939 resultados para globular clusters: individual (HP 1)


Relevância:

30.00% 30.00%

Publicador:

Resumo:

The objective of this study was to understand how organizational knowledge governance mechanisms affect individual motivation, opportunity, and the ability to share knowledge (MOA framework), and further, how individual knowledge-sharing conditions affect actual knowledge sharing behaviour. The study followed the knowledge governance approach and a micro-foundations perspective to develop a theoretical model and hypotheses, which could explain the casual relationships between knowledge governance mechanisms, individual knowledge sharing conditions, and individual knowledge sharing behaviour. The quantitative research strategy and multivariate data analysis techniques (SEM) were used in the hypotheses testing with a survey dataset of 256 employees from eleven military schools of Finnish Defence Forces (FDF). The results showed that “performance-based feedback and rewards” affects employee’s “intrinsic motivation towards knowledge sharing”, that “lateral coordination” affects employee’s “knowledge self-efficacy”, and that ”training and development” is positively related to “time availability” for knowledge sharing but affects negatively employee’s knowledge self-efficacy. Individual motivation and knowledge self-efficacy towards knowledge sharing affected knowledge sharing behaviour when work-related knowledge was shared 1) between employees in a department and 2) between employees in different departments, however these factors did not play a crucial role in subordinate–superior knowledge sharing. The findings suggest that individual motivation, opportunity, and the ability towards knowledge sharing affects individual knowledge sharing behaviour differently in different knowledge sharing situations. Furthermore, knowledge governance mechanisms can be used to manage individual-level knowledge sharing conditions and individual knowledge sharing behaviour but their affect also vary in different knowledge sharing situations.

Relevância:

30.00% 30.00%

Publicador:

Resumo:

Tämän työn tavoitteena oli tarkastella liikenneturvallisuuden kehittymistä moottoritien rakentamisen jälkeen valtatiellä 1 Varsinais-Suomen ja Uudenmaan ELY-keskusten alueilla välillä Turku – Lohja. Laadittu tarkastus perustui onnettomuustietoihin, tierekisteritietoihin sekä maastokäynteihin. Valtatien 1 liikenneturvallisuustaso on lähtökohtaisesti hyvä ja liikenneympäristön turvallisuusriskit ovat pienet. Liikenneturvallisuustilanne on parantunut merkittävästi moottoritieksi rakentamisen jälkeen. Valtatiellä 1 tapahtuneet henkilövahinkoon johtaneet onnettomuudet ovat vähentyneet 60 - 80 % moottoritien rakentamisen jälkeen, mikä tarkoittaa lähes 40 henkilövahinko-onnettomuutta vähemmän vuosittain. Kuolemaan johtaneiden onnettomuuksien vähenemä oli 2-3 onnettomuutta vuosittain. Moottoritiellä tapahtuneista henkilövahinkoon johtaneista onnettomuuksista yleisimpiä ovat yksittäisonnettomuudet ja peräänajo-onnettomuudet. Henkilövahinko-onnettomuuksista noin 60 % johtuu tieltä suistumisista. Onnettomuusrekisteritietojen mukaan henkilövahinkoon johtaneita kohtaamisonnettomuuksia ei tapahtunut vuosina 2007– 2011, vaikka väärään suuntaan ajamisesta johtuvat kuolonkolarit on aikaisemmin todettu vakiintuneeksi onnettomuustyypiksi moottoriteillä. Tehdyn onnettomuusanalyysin sekä maastokäyntien perusteella etenkin vanhempien moottoritieosuuksien liikenneturvallisuuden tilaa voidaan ja tulee kuitenkin edelleen parantaa ja liikenneturvallisuustasoa nostaa. Yksittäisonnettomuuksia voidaan estää ja niiden seurauksia merkittävästi lieventää reunaympäristöä kehittämällä. On kuitenkin huomattava, että kaikkia onnettomuuksia ei voida estää tieteknisin keinoin ja liikennejärjestelmää kehittämällä. Maastokäynneillä silmämääräisesti todettuihin puutteisiin pohdittiin parantamistoimenpiteitä Varsinais-Suomen ELY-keskuksen alueelle. Toimenpiteissä erityishuomiota on kiinnitetty tieympäristön törmäysturvallisuuteen ja väärään suuntaan ajamisen riskin estämiseen ramppiliittymissä. Tieympäristön törmäysturvallisuutta on esitetty parannettavaksi pääasiassa puuston raivauksella ja kaiteiden lisäämisellä. Kaiteiden lisäämisen sijasta on mahdollista parantaa törmäysturvallisuutta maatäytöllä niissä kohdissa, jossa ulkoluiska on liian matala kallioleikkauksen kohdalla. Ramppiliittymissä väärään suuntaan ajamisen riskiä pyritään taas estämään mm. lisäämällä kielletyn ajosuunnan liikennemerkkejä.

