Données actualisées sur la physiopathologie, les phénotypes et les traitements de la maladie de Still de l'adulte [Pathophysiology, subtypes, and treatments of adult-onset Still's disease: An update].

Adult-onset Still's disease is a rare and difficult to diagnose multisystemic disorder considered as a multigenic autoinflammatory syndrome. Its immunopathogenesis seems to be at the crossroads between inflammasomopathies and hemophagocytic lymphohistiocytosis, the most severe manifestation of the disease. According to recent insights in the pathophysiology and thanks to cohort studies and therapeutic trials, two phenotypes of adult-onset Still's disease may be distinguished: a systemic pattern, initially highly symptomatic and with a higher risk to exhibit life-threatening complications such as reactive hemophagocytic lymphohistiocytosis, where interleukin-1 blockade seems to be very effective, a chronic articular pattern, more indolent with arthritis in the foreground and less severe systemic manifestations, which would threat functional outcome and where interleukin-6 blockade seems to be more effective. This review focuses on these data.

Hiilidioksidipäästölaskurin kehittäminen toimistoille ja yleisötapahtumille

Diplomityössä on kehitetty websovelluksena toteutettavan ilmastolaskuripalvelun hiilidioksidipäästöjen laskentamoduulit, joiden avulla toimistot ja yleisötapahtumat voivat arvioida omasta toiminnastaan syntyviä hiilidioksidipäästöjä sähkönkulutuksen, lämmönkulutuksen, matkustamisen, kuljetusten ja paperin kulutuksen osalta. Tavoitteena oli kehittää ilmastolaskurista mahdollisimman helppokäyttöinen ja kohderyhmälle hyödyllinen websovellus. Työn kirjallisuusosiossa käsitellään toimistojen ja yleisötapahtumien ympäristövaikutuksia etenkin ilmastonmuutoksen näkökulmasta. Toimistot ja yleisötapahtumat vaikuttavat ilmastonmuutokseen pääasiassa kiinteistöjen sähkön- ja lämmönkulutuksen sekä liikenteen energiankulutuksesta syntyvien hiilidioksidipäästöjen muodossa. Rakennusten energiankulutuksen ja liikenteen yhteys kansalliseen CO2-päästötaseeseen sekä päästöjenvähennystavoitteisiin on merkittävä päästökauppadirektiivin sovellusalan ulkopuolella. Lisäksi tarkastellaan paino- ja paperituotteiden elinkaaren aikaisia ympäristövaikutuksia energiankulutuksen kannalta, sillä paperi on toimistojen ja usein myös tapahtumien merkittävin yksittäinen materiaalivirta. Ilmastolaskuriin kuuluvien hiilidioksidipäästöjen laskentamoduulien kehittämisessä pyrittiin huomioimaan mahdollisimman pitkälle käyttäjien tarpeet ja tiedonsaantimahdollisuudet. Ilmastolaskuri suunniteltiin toimistojen ja yleisötapahtumien ympäristövaikutuksia käsittelevän tutkimustiedon, ilmastolaskuriprojektissa toteutetun esimarkkinakyselyn tulosten, käyttäjähaastatteluista saadun palautteen sekä keskeisesti suunnitteluprosessissa mukana olleen asiantuntijaryhmän antamien kehitysehdotusten perusteella. Työssä on esitetty ilmastolaskurisovelluksen laadulliset kriteerit, tekninen vaatimusmäärittely sekä hiilidioksidipäästöjen laskentaosuuden toteutussuunnitelma, joka sisältää laskentamoduulien käyttöliittymämallit sekä päästölaskentaan liittyvät hiilidioksidipäästökertoimet, oletusarvot, päästölaskentakaavat ja huomautukset.

Manipulation of arthropod sex determination by endosymbionts: diversity and molecular mechanisms.

