Enhancement of optical absorption by modulation of the oxygen flow of TiO2 films deposited by reactive sputtering

Oxygen-deficient TiO2 films with enhanced visible and near-infrared optical absorption have been deposited by reactive sputtering using a planar diode radio frequency magnetron configuration. It is observed that the increase in the absorption coefficient is more effective when the O-2 gas supply is periodically interrupted rather than by a decrease of the partial O-2 gas pressure in the deposition plasma. The optical absorption coefficient at 1.5 eV increases from about 1 x 10(2) cm(-1) to more than 4 x 10(3) cm(-1) as a result of the gas flow discontinuity. A red-shift of similar to 0.24 eV in the optical absorption edge is also observed. High resolution transmission electron microscopy with composition analysis shows that the films present a dense columnar morphology, with estimated mean column width of 40nm. Moreover, the interruptions of the O-2 gas flow do not produce detectable variations in the film composition along its growing direction. X-ray diffraction and micro-Raman experiments indicate the presence of the TiO2 anatase, rutile, and brookite phases. The anatase phase is dominant, with a slight increment of the rutile and brookite phases in films deposited under discontinued O-2 gas flow. The increase of optical absorption in the visible and near-infrared regions has been attributed to a high density of defects in the TiO2 films, which is consistent with density functional theory calculations that place oxygen-related vacancy states in the upper third of the optical bandgap. The electronic structure calculation results, along with the adopted deposition method and experimental data, have been used to propose a mechanism to explain the formation of the observed oxygen-related defects in TiO2 thin films. The observed increase in sub-bandgap absorption and the modeling of the corresponding changes in the electronic structure are potentially useful concerning the optimization of efficiency of the photocatalytic activity and the magnetic doping of TiO2 films. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4724334]

Diseño e implementación de un convertidor numérico como aplicación Android

[ES] El Trabajo de Fin de Grado, Diseño e Implementación de un Convertidor Numérico como Aplicación Android es una aplicación desarrollada para terminales móviles con SO Android. Esta desarrollada en el entorno de desarrollo Eclipse, sobre el lenguaje de programación Java y hace uso de diferentes herramientas, las más importante de ellas el SDK TOOLS para Android. El objetivo o principal motivación por el cual he creado dicha aplicación es facilitarle al usuario final una forma más fácil y amena de acceder a toda la información proporcionada por el Servicio Web Números TIP. Esta aplicación podría tener gran uso en el campo de las enseñanzas primarias para enseñar a los niños a escribir números con letras y también podría ser de gran utilidad para las personas que no tengan un dominio extenso de nuestro idioma. La principal funcionalidad de la aplicación es realizar una consulta al Servicio Web Números TIP y luego mostrar por pantalla todos los datos devueltos. Todo el proceso de dibujo de la interfaz de usuario se realiza de manera dinámica y en tiempo de ejecución, logrando de esta manera adaptarnos a los datos que devuelva el servicio web. Para realizar la consulta al Servicio Web Números TIP el usuario introduce una ristra de caracteres sobre la cual se realizan determinadas comprobaciones en el servidor y se dibuja en la interfaz de usuario la respuesta devuelta. Esta ristra de caracteres puede contener cualquier signo, letra o número y el servicio web se encarga de devolver un error o reconocer un número, ya sea en su forma entera, fraccionaria, decimal o romana. La aplicación esta estandarizada para los cuatro tamaños generales reconocidos por Android y para sus densidades. Además se podría decir que la aplicación reconoce el idioma pre configurado en el teléfono y en base a ello solicita al servicio web las respuestas en español o en inglés.

Mobile TuCSoN: theoretical and technological requirements for TuCSoN's porting over Android mobile devices

Communication and coordination are two key-aspects in open distributed agent system, being both responsible for the system’s behaviour integrity. An infrastructure capable to handling these issues, like TuCSoN, should to be able to exploit modern technologies and tools provided by fast software engineering contexts. Thesis aims to demonstrate TuCSoN infrastructure’s abilities to cope new possibilities, hardware and software, offered by mobile technology. The scenarios are going to configure, are related to the distributed nature of multi-agent systems where an agent should be located and runned just on a mobile device. We deal new mobile technology frontiers concerned with smartphones using Android operating system by Google. Analysis and deployment of a distributed agent-based system so described go first to impact with quality and quantity considerations about available resources. Engineering issue at the base of our research is to use TuCSoN against to reduced memory and computing capability of a smartphone, without the loss of functionality, efficiency and integrity for the infrastructure. Thesis work is organized on two fronts simultaneously: the former is the rationalization process of the available hardware and software resources, the latter, totally orthogonal, is the adaptation and optimization process about TuCSoN architecture for an ad-hoc client side release.

