1000 resultados para Chromomycin A(3)
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Boletim elaborado pela Assessoria de Comunicação e Imprensa da Reitoria da UNESP
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This paper presents the characterization of an indoor Wimax radio channel using the Finite-Difference Time-Domain (FDTD) [1] method complemented with the Convolutional Perfect Matched Layer (CPML) technique [2]. An indoor 2D scenario is simulated in the 3.5GHz band (IEEE 802.16d-2004 and IEEE 802.16e-2005 [3]). In this study, we used two complementary techniques in both analysis, technique A and B for fading based on delay spread and technique C and D for fading based on Doppler spread. Both techniques converge to the same result. Simulated results define the channel as flat, slow and without inter-symbolic interference (ISI), making the application of the spatial diversity the most appropriate scheme.
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Background: There are now several lines of evidence to suggest that protein synthesis and translation factors are involved in the regulation of cell proliferation and cancer development. Aims: To investigate gene expression patterns of eukaryotic releasing factor 3 (eRF3) in gastric cancer. Methods: RNA was prepared from 25 gastric tumour biopsies and adjacent non-neoplastic mucosa. Real time TaqMan reverse transcription polymerase chain reaction (RT-PCR) was performed to measure the relative gene expression levels. DNA was isolated from tumour and normal tissues and gene dosage was determined by a quantitative real time PCR using SYBR Green dye. Results: Different histological types of gastric tumours were analysed and nine of the 25 tumours revealed eRF3/GSPT1 overexpression; moreover, eight of the 12 intestinal type carcinomas analysed overexpressed the gene, whereas eRF3/GSPT1 was overexpressed in only one of the 10 diffuse type carcinomas (Kruskal-Wallis Test; p , 0.05). No correlation was found between ploidy and transcript expression levels of eRF3/GSPT1. Overexpression of eRF3/GSPT1 was not associated with increased translation rates because the upregulation of eRF3/GSPT1 did not correlate with increased eRF1 levels. Conclusions: Overexpression of eRF3/GSPT1 in intestinal type gastric tumours may lead to an increase in the translation efficiency of specific oncogenic transcripts. Alternatively, eRF3/GSPT1 may be involved in tumorigenesis as a result of its non-translational roles, namely (dis)regulating the cell cycle, apoptosis, or transcription.
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Revista elaborada pela Assessoria de Comunicação e Imprensa da Reitoria da UNESP
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Revista elaborada pela Assessoria de Comunicação e Imprensa da Reitoria da UNESP
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Revista elaborada pela Assessoria de Comunicação e Imprensa da Reitoria da UNESP
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Revista elaborada pela Assessoria de Comunicação e Imprensa da Reitoria da UNESP
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Revista elaborada pela Assessoria de Comunicação e Imprensa da Reitoria da UNESP
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Revista elaborada pela Assessoria de Comunicação e Imprensa da Reitoria da UNESP
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Revista elaborada pela Assessoria de Comunicação e Imprensa da Reitoria da UNESP
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Revista elaborada pela Assessoria de Comunicação e Imprensa da Reitoria da UNESP
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Revista elaborada pela Assessoria de Comunicação e Imprensa da Reitoria da UNESP
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Revista elaborada pela Assessoria de Comunicação e Imprensa da Reitoria da UNESP
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Revista elaborada pela Assessoria de Comunicação e Imprensa da Reitoria da UNESP
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Revista elaborada pela Assessoria de Comunicação e Imprensa da Reitoria da UNESP