Arthropods exhibit a large variety of sex determination systems both at the chromosomal and molecular level. Male heterogamety, female heterogamety, and haplodiploidy occur frequently, but partially different genes are involved. Endosymbionts, such as Wolbachia, Cardinium,Rickettsia, and Spiroplasma, can manipulate host reproduction and sex determination. Four major reproductive manipulation types are distinguished: cytoplasmic incompatibility, thelytokous parthenogenesis, male killing, and feminization. In this review, the effects of these manipulation types and how they interfere with arthropod sex determination in terms of host developmental timing, alteration of sex determination, and modification of sexual differentiation pathways are summarized. Transitions between different manipulation types occur frequently which suggests that they are based on similar molecular processes. It is also discussed how mechanisms of reproductive manipulation and host sex determination can be informative on each other, with a special focus on haplodiploidy. Future directions on how the study of endosymbiotic manipulation of host reproduction can be key to further studies of arthropod sex determination are shown.

Vieraalla kielellä tapahtuvan sisäisen viestinnän vaikutukset organisaation tietovarantoon postmodernin tietokäsityksen viitekehyksessä

Tutkimus pohtii tiedon ja kielitaidon välistä suhdetta kansainvälisen organisaation sisäisessä viestinnässä. Työssä keskitytään erityisesti virallisen kielen vaihtamisen vaikutuksiin organisatorisentiedon laatuun ja määrään. Aihepiiriä lähestytään käsiteanalyyttisin keinoin. Työn on kvalitatiivinen ja siinä on käytetty kirjallista materiaalia, jonka kanssa tutkijalla ei ole ollut vuorovaikutuksessa. Tutkimustulokset osoittavat että on todennäköiseksi, jopa lähes varmaa, että organisaation virallisen kielen vaihtuminen muuttaa organisaation viestintärakennetta. En seurauksena kommunikaatiosuhteet eivät perustu enää osaamiseen tai viralliseen asemaan organisaatiossa. Uudet viestintäverkostot muodostuvat kielitaidon varaan jolloin väistämättä sivutetaan henkilöitä joilla olisi tietämystä, mutta ei kielitaitoa jakaa sitä organisaatiolle. Kansainvälistyminen tuo mukanaan laajemman potentiaalisentietovarannon, joka on mahdollista saada palvelemaan organisaatiota. Näiden kahden vastakkaisen seikan kokonaisvaikutus organisaation tietovarannolle kaipaa lisätutkimusta.

Estudi de noves estratègies encapsuladores d’antimalàrics i distribució de nanovectors polimèrics en Anopheles atroparvus

En aquest treball s’ha estudiat el comportament de compostos antimalàrics com els fàrmacs i els polímers en diferents situacions. Una de les barreres que ha estat identificada com a principal obstacle per a una millora de l’eficàcia dels compostos antimalàrics, és la limitació en la quantitat de fàrmac que pot ser encapsulada dins un liposoma, i que depèn de la seva solubilitat en medi aquós. Amb la inspiració de la descripció d’un nou tipus de nanocàpsules amb aplicacions oncològiques capaces d’encapsular grans quantitats de fàrmacs (protocells, Ashley et al., 2011). Els constructes formats per liposomes amb un nucli d’òxid de silici altament porós capaç de contenir el fàrmac, s’anomenen “protocells”, que en comparació als liposomes, tenen una major selectivitat i estabilitat, i permeten alliberar altes concentracions de droga directament al citosol de les cèl·lules cancerígenes. Aquest estudi es basa en la fabricació d’aquests nous nanovectors que continguin fàrmacs antimalàrics i té com a objectiu futur dirigir-los a eritròcits infectats per malària (pRBCs). Una altra part del treball és l’estudi de la distribució del polímer ISA-FITC en Anopheles atroparvus. Sabent que els polímers han estat utilitzats com a transportadors antimalàrics, es va pensar en l’opció d’eliminar el paràsit a dins del mateix mosquit, com una alternativa a tots el estudis realitzats fins ara centrats en les etapes d’infecció de l’hoste. Per aquest motiu es va idear l’experiment pensant en aquest polímer amb la intenció final de veure la seva localització en un mosquit Anopheles lliure del paràsit. OBJECTIUS: Determinació de la capacitat encapsuladora de tres tipus de nanopartícules, fabricades amb el mateix material però amb característiques de mida i càrrega diferents, incubant-les amb cinc fàrmacs antimalàrics. El blau de metilè, la primaquina, la cloroquina, la quinina i la curcumina, cadascun d’ells amb característiques de pH, solubilitat i estructura diferents. Alguns d’ells són fàrmacs que no s’han emprat en altres estudis degut a la seva toxicitat o elevada inespecificitat (la qual es pretén reduir un cop encapsulats en protocells). Construcció de “protocells” un cop determinada la millor nanopartícula encapsuladora i fàrmac candidat i determinació de la concentració de fàrmac que podien contenir, i el ritme d’alliberament d’aquest en PBS (simulant les condicions fisiològiques dels pRBCs). Estudi de la localització del polímer antimalàric ISA-FITC en l’anatomia del mosquit Anopheles Atroparvus. PROCEDIMENTS: Mètodes espectrofotomètrics Microscopia Cryo-electrònica de transmissió Microscopia confocal de fluorescència