In vitro generation and characterization of acute myeloid leukemia-reactive CD8 + cytotoxic T-lymphocyte clones from healthy donors

Donor-derived CD8+ cytotoxic T lymphocytes (CTLs) eliminating host leukemic cells mediate curative graft-versus-leukemia (GVL) reactions after allogeneic hematopoietic stem cell transplantation (HSCT). The leukemia-reactive CTLs recognize hematopoiesis-restricted or broadly expressed minor histocompatibility and leukemia-associated peptide antigens that are presented by human leukocyte antigen (HLA) class I molecules on recipient cells. The development of allogeneic CTL therapy in acute myeloid leukemia (AML) is hampered by the poor efficiency of current techniques for generating leukemia-reactive CTLs from unprimed healthy donors in vitro. In this work, a novel allogeneic mini-mixed lymphocyte/leukemia culture (mini-MLLC) approach was established by stimulating CD8+ T cells isolated from peripheral blood of healthy donors at comparably low numbers (i.e. 10e4/well) with HLA class I-matched primary AML blasts in 96-well microtiter plates. Before culture, CD8+ T cells were immunomagnetically separated into CD62L(high)+ and CD62L(low)+/neg subsets enriched for naive/central memory and effector memory cells, respectively. The application of 96-well microtiter plates aimed at creating multiple different responder-stimulator cell compositions in order to provide for the growth of leukemia-reactive CTLs optimized culture conditions by chance. The culture medium was supplemented with interleukin (IL)-7, IL-12, and IL-15. On day 14, IL-12 was replaced by IL-2. In eight different related and unrelated donor/AML pairs with complete HLA class I match, numerous CTL populations were isolated that specifically lysed myeloid leukemias in association with various HLA-A, -B, or -C alleles. These CTLs recognized neither lymphoblastoid B cell lines of donor and patient origin nor primary B cell leukemias expressing the corresponding HLA restriction element. CTLs expressed T cell receptors of single V-beta chain families, indicating their clonality. The vast majority of CTL clones were obtained from mini-MLLCs initiated with CD8+ CD62L(high)+ cells. Using antigen-specific stimulation, multiple CTL populations were amplified to 10e8-10e10 cells within six to eight weeks. The capability of mini-MLLC derived AML-reactive CTL clones to inhibit the engraftment of human primary AML blasts was investigated in the immunodeficient nonobese diabetic/severe combined immune deficient IL-2 receptor common γ-chain deficient (NOD/SCID IL2Rγnull) mouse model. The leukemic engraftment in NOD/SCID IL2Rγnull was specifically prevented if inoculated AML blasts had been pre-incubated in vitro with AML-reactive CTLs, but not with anti-melanoma control CTLs. These results demonstrate that myeloid leukemia-specific CTL clones capable of preventing AML engraftment in mice can be rapidly isolated from CD8+ CD62L(high)+ T cells of healthy donors in vitro. The efficient generation and expansion of these CTLs by the newly established mini-MLLC approach opens the door for several potential applications. First, CTLs can be used within T cell-driven antigen identification strategies to extend the panel of molecularly defined AML antigens that are recognizable by T cells of healthy donors. Second, because these CTLs can be isolated from the stem cell donor by mini-MLLC prior to transplantation, they could be infused into AML patients as a part of the stem cell allograft, or early after transplantation when the leukemia burden is low. The capability of these T cells to expand and function in vivo might require the simultaneous administration of AML-reactive CD4+ T cells generated by a similar in vitro strategy or, less complex, the co-transfer of CD8-depleted donor lymphocytes. To prepare clinical testing, the mini-MLLC approach should now be translated into a protocol that is compatible with good manufacturing practice guidelines.

