Estudo da conformação e atividade lítica de peptídeos antimicrobianos de vespas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Classificação fonética utilizando Boosting e SVM

Para compor um sistema de Reconhecimento Automático de Voz, pode ser utilizada uma tarefa chamada Classificação Fonética, onde a partir de uma amostra de voz decide-se qual fonema foi emitido por um interlocutor. Para facilitar a classificação e realçar as características mais marcantes dos fonemas, normalmente, as amostras de voz são pré- processadas através de um fronl-en'L Um fron:-end, geralmente, extrai um conjunto de parâmetros para cada amostra de voz. Após este processamento, estes parâmetros são insendos em um algoritmo classificador que (já devidamente treinado) procurará decidir qual o fonema emitido. Existe uma tendência de que quanto maior a quantidade de parâmetros utilizados no sistema, melhor será a taxa de acertos na classificação. A contrapartida para esta tendência é o maior custo computacional envolvido. A técnica de Seleção de Parâmetros tem como função mostrar quais os parâmetros mais relevantes (ou mais utilizados) em uma tarefa de classificação, possibilitando, assim, descobrir quais os parâmetros redundantes, que trazem pouca (ou nenhuma) contribuição à tarefa de classificação. A proposta deste trabalho é aplicar o classificador SVM à classificação fonética, utilizando a base de dados TIMIT, e descobrir os parâmetros mais relevantes na classificação, aplicando a técnica Boosting de Seleção de Parâmetros.

Enxertia em híbridos de berinjela (Solanum melongena), sob cultivo protegido

Pós-graduação em Agronomia (Horticultura) - FCA

A constitucionalidade da norma antielisiva no direito tributário brasileiro

Estudo que objetiva demonstrar a constitucionalidade da norma geral antielisiva introduzida no Direito Brasileiro com a alteração do artigo 116, parágrafo único, do Código Tributário Nacional, levando em consideração a atualidade e a interpretação que deve ser realizada em um contexto que necessita observar a Constituição Federal de 1988, com as diversas previsões de direitos sociais. A norma traz à tona a questão do individual frente ao social, da liberdade frente à igualdade, a busca da verdade material sem violação de direitos. Faz-se abordagem do intérprete e a interpretação das normas e princípios, a necessidade da aplicação do princípio da proporcionalidade, com a busca da verdade material e da justiça fiscal sem violação de direitos e garantias fundamentais da pessoa, em especial do contribuinte. Apresentação necessária para desmistificar argumentos positivistas que propositadamente esquecem os fundamentos constitucionais previstos nos artigos 1° e 3° da Constituição Federal de 1988. Paradigmas e preconceitos foram afastados para reconhecer o sentido da norma antielisiva no direito brasileiro. A demonstração da diferença de elisão e evasão fiscal tornou-se indispensável para posteriormente afastar as pedras do caminho, que eram as alegações de inconstitucionalidade da norma antielisão no Brasil, por possível afronta à legalidade e à liberdade. Argumentos foram utilizados com base na Constituição Federal e com o auxílio nas previsões do Novo Código Civil brasileiro. Após a demonstração da constitucionalidade partiu-se para firmar, dentro do contexto, qual o conteúdo do artigo 116, parágrafo único, do CTN, apresentando, ao final, sugestão de procedimentos a serem seguidos para a aplicação da antielisão no Direito brasileiro. Foi realizada pesquisa doutrinária com incursões em leis e na jurisprudência. Propositadamente não foi realizada comparação com legislação estrangeira, fixando como âmbito de estudo, exclusivamente, a aplicação da norma no Brasil.

Produção científica sobre gestão do conhecimento e gestão da informação no âmbito da Ciência da Informação: uma aplicação da Lei de Bradford

Aimed to analyze the scientific literature on information management and knowledge management in the most relevant journals in the Information Science field, noting in this way then relevance and impact to this field. It is a qualitative research and analyzed the scientific literature about this subject published in journals (online access) in the Information Science area and classified as Qualis of Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), specifically those who were assessed as level 'A' and 'B', covering a total of 26 journal titles. We applied the Bradford's Law for the scientific production analysis, especially in relation to the articles distribution in terms of proximity or distance variables. We observed that the terms 'information management' and 'knowledge management' are contemporary and have been gained relevance over time. We also founded that the general rule: few produces a lot and many produces a little is true if considered the characteristics of the studied data distribution.