Bosque y turismo

This paper presents a number of considerations on the recreational/tourism function offorests and some regulations that should be present in the planning of the public use of forestspace. We are going to examine studies on frequency of use, the features that condition theuse of forests and the criteria that should be present on planning of recreational use of forests

Feedback i oportunitats de millora: una avaluació orientada a l"aprenentatge actiu

This paper analyzes an innovative experience of formative assessment aimed at improving the teaching of Statistics, which could be easily extrapolated to other studies. We detail the implementation of the double correction, consisting of correcting students' work twice. With the first correction, carried out by classmates according to a rubric developed by the academic, possible errors or deficiencies are discovered, and students are provided with a feedback that allows them to correct and improve their work before being graded by the teacher; whereas in the second correction of the work, once upgraded, the professor evaluates and grades the work. As a result, there is a significant improvement in the quality of students" works, and an active learning from their own mistakes. Both contents and competencies are reinforced by the experience.

Comparison of acute non-visual bright light responses in patients with optic nerve disease, glaucoma and healthy controls.

This study examined the effect of optic nerve disease, hence retinal ganglion cell loss, on non-visual functions related to melanopsin signalling. Test subjects were patients with bilateral visual loss and optic atrophy from either hereditary optic neuropathy (n = 11) or glaucoma (n = 11). We measured melatonin suppression, subjective sleepiness and cognitive functions in response to bright light exposure in the evening. We also quantified the post-illumination pupil response to a blue light stimulus. All results were compared to age-matched controls (n = 22). Both groups of patients showed similar melatonin suppression when compared to their controls. Greater melatonin suppression was intra-individually correlated to larger post-illumination pupil response in patients and controls. Only the glaucoma patients demonstrated a relative attenuation of their pupil response. In addition, they were sleepier with slower reaction times during nocturnal light exposure. In conclusion, glaucomatous, but not hereditary, optic neuropathy is associated with reduced acute light effects. At mild to moderate stages of disease, this is detected only in the pupil function and not in responses conveyed via the retinohypothalamic tract such as melatonin suppression.

Barn owl feathers as biomonitors of mercury: sources of variation in sampling procedures.

Given their central role in mercury (Hg) excretion and suitability as reservoirs, bird feathers are useful Hg biomonitors. Nevertheless, the interpretation of Hg concentrations is still questioned as a result of a poor knowledge of feather physiology and mechanisms affecting Hg deposition. Given the constraints of feather availability to ecotoxicological studies, we tested the effect of intra-individual differences in Hg concentrations according to feather type (body vs. flight feathers), position in the wing and size (mass and length) in order to understand how these factors could affect Hg estimates. We measured Hg concentration of 154 feathers from 28 un-moulted barn owls (Tyto alba), collected dead on roadsides. Median Hg concentration was 0.45 (0.076-4.5) mg kg(-1) in body feathers, 0.44 (0.040-4.9) mg kg(-1) in primary and 0.60 (0.042-4.7) mg kg(-1) in secondary feathers, and we found a poor effect of feather type on intra-individual Hg levels. We also found a negative effect of wing feather mass on Hg concentration but not of feather length and of its position in the wing. We hypothesize that differences in feather growth rate may be the main driver of between-feather differences in Hg concentrations, which can have implications in the interpretation of Hg concentrations in feathers. Finally, we recommend that, whenever possible, several feathers from the same individual should be analysed. The five innermost primaries have lowest mean deviations to both between-feather and intra-individual mean Hg concentration and thus should be selected under restrictive sampling scenarios.

Impact of strong psychologically stressful events on the development of Alzheimer disease: a possible role of epigenetic?

