944 resultados para Ran GTPase


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Este documento se concentra en el estudio de las diferencias salariales mediante la comparación de las distribuciones de los salarios para las siete principales ciudades colombianas en el periodo 2001-2005 con datos de la Encuesta Continua de Hogares. Se detectan diferencias significativas que se explican a la luz de la teoría del capital humano y de segmentación laboral; mediante la estimación de ecuaciones de salarios a partir de las características socioeconómicas de los trabajadores junto con efectos particulares para región y rama de actividad económica que resultan significativos dando evidencia de segmentación del mercado laboralen Colombia. El componente de los salarios que es particular a la región y a la actividad económica se explica a partir de variables macroeconómicas como el crecimiento económico, la dotación sectorial de factores, el costo de vida y el desempleo a nivel regional.

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Cumple con los requisitos para la especificación OCR AS de Historia, unidad F964 sobre 'Investigaciones', opción A. Su contenido examina el papel cambiante, las políticas y estrategias de Estados Unidos durante la Guerra Fría en el Sudeste asiático, las cuales no pueden entenderse sin establecer un trasfondo histórico marcado por la alianza de las dos superpotencias durante la Segunda Guerra Mundial, que después se convirtieron en enemigas en Europa y Asia. Cada capítulo contiene actividades para ayudar a la comprensión del tema y desarrollar habilidades con la historia, análisis de acontecimientos relevantes, de debates y controversias, breves biografías de personas clave de la época y definiciones de palabras nuevas.

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The sociocultural changes that led to the genesis of Romance languages widened the gap between oral and written patterns, which display different discoursive and linguistic devices. In early documents, discoursive implicatures connecting propositions were not generally codified, so that the reader should furnish the correct interpretation according to his own perception of real facts; which can still be attested in current oral utterances. Once Romance languages had undergone several levelling processes which concluded in the first standardizations, implicatures became explicatures and were syntactically codified by means of univocal new complex conjunctions. As a consequence of the emergence of these new subordination strategies, a freer distribution of the information conveyed by the utterances is allowed. The success of complex structural patterns ran alongside of the genesis of new narrative genres and the generalization of a learned rhetoric. Both facts are a spontaneous effect of new approaches to the act of reading. Ancient texts were written to be read to a wide audience, whereas those printed by the end of the XV th century were conceived to be read quietly, in a low voice, by a private reader. The goal of this paper is twofold, since we will show that: a) The development of new complex conjunctions through the history of Romance languages accommodates to four structural patterns that range from parataxis to hypotaxis. b) This development is a reflex of the well known grammaticalization path from discourse to syntax that implies the codification of discoursive strategies (Givón 2 1979, Sperber and Wilson 1986, Carston 1988, Grice 1989, Bach 1994, Blackemore 2002, among others]