Population structure, sex ratio and growth of the seabob shrimp Xiphopenaeus kroyeri (Decapoda, Penaeidae) from coastal waters of southern Brazil

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Resultados e significados do programa de aquisição de alimentos (PAA) para os agricultores familiares de Pereira Barreto (SP)

Pós-graduação em Agronomia - FEIS

Children and teenagers working in artistic labor: Brazilian situation and international examples

This descriptive study about children and adolescents artistic labor verifies the applicable legislation, in Brazil, regarding the participation of children and adolescents in the entertainment industry and in advertising campaigns, as well as the judicial processes about the theme known by the Brazilian Superior Court of Justice up to October, 2010. The results permit to conclude that, due to the lack of specific regulation and general rule of child labor prohibition, the restrictions that tend to protect the health and security of children and adolescents that act in the artistic niche (television, advertising, fashion, movies etc.) have been, in Brazil, at subjective criteria of the judges and, in many cases, in the hands of producers themselves. Brief considerations on how other countries regulate the theme are also presented (the USA, Portugal and Argentina).

Concessioni di servizio in ambito interportuale, portuale e demaniale marittimo ed esercizio delle relative attività: l'impatto della disciplina comunitaria in materia di libera prestazioni di servizi.

Come si evince dal titolo della tesi, la ricerca effettuata dal presente candidato nel corso del dottorato di ricerca ha avuto ad oggetto l’analisi delle competenze che, a diverso livello, comunitario, nazionale e regionale, sono attribuite agli enti in materia di rilascio di concessioni di servizi in abito interportuale, portuale e demaniale marittimo. L’attenzione, pertanto, ha dovuto innanzitutto essere rivolta ai compiti ed alle facoltà che, in forza del trattato che istituisce la Comunità Europea, sono attribuite alla Comunità stessa. Si è provveduto, pertanto, ad analizzare l’evoluzione della normativa per giungere all’attuale sistema giuridico. Gli aspetti della disciplina delle concessioni, oggetto di ricerca, hanno dovuto ripercorrere i vari procedimenti di infrazione comminati dalla Corte Europea, per i quali il sistema giuridico nazionale si è dovuto adattare con non poche difficoltà, soprattutto per la presenza di posizioni e prassi, negli anni, divenute consolidate.

Pregnancy and breastfeeding in inflammatory bowel disease

Inflammatory bowel disease (IBD) is frequent in women during their peak reproductive years. Accordingly, a significant number of questions and uncertainties arise from this population regarding the risk of transmission of IBD to the offspring, the impact of the disease and therapies on the fertility, the role of the disease on the course of the pregnancy and the mode of delivery, the impact of the therapy on the pregnancy and fetal development as well as breastfeeding. The safety of medical therapy during pregnancy and lactation is a major concern for both pregnant women and their partners as well as for physicians. As a general rule, it can be stated that the benefit of continuing medical therapy in IBD during pregnancy outweighs the potential risks in the vast majority of instances. This article will review recent developments on this topic consistent with the European Crohn's and Colitis Organization guidelines.

Pharmacological and non-pharmacological therapy for arrhythmias in the pediatric population: EHRA and AEPC-Arrhythmia Working Group joint consensus statement