Alzheimer disease (AD) is the most common neurodegenerative dementia. It leads to a progressive loss of cognitive functions, especially memory. Most of AD cases are sporadic, resulting from the interplay of genetic and environmental factors which get involved in the regulation of expression of thousands of genes, a mechanism called epigenetic. Epigenetic modifications, by modifying genes transcription, help to orchestrate the phenotypical changes linked to development, aging or even diseases and cancer. In AD, recent studies showed rapid, dynamic and persistent epigenetic mutations that are believed to have consequences on brain functions. One of the earliest biomarker of AD is amylo ̈ıd-beta (Aβ) deposition in the brain. According to current studies, deposition of amylo ̈ıd-beta begins approximately 20 years before the first symptoms linked to the disease which questions us about what could have happened around or before that time. In this exploratory study, we searched if there could be any correlation between the experience of a strong psychologically stressful event in life, which could have lead to several epigenetic changes and therefore the occurrence of Mild Cognitive Impairment (MCI) or AD approximately 30 years later, and to see if there is a difference in the delay between amnestic MCI and AD patients.

Síntese e caracterização estrutural de complexos mono e bimetálicos de paládio e platina com ligantes contendo nitrogênio e enxofre

The synthesis of several mono- and bimetallic platinum and palladium complexes are reported. The monometallic complexes are of the type MCl2(PEt3)2L (L=2-aminothiazol; benzothiazol; 2-imidazolidithione; M=Pt; Pd), and the bimetallic complexes (M2Cl4(PEt3) 2L) are derived from them. Infrared spectroscopic characterization of the monometallic complexes shows that the metal centre are coordinated through the N-endocyclic (L=2-aminothiazol; benzothiazol) and through the sulphur when L=2-imidazolidithione. Coordination of a second metal fragment occurs via the sulphur atom (L=2-aminothiazol; benzothiazol) according to infrared studies. 31P{¹H} NMR spectroscopy suggest that the complexes have a cis- configuration since the ¹J Pt-P are around the value found for this type of compound.

Ozonólise das ligninas organossolve e kraft eucalipto. Parte II: cinética nos meios ácido e básico

Organosolv and kraft lignins were treated with ozone both in basic and acid media and the reaction was studied kinetically. In contrast to reported studies, ozone was more efective in basic medium. Kraft lignin was degraded faster than organosolv lignin in both media but in the basic medium the rate of reaction was very much faster than in the acid one: for kraft lignin, the observed degradation was 93% for 2 min of reaction in the basic medium and 56% for 10 min of reaction in the acid medium; for organosolv lignin, 47% and 25%, respectively, in the same times. Higher phenolic hydroxyl groups contents increase the reaction rate.

Rikostutkinta Kaakkois-Suomen rajavartiostossa ja siihen liittyvä erityispiirteet

Tutkielmassa tarkastellaan Kaakkois-Suomen rajavartioston näkökulmasta rajavartiolaitoksen esitutkintaan liittyviä toimivaltuuksia sekä esitutkinnan ja ulkomaalaislain mukaisten toimenpiteiden vaikutuksia rikosprosessiin. Lisäksi selvitetään uuden hallituksen esityksen vaikutuksia rajavartiointia koskevan lainsäädännön muuttamisesta. Tutkielma täydentää aikaisempia tutkimuksia tuomalla esiin systemaattiseen tarkasteluun koko rikosprosessin vaiheet nykyisen esitutkinnan aloittamisesta aina ulkomaalain mukaisiin hallinnollisiin toimenpiteisiin saakka. Luonteeltaan tutkielma on rikosoikeustieteellinen. Tutkielmassa käytetty tutkimusmenetelmä on lainoppi. Tutkielmaa varten haastateltiin yhteistyöviranomaisten edustajia Kaakkois-Suomen rajavartioston koko rikosprosessin toimittamiseen liittyen. Työn tuloksissa esitetään keskeiset esitutkintatoimintaan ja rikosprosessiin vaikuttavat tekijät, tutkintaan liittyvät eri-tyispiirteet ja yhteistyöviranomaisten näkemys Kaakkois-Suomen rajavartioston tutkintatoiminnasta.

