How can we agree on some product agnostic repository function fundamentals?

Presentation at Open Repositories 2014, Helsinki, Finland, June 9-13, 2014

Software product line for power converters

Työn tilaajana toimi Visedo Oy. Työn tavoitteina oli tutkia Visedo Oy:n ohjelmistokehityksen nykytila, tunnistaa seuraavat parannuskohteet ja antaa ohjeita havaittujen parannuskohteiden korjaamiseksi. Visedo Oy:n tehonmuokkain ohjelmistokehityksen nykytilaa käsiteltiin neljän valitun osa-alueen näkökulmasta: ohjelmistoarkkitehtuurityyli, komponenttipohjainen ohjelmistokehitys, ohjelmistotuotelinjojen kehitysmenetelmät ja ohjelmistovariaatioiden hallinta. Valituilla osa-alueilla havaittujen parannuskohteiden perusteella annettiin korjausehdotuksia: ohjelmistoarkkitehtuurin rakenteeseen, komponenttien jakautumiselle, komponenttien koostamiselle ja komponenttien versioinnille. Lisäksi ehdotettiin uudenlaista ohjelmistotuotelinja rakennetta, joka yhdistää kerros- ja komponenttipohjaiset arkkitehtuurityylit mahdollistaen ominaisuuksiltaan eroavien tehonmuokkain ohjelmistojen hallinnan.

Service paradox in a product oriented company: A service business development case

The master´s thesis had three aims; to develop a service portfolio, to support the management of services through the developed portfolio, and evaluate effects of service differentiation strategy on the future selection of services. The product oriented case company in service paradox is Hilti (Suomi) Oy, which is entering systematic service management era, supported by the late strategic change. Low return on service business investments is referred as service paradox. The project was carried out as a case study, where the primary information source was twenty-one conducted interviews. The theory part focuses on marketing logics, service strategies, and categorization of services. The empirical part contributes in solving the aim related research questions. As a result of the case study a service portfolio was created, next further steps in service management were suggested, and the effect on selection of services by service differentiation strategy was evaluated. The main goal of creating service portfolio contributes to systematic management of services, which required revising at the case company.

Purification of bovine pancreatic glucagon as a by-product of insulin production

A process for purifying bovine pancreatic glucagon as a by-product of insulin production is described. The glucagon-containing supernatant from the alkaline crystallization of insulin was precipitated using ammonium sulfate and isoelectric precipitation. The isoelectric precipitate containing glucagon was then purified by ion-exchange chromatography on Q-Sepharose FF, gel filtration on Sephadex G-25 and ion-exchange chromatography on S-Sepharose FF. A pilot scale test was performed with a recovery of 87.6% and a purification factor of 8.78 for the first chromatographic step, a recovery of 75.1% and a purification factor of 3.90 for the second, and a recovery of 76.2% and a purification factor of 2.36 for the last one. The overall yield was 50%, a purification factor of 80.8 was obtained and the fraction containing active glucagon (suitable for pharmaceutical preparations) was 84% pure as analyzed by HPLC

Post-exercise changes in blood pressure, heart rate and rate pressure product at different exercise intensities in normotensive humans

To evaluate the effect of exercise intensity on post-exercise cardiovascular responses, 12 young normotensive subjects performed in a randomized order three cycle ergometer exercise bouts of 45 min at 30, 50 and 80% of VO2peak, and 12 subjects rested for 45 min in a non-exercise control trial. Blood pressure (BP) and heart rate (HR) were measured for 20 min prior to exercise (baseline) and at intervals of 5 to 30 (R5-30), 35 to 60 (R35-60) and 65 to 90 (R65-90) min after exercise. Systolic, mean, and diastolic BP after exercise were significantly lower than baseline, and there was no difference between the three exercise intensities. After exercise at 30% of VO2peak, HR was significantly decreased at R35-60 and R65-90. In contrast, after exercise at 50 and 80% of VO2peak, HR was significantly increased at R5-30 and R35-60, respectively. Exercise at 30% of VO2peak significantly decreased rate pressure (RP) product (RP = HR x systolic BP) during the entire recovery period (baseline = 7930 ± 314 vs R5-30 = 7150 ± 326, R35-60 = 6794 ± 349, and R65-90 = 6628 ± 311, P<0.05), while exercise at 50% of VO2peak caused no change, and exercise at 80% of VO2peak produced a significant increase at R5-30 (7468 ± 267 vs 9818 ± 366, P<0.05) and no change at R35-60 or R65-90. Cardiovascular responses were not altered during the control trial. In conclusion, varying exercise intensity from 30 to 80% of VO2peak in young normotensive humans did not influence the magnitude of post-exercise hypotension. However, in contrast to exercise at 50 and 80% of VO2peak, exercise at 30% of VO2peak decreased post-exercise HR and RP.

