Dinámicas complejas en el flujo: diferencias entre trabajo y no trabajo

Esta investigación se interesó por la dinámica del flujo (flow) en contextos laborales y no laborales con el objetivo de conocer diferencias y semejanzas de dicha experiencia motivacional. Sesenta empleados de ocupaciones variadas contestaron un diario de flujo seis veces al día durante veintiún días consecutivos (6982 registros). Los datos fueron analizados a nivel entre e intra-sujeto y se utilizaron modelos lineales (i.e. regresión lineal) y no lineales (i.e. modelo de catástrofes) para conocer la capacidad predictiva del ajuste reto-habilidades sobre el flujo. Contextos laboral y no laboral han mostrado dos diferencias fundamentales: mayores fluctuaciones en el flujo en el segundo (desviaciones tipo mayores en las variables habilidades, disfrute, interés y absorción) y un significado distinto del reto. Por otro lado, la capacidad de predicción del modelo no lineal ha sido claramente mayor que su homólogo lineal (42% frente al 19%, en el caso del no trabajo; 44% frente a 33% en el trabajo). El flujo, tanto en contextos laborales como no laborales, muestra dinámicas no lineales que combinan cambios graduales y cambios abruptos. La investigación e intervención interesadas en este proceso deberían centrarse en la variable reto que se ha mostrado clave para entender dichas dinámicas complejas en el flujo.

Potential Microbiological Effects of Higher Dosing of Echinocandins.

The antifungal "paradoxical effect" has been described as the reversal of growth inhibition at high doses of echinocandins, most usually caspofungin. This microbiological effect appears to be a cellular compensatory response to cell wall damage, resulting in alteration of cell wall content and structure as well as fungal morphology and growth. In vitro studies demonstrate this reproducible effect in a certain percentage of fungal isolates, but animal model and clinical studies are less consistent. The calcineurin and Hsp90 cell signaling pathways appear to play a major role in regulating these cellular and structural changes. Regardless of the clinical relevance of this paradoxical growth effect, understanding the specific actions of echinocandins is paramount to optimizing their use at either standard or higher dosing schemes, as well as developing future improvements in our antifungal arsenal.

Drug abuse, brain calcification and glutamate-induced neurodegeneration

Positive and negative reinforcing systems are part of the mechanism of drug dependence. Drugs with abuse potential may change the manner of response to negative emotional stimuli, activate positive emotional reactions and possess primary reinforcing properties. Catecholaminergic and peptidergic processes are of importance in these mechanisms. Current research needs to understand the types of adaptations that underlie the particularly long-lived aspects of addiction. Presently, glutamate is candidate to play a role in the enduring effects of drugs of abuse. For example, it participates in the chronic pathological changes of corticostriatal terminals produced by methamphetamine. At the synaptic level, a link between over-activation of glutamate receptors, [C(a2+)](i) increase and neuronal damage has been clearly established leading to neurodegeneration. Thus, neurodegeneration can start after an acute over-stimulation whose immediate effects depend on a diversity of calcium-activated mechanisms. If sufficient, the initial insult results in calcification and activation of a chronic on-going process with a progressive loss of neurons. At present, long-term effects of drug dependence underlie an excitotoxicity process linked to a polysynaptic pathway that dynamically regulates synaptic glutamate. Retaliatory mechanisms include energy capability of the neurons, inhibitory systems and cytoplasmic calcium precipitation as part of the neuron-glia interactions. This paper presents an integrated view of these molecular and cellular mechanisms to help understand their relationship and interdependence in a chronic pathological process that suggest new targets for therapeutic intervention.

A Randomized, Placebo-controlled Trial of Preemptive Antifungal Therapy for the Prevention of Invasive Candidiasis Following Gastrointestinal Surgery for Intra-abdominal Infections.

BACKGROUND: Patients undergoing emergency gastrointestinal surgery for intra-abdominal infection are at risk of invasive candidiasis (IC) and candidates for preemptive antifungal therapy. METHODS: This exploratory, randomized, double-blind, placebo-controlled trial assessed a preemptive antifungal approach with micafungin (100 mg/d) in intensive care unit patients requiring surgery for intra-abdominal infection. Coprimary efficacy variables were the incidence of IC and the time from baseline to first IC in the full analysis set; an independent data review board confirmed IC. An exploratory biomarker analysis was performed using logistic regression. RESULTS: The full analysis set comprised 124 placebo- and 117 micafungin-treated patients. The incidence of IC was 8.9% for placebo and 11.1% for micafungin (difference, 2.24%; [95% confidence interval, -5.52 to 10.20]). There was no difference between the arms in median time to IC. The estimated odds ratio showed that patients with a positive (1,3)-β-d-glucan (ßDG) result were 3.66 (95% confidence interval, 1.01-13.29) times more likely to have confirmed IC than those with a negative result. CONCLUSIONS: This study was unable to provide evidence that preemptive administration of an echinocandin was effective in preventing IC in high-risk surgical intensive care unit patients with intra-abdominal infections. This may have been because the drug was administered too late to prevent IC coupled with an overall low number of IC events. It does provide some support for using ßDG to identify patients at high risk of IC. CLINICAL TRIALS REGISTRATION: NCT01122368.

