998 resultados para RES-direktiivi
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Peer reviewed
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La prévalence importante des troubles d’adaptation au sein de la population d’enfants et d’adolescents du Québec appuient l’importance d’accorder une attention particulière aux piliers développementaux influençant leur trajectoire (Ministère de la Santé et des Services sociaux du Québec, 2002). Dans ce sens, des données longitudinales ont permis de statuer sur la nature de l’impact de la relation d’attachement entre le parent et l’enfant sur son adaptation ultérieure (Sroufe, Egeland, Carlson, & Collins, 2005). La sécurité d’attachement aurait un rôle protecteur, mais cette relation a aussi été identifiée comme le système le plus influent dans la compromission du développement de l’enfant (Cicchetti & Valentino, 2006). Parmi les interventions disponibles, le programme d’intervention Circle of Security Parenting (COS-P) (Powell, Cooper, Hoffman, & Marvin, 2009) s’avère particulièrement prometteur étant donnée la qualité de l’intégration théorique et clinique qui le sous-tend. Cependant, aucune donnée n’est encore disponible pour appuyer son efficacité au sein de la population québécoise dans un contexte de soins de première ligne. La présente étude vise ainsi à amorcer cette démarche avec un devis pré/post tests en explorant les effets du protocole d’intervention COS-P auprès de quatre mères et leur enfant d’âge préscolaire. À ces fins, des mesures cernant la fonction réflexive parentale et les dimensions des représentations de l’expérience affective du parent (Parent Development Interview – PDI; Aber, Slade, Berger, Bresgi & Kaplan, 1985) sont recueillies avant et après l’intervention. Les retombées de l’intervention sont aussi examinées chez les parents au niveau du stress parental (Parental Stress Index — PSI; Abidin, 1995; Bigras, LaFrenière, & Abidin, 1996) et au niveau des problèmes comportementaux et émotionnels chez les enfants (Child Behavior Checklist – CBCL; Achenbach & Rescorla, 2000). L’ensemble de ces données est analysé dans un premier temps avec perspective groupale et dans un deuxième temps, avec une perspective individuelle descriptive détaillant les résultats pour chaque participante. Les analyses ne permettent pas de démontrer une amélioration des représentations parentales et une augmentation de la fonction réflexive parentale, tel qu’attendu. Toutefois, le stress parental et les problèmes intériorisés des enfants diminuent, bien que de façon non significative. Il est proposé que l’effet de l’intervention soit compris en considérant le parent à l’intérieur d’un système dynamique, lui permettant de s’approprier l’intervention à travers un ensemble de facteurs qui lui sont propres. Des suggestions pour les études futures sont formulées en regard des constats méthodologiques et cliniques qui se dégagent de la présente étude notamment quant à la pertinence de mesures de relance (Navarro, manuscrit en préparation) et à la poursuite de la démonstration de l’efficacité du protocole avec un devis expérimental (Lemieux, manuscrit en préparation).
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Este artículo analiza uno de los personajes secundarios más relevantes de las Res Gestae (RG) de Amiano Marcelino, el magister peditum Barbación. El historiador presenta a Barbación como un ser infame: colaborador en la muerte de Galo, cobarde, arrogante y desleal con Juliano durante la campaña militar del 357, delator de falsedades ante Constancio, merecedor de una muerte indigna. Sin embargo, un estudio de conjunto de los pasajes de Res Gestae, tomando como apoyo metodológico las técnicas de argumentación aplicadas al retrato y el concepto de ‘argumentación implícita’ de Sabbah 1978 y los métodos de caracterización de personajes de Pauw 1977, corrige esta visión comúnmente aceptada y demuestra la parcialidad del historiador. Así mismo se pone de manifiesto que el personaje, como otros actantes secundarios en las RG, es una réplica del carácter de Constancio II.
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Includes bibliographical references.