Una piattaforma per la localizzazione indoor tramite crowdsensing

Questo elaborato studia e analizza il comportamento di tre algoritmi di base per quanto riguarda la localizzazione indoor e in particolare la tecnica del fingerprint. L'elaborato include l'analisi di come l'eterogeneita dei dispositivi possa influenzare gli algoritmi e la loro accuratezza nel produrre il risultato. Si include inoltre l'analisi dello stato dell'arte la progettazione e lo sviluppo di un'applicazione Android e di un web service. L'illustrazione dei test effettuati e le considerazioni finali concludono la tesi.

DYNAMICS AND CONTROL OF REACTIVE DISTILLATION PROCESS FOR MONOMER SYNTHESIS OF POLYCARBONATE PLANTS

Polycarbonate (PC) is an important engineering thermoplastic that is currently produced in large industrial scale using bisphenol A and monomers such as phosgene. Since phosgene is highly toxic, a non-phosgene approach using diphenyl carbonate (DPC) as an alternative monomer, as developed by Asahi Corporation of Japan, is a significantly more environmentally friendly alternative. Other advantages include the use of CO2 instead of CO as raw material and the elimination of major waste water production. However, for the production of DPC to be economically viable, reactive-distillation units are needed to obtain the necessary yields by shifting the reaction-equilibrium to the desired products and separating the products at the point where the equilibrium reaction occurs. In the field of chemical reaction engineering, there are many reactions that are suffering from the low equilibrium constant. The main goal of this research is to determine the optimal process needed to shift the reactions by using appropriate control strategies of the reactive distillation system. An extensive dynamic mathematical model has been developed to help us investigate different control and processing strategies of the reactive distillation units to increase the production of DPC. The high-fidelity dynamic models include extensive thermodynamic and reaction-kinetics models while incorporating the necessary mass and energy balance of the various stages of the reactive distillation units. The study presented in this document shows the possibility of producing DPC via one reactive distillation instead of the conventional two-column, with a production rate of 16.75 tons/h corresponding to start reactants materials of 74.69 tons/h of Phenol and 35.75 tons/h of Dimethyl Carbonate. This represents a threefold increase over the projected production rate given in the literature based on a two-column configuration. In addition, the purity of the DPC produced could reach levels as high as 99.5% with the effective use of controls. These studies are based on simulation done using high-fidelity dynamic models.

Nitric oxide induces cell death in canine cruciate ligament cells by activation of tyrosine kinase and reactive oxygen species

BACKGROUND: There is increasing evidence suggesting that development of progressive canine cranial cruciate ligament (CCL) rupture involves a gradual degeneration of the CCL itself, initiated by a combination of factors, ranging from mechanical to biochemical. To date, knowledge is lacking to what extent cruciate disease results from abnormal biomechanics on a normal ligament or contrary how far preliminary alterations of the ligament due to biochemical factors provoke abnormal biomechanics. This study is focused on nitric oxide (NO), one of the potential biochemical factors. The NO-donor sodium nitroprusside (SNP) has been used to study NO-dependent cell death in canine cranial and caudal cruciate ligament cells and to characterize signaling mechanisms during NO-stimulation. RESULTS: Sodium nitroprusside increased apoptotic cell death dose- and time-dependently in cruciate ligamentocytes. Cells from the CCL were more susceptible to apoptosis than CaCL cells. Caspase-3 processing in response to SNP was not detected. Testing major upstream and signal transducing pathways, NO-induced cruciate ligament cell death seemed to be mediated on different levels. Specific inhibition of tyrosine kinase significantly decreased SNP-induced cell death. Mitogen activated protein kinase ERK1 and 2 are activated upon NO and provide anti-apoptotic signals whereas p38 kinase and protein kinase C are not involved. Moreover, data showed that the inhibition reactive oxygen species (ROS) significantly reduced the level of cruciate ligament cell death. CONCLUSIONS: Our data support the hypothesis that canine cruciate ligamentocytes, independently from their origin (CCL or CaCL) follow crucial signaling pathways involved in NO-induced cell death. However, the difference on susceptibility upon NO-mediated apoptosis seems to be dependent on other pathways than on these tested in the present study. In both, CCL and CaCL, the activation of the tyrosine kinase and the generation of ROS reveal important signaling pathways. In perspective, new efforts to prevent the development and progression of cruciate disease may include strategies aimed at reducing ROS.

