Telomerase activity in the vaginal margins of radical hysterectomy in patients with carcinoma of the cervix: Correlation with histology and human papillomavirus

This study was undertaken to evaluate the telomerase activity both in the tumor and in the vaginal margins of radical hysterectomy in patients with squamous cell carcinoma (SCC) of the cervix. Thirty-three patients with SCC of the cervix (study group) and 13 patients with uterine myoma (control group) were prospectively studied. Tissue samples were taken from the tumor or cervix, anterior vaginal margin (AVM), and posterior vaginal margin (PVM). The specimens were analyzed by histopathology, by a telomerase PCR-TRAP-ELISA kit, and by polymerase chain reaction using human papillomavirus (HPV) DNA. The telomerase activity was significantly higher in the tumor than in the benign cervix (P < 0.001). There was no difference in telomerase activity in the AVM and PVM in patients with cervical carcinoma compared to the control group. Telomerase activity was associated with the presence of histologic malignancy in the PVM of patients submitted to radical hysterectomy (P = 0.03). This association was not observed with the presence of HPV in AVM or PVM in the study group. Telomerase activity is a marker of histologic malignancy in patients with SCC of the cervix. There was no association between the telomerase activity and the presence of HPV in vaginal margins of patients submitted to radical hysterectomy. © 2006, Copyright the Authors.

The effect of pH on horseradish peroxidase-catalyzed oxidation of melatonin: Production of N1-acetyl-N2-formyl-5- methoxykynuramine versus radical-mediated degradation

There is a growing body of evidence that melatonin and its oxidation product, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), have anti-inflammatory properties. From a nutritional point of view, the discovery of melatonin in plant tissues emphasizes the importance of its relationship with plant peroxidases. Here we found that the pH of the reaction mixture has a profound influence in the reaction rate and products distribution when melatonin is oxidized by the plant enzyme horseradish peroxidase. At pH 5.5, 1 mm of melatonin was almost completely oxidized within 2 min, whereas only about 3% was consumed at pH 7.4. However, the relative yield of AFMK was higher in physiological pH. Radical-mediated oxidation products, including 2-hydroxymelatonin, a dimer of 2-hydroxymelatonin and O-demethylated dimer of melatonin account for the fast consumption of melatonin at pH 5.5. The higher production of AFMK at pH 7.4 was explained by the involvement of compound III of peroxidases as evidenced by spectral studies. On the other hand, the fast oxidative degradation at pH 5.5 was explained by the classic peroxidase cycle. © 2007 The Authors.

Myeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitens

Two new flavone glucosides, nitensosides A and B (1, 2), together with four known compounds, sorbifolin (3), sorbifolin 6-O-β-glucopyranoside (4), pedalitin (5), and pedalitin 6-O-β-glucopyranoside (6) were isolated from Pterogyne nitens. Their structures were elucidated from 1D and 2D NMR analysis, as well as by high resolution mass spectrometry. All the isolated flavones were evaluated for their myeloperoxidase (MPO) inhibitory activity. The most active compound, pedalitin, exhibited IC 50 value of 3.75 nM on MPO. Additionally, the radical-scavenging capacity of flavones 1-6 was evaluated towards ABTS and DPPH radicals and compared to standard compounds quercetin and Trolox®. © 2008 Pharmaceutical Society of Japan.

Estudio Económico de América Latina y el Caribe 2013: tres décadas de crecimiento económico desigual e inestable

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Crecimiento, desequilibrio y disparidades: interpretación del proceso de desarrollo económico

Documento en inglés (88751) y también en portugués: Interpretação do proceso de desenvolvimento econômico da América Latina. Estudos Econômicos, São Paulo, v, 1, No 3-4, p. 271-308, setembro e dezembro 1950; y en Revista Brasileira de Economia, Rio de Janeiro, año 5, No 1, p. 7-135, março 1951, con un resumen en inglés y francés, p. 117-135 (78593); y también en Prebisch, Raúl: Interpretación del proceso de desarrollo latinoamericano en 1949. Santiago, CEPAL, 1973, p. 1-92, Serie conmemorativa del XXV aniversario de la CEPAL, febrero 1973 (8962); y en Gurrieri, Adolfo, comp.: La obra de Prebisch en la CEPAL. México, DF, Fondo de Cultura Económica, 1982, Tomo I, p. 156-247, Lecturas, No 46 (11934), ingresado en Biblioteca

Estímulo de la demanda, las inversiones y la aceleración del ritmo de crecimiento