Eliminating Software Failures - A Literature Survey

Software faults are expensive and cause serious damage, particularly if discovered late or not at all. Some software faults tend to be hidden. One goal of the thesis is to figure out the status quo in the field of software fault elimination since there are no recent surveys of the whole area. Basis for a structural framework is proposed for this unstructured field, paying attention to compatibility and how to find studies. Bug elimination means are surveyed, including bug knowhow, defect prevention and prediction, analysis, testing, and fault tolerance. The most common research issues for each area are identified and discussed, along with issues that do not get enough attention. Recommendations are presented for software developers, researchers, and teachers. Only the main lines of research are figured out. The main emphasis is on technical aspects. The survey was done by performing searches in IEEE, ACM, Elsevier, and Inspect databases. In addition, a systematic search was done for a few well-known related journals from recent time intervals. Some other journals, some conference proceedings and a few books, reports, and Internet articles have been investigated, too. The following problems were found and solutions for them discussed. Quality assurance is testing only is a common misunderstanding, and many checks are done and some methods applied only in the late testing phase. Many types of static review are almost forgotten even though they reveal faults that are hard to be detected by other means. Other forgotten areas are knowledge of bugs, knowing continuously repeated bugs, and lightweight means to increase reliability. Compatibility between studies is not always good, which also makes documents harder to understand. Some means, methods, and problems are considered method- or domain-specific when they are not. The field lacks cross-field research.

Percepció i coneixements dels estudiants d'infermeria sobre la violència en la parella

Les últimes dades de l'estudi europeu del 2014, sobre la violència de parella indiquen que gairebé 62 milions de dones europees, havien sofert actes de violència de gènere, entre els quals es destaca els relacionats amb la violència de parella (VP). Els maltractaments constitueixen un problema molt greu que genera al nostre país cada vegada més alarma social i més actuacions legals i professionals per fer-li front. El sistema de salut és, amb freqüència, el primer lloc al que les víctimes de violència domèstica acudeixen a la recerca d'assessorament i ajuda, sent aquest el motiu pel qual els professionals de la salut tenen un paper central per a la seva assistència. Aquests formen part implicada en el sistema de detecció, atenció i actuació. Per això, els plans d'estudi de Grau d'Infermeria recullen en el BOE la formació en VP des de l’àmbit universitari. L’objectiu del nostre estudi consisteix en la identificació de la percepció i dels coneixements en relació a la violència de parella dels estudiants del Grau d’Infermeria de la Universitat de Girona durant el curs acadèmic 2012-2013. Per a dur-lo a terme es va realitzar un anàlisi quantitatiu dels resultats a través de l’administració d’una enquesta sobre sis aspectes de la VP, l’enquesta incloïa el perfil demogràfic (sexe, edat i anys d'estudi) dels estudiants i les declaracions relatives a les seves percepcions i coneixements sobre la VP: causes d'abús; la identificació de les dones objecte de VP i del seus autors; creences de les infermeres; funcions perceptibles; i la preparació educativa. Els estudiants del Grau d’Infermeria mostren tenir un bon coneixement sobre les causes del abús en VP, així com una formació adequada. També cal destacar que un 54,42% dels alumnes enquestats es veuen capacitats per afrontar un cas de VP com a infermer/a. S’observa una millora de la formació educativa en el transcurs acadèmic. En 1r curs un 40,09% té una bona formació, aquest valor augmenta fins a un 56,58% a tercer curs, baixant lleugerament fins un 44,27% a 4rt curs. Els resultats obtinguts són semblats a estudis de mostres similars en estudiants d'infermeria de Memphis (EUA) i de la University of Southern Queensland (Austràlia) quant a coneixements i percepció sobre la VP. Encara que els resultats mostren un coneixement i una percepció sobre la VP adequada, destaquem que això no succeeix en gairebé un 40% dels enquestats. La introducció de matèries específiques sobre igualtat i sobre violència contra la dona en els plans d’estudis, pot esdevenir una mesura preventiva per revisar i corregir possibles mites i creences en VP. Per tant, és necessari millorar la formació del currículum en estudiants d'infermeria per la importància d'aquest greu problema de salut pública, donant major èmfasis en la satisfacció de les necessitats emocionals i en la comprensió dels diferents enfocaments en VP, especialment en mesures de prevenció i educació