Reactive mass transport modelling of a three-dimensional vertical fault zone with a finger-like convective flow regime

For a three-dimensional vertically-oriented fault zone, we consider the coupled effects of fluid flow, heat transfer and reactive mass transport, to investigate the patterns of fluid flow, temperature distribution, mineral alteration and chemically induced porosity changes. We show, analytically and numerically, that finger-like convection patterns can arise in a vertically-oriented fault zone. The onset and patterns of convective fluid flow are controlled by the Rayleigh number which is a function of the thermal properties of the fluid and the rock, the vertical temperature gradient, and the height and the permeability of the fault zone. Vigorous fluid flow causes low temperature gradients over a large region of the fault zone. In such a case, flow across lithological interfaces becomes the most important mechanism for the formation of sharp chemical reaction fronts. The degree of rock buffering, the extent and intensity of alteration, the alteration mineralogy and in some cases the formation of ore deposits are controlled by the magnitude of the flow velocity across these compositional interfaces in the rock. This indicates that alteration patterns along compositional boundaries in the rock may provide some insights into the convection pattern. The advective mass and heat exchanges between the fault zone and the wallrock depend on the permeability contrast between the fault zone and the wallrock. A high permeability contrast promotes focussed convective flow within the fault zone and diffusive exchange of heat and chemical reactants between the fault zone and the wallrock. However, a more gradual permeability change may lead to a regional-scale convective flow system where the flow pattern in the fault affects large-scale fluid flow, mass transport and chemical alteration in the wallrocks

Control de módulo 3G mediante aplicación Android

Este proyecto describe la metodología a seguir para conectar la plataforma Arduino a dispositivos Android y establecer una conexión que permita controlar dicha plataforma. Sobre Arduino se acoplará un módulo 3G que permitirá hacer uso de funcionalidades propias de los teléfonos móviles. El objetivo final del proyecto era el control del módulo 3G mediante comandos AT enviados desde un dispositivo Android (tableta) conectado a través de USB. Para ello, se ha desarrollado una aplicación de demostración que permite el uso de algunas de las funcionalidades de comunicación del módulo 3G. Para alcanzar el objetivo propuesto se ha investigado sobre temas tales como: internet de las cosas, las tecnologías de comunicaciones móviles, el sistema operativo Android y el desarrollo de aplicaciones móviles, la plataforma Arduino, el funcionamiento del módulo 3G y sobre la comunicación serie que permitirá comunicarse entre Android y módulo 3G. El proyecto proporciona una guía de iniciación con explicaciones de los diferentes dispositivos, tecnologías y pasos a seguir para la integración de las diferentes plataformas que se han usado en el proyecto: Arduino, Módulo de comunicaciones 3G, y Android. ABSTRACT. This project describes the methodology to connect the Arduino platform to Android devices and establish a connection to allow the platform control. A 3G module will be engaged on Arduino allowing the usage of mobile phones functionalities. The main objective of the project was the control of 3G module through AT commands sent from an Android device (tablet) connected via USB. For that, a demonstration application was developed to permit the use of some communication features of 3G module. To achieve the target, an investigation has been carried out about issues such as: internet of things, mobile communications technologies, the Android operating system and mobile applications development, the Arduino platform, the 3G module operation and serial communication that allows the communication between Android and the 3G module. The project provides a starter guide with explanations of the different devices, technologies and steps for the integration of the different platforms that have been used in the project: Arduino, 3G communications module and Android.