Documento en inglés (88754) y también en: Gurrieri, Adolfo, comp.: La obra de Prebisch en la CEPAL. México, DF, Fondo de Cultura Económica, 1982, Tomo I, p. 394-423, Lecturas, No 46, (11934), ingresados en Biblioteca

The role of membranous urethral afferent autonomic innervation in the continence mechanism after nerve sparing radical prostatectomy: a clinical and prospective study

Purpose: We evaluated the somatic and autonomic innervation of the pelvic floor and rhabdosphincter before and after nerve sparing radical retropubic prostatectomy using neurophysiological tests and correlated findings with clinical parameters and urinary continence. Materials and Methods: From February 2003 to October 2005, 46 patients with prostate cancer were enrolled in a controlled, prospective study. Patients were evaluated before and 6 months after nerve sparing radical retropubic prostatectomy using the UCLA-PCI urinary function domain and neurophysiological tests, including somatosensory evoked potential, and the pudendo-urethral, pudendo-anal and urethro-anal reflexes. Clinical parameters and urinary continence were correlated with afferent and efferent innervation of the membranous urethra and pelvic floor. We used strict criteria to define urinary continence as complete dryness with no leakage at all, not requiring any pads or diapers and with a UCLA-PCI score of 500. Patients with a sporadic drop of leakage, requiring up to 1 pad daily, were defined as having occasional urinary leakage. Results: Two patients were excluded from study due to urethral stricture postoperatively. We evaluated 44 patients within 6 months after surgery. The pudendo-anal and pudendo-urethral reflexes were unchanged postoperatively (p = 0.93 and 0.09, respectively), demonstrating that afferent and efferent pudendal innervation to this pelvic region was not affected by the surgery. Autonomic afferent denervation of the membranous urethral mucosa was found in 34 patients (77.3%), as demonstrated by a postoperative increase in the urethro-anal reflex sensory threshold and urethro-anal reflex latency (p <0.001 and 0.0007, respectively). Six of the 44 patients used pads. One patient with more severe leakage required 3 pads daily and 23 showed urinary leakage, including 5 who needed 1 pad per day and 18 who did not wear pads. Afferent autonomic denervation at the membranous urethral mucosa was found in 91.7% of patients with urinary leakage. Of 10 patients with preserved urethro-anal reflex latency 80% were continent. Conclusions: Sensory and motor pudendal innervation to this specific pelvic region did not change after nerve sparing radical retropubic prostatectomy. Significant autonomic afferent denervation of the membranous urethral mucosa was present in most patients postoperatively. Impaired membranous urethral sensitivity seemed to be associated with urinary incontinence, particularly in patients with occasional urinary leakage. Damage to the afferent autonomic innervation may have a role in the continence mechanism after nerve sparing radical retropubic prostatectomy.

El futuro de la estrategia de crecimiento de América Latina

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Comentarios a la presentación de Ricardo Hausmann "futuro de la estrategia de crecimiento de América Latina"

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Comentarios a la presentación de Ricardo Hausmann "futuro de la estrategia de crecimiento de América Latina"

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Efecto de la fertirrigación con n y k en el crecimiento de la palma de coco enano Verde de jiqui

The coconut palm crop has increased with the use of the fertigation technique in Brazil in the last years. The objective of this work was to evaluate the influence of N and K rates via fertigation, on vegetative growth of three year old palms, cultivated in the littoral region of the Ceará State, Brazil, with tropical rainy climate. The study was conducted in a sandy soil using the variety of green dwarfed Jiqui coconut palm. The experimental design was a randomized complete block, with 10 treatments, including five nitrogen and five of potassium rates, according to the model of the experimental matrix Plan Puebla III. The nitrogen and potassiun applications via fertigation influenced significantly the plant height, stem perimeter, and the number of leaves and folioles. © 2009 Universidad Centroccidental Lisandro Alvarado (UCLA).

Modelos no lineales para describir el crecimiento de bufalinos de la raza Murrah

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Hacia un crecimiento inclusivo

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Crecimiento con equidad 1990-2006

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La economía coreana: seis décadas de crecimiento y desarrollo

El presente documento corresponde a la versión en español del libro The Korean Economy: Six Decades of Growth and Development, publicado originalmente por el Instituto Coreano de Desarrollo en 2010. La Comisión Económica para América Latina y el Caribe (CEPAL) tradujo y publicó el libro en español, para lo cual contó con el valioso apoyo del Consejo Coreano para América Latina y el Caribe (KCLAC).