Evidencing and Sharing Value with Decision Making Models in an Industrial Maintenance Network

The objective of this thesis is to concretize the potential benefits that the industrial maintenance case network could achieve through using the value-based life-cycle model and the flexible asset management model. It is also inspected what factors prevent value creation and sharing in the maintenance contract practices of the case network. This thesis is a case study which utilizes modelling. Four scenarios were developed to demonstrate value creation in the future. The data was partly provided by the collaborating company, partly gathered from public financial statement information. The results indicate that value has been created through the past maintenance of the collaborating company’s rod mill and that profitability of the collaborating company has been mostly on satisfactory level during the past few years. Potential value might be created by increasing the share of proactive maintenance of the rod mill in the future. Profitability of the network could be improved in the future through flexible asset management operations. The main obstacle for value creation and sharing seems to be the lack of sufficient trust between the network members.

The requirements and needs of global data usage in product lifecycle management

This study was done for ABB Ltd. Motors and Generators business unit in Helsinki. In this study, global data movement in large businesses is examined from a product data management (PDM) and enterprise resource planning (ERP) point-of-view. The purpose of this study was to understand and map out how a large global business handles its data in a multiple site structure and how it can be applied in practice. This was done by doing an empirical interview study on five different global businesses with design locations in multiple countries. Their master data management (MDM) solutions were inspected and analyzed to understand which solution would best benefit a large global architecture with many design locations. One working solution is a transactional hub which negates the effects of multisite transfers and reduces lead times. Also, the requirements and limitations of the current MDM architecture were analyzed and possible reform ideas given.  

Production planning and optimization of a pulp mill: introduction of the optimisation based scheduling software for pulp industry

The objective of this project was to introduce a new software product to pulp industry, a new market for case company. An optimization based scheduling tool has been developed to allow pulp operations to better control their production processes and improve both production efficiency and stability. Both the work here and earlier research indicates that there is a potential for savings around 1-5%. All the supporting data is available today coming from distributed control systems, data historians and other existing sources. The pulp mill model together with the scheduler, allows what-if analyses of the impacts and timely feasibility of various external actions such as planned maintenance of any particular mill operation. The visibility gained from the model proves also to be a real benefit. The aim is to satisfy demand and gain extra profit, while achieving the required customer service level. Research effort has been put both in understanding the minimum features needed to satisfy the scheduling requirements in the industry and the overall existence of the market. A qualitative study was constructed to both identify competitive situation and the requirements vs. gaps on the market. It becomes clear that there is no such system on the marketplace today and also that there is room to improve target market overall process efficiency through such planning tool. This thesis also provides better overall understanding of the different processes in this particular industry for the case company.

Customer-driven service product development

This thesis studies customer-driven service product development and how to manage customer involvement in the service product development process. The theory part of this thesis is a literature review of the prior studies and the thesis also includes empirical evidence in the form of a case study about ABB.