Aplicación móvil de localización de ocio para Android

¿No sabes dónde comer un plato típico cuando estás de vacaciones? ¿Quieres ir con amigos a comer a un sitio distinto? ¿Quieres disfrutar de esa comida que tanto te gusta y no sabes dónde hacerlo? Con afán de responder a estas preguntas y gracias a las capacidades que nos brindan las nuevas tecnologías de dispositivos móviles, surge la aplicación que se presenta en este proyecto fin de carrera. Se trata de una aplicación para dispositivos móviles con sistema operativo Android que nos brindará la opción de encontrar restaurantes en nuestro entorno que nos ofrezcan esa comida que queremos. Además, a modo de red social, incluye la opción de poder puntuar los platos degustados en los restaurantes e insertar restaurantes nuevos, lo que hace que la aplicación tenga una mayor versatilidad. En este documento se podrán encontrar los diagramas UML que modelan el proyecto, tanto la parte de la aplicación como la parte del servidor. En él también podremos encontrar otra documentación como: un manual de usuario de la aplicación, el código fuente de la misma y proposiciones de futuras versiones y mejoras de la aplicación actual. ABSTRACT. Don’t you know where you can eat a typical dish when you are on holidays? Do you want to go to eat to a different place? Do you want to enjoy that meal you love and you don’t know where you can do it? To answer those questions and thanks to the possibilities of modern smartphones’ technology, we present this application in my degree’s final project. This application, which runs with an Android operative system, gives us the option to find restaurants in our environment that offer the meal we really want. In addition, as a social network, it includes the option to rate the tasted dishes or to add new restaurants, giving the application versatility. Nowadays our society is used to the use of smartphones and their possibilities. That is why we must to explore its potential to obtain better amenities. In the last few years the amount of available applications for these devices has increased too much, offering a huge variety of them. If we realize a research about their functionalities and uses we will discover that most of them are oriented to leisure. That is why we are going to start the inquiry of a software engineering project developing a restaurant localization restaurant for Android smartphones, In this document you can find the UMI diagrams which model the project, both the application part and the server part. Besides, you can find other documents as: an application user manual, the source and proposals for future versions and improvements.

Control remoto de presentaciones mediante Raspberry PI y Android

Este proyecto fin de carrera trata de mejorar los sistemas actuales de control en la visualización de diapositivas. La solución adoptada constará de un sistema con modelo cliente-servidor. El servidor formado por un mini ordenador, en este caso una Raspberry Pi, que estará conectado al proyector de video. Este servidor se mantendrá a la espera de recibir una conexión entrante vía Bluetooth. Una vez se realice la conexión interpretará los comandos mandados por el cliente a través de una API con formato JSON y realizará las acciones indicadas para el control de la presentación. El cliente será una aplicación móvil para dispositivos Android. A través de ella el profesor accederá al servidor escaneando un código QR que será proyectado y una vez conectado enviará los comandos de control de la presentación, tales como abrir una presentación, avanzar y retroceder diapositiva, etc. La solución final deberá ser eficiente, sencilla de utilizar y con un bajo coste para resultar atractiva y ser así útil en el mundo real. Para ello se contará con valores añadidos como el poder iniciar la presentación desde el dispositivo móvil, el mostrar las notas de la diapositiva actual o contar con un temporizador para permitir un mejor control sobre el tiempo disponible para la presentación. ABSTRACT. This final project pursues the improvement of the current presentation control systems. The solution it provides is based on a server-client architecture. The server will be a mini PC, a Raspberry Pi model in this case, that will be connected to a video projector or a screen monitor. This server will remain idle waiting for an incoming Bluetooth connection. Once the connection is accepted the server will parse the commands sent by the client through a JSON API and will execute them accordingly to control the system. The client we decided to develop is an Android application. The speaker will be able to connect with the server by scanning a QR code that will be generated and displayed into the projector or screen monitor. Once the connection is accepted the client will sent the commands to control the slides, such as opening a presentation, move forward and backwards, etc. The adopted solution must be efficient, easy to use and with low cost to be appealing and useful to the real world. To accomplish the task this project will count with improvements over the current systems, such as the possibility to open a presentation from the smartphone, the visualization of the current slide notes from the mobile phone and a countdown timer to have a better control over the available time for the presentation.