In children with structurally normal hearts, the mechanisms of arrhythmias are usually the same as in the adult patient. Some arrhythmias are particularly associated with young age and very rarely seen in adult patients. Arrhythmias in structural heart disease may be associated either with the underlying abnormality or result from surgical intervention. Chronic haemodynamic stress of congenital heart disease (CHD) might create an electrophysiological and anatomic substrate highly favourable for re-entrant arrhythmias. As a general rule, prescription of antiarrhythmic drugs requires a clear diagnosis with electrocardiographic documentation of a given arrhythmia. Risk-benefit analysis of drug therapy should be considered when facing an arrhythmia in a child. Prophylactic antiarrhythmic drug therapy is given only to protect the child from recurrent supraventricular tachycardia during this time span until the disease will eventually cease spontaneously. In the last decades, radiofrequency catheter ablation is progressively used as curative therapy for tachyarrhythmias in children and patients with or without CHD. Even in young children, procedures can be performed with high success rates and low complication rates as shown by several retrospective and prospective paediatric multi-centre studies. Three-dimensional mapping and non-fluoroscopic navigation techniques and enhanced catheter technology have further improved safety and efficacy even in CHD patients with complex arrhythmias. During last decades, cardiac devices (pacemakers and implantable cardiac defibrillator) have developed rapidly. The pacing generator size has diminished and the pacing leads have become progressively thinner. These developments have made application of cardiac pacing in children easier although no dedicated paediatric pacing systems exist.

Structure/affinity studies in the bicyclo-DNA series: Synthesis and properties of oligonucleotides containing bcen-T and iso-tricyclo-T nucleosides

We present the synthesis of the two novel nucleosides iso-tc-T and bcen-T, belonging to the bicyclo-/tricyclo-DNA molecular platform. In both modifications the torsion around C6’–C7’ within the carbocyclic ring is planarized by either the presence of a C6’–C7’ double bond or a cyclopropane ring. Structural analysis of these two nucleosides by X-ray analysis reveals a clear preference of torsion angle γ for the gauche orientation with the furanose ring in a near perfect 2’-endo conformation. Both modifications were incorporated into oligodeoxynucleotides and their thermal melting behavior with DNA and RNA as complements was assessed. We found that the iso-tc-T modification was significantly more destabilizing in duplex formation compared to the bcen-T modification. In addition, duplexes with complementary RNA were less stable as compared to duplexes with DNA as complement. A structure/affinity analysis, including the already known bc-T and tc-T modifications, does not lead to a clear correlation of the orientation of torsion angle γ with DNA or RNA affinity. There is, however, some correlation between furanose conformation (N- or S-type) and affinity in the sense that a preference for a 3’-endo like conformation is associated with a preference for RNA as complement. As a general rule it appears that Tm data of single modifications with nucleosides of the bicyclo-/tricyclo-DNA platform within deoxyoligonucleotides are not predictive for the stability of fully modified oligonucleotides.

Flood triggering in Switzerland: the role of daily to monthly preceding precipitation

Determining the role of different precipitation periods for peak discharge generation is crucial for both projecting future changes in flood probability and for short- and medium-range flood forecasting. In this study, catchment-averaged daily precipitation time series are analyzed prior to annual peak discharge events (floods) in Switzerland. The high number of floods considered – more than 4000 events from 101 catchments have been analyzed – allows to derive significant information about the role of antecedent precipitation for peak discharge generation. Based on the analysis of precipitation times series, a new separation of flood-related precipitation periods is proposed: (i) the period 0 to 1 day before flood days, when the maximum flood-triggering precipitation rates are generally observed, (ii) the period 2 to 3 days before flood days, when longer-lasting synoptic situations generate "significantly higher than normal" precipitation amounts, and (iii) the period from 4 days to 1 month before flood days when previous wet episodes may have already preconditioned the catchment. The novelty of this study lies in the separation of antecedent precipitation into the precursor antecedent precipitation (4 days before floods or earlier, called PRE-AP) and the short range precipitation (0 to 3 days before floods, a period when precipitation is often driven by one persistent weather situation like e.g., a stationary low-pressure system). A precise separation of "antecedent" and "peak-triggering" precipitation is not attempted. Instead, the strict definition of antecedent precipitation periods permits a direct comparison of all catchments. The precipitation accumulating 0 to 3 days before an event is the most relevant for floods in Switzerland. PRE-AP precipitation has only a weak and region-specific influence on flood probability. Floods were significantly more frequent after wet PRE-AP periods only in the Jura Mountains, in the western and eastern Swiss plateau, and at the outlet of large lakes. As a general rule, wet PRE-AP periods enhance the flood probability in catchments with gentle topography, high infiltration rates, and large storage capacity (karstic cavities, deep soils, large reservoirs). In contrast, floods were significantly less frequent after wet PRE-AP periods in glacial catchments because of reduced melt. For the majority of catchments however, no significant correlation between precipitation amounts and flood occurrences is found when the last 3 days before floods are omitted in the precipitation amounts. Moreover, the PRE-AP was not higher for extreme floods than for annual floods with a high frequency and was very close to climatology for all floods. The fact that floods are not significantly more frequent nor more intense after wet PRE-AP is a clear indicator of a short discharge memory of Pre-Alpine, Alpine and South Alpine Swiss catchments. Our study poses the question whether the impact of long-term precursory precipitation for floods in such catchments is not overestimated in the general perception. The results suggest that the consideration of a 3–4 days precipitation period should be sufficient to represent (understand, reconstruct, model, project) Swiss Alpine floods.

