Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages.

Human macrophages are believed to damage host tissues in chronic inflammatory disease states, but these cells have been reported to express only modest degradative activity in vitro. However, while examining the ability of human monocytes to degrade the extracellular matrix component elastin, we identified culture conditions under which the cells matured into a macrophage population that displayed a degradative phenotype hundreds of times more destructive than that previously ascribed to any other cell population. The monocyte-derived macrophages synthesized elastinolytic matrix metalloproteinases (i.e., gelatinase B and matrilysin) as well as cysteine proteinases (i.e., cathepsins B, L, and S), but only the cathepsins were detected in the extracellular milieu as fully processed, mature enzymes by either vital fluorescence or active-site labeling. Consistent with these observations, macrophage-mediated elastinolytic activity was not affected by matrix metalloproteinase inhibitors but could be almost completely abrogated by inhibiting cathepsins L and S. These data demonstrate that human macrophages mobilize cysteine proteinases to arm themselves with a powerful effector mechanism that can participate in the pathophysiologic remodeling of the extracellular matrix.

Exposure to Chinese imports andlocal labor market outcomes. An Analysis for Spanish provinces

In the period 1999-2007 Spanish imports from China multiplied by six, making that Asian country the fourth largest supplier to the Spanish economy. In this paper, we analyse whether this massive increase in imports impacted on the labour markets of Spanish provinces to differing degrees, due to differences in their initial productive specialization. Our results show that Spanish provinces with a higher exposure to Chinese imports experienced larger drops in manufacturing employment as a share of the working-age population. However, this reduction was compensated for by increases in non-manufacturing employment.

The cognitive mobilization index: crises and political generations

This article shows how the cognitive mobilization index, designed for use in observing potential political participation, can be used as an indicator of the political climate that a particular society is going through. Following a discussion of the theoretical elaborations (and their working definitions) of the concept of cognitive mobilization, a longitudinal study of various European countries is used to consider the question of how political crises influence cognitive mobilization indexes and what effects they have on the political socialization process among the youngest cohorts.

La labor científica de fray Jerónimo de Alcalá, OFM: una etnografía misionera del siglo XVI

En el presente artículo revisamos el trabajo etnográfico que un misionero franciscano del siglo XVI, fray Jerónimo de Alcalá, realizó por medio de la traducción. Su principal obra, la Relación de Michoacán, constituye uno de los más valiosos manuscritos coloniales de toda América. Para su elaboración recopiló, tradujo y fijó en el papel la tradición oral purépecha, rescatando del olvido el testimonio histórico y antropológico de la riqueza cultural michoacana. El rigor científico de su trabajo de campo, que acometió humildemente como “fiel intérprete” y con mera intención misional, ha hecho de su obra una fuente documental imprescindible.

Conditions of labor in American industries: a summarization of the results of recent investigations

by W. Jett Lauck and Edgar Sydenstricker.

Immigration and labor: the economic aspects of European immigration to the United States

by Isaac A. Hourwich.

The college, the market, and the court, or, Woman's relation to education, labor, and law

by Caroline H. Dall.

The condition of women workers under the present industrial system: an address by Ida M. Van Etten at the National Convention of the American Federation of Labor held at Detroit, Michigan, December 8th, 1890

At head of title: Publication of the American Federation of Labor.

How one juvenile court helps to make child labor legislation effective

by Mabel Brown Ellis.

Index of all reports issued by Bureaus of Labor Statistics in the United States, prior to March 1, 1902

prepared under the direction of Carroll D. Wright ; for the use of the United States Department of Labor.

Comparative wages, prices, and cost of living: (from the Sixteenth annual report of the Massachusetts Bureau of Statistics of Labor, for 1885)

Historical review of wages and prices. 1752-1860 -- Comparative wages, prices, and cost of living: Massachusetts and Great Britain. 1860-1883.

Uniform child labor laws

by Owen R. Lovejoy.