Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy


Autoria(s): Victoria Preciado, Maria; Valva, Pamela; Escobar-Gutierrez, Alejandro; Rahal, Paula; Ruiz-Tovar, Karina; Yamasaki, Lilian; Vazquez-Chacon, Carlos; Martinez-Guarneros, Armando; Carlos Carpio-Pedroza, Juan; Fonseca-Coronado, Salvador; Cruz-Rivera, Mayra
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

18/03/2015

18/03/2015

21/11/2014

Resumo

Hepatitis C virus (HCV) infection represents an important public health problem worldwide. Reduction of HCV morbidity and mortality is a current challenge owned to several viral and host factors. Virus molecular evolution plays an important role in HCV transmission, disease progression and therapy outcome. The high degree of genetic heterogeneity characteristic of HCV is a key element for the rapid adaptation of the intrahost viral population to different selection pressures (e.g., host immune responses and antiviral therapy). HCV molecular evolution is shaped by different mechanisms including a high mutation rate, genetic bottlenecks, genetic drift, recombination, temporal variations and compartmentalization. These evolutionary processes constantly rearrange the composition of the HCV intrahost population in a staging manner. Remarkable advances in the understanding of the molecular mechanism controlling HCV replication have facilitated the development of a plethora of direct-acting antiviral agents against HCV. As a result, superior sustained viral responses have been attained. The rapidly evolving field of anti-HCV therapy is expected to broad its landscape even further with newer, more potent antivirals, bringing us one step closer to the interferon-free era. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

Formato

15992-16013

Identificador

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239486/

World Journal Of Gastroenterology. Pleasanton: Baishideng Publishing Group Inc, v. 20, n. 43, p. 15992-16013, 2014.

1007-9327

http://hdl.handle.net/11449/117725

10.3748/wjg.v20.i43.15992

WOS:000346050500005

Idioma(s)

eng

Publicador

Baishideng Publishing Group Inc

Relação

World Journal Of Gastroenterology

Direitos

closedAccess

Palavras-Chave #Hepatitis C virus #Evolution #Phylogenetics #Drug resistance #Clinical outcome
Tipo

info:eu-repo/semantics/article