Voyages de Gulliver dans les contrées lointaines,

Mode of access: Internet.

The Intelligencer.

Title from vol. t.p.

An eighteenth century miscellany; the classics of the eighteenth century which typify and reveal an era: Jonathan Swift, Alexander Pope, John Gay...[and others]

Swift, Jonathan. The Drapier's letters.--Pope, Alexander. The Dunciad.--Gay, John. The beggar's opera.--Chesterfield, Earl of. Selected letters to his son.-- Sterne, Laurence. A sentimental journey through France and Italy.--Walpole, Horace. The castle of Otranto.--Sheridan, R. B. The school for scandal.--Gibbon, Edward. Memoirs of my life and writings.--Blake, William. Songs of innocence and songs of experience.

SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses

The incidence of allergy and asthma in developed countries is on the increase and this trend looks likely to continue. CD4(+) T helper 2 (Th2) cells are major drivers of these diseases and their commitment is controlled by cytokines such as interleukin 4, which are in turn regulated by the suppressor of cytokine signaling (SOCS) proteins. We report that SOCS2(-/-) CD4(+) T cells show markedly enhanced Th2 differentiation. SOCS2(-/-) mice, as well as RAG1(-/-) mice transferred with SOCS2(-/-) CD4(+) T cells, exhibit elevated type 2 responses after helminth antigen challenge. Moreover, in in vivo models of atopic dermatitis and allergen-induced airway inflammation, SOCS2(-/-) mice show significantly elevated IgE, eosinophilia, type 2 responses, and inflammatory pathology relative to wild-type mice. Finally, after T cell activation, markedly enhanced STAT6 and STAT5 phosphorylation is observed in SOCS2(-/-) T cells, whereas STAT3 phosphorylation is blunted. Thus, we provide the first evidence that SOCS2 plays an important role in regulating Th2 cell expansion and development of the type 2 allergic responses.

Gulliver's travels

UANL

Quaedam Theses extractae potissimii ex Enchiridio Metaphisico ca. 1718

Small paper notebook with a handwritten copy of a Latin text titled “Quaedam Theses extractae potissimii ex Enchiridio Metaphisico” attributed to John Clark and J. Remington and copied by a Harvard student, likely Richard Dana (Harvard AB 1718). The text is a précis of sections of Jean Le Clerc's "Ontologia et Pneumatologia" prepared by Harvard Tutor Jonathan Remington (Harvard AB 1696). The paper cover is inscribed “Carpenter” and the first page includes the inscriptions “Rosewell Saltonstall,” “Ezra Carpenter,” and "R. Dana” indicating the book was once owned by Harvard students Richard Dana (Harvard AB 1718), Roswell Saltonstall (Harvard AB 1720), and Ezra Carpenter (Harvard AB 1720).

Inscription for Mr. Remington's grave stone, ca. 1800

This one-page undated and unattributed document contains a handwritten copy of the Latin inscription made for Jonathan Remington's gravestone.

Prefaces biographical and critical, to the works of the english poets /

Mode of access: Internet.

Jonathan Swift's Critique of Consequentialism?

Jonathan Swift’s Modest Proposal for preventing the children of poor people from being a burthen to their parents or country, and for making them beneficial to the public can be regarded as a critique of consequentialism, perhaps the finest and most effective that has ever been written. Swift’s argument is not explicit but his use of consequentialist reasoning shows how it is possible to rationally justify a course of action which is grotesque and barbaric. This interpretation of Swift’s pamphlet is supported by considering it in relation to works by Bernard Mandeville and William Petty. Both authors employed consequentialist reasoning and Swift is likely to have been familiar with their work.

The Political Economy of Swift's Satires and other Prose Works

Jonathan Swift wrote perceptively about the emerging commercial society
in Britain in the early eighteenth century. His particular focus was on the
financial revolution and its implications for economic and political stability
as well as for shifts of power between the landed and commercial
classes. Following his return to Ireland Swift’s focus shifted to the developmental
problems of his native country. In several pamphlets he advocated
consumption of domestic products, challenged existing political
structures and made trenchant criticisms of absenteeism and other dysfunctional
aspects of the land tenure system. Swift’s politico-economic
concerns are fully reflected in his best known work, Gulliver’s Travels but
his most pointed criticism of the emerging commercial system is contained
in A Modest Proposal. Written in the form of an economic pamphlet, A
Modest Proposal is ostensibly designed to address the problem of poverty
in Ireland. In addition to its implicit criticism of economic policy in Ireland,
the pamphlet challenges the separation of economics and morality as
evidenced in the writings of William Petty and Bernard Mandeville. Swift
parodies Petty’s political arithmetic but it is suggested here that he also
had in his sights the consequentialist reasoning present in the work of
both authors but explicitly so in Mandeville.
Keywords: financial revolution, public debt, paper credit, rationality, political
arithmetic, consequentialism, Petty (William), Mandeville (Bernard)

Papiers de l'architecte Robert DE COTTE, surintendant des bâtiments du roi. (1667-1739).

Contient : Agrandissements des palais du Louvre el des Tuileries (1664-1667) ; « Description de la nouvelle église de l'Hostel royal des Invalides » ; « Mémoires des despenses que le Roy a faites dans ses bâtimens depuis l'année 1664 jusques en l'année 1690 inclusivement » ; « Estat au vray de la dépence ordinnaire des bàtimens du Roy pendant l'année 1702, » et pendant l'année 1708 (fol. 106) ; États divers pour le Garde-meuble et le château de « la Meüte » (1719-1721) ; Provision de la charge de surintendant des bâtiments du Roi en faveur de Jules Hardouin Mansart (1699) ; Pièces relatives aux châteaux d'Amboise et de Meudon, accordés à la duchesse de Berry et restaurés par R. de Cotte (1718), etc ; Pièces diverses relatives aux intendants et contrôleurs des bâtiments du Roi ; « Thoisé des marbres d'Écosse pour les bâtimens du Roy » (1705) ; Don par Louis XIII d'une pièce de terre attenant au jardin des Tuileries (1637) ; Mémoire sur l'hôtel de La Vieuville ; Pièces diverses relatives aux bâtiments du Collège de France, aux boursiers du Collège de Tréguier, et au Collège de Cambray ; Pièces diverses relatives aux bâtiments de la Bibliothèque du Roy (1727) ; « État général des gages, apointemens, pensions et gratifications des officiers, et employez dans les bâtimens du Roy. — État des logemens occuppés par les officiers du Roy dans ses maisons royalles à Paris, » etc ; Pièces diverses relatives à la chapelle du château de Versailles, et différentes devises ; Résiliations de marchés pour des entreprises de travaux (1688-1720) ; « Régie de la manufacture royale des Goblins... 1745, » et autres pièces relatives à la manufacture de la Savonnerie (1737) ; Manufacture des glaces [miroirs] de Paris ; mémoire adressé à R. de Cotte ; « Mémoire concernant les incendies. — Incendie du chantier du sr Boulle » (1720) ; « Estat des personnes à qui on distribuoit de la glace des glacierres du Louvre et du château de Vincennes » (1738) ; Inventaire des papiers et dessins de feu M. d'Orbay, architecte ordinaire des bâtiments du Roi (1697) ; « État des personnes qui désirent aller à St Pétersbourg pour travailler au service de Sa Majesté Czarienne » (1716) ; Papiers relatifs aux Keller, fondeurs royaux (1692-1718) ; « Arpentement et visite générale des bois et du palais de l'évêché de Verdun restauré par R. de Cotte » (1724) ; « Règles de l'agréable jeu des Passes »