Teollisuuspuhaltimille tarkoitetun suunnittelujärjestelmän kehittäminen

Diplomityön tavoitteena oli kehittää Dust Control Systems Oy:n nykyistä suunnittelujärjestelmää yrityksen toiminnan laadun ja suunnittelun tehokkuuden parantamiseksi. Suunnittelun suurin pullonkaula on valmistusdokumenttien tuottaminen, joten keskeinen tehtävä oli dokumenttien laadun parantaminen ja tuottamisen nopeuttaminen. Lisäksi tärkeää oli selkeyttää nykyistä nimikkeiden hallintaa ja ylläpitoa. Kehitystyö keskittyi suurelta osin suunnittelujärjestelmän ohjelmistoympäristön päivittämiseen ja sen muokkaamiseen. Teoriaosuudessa käsiteltiin nykyaikaista suunnittelua ja sen kehittämismahdollisuuksia. Lisäksi tarkasteltiin suunnittelun automatisoinnin tuomia hyötyjä sekä erilaisia tuotannon tehostamismenetelmiä. Kehitysosiossa tutkittiin yrityksen nykyistä suunnittelujärjestelmää ja ohjelmistoympäristöä, tuotteiden asettamia vaatimuksia sekä järjestelmän puutteita. Näihin liittyi suuresti yhteistyö henkilöstön sekä ohjelmistotoimittajan kanssa. Tutkimuksen perusteella ryhdyttiin kehittämään uutta järjestelmäkokonaisuutta, johon liitettiin tarvittavia ohjelmistoja ja päivityksiä. Käyttöönottoa varten ohjelmistot konfiguroitiin yrityksen tarpeita vastaaviksi. Työn tuloksena saatiin kehittyneempi ja nykyaikaisempi suunnittelujärjestelmä ja ohjelmistoympäristö. Suunnittelijoiden työtaakkaa saadaan kevennettyä toistuvien työvaiheiden pidemmälle viedyllä automatisoinnilla. Uudistettu ohjelmistoympäristö luo osaltaan ehtoja ja sääntöjä, jotta virheitä syntyy yhä vähemmän. Lisäksi suunnittelun läpimenoaikaa saadaan lyhennettyä parannetulla dokumenttien tuottamisella.

Kevyen istutuskoneen suunnittelu puuntaimille

Työssä pyritään suunnittelemaan kevyempi versio jo olemassa olevasta puuntaimien istutuslaitteesta. Työ koostuu kahdesta osasta. Ensimmäisessä teoria osuudessa käydään läpi mekatronisen koneen suunnittelussa huomioitavia seikkoja ja järjestelmällistä tuotekehitysprosessia yleisesti. Toisessa osassa esitellään nykyisten istutuslaitteiden kehityshistoriaa ja nykyisin koneellisessa metsänistutuksessa käytössä olevia laitteita. Loppuratkaisujen aikaan saamisessa pyritään QFD-menetelmää käyttämällä saamaan aikaan kevyen istutuskoneen vaatimusprofiili ja profiilissa ilmi tulleiden vaatimusten ja toiveiden pohjalta kehitettiin ratkaisuja joilla perinteistä koneellista istutus toimintaa voidaan uudistaa. Materiaalinvalinnan avulla optimoitiin kevyttä istutuskonetta pyrkimällä löytämään ympäristöystävälliset materiaalit jotka ovat tuotteen elinkaarta kokonaisuutena ajatellen parhaat mahdolliset. Työssä saatiin aikaan malli jolla on mahdollista jatkokehittelyn jälkeen ja kunnolla tuotteistettuna edistää koneellisen metsänistutuksen yleistymistä. Työn aikana huomattiin, että suurimmat esteet metsän istutuksen koneellistumiselle ovat nykyisten koneiden korkeat hankinta- ja käyttökustannukset sekä koneiden käyttämisen vaatima ammattitaito. Kustannuksia alentamalla ja käyttökynnystä madaltamalla voi edistää koneellisen metsänistutuksen yleistymistä tehostamisen rinnalla.

A calcineurin inhibitory protein overexpressed in Down's syndrome interacts with the product of a ubiquitously expressed transcript

The Down's syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21, interacts with calcineurin and is overexpressed in Down's syndrome patients. As an approach to clarifying a putative function for this protein, in the present study we used the yeast two-hybrid system to identify DSCR1 partners. The two-hybrid system is a method that allows the identification of protein-protein interactions through reconstitution of the activity of the yeast GAL 4 transcriptional activator. The gene DSCR1 fused to the GAL 4 binding domain (BD) was used to screen a human fetal brain cDNA library cloned in fusion with the GAL 4 activation domain (AD). Three positive clones were found and sequence analysis revealed that all the plasmids coded for the ubiquitously expressed transcript (UXT). UXT, which is encoded in human Xp11, is a 157-amino acid protein present in both cytosol and nucleus of the cells. This positive interaction of DSCR1 and UXT was confirmed in vivo by mating the yeast strain AH109 (MATa)expressing AD-UXT with the strain Y187 (MATalpha) expressing BD-DSCR1, and in vitro by co-immunoprecipitation experiments. These results may help elucidate a new function for DSCR1 and its participation in Down's syndrome pathogenesis.