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RESUMO: Este projecto de intervenção, fundamentado na investigação/acção, teve como objectivo melhorar a oralidade, leitura e escrita funcionais numa aluna com Défice cognitivo moderado e, consequentemente, promover a sua inclusão em contexto escolar, bem como desenvolver nos restantes colegas atitudes de entreajuda, respeito e cooperação. Decorreu de Fevereiro de 2009 até Junho do mesmo ano. “B” é o nome fictício da aluna em estudo que, aquando a nossa intervenção, frequentava o 3º ano do 1º ciclo numa escola pública. A escolha da questão de partida prendeu-se com a emergência de dar resposta à necessidade que os pais, professores e a criança em questão tinham para que esta desenvolvesse competências de leitura, expressão oral e escrita O enquadramento teórico teve como objectivo facilitar a compreensão da intervenção. Para recolher informações sobre a “B” e sobre os contextos em que a mesma estava inserida, utilizámos como suporte metodológico, a pesquisa documental, o teste sociométrico, as entrevistas semi-directivas à professora de turma e à professora de Educação Especial, a observação naturalista e questionários à mãe da aluna. Foi feito um trabalho conjunto com a professora do ensino regular, com a professora de educação especial e com os pais, no sentido de delinear as estratégias/actividades mais benéficas, de modo a dar resposta às competências a desenvolver com a aluna. No fim da nossa intervenção, em Junho de 2009, esta já sabia escrever o seu nome sem modelo, desenvolveu o vocabulário e melhorou a construção frásica oral. Ao seu ritmo, envolveu-se mais nas actividades da sala de aula. Na aquisição de conceitos e competências, estas tiveram de ser muito simples, reais e concretas para que fossem adquiridas e aplicadas. No entanto, ainda tinha dificuldade em concentrar a atenção sem ajuda. No que diz respeito ao desenvolvimento da linguagem, o discurso utilizado pela “B” melhorou significativamente, passando a construir frases simples com linguagem mais perceptiva, apesar de comunicar com frases curtas e com pouca expressividade. ABSTRACT: This intervention project, based on research / action, was aimed to improve speaking, reading and writing skills in a functional student with moderate cognitive deficit, promote her inclusion in the school context and develop mutual help, respect and cooperation in her classmates attitudes. It ran from February until June, 2009."B" is the fictional name of the student in this study that during our intervention, attended the 3rd year of Primary school in a public school. The choice of the starting point had to do with the urgency of answering the parents, teachers and the child needs in what concerns the development of the reading, writing and speaking skills. The theoretical framework was aimed to facilitate understanding of the intervention. To gather information about "B" and the contexts in which she was placed, it was used, as a methodological support, research documents, the sociometric test, the semi-directive interviews to the class teacher and the Special Education teacher, the naturalist observation and the questionnaires to the student’s mother. Team work was done with the class teacher, the Special Education teacher and the parents, to outline the strategies / activities most beneficial, in order to establish the skills to be developed with the student. At the end of our intervention in June 2009, she could already write her name without a model, had developed and improved vocabulary oral sentence construction. At her own pace, she became more involved in the classroom activities. Concepts and skills acquisition had to be very simple, real and concrete to be acquired and applied. However, she still had some difficulty in focusing attention without help. What concerns language development, “B” has improved significantly from the simple sentences in more perceptive language, although she still communicates with short sentences and with little expression.

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With temperatures in the Arctic rising at twice the pace of anywhere else in the world, the European Union (EU) decided in 2008 to begin formulating an overall Arctic policy tackling maritime, environmental, energy and transport challenges. This attempt to draft a comprehensive policy on a topic that the EU had rarely touched upon unavoidably ran up against other existing strategies from Arctic and non-Arctic states. Against this background, this paper examines whether the EU’s current Arctic policy is conducive to framing a strategy that is both correctly targeted and flexible enough to represent Europe’s interests. It shows that the EU’s approach can serve as an effective foreign policy tool to establish the Union’s legitimacy as an Arctic player. However, the EU’s Arctic policy is still underestimating its potential to find common grounds with the strategic partners Russia and China. A properly targeted Arctic policy could help influence Russia over the EU’s interests in the Northern Sea Route and strengthen cooperation with China in an endeavour to gain recognition as relevant Arctic players.

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To identify the causes of population decline in migratory birds, researchers must determine the relative influence of environmental changes on population dynamics while the birds are on breeding grounds, wintering grounds, and en route between the two. This is problematic when the wintering areas of specific populations are unknown. Here, we first identified the putative wintering areas of Common House-Martin (Delichon urbicum) and Common Swift (Apus apus) populations breeding in northern Italy as those areas, within the wintering ranges of these species, where the winter Normalized Difference Vegetation Index (NDVI), which may affect winter survival, best predicted annual variation in population indices observed in the breeding grounds in 1992–2009. In these analyses, we controlled for the potentially confounding effects of rainfall in the breeding grounds during the previous year, which may affect reproductive success; the North Atlantic Oscillation Index (NAO), which may account for climatic conditions faced by birds during migration; and the linear and squared term of year, which account for nonlinear population trends. The areas thus identified ranged from Guinea to Nigeria for the Common House-Martin, and were located in southern Ghana for the Common Swift. We then regressed annual population indices on mean NDVI values in the putative wintering areas and on the other variables, and used Bayesian model averaging (BMA) and hierarchical partitioning (HP) of variance to assess their relative contribution to population dynamics. We re-ran all the analyses using NDVI values at different spatial scales, and consistently found that our population of Common House-Martin was primarily affected by spring rainfall (43%–47.7% explained variance) and NDVI (24%–26.9%), while the Common Swift population was primarily affected by the NDVI (22.7%–34.8%). Although these results must be further validated, currently they are the only hypotheses about the wintering grounds of the Italian populations of these species, as no Common House-Martin and Common Swift ringed in Italy have been recovered in their wintering ranges.