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Los orígenes de esta investigación, tienen como base la implementación de un sello de inocuidad en la empresa DIKA S.A. de C.V. Para mejorar sus procesos en los destaces de las reses en su rastro, ya que en la actualidad los rastros no brindan un servicio de buena calidad para sus clientes. El objetivo primordial de la investigación es: Determinar mediante el trabajo de campo, si los clientes están dispuestos a pagar un precio adicional por carne de res certificada; y de acuerdo a la información obtenida la empresa pueda tomar las decisiones sobre la implementación del sello de inocuidad. La metodología que se utilizó fue, por la naturaleza de la investigación, basada en el tipo de muestreo no probabilístico ya que en Súper Selectos (principal intermediario) tienen como política no permitir encuestadores en sus locales de venta, esto nos obligó a tomar otras medidas de recolección de información, como los mencionados anterior mente. Los resultados obtenidos indicaron que de los 104 encuestados, el 64.4% está a favor o dispuesto a pagar un precio adicional, por el contrario u opinión diferente se encuentra el 35.6%. Estos porcentajes indican, que la inversión podría ser rentable. Después de analizar los datos brindados por las encuestas, concluimos que sí, el sello debe ser implementado; pero el alza en los precios debe ser pausado y estratégicamente, además buscar recuperar la inversión no solo en los precios sino en otras estrategias, las cuales recomendamos en el Capítulo III.
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I compilatori di Giustiniano inserirono la formula Res iudicata pro veritate accipitur, utilizzata da Ulpiano D.1.5.25 come motivazione, nel passo D.50.17.207 delle loro regulae iuris antiqui. Essi non vi inserirono però il principio opposto, di importanza pratica notevolmente maggiore, Res inter alios iudicata aliis non praeiudicat.
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Le Res cottidianae sive Aurea sono un’opera giuridica elementare di diritto privato romano. A differenza delle Institutiones di Gaio, di cui abbiamo conoscenza in larga misura grazie al palinsesto Codice Veronese, tutto ciò che sappiamo delle res cottidianae si arresta a ventisei frammenti che ci sono tramandati dal Digesto. Dibattuta è la loro paternità, dibattuta la genuinità del loro contenuto, dibattuti sono il titolo che recavano e di quanti libri fossero composte. La presente ricerca tenta di rispondere a queste vexatae quaestiones e offrire nuove prospettive alla risoluzione del c.d. «enigma gaiano». Punto di partenza sarà una indagine preliminare sul rapporto intercorrente tra le res cottidianae e le Institutiones di Gaio, volta a mostrare la struttura parallela delle due opere, le analogie testuali, i punti di contatto e divergenza. Ci si addentrerà, in seguito, nei ventisei frammenti delle res cottidianae, posto che qualsiasi riflessione scientifica sull’opera non può essere svincolata dall’analisi testuale. Si offrirà infine un bilancio complessivo delle res cottidianae, anche in relazione all’effettiva portata del lascito gaiano agli studi giuridici di diritto positivo.
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Disconnectivity between the Default Mode Network (DMN) nodes can cause clinical symptoms and cognitive deficits in Alzheimer׳s disease (AD). We aimed to examine the structural connectivity between DMN nodes, to verify the extent in which white matter disconnection affects cognitive performance. MRI data of 76 subjects (25 mild AD, 21 amnestic Mild Cognitive Impairment subjects and 30 controls) were acquired on a 3.0T scanner. ExploreDTI software (fractional Anisotropy threshold=0.25 and the angular threshold=60°) calculated axial, radial, and mean diffusivities, fractional anisotropy and streamline count. AD patients showed lower fractional anisotropy (P=0.01) and streamline count (P=0.029), and higher radial diffusivity (P=0.014) than controls in the cingulum. After correction for white matter atrophy, only fractional anisotropy and radial diffusivity remained significantly lower in AD compared to controls (P=0.003 and P=0.05). In the parahippocampal bundle, AD patients had lower mean and radial diffusivities (P=0.048 and P=0.013) compared to controls, from which only radial diffusivity survived for white matter adjustment (P=0.05). Regression models revealed that cognitive performance is also accounted for by white matter microstructural values. Structural connectivity within the DMN is important to the execution of high-complexity tasks, probably due to its relevant role in the integration of the network.