Isotopic and trace element composition of basalts from DSDP Leg 82 Holes

Sr and Nd isotopic composition of 23 basalts from Sites 556-559 and 561-564. are reported. The 87Sr/86Sr ratios in fresh glasses and leached whole rocks range from 0.7025 to 0.7034 and are negatively correlated with the initial 143Nd/ 144Nd compositions, which range from 0.51315 to 0.51289. The Sr and Nd isotopic compositions (in glasses or leached samples) lie within the fields of mid-ocean ridge basalts (MORB) and ocean island basalts (OIB) from the Azores on the Nd-Sr mantle array/fan plot. In general, there is a correlation between the trace element characteristics and the 143Nd/144Nd composition (i.e., samples with Hf/Ta>7 and (Ce/Sm)N<1 [normal-MORB] have initial 143Nd/144Nd>0.51307, whereas samples with Hf/Ta<7 and (Ce/Sm)N>1 (enriched-MORB) have initial 143Nd/144Nd compositions <0.51300). A significant deviation from this general rule is found in Hole 558, where the N-MORB can have, within experimental limits, identical isotopic compositions to those found in associated E-MORB. The plume-depleted asthenosphere mixing hypothesis of Schilling (1975), White and Schilling (1978) and Schilling et al. (1977) provides a framework within which the present data can be evaluated. Given the distribution and possible origins of the chemical and isotopic heterogeneity observed in Leg 82 basalts, and some other basalts in the area, it would appear that the Schilling et al. model is not entirely satisfactory. In particular, it can be shown that trace element data may incorrectly estimate the plume component and more localized mantle heterogeneity (both chemical and isotopic) may be important.

Pedestrian wind comfort: feasibility study of criteria homogenisation

One of the aims of COST C14 action is the assessment and evaluation of pedestrian wind comfort. At present there is no general rule available that is applied across Europe. There are several criteria that have been developed and applied in different countries. These criteria are based on the definition of two independent parameters, a threshold effective wind speed and a probability of exceedence of this threshold speed. The difficulty of the criteria comparison arises from the two-dimensional character of the criteria definition. An effort is being made to compare these criteria, trying both to find commonalities and to clearly identify differences, in order to build up the basis for the next step: to try to define common criteria (perhaps with regional and seasonal variations). The first point is to define clearly the threshold effective wind speed (mean velocity definition parameters: averaging interval and reference height) and equivalence between different ways of defining the threshold effective wind speed (mean wind speed, gust equivalent mean, etc.) in comparable terms (as far as possible). It can be shown that if the wind speed at a given location is defined in terms of a probability distribution, e.g. Weibull function, a given criterion is satisfied by an infinite set of wind conditions, that is, of probability distributions. The criterion parameters and the Weibull function parameters are linked to each other, establishing a set called iso-criteria lines (the locus of the Weibull function parameters that fulfil a given criterion). The relative position of iso-criteria lines when displayed in a suitable two-dimensional plane facilitates the comparison of comfort criteria. The comparison of several wind comfort criteria, coming from several institutes is performed, showing the feasibility and limitations of the method.