Blockade of T- and B-lymphocyte development by antibody to the gamma c subunit of the receptors for interleukins 2, 4, and 7.

Cytokines are important regulators of hematopoesis. Mutations in gamma c, which is a subunit shared by the receptors for interleukin (IL) 2, IL-4, and IL-7, have been causally associated with human X chromosome-linked severe combined immunodeficiency disease. This finding indicates a mandatory role for cytokine receptor signaling at one or more stages of lymphocyte development. To evaluate the cellular level at which gamma c is critical for lymphopoiesis, the effect of monoclonal antibodies to gamma c on the capacity of syngeneic bone marrow cells to reconstitute the hematopoietic compartment of lethally irradiated recipient mice was examined. We show that monoclonal antibody to gamma c blocked lymphocyte development at or before the appearance of pro-B cells and prior to or at the seeding of the thymus by precursor cells while erythromyeloid cell development was normal. These results suggest that one level of lymphocyte development that requires gamma c is a point in hematopoietic cell differentiation near the divergence of lymphopoiesis and erythromyelopoesis.

A B C of gothic architecture /

Includes index.

Sumerian mythology, a study of spiritual and literary achievement in the third millennium, B.C.

Frontispiece accompanied by leaf with descriptive letterpress.

Zenon papyri; business papers of the third century B.C. dealing with Palestine and Egypt,

Vol. 2 cite as: P.Col. IV

Dedications from the Athenian Akropolis; a catalogue of the inscriptions of the sixth and fifth centuries B. C.

Includes bibliographical references.

Geology and ore-deposits of Rossland, B.C. /

Vita.

A B C of Gothic architecture /

Includes index.

A B C of gothic architecture /

Includes index.

A B C of gothic architecture /

Mode of access: Internet.

Aristophanous Eirēnē. The peace of Aristophanes. Acted at Athens at the great Dionysia, B.C. 421. The Greek text revised; with a translation into corresponding metres, and original notes.

Edited and translated by Benjamin Bickley Rogers.

The A.B.C. of canning : preserving, drying, smoking and pickling of foods /

Includes index.

The congress guide and scientific programme [of the] 5th Pacific Science Congress, Victoria, B. C., June 1-4; Vancouver, B. C., June 5-14; Canada, 1933.

Mode of access: Internet.

From B.C. to Baisieux : being the narrative of the 102nd Canadian Infantry Battalion /

Mode of access: Internet.