to be contacted via telephone to assess quality of life (QoL) at the time of the telephone interview. The standard EORTC QoL Questionnaire C30 (EORTC QLQ-C30) and the EORTC QLQ-Brain Cancer Module (QLQ-BN20) were used. 64 adult patients with intracranial ependymomas were included in the study. The only factor that was associated with increased survival was age <55 years (p < 0.001). Supratentorial location was correlated with shorter progression free survival than infratentorial location (PFS; p = 0.048). In WHO Grade II tumors local irradiation did not lead to increased PFS (p = 0.888) or overall survival (p = 0.801). Even for incompletely resected Grade II tumors local irradiation did not lead to a benefit in PFS (p = 0.911). In a multivariate analysis of QoL, irradiated patients had significantly worse scores in the item "fatigue" (p = 0.037) than non-irradiated patients. Here we present QoL data of adult patients with intracranial ependymomas. Our data show that local radiation therapy may have long-term effects on patients' QoL. Since in the incompletely resected Grade II tumors local irradiation did not lead to a benefit in PFS in this retrospective study, prospective randomized studies are necessary. In addition to age, supratentorial tumor location is associated with a worse prognosis in adult ependymoma patients.

Formato

application/pdf

Identificador

http://boris.unibe.ch/39254/1/art%253A10.1007%252Fs11060-013-1187-2.pdf

Dützmann, Stephan; Schatlo, Bawarjan; Lobrinus, Alexander; Murek, Michael; Wostrack, Maria; Weiss, Carolin; Schaller, Karl; Raabe, Andreas; Meyer, Bernhard; Goldbrunner, Roland; Franz, Kea; Seifert, Volker; Senft, Christian (2013). A multi-center retrospective analysis of treatment effects and quality of life in adult patients with cranial ependymomas. Journal of neuro-oncology, 114(3), pp. 319-327. Boston, Mass.: Springer 10.1007/s11060-013-1187-2 <http://dx.doi.org/10.1007/s11060-013-1187-2>

doi:10.7892/boris.39254

info:doi:10.1007/s11060-013-1187-2

info:pmid:23813228

urn:issn:0167-594X

Idioma(s)

eng

Publicador

Springer

Relação

http://boris.unibe.ch/39254/

Direitos

info:eu-repo/semantics/restrictedAccess

Fonte

Dützmann, Stephan; Schatlo, Bawarjan; Lobrinus, Alexander; Murek, Michael; Wostrack, Maria; Weiss, Carolin; Schaller, Karl; Raabe, Andreas; Meyer, Bernhard; Goldbrunner, Roland; Franz, Kea; Seifert, Volker; Senft, Christian (2013). A multi-center retrospective analysis of treatment effects and quality of life in adult patients with cranial ependymomas. Journal of neuro-oncology, 114(3), pp. 319-327. Boston, Mass.: Springer 10.1007/s11060-013-1187-2 <http://dx.doi.org/10.1007/s11060-013-1187-2>

Palavras-Chave #610 Medicine & health
Tipo

info:eu-repo/semantics/article

info:eu-repo/semantics/publishedVersion

PeerReviewed