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Viscosupplements, used for treating joint and cartilage diseases, restore the rheological properties of synovial fluid, regulate joint homeostasis and act as scaffolds for cell growth and tissue regeneration. Most viscosupplements are hydrogels composed of hyaluronic acid (HA) microparticles suspended in fluid HA. These microparticles are crosslinked with chemicals to assure their stability against enzyme degradation and to prolong the action of the viscosupplement. However, the crosslinking also modifies the mechanical, swelling and rheological properties of the HA microparticle hydrogels, with consequences on the effectiveness of the application. The aim of this study is to correlate the crosslinking degree (CD) with these properties to achieve modulation of HA/DVS microparticles through CD control. Because divinyl sulfone (DVS) is the usual crosslinker of HA in viscosupplements, we examined the effects of CD by preparing HA microparticles at 1:1, 2:1, 3:1, and 5:1 HA/DVS mass ratios. The CD was calculated from inductively coupled plasma spectrometry data. HA microparticles were previously sized to a mean diameter of 87.5 µm. Higher CD increased the viscoelasticity and the extrusion force and reduced the swelling of the HA microparticle hydrogels, which also showed Newtonian pseudoplastic behavior and were classified as covalent weak. The hydrogels were not cytotoxic to fibroblasts according to an MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2014.
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In this work the archaea and eubacteria community of a hypersaline produced water from the Campos Basin that had been transported and discharged to an onshore storage facility was evaluated by 16S recombinant RNA (rRNA) gene sequence analysis. The produced water had a hypersaline salt content of 10 (w/v), had a carbon oxygen demand (COD) of 4,300 mg/l and contains phenol and other aromatic compounds. The high salt and COD content and the presence of toxic phenolic compounds present a problem for conventional discharge to open seawater. In previous studies, we demonstrated that the COD and phenolic content could be largely removed under aerobic conditions, without dilution, by either addition of phenol degrading Haloarchaea or the addition of nutrients alone. In this study our goal was to characterize the microbial community to gain further insight into the persistence of reservoir community members in the produced water and the potential for bioremediation of COD and toxic contaminants. Members of the archaea community were consistent with previously identified communities from mesothermic reservoirs. All identified archaea were located within the phylum Euryarchaeota, with 98 % being identified as methanogens while 2 % could not be affiliated with any known genus. Of the identified archaea, 37 % were identified as members of the strictly carbon-dioxide-reducing genus Methanoplanus and 59 % as members of the acetoclastic genus Methanosaeta. No Haloarchaea were detected, consistent with the need to add these organisms for COD and aromatic removal. Marinobacter and Halomonas dominated the eubacterial community. The presence of these genera is consistent with the ability to stimulate COD and aromatic removal with nutrient addition. In addition, anaerobic members of the phyla Thermotogae, Firmicutes, and unclassified eubacteria were identified and may represent reservoir organisms associated with the conversion hydrocarbons to methane.
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To evaluate associations between polymorphisms of the N-acetyltransferase 2 (NAT2), human 8-oxoguanine glycosylase 1 (hOGG1) and X-ray repair cross-complementing protein 1 (XRCC1) genes and risk of upper aerodigestive tract (UADT) cancer. A case-control study involving 117 cases and 224 controls was undertaken. The NAT2 gene polymorphisms were genotyped by automated sequencing and XRCC1 Arg399Gln and hOGG1 Ser326Cys polymorphisms were determined by Polymerase Chain Reaction followed by Restriction Fragment Length Polymorphism (PCR-RFLP) methods. Slow metabolization phenotype was significantly associated as a risk factor for the development of UADT cancer (p=0.038). Furthermore, haplotype of slow metabolization was also associated with UADT cancer (p=0.014). The hOGG1 Ser326Cys polymorphism (CG or GG vs. CC genotypes) was shown as a protective factor against UADT cancer in moderate smokers (p=0.031). The XRCC1 Arg399Gln polymorphism (GA or AA vs. GG genotypes), in turn, was a protective factor against UADT cancer only among never-drinkers (p=0.048). Interactions involving NAT2, XRCC1 Arg399Gln and hOGG1 Ser326Cys polymorphisms may modulate the risk of UADT cancer in this population.