Relevância:

30.00% 30.00%

Publicador:

Resumo:

Reports have shown that a growing number of students are leaving school without adequate reading and writing skills. At the same time, finnish children have improved in reading lit-eracy over the past decade. The school´s primary mission is to support student´s reading and writing development and follow it over time. Not only individual students´development has to be followd over time, as seen in this study, to be able to plan interventions. The purpose of this licentiate thesis is to study how the results in grades 1–6 exhibit in reading compre-hension and spelling over time in a school for the Swedish-speaking minority in Finland. Even gender differences in reading comprehension and spelling are being examined, as well as students with low performance. The data collection has been done during a period of twelwe years, 1997–2009, where data from practically every two years has been used for this study. Results are reported for the years 1997, 2000, 2001, 2003, 2007 and 2009. The measuring instruments are standardized and normative tests in reading comprehension and spelling. The same instruments were used all of the years. The number of students was 1 037 and when possible, students partici-pated more than once. There was a minimal loss of data. The groups of students mostly came from urban districts, and a smaller number came from rural districts. Students with special needs were included in the group, but none of the students in special units participat-ed. The results show that the skills in reading comprehension and spelling haven´t changed appreciably over time. The trend shows slightly positive or unchanged direction except in spelling in grade 1 and reading comprehension in grade 5 where the trend is slightly nega-tive. The most obvious change can be noticed over time in reading comprehension in grade 2, where performance has improved significantly. Significant differences between boys´and girls´performances occur some years and in favor of the girls, but more often in spelling than in reading comprehension. In grade 4, there are no differences in results between boys and girls in any year, neither in reading comprehension nor in spelling, nor in grade 2 in reading comprehension. When the results shows gender differences, there are always differ-ences in both reading comprehension and spelling. Poor performances are also analyzed over time. Isolated reading comprehension difficulties were common for those who was performing poorly. In grade 2, as the only grade, most common was a double deficit in both reading comprehension and spelling, and in grade 4, most students who performed poorly had isolated difficulties in spelling. The amount of poor results varies over time, and no particular trend can be discerned. In grade 2, however, the poor results decreased over time, especially for the boys. Even in reading comprehension for grade 6 the amount of poor results, especially for the boys (10th percentile), has decreased over time, at least in the later years, while the poor results in-creased in spelling generally. In grade 4 the amount of poor results in spelling (10th perc.) seems to be reduced for the girls.

Relevância:

30.00% 30.00%

Publicador:

Resumo:

Den evolutionära förklaringen till den allmänt utbredda incestaversionen, dvs. motviljan för sex med nära släktingar, försöker besvara såväl frågan om varför incestaversionen gynnats i det naturliga urvalet som frågan om hur denna aversion regleras på individuell nivå. Eftersom inavlade barn har en försämrad biologisk duglighet än andra barn, medför kostnaderna av denna icke-optimala reproduktion ett selektionstryck mot inavel. I en serie studier visade vi att eftersom kvinnor i allmänhet satsar mer biologiska resurser på sina barn än vad män gör, känner kvinnor starkare incestaversion än män och eftersom det endast är fertila kvinnor som riskerar satsa resurser i en inavlad avkomma har även fertila kvinnor högre incestaversion än icke-fertila kvinnor. Vi visade också att de biologiska kostnaderna av inavel inte begränsas till enbart de individer som har incest. Eftersom alla våra biologiska släktingar sannolikt delar våra alleler speglar incestaversionen även de biologiska kostnader som incest mellan våra släktingar medför åt oss. Den psykologiska mekanism med vilken incestsituationer bedöms har hittills varit okänd. I våra studier testades teorin om självreflekterande empati. Enligt den teorin bedöms sådana situationer emotionellt genom att man själv föreställer sig ha sex med motsvarande släkting och känslan som väcks i denna process ger därefter emotionell information till bedömningen av andras incest. I tre delstudier fann vi att självreflektion var positivt associerat med styrkan av aversion gentemot andras incest, vilket stöder teorin om självreflekterande empati.

Relevância:

30.00% 30.00%

Publicador:

Resumo:

The main objective of this doctoral dissertation is to reach a holistic and indepth understanding of the intercultural interaction within dyadic business relationships through the perspective of individual managers. The empirical setting is dyadic business relationships between Russian and Finnish firms in construction and engineering industries. The motivation for the study mainly arose from: 1) the lack of business marketing literature considering cultural and individual perspectives; 2) the need to find ways to study intercultural issues in business relationships, other than through the application of models derived from the work of Hofstede (1980). The study consists of two parts, an introductory essay containing the research objectives, theoretical foundations, methodological choices, limitations and contributions, and original research articles. The four articles each address a sub-objective: 1) to develop an understanding of intercultural business relationships development, cultural adaptation, and its role in the development of trust (Article 1); 2) to develop an appropriate methodological framework for studying business interaction from a cultural and individual perspective (Article 2); 3) to develop an understanding of the role of culture in individual manager’s sensemaking of interaction events in business relationships (Article 3); and 4) to develop an appropriate theoretical framework for studying interactive intercultural business relationships in international industrial markets (Article 4). The ontological and epistemological foundations are built on the interpretivist/ social constructivist view of reality. Interaction, in this study, is seen as being conducted between individuals, who are the key representative actors of their firms. In turn, culture is regarded both as an independent context existing prior to the individuals’ participation in it, and as knowledge incorporated by the individuals, who use it in sensemaking and interaction across cultures. The methods applied in the articles are: an interpretive qualitative study (Article 1), a literature review and conceptual analysis (Article 2), a structural analysis of the narratives and a metaphor analysis (Article 3), and a literature review and conceptual analysis (Article 4). The main contributions are the following. First, it contributes to business marketing literature by developing the theoretical, conceptual, and methodological underpinning of IMP theories in relation to culture. Second, the thesis contributes to the growing literature on managerial sensemaking in industrial markets by looking at it from a cultural perspective, as well as emphasizing the importance of figurative language in cultural sensemaking.

Relevância:

30.00% 30.00%

Publicador:

Resumo:

Em monoculturas, normalmente se observa uma variação de produção entre plantas, que pode estar ocorrendo desde o estabelecimento da população, pela habilidade competitiva destas. Este trabalho foi desenvolvido com o objetivo de selecionar parâmetros de habilidade competitiva, durante o estabelecimento, que se relacionam com o potencial de produção, no final do desenvolvimento. Plantas de trigo (EMBRAPA 16) e aveia (UFRGS 15) foram cultivadas em canteiros e a campo, correlacionando-se parâmetros morfológicos, nos estádios de afilhamento e florescimento. No afilhamento, nossos resultados revelaram que o diâmetro do pseudocolmo e o desenvolvimento foliar foram os parâmetros mais relevantes na caracterização da habilidade competitiva, pela alta associação com a massa seca, independente da espécie e do ambiente. Nestas populações, a ordem com que as plantas emergiram foi inversamente relacionada com o estádio de desenvolvimento apical (para inflorescência) e com os parâmetros que definiram a habilidade competitiva. Esta habilidade de competição inicial foi diretamente relacionada com o tamanho e a potencialidade de produção (espiguetas por inflorescência) das plantas, no estádio de florescimento. Os resultados indicam que o potencial de produção individual pode ser estimado por medidas de parâmetros não destrutivos, da capacidade de competição, nos primeiros estádios de desenvolvimento das plantas.

