Report on a special investigation of the City of Adair for the period January 1, 2007 through July 31, 2010

Report on a special investigation of the City of Adair for the period January 1, 2007 through July 31, 2010

Lottery Action Newsletter, Special Edition, February 14, 2011

Lottery Newsletter for Lottery Retailers

Lottery Action Newsletter Special Edition, June 28, 2010

Lottery Newsletter for Lottery Retailers

Report on a special investigation of the Tama County Sheriff’s Office for the period January 1, 2007 through December 31, 2010

Report on a special investigation of the Tama County Sheriff’s Office for the period January 1, 2007 through December 31, 2010

Enantiomers' potential in psychopharmacology--a critical analysis with special emphasis on the antidepressant escitalopram

Stereochemistry is now influencing most areas of pharmacotherapy, with a growing awareness in the field of psychiatry and, more specifically, depression. This is due to the fact that the enantiomers of many chiral drugs may have distinct pharmacological, pharmacokinetic and/or pharmacogenetic profiles. Consequently, in some instances there may be an advantage in using a single enantiomer over the racemic form-thus providing a basis for the development of new therapeutic agents, as well as the potential to improve current treatments. This review highlights some of the potential advantages and disadvantages that using single enantiomers might offer. The principles are exemplified through reference to the stereoselective properties of several established chiral psychotropic drugs, including thioridazine, methadone, trimipramine, mianserin, mirtazapine, fluoxetine and citalopram. Emphasis is given to the treatment of depression and how the potential of one pure enantiomer-escitalopram, the S-enantiomer of the selective serotonin reuptake inhibitor citalopram-appears to be fulfilling its preclinical promise in the clinic.

Report on a special investigation of the City of Stockton for the period July 1, 2004 to October 31, 2010

Report on a special investigation of the City of Stockton for the period July 1, 2004 to October 31, 2010

Report on a special investigation of the Lake Mills Community School District for the period July 1, 2005 through December 31, 2010

Report on a special investigation of the Lake Mills Community School District for the period July 1, 2005 through December 31, 2010

Report on a special investigation of the City of Garner for the period January 1, 2006 through February 22, 2011

Report on a special investigation of the City of Garner for the period January 1, 2006 through February 22, 2011

Special investigation of the Glenwood Resource Center Client Activity Clearing Account for the period January 1, 2009 through June 30, 2010

Special investigation of the Glenwood Resource Center Client Activity Clearing Account for the period January 1, 2009 through June 30, 2010

Final Report-Freeway Operations Analysis of I-80 to I-29 Interchange, January 1974

A t the request of the Iowa State Highway Commission, the Engineering Research Institute observed the traffic operations at the Interstate 29 (1-29) and Interstate 80 (1-80) interchange in the southwest part of Council Bluffs. The general location of the site is shown in Figure 1. Before limiting the analysis to the diverging area the project staff drove the entire Council Bluffs freeway system and consulted with M r . Philip Hassenstab (Iowa State Highway Commission, District 4, Resident Maintenance Engineer at Council Bluffs). The final study scope was delineated as encompassing only the operational characteristics of the diverge area where 1-29 South and 1-80 East divide and the ramp to merge area where 1-80 West joins 1-29 North (both areas being contained within the aforementioned interchange). Supplementing the traffic operations scope, was an effort to delineate and document the applicability of video-tape techniques to traffic engineering studies and analyses. Documentation was primarily in the form of a demonstration video-tape.

Special investigation of the Bremer County Sheriff’s Office for the period January 1, 2009 through March 17, 2011

Special investigation of the Bremer County Sheriff’s Office for the period January 1, 2009 through March 17, 2011