HIV-1 Transmission During Recent Infection and During Treatment Interruptions as Major Drivers of New Infections in the Swiss HIV Cohort Study.

BACKGROUND: Reducing the fraction of transmissions during recent human immunodeficiency virus (HIV) infection is essential for the population-level success of "treatment as prevention". METHODS: A phylogenetic tree was constructed with 19 604 Swiss sequences and 90 994 non-Swiss background sequences. Swiss transmission pairs were identified using 104 combinations of genetic distance (1%-2.5%) and bootstrap (50%-100%) thresholds, to examine the effect of those criteria. Monophyletic pairs were classified as recent or chronic transmission based on the time interval between estimated seroconversion dates. Logistic regression with adjustment for clinical and demographic characteristics was used to identify risk factors associated with transmission during recent or chronic infection. FINDINGS: Seroconversion dates were estimated for 4079 patients on the phylogeny, and comprised between 71 (distance, 1%; bootstrap, 100%) to 378 transmission pairs (distance, 2.5%; bootstrap, 50%). We found that 43.7% (range, 41%-56%) of the transmissions occurred during the first year of infection. Stricter phylogenetic definition of transmission pairs was associated with higher recent-phase transmission fraction. Chronic-phase viral load area under the curve (adjusted odds ratio, 3; 95% confidence interval, 1.64-5.48) and time to antiretroviral therapy (ART) start (adjusted odds ratio 1.4/y; 1.11-1.77) were associated with chronic-phase transmission as opposed to recent transmission. Importantly, at least 14% of the chronic-phase transmission events occurred after the transmitter had interrupted ART. CONCLUSIONS: We demonstrate a high fraction of transmission during recent HIV infection but also chronic transmissions after interruption of ART in Switzerland. Both represent key issues for treatment as prevention and underline the importance of early diagnosis and of early and continuous treatment.

Síntesi de pólvores de superconductors d’alta temperatura : YBa2Cu3O7 i GdBa2Cu3O7 per via de dissolució-polimerització

L’objectiu del projecte és obtenir pólvores dels superconductors d’alta temperatura YBa2Cu3O7 i GdBa2Cu3O7 per la via de dissolució-polimerització. Aquestes pólvores seran obtingudes a partir d’òxids (Itri o Gadolini i Coure) i carbonat de bari amb àcid nítric en una dissolució aquosa de Polietinenglicol (PEG), per tal de convertir aquests òxids en nitrats coordinats amb les cadenes de PEG. Aquest producte intermedi es sotmetrà a una piròlisis per tal d’obtenir òxids i carbonats, però amb una mida més reduïda respecte als productes inicials i un grau de barreja més íntim, permetent que reaccionin entre ells amb més facilitat. Finalment, per tal d’obtenir els superconductors YBa2Cu3O7 i GdBa2Cu3O7 es farà un últim tractament tèrmic a alta temperatura en el qual es produirà la reacció desitjada. Durant tot el procés es duran a terme anàlisis d’aquest per mitjà de tècniques de Termogravimetria (TGA), d’Anàlisi Tèrmica Diferencial (DTA), espectroscòpia Infraroja (IR) i la difracció de raig X (DRX) . També s’analitzaran els diferents productes que es van obtenint (intermedis i finals) amb l’ajuda de l’espectrometria IR i la difracció de pólvores. En base a aquests resultats, es variaran els paràmetres de la reacció (concentracions, temperatures, etc.) i dels tractaments tèrmics (atmosfera, temperatura, temps, etc.) per tal d’optimitzar el producte

Formació i tecnologies de la traducció

Aquest número de la Revista Tradumàtica proposa una reflexió sobre la necessària imbricació entre les tecnologies i la formació de traductors. L’objectiu és presentar punts de vista diferents i sovint complementaris relacionats amb els diversos papers que hi entren en joc: interessa saber el que pensen les persones responsables de la formació i conèixer quines característiques té l’oferta docent, però també convé veure com es situen els estudiants. D’igual manera volem pensar en el futur, sense perdre de vista el present d’un context tan àgil i canviant com el que es descriu aquí.

Excavacions arqueologiques al jaciment d'Abasiya. Recerca, interpretació i projecte de conservació d'un conjunt arqueológic a Karima, Sudan

Remuntant el riu Nil es troba la muntanya sagrada de Dyebel Bar kal identificada pels egipcis i pels nubis com el lloc on va néixer el déu Aman. Els fa raons egipcis durant la XVIII dinastia van construir un temple dedicat a aquesta divinitat ¡ van fer d'aquesta zona (coneguda a I'antiguitat amb el nomde Napata) un dels principals centres religiosos de I'antiga Núbia. La historia compartida entre Núbiai Egipte compren segles de relacions i va culminar amb la conquesta egípcia que va suposar una egiptizació dels costums nubis. Tant es així que després d'alguns segles, els reis nubis van unificarels territoris i es van proclamar faraons de les dues terres.El jaciment arqueològic d'Abasiya que pertany a I'àrea arqueològica de Dyebel Barkal (Figura 1)es troba en la actual ciutat de Karima, a uns 400km de Khartum la capital de Sudan. És avuien dia una plac;a urbana de Karima a només700m de I'àrea arqueològica de DyebelBarkal, on simultàniament estan treballantequips arqueològics de diferents països.Abasiya compren, fins el moment, quatresectors que corresponen a I'acumulació derestes arquitectòniques. Durant 5 campanyes s'han excavat totalment els sectors A, CiD, i parcialment el Sector B, que encara esta en procés d'excavació.