Relevância:

30.00% 30.00%

Publicador:

Resumo:

The aim of this study was to analyse mothers’ working time patterns across 22 European countries. The focus was on three questions: how much mothers prefer to work, how much they actually work, and to what degree their preferred and actual working times are (in)consistent with each other. The focus was on cross-national differences in mothers’ working time patterns, comparison of mothers’ working times to that of childless women and fathers, as well as on individual- and country-level factors that explain the variation between them. In the theoretical background, the departure point was an integrative theoretical approach where the assumption is that there are various kinds of explanations for the differences in mothers’ working time patterns – namely structural, cultural and institutional – , and that these factors are laid in two levels: individual- and country-levels. Data were extracted from the European Social Survey (ESS) 2010 / 2011. The results showed that mothers’ working time patterns, both preferred and actual working times, varied across European countries. Four clusters were formed to illustrate the differences. In the full-time pattern, full-time work was the most important form of work, leaving all other working time forms marginal. The full-time pattern was perceived in terms of preferred working times in Bulgaria and Portugal. In polarised pattern countries, fulltime work was also important, but it was accompanied by a large share of mothers not working at all. In the case of preferred working times, many Eastern and Southern European countries followed it whereas in terms of actual working times it included all Eastern and Southern European countries as well as Finland. The combination pattern was characterised by the importance of long part-time hours and full-time work. It was the preferred working time pattern in the Nordic countries, France, Slovenia, and Spain, but Belgium, Denmark, France, Norway, and Sweden followed it in terms of actual working times. The fourth cluster that described mothers’ working times was called the part-time pattern, and it was illustrated by the prevalence of short and long part-time work. In the case of preferred working times, it was followed in Belgium, Germany, Ireland, the Netherlands and Switzerland. Besides Belgium, the part-time pattern was followed in the same countries in terms of actual working times. The consistency between preferred and actual working times was rather strong in a majority of countries. However, six countries fell under different working time patterns when preferred and actual working times were compared. Comparison of working mothers’, childless women’s, and fathers’ working times showed that differences between these groups were surprisingly small. It was only in part-time pattern countries that working mothers worked significantly shorter hours than working childless women and fathers. Results therefore revealed that when mothers’ working times are under study, an important question regarding the population examined is whether it consists of all mothers or only working mothers. Results moreover supported the use of the integrative theoretical approach when studying mothers’ working time patterns. Results indicate that mothers’ working time patterns in all countries are shaped by various opportunities and constraints, which are comprised of structural, cultural, institutional, and individual-level factors.

Relevância:

30.00% 30.00%

Publicador:

Resumo:

