959 resultados para Asignación universal por hijo
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Protein-protein interactions (PPIs) are essential for understanding the function of biological systems and have been characterized using a vast array of experimental techniques. These techniques detect only a small proportion of all PPIs and are labor intensive and time consuming. Therefore, the development of computational methods capable of predicting PPIs accelerates the pace of discovery of new interactions. This paper reports a machine learning-based prediction model, the Universal In Silico Predictor of Protein-Protein Interactions (UNISPPI), which is a decision tree model that can reliably predict PPIs for all species (including proteins from parasite-host associations) using only 20 combinations of amino acids frequencies from interacting and non-interacting proteins as learning features. UNISPPI was able to correctly classify 79.4% and 72.6% of experimentally supported interactions and non-interacting protein pairs, respectively, from an independent test set. Moreover, UNISPPI suggests that the frequencies of the amino acids asparagine, cysteine and isoleucine are important features for distinguishing between interacting and non-interacting protein pairs. We envisage that UNISPPI can be a useful tool for prioritizing interactions for experimental validation. © 2013 Valente et al.
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Universal properties of weakly-bound four-boson systems near the scaling limit are discussed by considering recent results obtained from the solution of Faddeev-Yakubovsky (FY) equations, which confirm a previous conjecture on a four-body scale dependence. In the present contribution, within a discussion on our numerical results obtained for the binding energies of two consecutive tetramer states, we are analyzing the relative relevance of the two possible configurations of the four-body system. © 2013 Springer-Verlag Wien.
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The universal properties of weakly-bound tetramers close to the scaling limit are investigated by solving a subtracted set of Faddeev-Yakubovsky (FY) equations for identical bosons with a zero-range interaction. The solution demands a four-body scale independent of the trimer properties. Furthermore, the effect of a finite effective range is introduced in the FY equations, which we show produces results that are distinct from the scale variation. In particular range effects to two universal scaling functions for the tetramers are investigated. The correlation between successive tetramer energies corresponding to states within two Efimov trimer energies, proposed before and studied close to the unitary limit; and the correlation between the position of the four-atom recombination peaks. In this case, we found a shift in the scaling function due to the range, which can be associated to the shift of the data found for caesium atoms, with respect to zero-range calculations, due to a nonvanishing range in the actual experimental setups. © 2013 Springer-Verlag Wien.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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El análisis de los procedimientos basados en la sobrevivencia del hijo anterior, ya sea obtenido a través de una entrevista en terreno o al momento de la mujer tener un nuevo hijo, es en general alentador. La experiencia en República Dominicana indica que la estimación de la mortalidad infantil a partir de censos o encuestas esta poco afectada por sesgos propios del procedimiento que no superan el 5 por ciento. Otra fuente de posible sesgo, también de poca importancia, es la estimación de las defunciones correspondientes a nacimientos el ano anterior al considerado que podría estar afectada por el uso de un factor de separación erróneo. La mala calidad de los datos si constituye una fuente importante de error y el único camino para lograr buenas estimaciones es mejorar la recolección de los datos en el terreno. La situación del procedimiento es mas compleja en el contexto hospitalario por el mayor numero de sesgos existentes, pero aun asi es posible obtener buenas estimaciones.