Obstacle Crossing with Dual Tasking is a Danger for Individuals with Alzheimer's Disease and for Healthy Older People

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Possible interspecific origin of the B chromosome of Hypsiboas albopunctatus (Spix, 1824) (Anura, Hylidae), revealed by microdissection, chromosome painting, and reverse hybridisation

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Associações anestésicas baseadas em fármacos dissociativos reduzem a pressão intraocular (PIO) em coelhos

The aim of this study was evaluate the effects of three anesthetic combinations, ketamine-midazolam, ketamine-xylazine and tiletamine-zolazepam, on IOP in rabbits. In a experimental, blind, randomized, crossover study, six rabbits were anesthetized with each of 3 treatments in random order. Groups KM (ketamine, 30 mg/kg + midazolam, 1 mg/kg); KX (ketamine, 30 mg/kg + xylazine, 3 mg/kg); and TZ (tiletamine + zolazepam, 20 mg/kg). The drugs were mixed in the same syringe injected intramuscularly (IM) into the quadriceps muscle. IOP was measured before drug administration (baseline) and at 5-minute intervals for 30 minutes. The data were analyzed by a 2-way repeated measures ANOVA followed by Bonferroni test. All groups had significant decreases in IOP compared to baseline (p < 0.001). There was no difference between groups at any of the time points assessed (p > 0.05). Administration of either ketamine-midazolam, ketamine-xylazine, or tiletamine-zolazepam similarly decrease IOP in rabbits within 30 minutes of injection.

Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy

Hepatitis C virus (HCV) infection represents an important public health problem worldwide. Reduction of HCV morbidity and mortality is a current challenge owned to several viral and host factors. Virus molecular evolution plays an important role in HCV transmission, disease progression and therapy outcome. The high degree of genetic heterogeneity characteristic of HCV is a key element for the rapid adaptation of the intrahost viral population to different selection pressures (e.g., host immune responses and antiviral therapy). HCV molecular evolution is shaped by different mechanisms including a high mutation rate, genetic bottlenecks, genetic drift, recombination, temporal variations and compartmentalization. These evolutionary processes constantly rearrange the composition of the HCV intrahost population in a staging manner. Remarkable advances in the understanding of the molecular mechanism controlling HCV replication have facilitated the development of a plethora of direct-acting antiviral agents against HCV. As a result, superior sustained viral responses have been attained. The rapidly evolving field of anti-HCV therapy is expected to broad its landscape even further with newer, more potent antivirals, bringing us one step closer to the interferon-free era. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

Positive effects of auditory cue in locomotor pattern of people with Parkinson's disease (off and on medication)

Gait disorders are identified in people with Parkinson’s disease. The aim of this study was to investigate the effect of auditory cues and medication on kinematic, kinetic and EMG parameters, during different gait phases of people with PD and healthy elderly. Thirty subjects distributed in two groups (Group 1, PD patients off and on medication; Group 2, healthy elderly) participated in this study and were instructed to walk in two experimental conditions: non-cued and cued. Therefore, kinematic, kinetic and electromyography analyses were utilized to investigate the locomotor pattern. Changes in locomotor pattern (greater muscular activity) with auditory cue were observed for PD patients. Regarding the medication, locomotor parameter improvement was observed after levodopa intake in association with the auditory cue. These results confirm the hypothesis about the external cues therapy that could be used as a complement to drug therapy to achieve improvement in the locomotor pattern of PD patients.

Grande reportagem impressa: construindo pontes

Este trabalho é uma proposta de grande reportagem para a revista Época em sua versão impressa. Diante da constatação segundo a qual a religião é assunto cada vez mais evidente na sociedade, o objetivo dessa produção é pautar um tema que é pouco difundido nos meios de comunicação de informação geral: o ecumenismo. A abordagem desse tema implicou desde a definição do conceito de ecumenismo, passando por uma breve trajetória histórica (limitações e progressos) até o relato da ação de organizações e pessoas que se envolvem concreta e cotidianamente com o ideal ecumênico. O processo de produção desse trabalho está descrito neste relatório e inclui as técnicas jornalísticas utilizadas, bem como a fundamentação teórica sobre jornalismo e sobre o tema

Reflexões sobre a prática pedagógica nas atividades de ensino: monitoria, no ensino médio em escola particular e estadual em Rio Claro

The difficulties related to physics teaching are related to methodology, that hinder learning, because some physical concepts beyond the common sense of most students. Just as poor training of some physics instructors in teaching is pedagogical difficulties. And also factors of infrastructure, heterogeneity in students' previous training etc.. It is proposed aim of this work to use reflection of teaching practice as a methodology. Practiced in a private school, mostly state and, in high school in Rio Claro. The method consists of preparing a daily pedagogical practice in parallel to the development of teaching, for analysis and identification of factors that result in improving the teaching of physics and physics teacher qualification