The human immune system is constantly interacting with the surrounding stimuli and microorganisms. However, when directed against self or harmless antigens, these vital defense mechanisms can cause great damage. In addition, the understanding the underlying mechanism of several human diseases caused by aberrant immune cell functions, for instance type 1 diabetes and allergies, remains far from being complete. In this Ph.D. study these questions were addressed using genome-wide transcriptomic analyses. Asthma and allergies are characterized by a hyperactive response of the T helper 2 (Th2) immune cells. In this study, the target genes of the STAT6 transcription factor in naïve human T cells were identified with RNAi for the first time. STAT6 was shown to act as a central activator of the genes expression upon IL-4 signaling, with both direct and indirect effects on Th2 cell transcriptome. The core transcription factor network induced by IL-4 was identified from a kinetic analysis of the transcriptome. Type 1 diabetes is an autoimmune disease influenced by both the genetic susceptibility of an individual and the disease-triggering environmental factors. To improve understanding of the autoimmune processes driving pathogenesis in the prediabetic phase in humans, a unique series of prospective whole-blood RNA samples collected from HLA-susceptible children in the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) study was studied. Changes in different timewindows of the pathogenesis process were identified, and especially the type 1 interferon response was activated early and throughout the preclinical T1D. The hygiene hypothesis states that allergic diseases, and lately also autoimmune diseases, could be prevented by infections and other microbial contacts acquired in early childhood, or even prenatally. To study the effects of the standard of hygiene on the development of neonatal immune system, cord blood samples from children born in Finland (high standard of living), Estonia (rapid economic growth) and Russian Karelia (low standard of living) were compared. Children born in Russian Karelia deviated from Finnish and Estonian children in many aspects of the neonatal immune system, which was developmentally more mature in Karelia, resembling that of older infants. The results of this thesis offer significant new information on the regulatory networks associated with immune-mediated diseases in human. The results will facilitate understanding and further research on the role of the identified target genes and mechanisms driving the allergic inflammation and type 1 diabetes, hopefully leading to a new era of drug development.

Relevância:

30.00% 30.00%

Publicador:

Resumo:

The objective of this study was to evaluate the effect of metabolic syndrome (MetS) and its individual components on the renal function of patients with type 2 diabetes mellitus (DM). A cross-sectional study was performed in 842 type 2 DM patients. A clinical and laboratory evaluation, including estimated glomerular filtration rate (eGFR) calculated by the modification of diet in renal disease formula, was performed. MetS was defined according to National Cholesterol Education Program - Adult Treatment Panel III criteria. Mean patient age was 57.9 ± 10.1 years and 313 (37.2%) patients were males. MetS was detected in 662 (78.6%) patients. A progressive reduction in eGFR was observed as the number of individual MetS components increased (one: 98.2 ± 30.8; two: 92.9 ± 28.1; three: 84.0 ± 25.1; four: 83.8 ± 28.5, and five: 79.0 ± 23.0; P < 0.001). MetS increased the risk for low eGFR (<60 mL·min-1·1.73 (m²)-1) 2.82-fold (95%CI = 1.55-5.12, P < 0.001). Hypertension (OR = 2.2, 95%CI = 1.39-3.49, P = 0.001) and hypertriglyceridemia (OR = 1.62, 95%CI = 1.19-2.20, P = 0.002) were the individual components with the strongest associations with low eGFR. In conclusion, there is an association between MetS and the reduction of eGFR in patients with type 2 DM, with hypertension and hypertriglyceridemia being the most important contributors in this sample. Interventional studies should be conducted to determine if treatment of MetS can prevent renal failure in type 2 DM patients.

Relevância:

30.00% 30.00%

Publicador:

Resumo:

In order to determine the variability of pequi tree (Caryocar brasiliense Camb.) populations, volatile compounds from fruits of eighteen trees representing five populations were extracted by headspace solid-phase microextraction and analyzed by gas chromatography-mass spectrometry. Seventy-seven compounds were identified, including esters, hydrocarbons, terpenoids, ketones, lactones, and alcohols. Several compounds had not been previously reported in the pequi fruit. The amount of total volatile compounds and the individual compound contents varied between plants. The volatile profile enabled the differentiation of all of the eighteen plants, indicating that there is a characteristic profile in terms of their origin. The use of Principal Component Analysis and Cluster Analysis enabled the establishment of markers (dendrolasin, ethyl octanoate, ethyl 2-octenoate and β-cis-ocimene) that discriminated among the pequi trees. According to the Cluster Analysis, the plants were classified into three main clusters, and four other plants showed a tendency to isolation. The results from multivariate analysis did not always group plants from the same population together, indicating that there is greater variability within the populations than between pequi tree populations.