Multifaceted Role of Heme during Severe Plasmodium falciparum Infections in India

Several immunomodulatory factors are involved in malaria pathogenesis. Among them, heme has been shown to play a role in the pathophysiology of severe malaria in rodents, but its role in human severe malaria remains unclear. Circulating levels of total heme and its main scavenger, hemopexin, along with cytokine/chemokine levels and biological parameters, including hemoglobin and creatinine levels, as well as transaminase activities, were measured in the plasma of 237 Plasmodium falciparum-infected patients living in the state of Odisha, India, where malaria is endemic. All patients were categorized into well-defined groups of mild malaria, cerebral malaria (CM), or severe noncerebral malaria, which included acute renal failure (ARF) and hepatopathy. Our results show a significant increase in total plasma heme levels with malaria severity, especially for CM and malarial ARF. Spearman rank correlation and canonical correlation analyses have shown a correlation between total heme, hemopexin, interleukin-10, tumor necrosis factor alpha, gamma interferon-induced protein 10 (IP-10), and monocyte chemotactic protein 1 (MCP-1) levels. In addition, canonical correlations revealed that heme, along with IP-10, was associated with the CM pathophysiology, whereas both IP-10 and MCP-1 together with heme discriminated ARF. Altogether, our data indicate that heme, in association with cytokines and chemokines, is involved in the pathophysiology of both CM and ARF but through different mechanisms.

Sedimentology on a core from Lonar Lake in India

Concerns about the regional impact of global climate change in a warming scenario have highlighted the gaps in our understanding of the Indian Summer Monsoon (ISM, also referred to as the Indian Ocean summer monsoon) and the absence of long term palaeoclimate data from the central Indian core monsoon zone (CMZ). Here we present the first high resolution, well-dated, multiproxy reconstruction of Holocene palaeoclimate from a 10 m long sediment core raised from the Lonar Lake in central India. We show that while the early Holocene onset of intensified monsoon in the CMZ is similar to that reported from other ISM records, the Lonar data shows two prolonged droughts (PD, multidecadal to centennial periods of weaker monsoon) between 4.6-3.9 and 2-0.6 cal?ka. A comparison of our record with available data from other ISM influenced sites shows that the impact of these PD was observed in varying degrees throughout the ISM realm and coincides with intervals of higher solar irradiance. We demonstrate that (i) the regional warming in the Indo-Pacific Warm Pool (IPWP) plays an important role in causing ISM PD through changes in meridional overturning circulation and position of the anomalous Walker cell; (ii) the long term influence of conditions like El Niño-Southern Oscillation (ENSO) on the ISM began only ca. 2 cal?ka BP and is coincident with the warming of the southern IPWP; (iii) the first settlements in central India coincided with the onset of the first PD and agricultural populations flourished between the two PD, highlighting the significance of natural climate variability and PD as major environmental factors affecting human settlements.

Financial planning in transit: use of commercially available microcomputer software. Final report.

Urban Mass Transportation Administration, Washington, D.C.

Report on the diseases of silkworms in India,

Bibliography: p. 162-163.

Cow-keeping in India : a simple and practical book on their care and treatment, their various breeds, and the means of rendering them profitable /

Includes index.

Studies on the ice age in India and associated human cultures,

"Literature references": p. 337-340.

Prices and wages in India.

At head of title, 31st-37th issue: Dept. of Statistics, India.

An American girl in India : a novel /

Mode of access: Internet.

Lucas' progressive drawing book, in three parts: : Part I--The principles of drawing in pencil, Part II--Colouring and shading in india ink, Part III--A treatise on perspective; : consisting chiefly of original views of American scenery, and embracing the latest and best improvements in the mode of instruction.

Poem "The colours" by E. Van Blon, part 2, p. [65]-66.