Excavacions arqueologiques al jaciment d'Abasiya. Recerca, interpretació i projecte de conservació d'un conjunt arqueológic a Karima, Sudan

Remuntant el riu Nil es troba la muntanya sagrada de Dyebel Bar kal identificada pels egipcis i pels nubis com el lloc on va néixer el déu Aman. Els fa raons egipcis durant la XVIII dinastia van construir un temple dedicat a aquesta divinitat ¡ van fer d'aquesta zona (coneguda a I'antiguitat amb el nomde Napata) un dels principals centres religiosos de I'antiga Núbia. La historia compartida entre Núbiai Egipte compren segles de relacions i va culminar amb la conquesta egípcia que va suposar una egiptizació dels costums nubis. Tant es així que després d'alguns segles, els reis nubis van unificarels territoris i es van proclamar faraons de les dues terres.El jaciment arqueològic d'Abasiya que pertany a I'àrea arqueològica de Dyebel Barkal (Figura 1)es troba en la actual ciutat de Karima, a uns 400km de Khartum la capital de Sudan. És avuien dia una plac;a urbana de Karima a només700m de I'àrea arqueològica de DyebelBarkal, on simultàniament estan treballantequips arqueològics de diferents països.Abasiya compren, fins el moment, quatresectors que corresponen a I'acumulació derestes arquitectòniques. Durant 5 campanyes s'han excavat totalment els sectors A, CiD, i parcialment el Sector B, que encara esta en procés d'excavació.

La autoeficacia docente e investigadora del profesorado universitario: relación con su estilo docente e influencia en sus concepciones sobre el nexo docencia-investigación

The aim of this paper was to explore whether self-efficacy as teacher and researcher perceived by university lecturers was related to teaching styles and approaches. Two instruments were administered to 259 teachers at the University of Girona (Spain), who were active researchers and had a teaching workload of 9 ECTS or above. The results showed that self-efficacy as a researcher was the variable which yielded most differences. The higher the self-efficacy of the researcher, the stronger the belief that teaching was guided by research. Certain beliefs about the teaching-research nexus were very different according to the degree of self-efficacy as a researcher, while there were fewer differences in terms of gender and field of study

Estudio sobre el desarrollo de la identidad en la adolescencia

The aim of this study was to determine how adolescents construct their own identity during this important stage of their lifecycle.We evaluated the identity of a group of 42 adolescents between 11 and 12 years (early adolescence) and between 14 and 15 years (late adolescence), from EOMEIS-II (Extended Version of the Objective Mesure of Ego Identity Estatus created by Adams, Benion and Huh, 1989) which is part of an Ericksonian conceptualization of identity. In the results obtained we can see that students have higher scores on a global level, the most active and mature estatus (identity achieved and moratorium) in the passive and immature estatus (identity foreclosed and diffused). The boys have a higher score than girls in stating the identity moratorium on free time and political identity achieved

Técnicas de estudio en estudiantes de Secundaria que asisten a clases extraescolares en la provincia de Girona

Study techniques in out of school secondary education in the province of Girona. It is important to provide students with different ways to study so they can find the most appropriate method for them. Our research focuses on the study techniques used in secondary education by those students attending classes out of school time. In order to conduct this research, we have developed a general questionnaire after reviewing the existing literature on the topic. Some of the results obtained with this study are the following: adolescents attach great importance to learn study techniques, being summaries, diagrams and underlining the most well-known strategies for them, and mind maps and teamwork the least popular ones; they prefer dynamic teaching and learning methodologies, such as making interactive discussions; tutoring is the most valued element. Based on the results obtained with the study, we have developed some proposals to facilitate the work of the teacher when teaching study techniques and helping students to improve their academic performance

Percepciones del profesorado ante la incorporación de las competencias genéricas en la formación universitaria

What are the mindsets of teachers regarding the incorporation of generic competencies into university education within the framework of the European space for higher education? After clarifying the concept of competency and generic competencies, we selected a reference set of ten generic competencies and delimited the possible ways or strategies of intervention.A sample of 277 teachers in the University of Girona completed a questionnaire in which they evaluated the importance of each one of the competencies selected for the education profile and the preferred courses of action. There was a general acceptance on the part of the teaching staff of the need for the development of generic competencies. However, it is obvious they were reticent to incorporate them into the academic curriculum, which can be attributed to gaps in their teacher training. In order to make progress on this interesting aspect of higher education, a number of possible steps are put forward