A fragmentação espacial fitogeográfica e a proposta dos corredores ecológicos

This paper aims to study the proposal of ecological corridors as integration solution spaces that present fragmentation of vegetation. The geographic space is composed of physical and human characteristics and interrelation between the different variables result in different landscapes. The landscape ecology provides an understanding of the heterogeneous landscape, which combines the space and ecosystem components. The spatial fragmentation of vegetation and is often the result of a number of factors. This new landscape composition presents different forms of economic exploitation of the soil (agriculture, pasture). The corridors are considered optional connection of plant debris, providing greater flow of species of fauna and flora reconstituting somehow Ecosystem site. The research aims to propose the restoration of an area devoid of natural plant its constitution, becoming restoration tool in a particular area of vegetation fragmented

Qual o papel da mídia na aprendizagem e desenvolvimento da criança de educação fundamental I, em idade de alfabetização: ela forma, informa, dificulta, diverte ou deseduca?

Este trabalho de conclusão de curso tem como objetivo analisar a mídia televisiva, no que diz respeito a seus interesses e programações, levando em consideração a conseqüente relação conflituosa entre esta e as crianças brasileiras, uma vez que a mídia não oferece programas de qualidade que respeitem a diversidade cultural. O trabalho analisa os conteúdos dos programas oferecidos pela mídia e compara-os com o que se propõem a Convenção da ONU realizada em 1989 Sobre os Diretos da Criança, no que diz respeito a mídia em geral. A partir de base teórica busca refletir sobre o impacto das mensagens dos programas de televisão na mente da criança e consequentemente afetando seu desenvolvimento cognitivo, moral e emocional. Sendo que percorrendo esse caminho de análise, procura-se mostrar uma possível reflexão e mudança através da educação para mídia e participação na mesma, envolvendo pais, professores, as políticas públicas e as próprias crianças.

Um estudo longitudinal sobre as hipersegmentações de palavras escritas nos anos finais do ensino fundamental

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Indicadores Antropométricos do Estado Nutricional de Idosas Praticantes e Não Praticantes de Exercício Fisíco na Zona Norte de São José do Rio Preto-SP

Although the regular practice of physical exercise for the maintenance of the nutritional state and quality of life is important, it is not a common habit among the elderly, especially those of the lower income social bracket. The objective was to characterize and compare according to social-economic conditions and anthropometric indexes of the nutritional state of the elderly who regularly practice and those who do not practice exercises, offered at no cost, in the Northern zone of São José do Rio Preto-SP. In this study, 110 elderly women participated, of which 60 (group P) exercised regularly and 50 did not (group NP). Group P participated in a special gym program, free of charge, for at least 2 years, 2 to 3 times a week, one hour a day. Group NP was recruited from the same location as Group P. The comparison between the groups of elderly women was proportionately distributed according to marital status, level of education, means of locomotion, results of body mass index (IMC), waist to hip ratio (RCQ) and calf circumference, using the chi-square test. Comparisons were also made of average age, per capita family income, individual income, IMC, arm and triceps skin fold measured by t-Test. Differences were not found in all the comparisons made. The variables that stood out were the IMC (overweight) and RCQ (risk of chronic diseases) results, which were above what was expected, and the high frequency of walking and riding buses for both groups of elderly women (about 60%). We came to the conclusion that the low-intensity exercise program evaluated made no difference in the nutritional profile of the elderly who also used walking as a means of getting around.

The stream fish fauna from the rio Machado basin, Rondônia State, Brazil

The rio Machado (also known as Ji-Paraná) is a tributary of the rio Madeira in the Amazon basin. Currently, the rio Madeira contains the greatest fish species richness of the world, with approximately 1,000 species. The present study presents the fish inventory from streams of the rio Machado basin. In total, 75 stream reaches, 80 meter-length, randomly selected, were sampled in 2011 (August to October) and 2012 (June to July). Overall, 22,875 fish in eight orders, 32 families, 89 genera, and 140 species were collected. Richness estimators indicate that almost 90% of the expected richness was registered. The great majority of specimens (52.2%) was represented by small sized piabas such as Serrapinnus aff. notomelas, Moenkhausia collettii, Serrapinnus microdon, and Hemigrammus melanochrous. Of the total richness, 25 species were restricted to 9°00’ S and 10°00’ S; among them, 14 were exclusive to the lower portion of the basin, which exhibits the larger proportion of native vegetation covering.

Effect of sublethal doses of the insecticide imidacloprid on adaptive traits of Drosophila melanogaster: Response to treatment over and after 15 consecutive generations

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)