Ion channel genes and human neurological disease: Recent progress, prospects, and challenges

What do epilepsy, migraine headache, deafness, episodic ataxia, periodic paralysis, malignant hyperthermia, and generalized myotonia have in common? These human neurological disorders can be caused by mutations in genes for ion channels. Many of the channel diseases are “paroxysmal disorders” whose principal symptoms occur intermittently in individuals who otherwise may be healthy and active. Some of the ion channels that cause human neurological disease are old acquaintances previously cloned and extensively studied by channel specialists. In other cases, however, disease-gene hunts have led the way to the identification of new channel genes. Progress in the study of ion channels has made it possible to analyze the effects of human neurological disease-causing channel mutations at the level of the single channel, the subcellular domain, the neuronal network, and the behaving organism.

Sermon on redemption by David Tappan, 1781

Sewn notebook containing a forty-six page handwritten sermon composed by David Tappan based on the Biblical text Isaiah 65: 17, 18 and the subject of redemption. Tappan delivered the sermon multiple times as evidenced by the note on the first page, "March 11, 18, 25 Spring April 1781 Frisbee July 1782, Byfield July 1783, Lynn, Kimball. Dr. Huntington, Deerfield, French, Merrill, Dana."

Exclusive dealing and vertical integration : the efficiency of contracts in the tuna industry /

Item 535

Marine Corps aviation : the early years, 1912-1940 /

Mode of access: Internet.

Elementary pile theory /

Mode of access: Internet.

Das illustrirte Mississippithal : dargestellt in 80 nach der Natur aufgenommenen Ansichten vom Wasserfalle zu St. Anthony an bis zum Golf von Mexico (eine Entfernung von ungefähr 2300 englischen Meilen) /

Cf. Sabin 40807.

The colleges and the courts : recent judicial decisions regarding higher education in the United States /

Vol.[3] published by Columbia University Press.

A handbook of vaccination. /

Mode of access: Internet.

The Monist.

Vols. 2 and 5 include appendices.

Library of the world's best literature : ancient and modern /

Vols. 1-41, 42-43, and 44-45 paged continuously.

Traditionary stories and legendary illustrations.

Checklist of American Imprints (1833), 20716.

The code of Virginia ; with the Declaration of independence and the Constitution of the United States and the constitution of Virginia /

Includes index.

Circular /

Directors: 1895-1917 (no. 1-200), E.C. Pickering; 1917- (no. 201- Harlow Shapley.

The targeted jobs tax credit in Maryland and Missouri, 1982-1987 /

Mode of access: Internet.

Elements of physical manipulation /

Appendices : A. Electricity. B. Tables. C. Physical laboratories. Books of reference. Additional experimenrts.