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This paper summarizes some of the geoarchaeological evidence for early arable agriculture in Britain and Europe, and introduces new evidence for small-scale but very intensive cultivation in the Neolithic, Bronze Age and Iron Age in Scotland. The Scottish examples demonstrate that, from the Neolithic to the Iron Age, midden heaps were sometimes ploughed in situ; this means that, rather than spreading midden material onto the fields, the early farmers simply ran an ard over their compost heaps and sowed the resulting plots. The practice appears to have been common in Scotland, and may also have occurred in England. Neolithic cultivation of a Mesolithic midden is suggested, based on thin-section analysis of the middens at Northton, Harris. The fertility of the Mesolithic middens may partly explain why Neolithic farmers re-settled Mesolithic sites in the Northern and Western Isles.

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Laboratory animals should be provided with enrichment objects in their cages; however, it is first necessary to test whether the proposed enrichment objects provide benefits that increase the animals’ welfare. The two main paradigms currently used to assess proposed enrichment objects are the choice test, which is limited to determining relative frequency of choice, and consumer demand studies, which can indicate the strength of a preference but are complex to design. Here, we propose a third methodology: a runway paradigm, which can be used to assess the strength of an animal’s motivation for enrichment objects, is simpler to use than consumer demand studies, and is faster to complete than typical choice tests. Time spent with objects in a standard choice test was used to rank several enrichment objects in order to compare with the ranking found in our runway paradigm. The rats ran significantly more times, ran faster, and interacted longer with objects with which they had previously spent the most time. It was concluded that this simple methodology is suitable for measuring rats’ motivation to reach enrichment objects. This can be used to assess the preference for different types of enrichment objects or to measure reward system processes.

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Varicella-zoster virus (VZV) is a member of the Herpesviridae family, primary infection with which causes varicella, more commonly known as chicken pox. Characteristic of members of the alphaherpesvirus subfamily, VZV is neurotropic and establishes latency in sensory neurons. Reactivation of VZV causes herpes zoster, also known as shingles. The most frequent complication following zoster is chronic and often debilitating pain called postherpetic neuralgia (PHN), which can last for months after the disappearance of a rash. During episodes of acute zoster, VZV viremia occurs in some, but not all, patients; however, the effect of the viral load on the disease outcome is not known. Here we describe the development of a highly specific, sensitive, and reproducible real-time PCR assay to investigate the factors that may contribute to the presence and levels of baseline viremia in patients with zoster and to determine the relationship between viremia and the development and persistence of PHN. VZV DNA was detected in the peripheral blood mononuclear cells (PBMCs) of 78% of patients with acute zoster and in 9% of healthy asymptomatic blood donors. The presence of VZV in the PBMCs of patients with acute zoster was independently associated with age and being on antivirals but not with gender, immune status, extent of rash, the age of the rash at the time of blood sampling, having a history of prodromal pain, or the extent of acute pain. Prodromal pain was significantly associated with higher baseline viral loads. Viral load levels were not associated with the development or persistence of PHN at 6, 12, or 26 weeks.