Yrityksen vaihto-omaisuustavoitteet kunnossapidon näkökulmasta

Varaosavarastoihin kohdistuu entistä enemmän samoja vaihto-omaisuuden hallinnan vaatimuksia kuin raaka-aine ja lopputuotevarastoihin. Tämän tutkimuksen tavoitteena oli selvittää, miten kunnossapito-organisaatio voi vastata näihin tavoitteisiin heikentämättä koneiden ja laitteiden teknistä käytettävyyttä ja lisäämättä riskiä tuotannon menetyksille. Kirjallisuudessa on esitetty suuri joukko eri lähtökohdista kehitettyjä analysointimalleja ja varastonpitopolitiikoita. Niiden avulla varaosia voidaan jakaa eri luokkiin ja niiden muodostamaa kokonaisuutta hallita. Teoriaosiossa on suoritettu kirjallisuuskatsaus käytetyimpiin menetelmiin ja tapaustutkimuksiin. Empiiriaosiossa menetelmien soveltuvuutta tutkittiin käytännössä. Tiedonkeruussa käytettiin case-yrityksen dokumentteja ja tietojärjestelmistä saatavaa tietoa, sekä havainnointia ja avoimia haastatteluita. Tutkimuksen tuloksena havaittiin merkittävä kehityspotentiaali, jonka hyödyntämiseksi saatiin määriteltyä tarpeisiin ja tutkimuksen lähtökohtana olleeseen viitekehykseen sopivat analysointi- ja varastonhallintamenetelmät. Varastokokonaisuuden hallintapolitiikka ehdotettiin lisättäväksi osaksi laatujärjestelmää. Sen avulla menetelmien johdonmukainen noudattaminen ja ohjeiden ajan tasalla pitäminen toteutuvat myös käytännössä.

Service product internationalisation : market selection for new service products in a multinational financial service firm

The significance and impact of services in the modern global economy has become greater and there has been more demand for decades in the academic community of international business for further research into better understanding internationalisation of services. Theories based on the internationalisation of manufacturing firms have been long questioned for their applicability to services. This study aims at contributing to understanding internationalisation of services by examining how market selection decisions are made for new service products within the existing markets of a multinational financial service provider. The study focused on the factors influencing market selection and the study was conducted as a case study on a multinational financial service firm and two of its new service products. Two directors responsible for the development and internationalisation of the case service products were interviewed in guided semi-structured interviews based on themes adopted from the literature review and the outcome theoretical framework. The main empirical findings of the study suggest that the most significant factors influencing the market selection for new service products within a multinational financial service firm’s existing markets are: commitment to the new service products by both the management and the rest of the product related organisation; capability and competence by the local country organisations to adopt new services; market potential which combines market size, market structure and competitive environment; product fit to the market requirements; and enabling partnerships. Based on the empirical findings, this study suggests a framework of factors influencing market selection for new service products, and proposes further research issues and methods to test and extend the findings of this research.

Inventive design and product development of a mechanical element

The thesis is dedicated to enhancement and development of a Mechanism in Company X in order to increase its key parameters and approve its workability. Current Mechanism model is described in details. The basis of various analysis, models and theories that are reflecting the working process of the Mechanism are included in the thesis. According to these three directions of enhancements are chosen: from mechanical, tribological and conceptual points of view. As the result the list of improvements is presented. The new models of Mechanism are built. The efficiency and lifetime value are obtained in accordance with corresponding estimations. The comparative analysis confirms the necessity of conducted changes. Recommendations for the Company X specialists are represented in the thesis. Proposals for deeper research are also suggested.