The Business Models and Economics of Peer-to-Peer lending. ECRI Research Report No 17, May 2016

This paper reviews peer-to-peer (P2P) lending, its development in the UK and other countries, and assesses the business and economic policy issues surrounding this new form of intermediation. P2P platform technology allows direct matching of borrowers’ and lenders’ diversification over a large number of borrowers without the loans having to be held on an intermediary balance sheet. P2P lending has developed rapidly in both the US and the UK, but it still represents a small fraction, less than 1%, of the stock of bank lending. In the UK – but not elsewhere – it is an important source of loans for smaller companies. We argue that P2P lending is fundamentally complementary to, and not competitive with, conventional banking. We therefore expect banks to adapt to the emergence of P2P lending, either by cooperating closely with third-party P2P lending platforms or offering their own proprietary platforms. We also argue that the full development of the sector requires much further work addressing the risks and business and regulatory issues in P2P lending, including risk communication, orderly resolution of platform failure, control of liquidity risks and minimisation of fraud, security and operational risks. This will depend on developing reliable business processes, the promotion to the full extent possible of transparency and standardisation and appropriate regulation that serves the needs of customers.

Pro-inflammatory cytokines IL6, TNF-α, IL1β, procalcitonin, lipopolysaccharide binding protein and C-reactive protein in infective endocarditis

Objective: To evaluate the serum levels and diagnostic value of cytokines and acute phase proteins in patients with infective endocarditis (IE). Patients and methods: Serum samples from 63 patients diagnosed with IE and 71 control patients were analysed for the following markers: interleukin-6 (IL6), tumour necrosis factor-α (TNF-α), interleukin 1-β (IL1β), procalcitonin (PCT), lipopolysaccharide binding protein (LBP) and C-reactive protein (CRP). Results: Serum levels of IL6, IL1β and CRP were significantly elevated in patients with IE as compared to controls. PCT, TNF-α and LBP were not elevated. Conclusion: Serum CRP and IL6 are elevated in IE. IL 6 may aid in establishing the diagnosis. There was no correlation between IL 6 levels and CRP, causative microorganism, echocardiographic features or outcome. © 2007 The British Infection Society.

Role of reactive oxygen species in protein degradation in murine myotubes induced by proteolysis-inducing factor and angiotensin II

The antioxidants butylated hydroxytoluene (BHT, 1 mM) and d-α-tocopherol (10 μM) completely attenuated protein degradation in murine myotubes in response to both proteolysis-inducing factor (PIF) and angiotensin II (Ang II), suggesting that the formation of reactive oxygen species (ROS) plays an important role in this process. Both PIF and Ang II induced a rapid and transient increase in ROS formation in myotubes, which followed a parabolic dose-response curve, similar to that for total protein degradation. Antioxidant treatment attenuated the increase in expression and activity of the ubiquitin-proteasome proteolytic pathway by PIF and Ang II, by preventing the activation of the transcription factor nuclear factor-κB (NF-κB), through inhibition of phosphorylation of the NF-κB inhibitor protein (I-κB) and its subsequent degradation. ROS formation by both PIF and Ang II was attenuated by diphenyleneiodonium (10 μM), suggesting that it was mediated through the NADPH oxidase system. ROS formation was also attenuated by trifluoroacetyl arachidonic acid (10 μM), a specific inhibitor of cytosolic phospholipase A2, U-73122 (5 μM) and D609 (200 μM), inhibitors of phospholipase C and calphostin C (300 nM), a highly specific inhibitor of protein kinase C (PKC), all known activators of NADPH oxidase. Myotubes containing a dominant-negative mutant of PKC did not show an increase in ROS formation in response to either PIF or Ang II. The two Rac1 inhibitors W56 (200 μM) and NSC23766 (10 μM) also attenuated both ROS formation and protein degradation induced by both PIF and Ang II. Rac1 is known to mediate signalling between the phosphatidylinositol-3 kinase (PI-3K) product and NADPH oxidase, and treatment with LY24002 (10 μM), a highly selective inhibitor of PI-3K, completely attenuated ROS production in response to both PIF and Ang II, and inhibited total protein degradation, while the inactive analogue LY303511 (100 μM) had no effect. ROS formation appears to be important in muscle atrophy in cancer cachexia, since treatment of weight losing mice bearing the MAC16 tumour with d-α-tocopherol (1 mg kg- 1) attenuated protein degradation and increased protein synthesis in skeletal muscle. © 2007 Elsevier Inc. All rights reserved.