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We have developed a novel Hill-climbing genetic algorithm (GA) for simulation of protein folding. The program (written in C) builds a set of Cartesian points to represent an unfolded polypeptide's backbone. The dihedral angles determining the chain's configuration are stored in an array of chromosome structures that is copied and then mutated. The fitness of the mutated chain's configuration is determined by its radius of gyration. A four-helix bundle was used to optimise simulation conditions, and the program was compared with other, larger, genetic algorithms on a variety of structures. The program ran 50% faster than other GA programs. Overall, tests on 100 non-redundant structures gave comparable results to other genetic algorithms, with the Hill-climbing program running from between 20 and 50% faster. Examples including crambin, cytochrome c, cytochrome B and hemerythrin gave good secondary structure fits with overall alpha carbon atom rms deviations of between 5 and 5.6 Angstrom with an optimised hydrophobic term in the fitness function. (C) 2003 Elsevier Ltd. All rights reserved.

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The immediate impetus for the colony at Lingfield in Surrey was the desire by the Women's Farm and Garden Association to enable women who had worked on the land during the First World War to be able to farm on their own account. However the motivation for the colony can also be traced back to late nineteenth-century ideals. The colony soon ran into problems which were exacerbated by the adverse agricultural conditions of the early 1920s. The association responded constructively but the colony was wound down from 1929. At one level the colony could be seen as a failure, yet this article argues that the 19 colony provided a rural community where single women lived in a mutually supportive environment.

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This study was an attempt to identify the epistemological roots of knowledge when students carry out hands-on experiments in physics. We found that, within the context of designing a solution to a stated problem, subjects constructed and ran thought experiments intertwined within the processes of conducting physical experiments. We show that the process of alternating between these two modes- empirically experimenting and experimenting in thought- leads towards a convergence on scientifically acceptable concepts. We call this process mutual projection. In the process of mutual projection, external representations were generated. Objects in the physical environment were represented in an imaginary world and these representations were associated with processes in the physical world. It is through this coupling that constituents of both the imaginary world and the physical world gain meaning. We further show that the external representations are rooted in sensory interaction and constitute a semi-symbolic pictorial communication system, a sort of primitive 'language', which is developed as the practical work continues. The constituents of this pictorial communication system are used in the thought experiments taking place in association with the empirical experimentation. The results of this study provide a model of physics learning during hands-on experimentation.

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Two studies investigated the degree to which the relationship between rapid automatized naming (RAN) performance and reading development is driven by shared phonological processes. Study 1 assessed RAN, phonological awareness, and reading performance in 1010 7- to -10 year-olds. Results showed that RAN deficits occurred in the absence of phonological awareness deficits. These were accompanied by modest reading delays. In structural equation modeling, solutions where RAN was subsumed within a phonological processing factor did not provide a good fit to the data, suggesting that processes outside phonology may drive RAN performance and its association with reading. Study 2 investigated Kail’s proposal that speed of processing underlies this relationship. Children with single RAN deficits showed slower speed of processing than did closely matched controls performing normally on RAN. However, regression analysis revealed that RAN made a unique contribution to reading even after accounting for processing speed. Theoretical implications are discussed.

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Priming effects of cooperation vs. individualism were investigated on changeover speed within a 4 x 100-m relay race. Ten teams of four adult beginner athletes ran two relays, a pretest race and an experimental race 3 weeks later. Just before the experimental race, athletes were primed with either cooperation or individualism through a scrambled-sentence task. Comparing to the pretest performance, cooperation priming improved baton speed in the exchange zone (+30 cm/s). Individualism priming did not impair changeover performance. The boundary conditions of priming effects applied to collective and interdependent tasks are discussed within the implicit coordination framework.

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The study examined: (a) the role of phonological, grammatical, and rapid automatized naming (RAN) skills in reading and spelling development; and (b) the component processes of early narrative writing skills. Fifty-seven Turkish-speaking children were followed from Grade 1 to Grade 2. RAN was the most powerful longitudinal predictor of reading speed and its effect was evident even when previous reading skills were taken into account. Broadly, the phonological and grammatical skills made reliable contributions to spelling performance but their effects were completely mediated by previous spelling skills. Different aspects of the narrative writing skills were related to different processing skills. While handwriting speed predicted writing fluency, spelling accuracy predicted spelling error rate. Vocabulary and working memory were the only reliable longitudinal predictors of the quality of composition content. The overall model, however, failed to explain any reliable variance in the structural quality of the compositions