Measuring Shared Value: How to Unlock Value by Linking Social and Business Results

Competitividad y valor compartido

City of Hamilton land abstracts (lots 93-203), 1865

An abstract of title for multiple lots in Peter H. Hamilton’s survey, south of Hunter Street, in the City of Hamilton. The lots involved range from lots 93-203 (non-inclusive). The document is dated November 10, 1865. The entries are dated from 1798 to 1865 and include the grantor, grantee, lands and instrument. The name Geo. S. Papps, Esq. appears centred at the top of the page. The document is signed at the bottom by John H. Greer, Registrar. A note on the reverse side of the document reads “Re Angus Abstract”.

Las manifestaciones del poder constituyente y el poder constituido en la construcción de consejos comunales en el Estado Táchira, Venezuela (2005 - 2012)

La presente monografía busca proveer elementos de análisis acerca del proceso de construcción de consejos comunales que ha tenido lugar en la Venezuela contemporánea. Por sus rasgos diferenciadores y llamativos, el caso particular escogido es el del Estado Táchira. El trabajo se enfocará en las características y modos de operación de los actores que ostentan un rol preponderante en el proceso. De igual modo, se recurrirá a los planteamientos teóricos fundamentales de Antonio Negri en lo relacionado con los conceptos de poder constituyente y poder constituido, con el objetivo de abordar las interacciones de dichos actores. Se afirma que la dinámica de colaboración-confrontación que distingue aquellas interacciones, se puede analizar a la luz del dualismo que protagonizan las manifestaciones de los poderes recién mencionados. Este aspecto arroja información valiosa para procurar la comprensión del fenómeno en cuestión.

Estudio de caso: análisis de la influencia del movimiento pro-choice estadounidense en la promoción de los derechos sexuales y reproductivos en Colombia en el periodo de 2001 – 2011.

Los procesos transnacionales han marcado un cambio en las relaciones entre los actores del sistema internacional, permitiendo el trabajo por diversas causas a través de las fronteras. Esto ha sido aprovechado por los movimientos sociales, para que su lucha no quede enmarcada simplemente en su país, sino que a partir de objetivos, problemáticas, valores y acciones similares se vea reflejado en diferentes Estados y se de una acción común y colectiva para generar un cambio. Este fenómeno ha sido tomado como referente el Movimiento Pro-choice para articularse transnacionalmente en Colombia para la promoción de los Derechos Sexuales y Reproductivos en el periodo de 2001 a 2011, alcanzando una serie de objetivos importantes que han permitido cambios legales al interior del país, generando también un cambio dentro de la sociedad colombiana. El estudio, análisis y comprensión de la articulación del movimiento prochoice a partir de una dinámica transnacional para la promoción de los derechos sexuales y reproductivos en Colombia, se perfila como un tema de importancia por su coyuntura actual en el mundo, puesto que ha estado latente en los últimos veinte años. Igualmente, la identificación de la acción de los MST como otros actores internacionales en la transformación de las sociedades tanto locales como internacionales, traducido como un fenómeno que se puede explicar dentro de las Relaciones Internacionales.

Julio Palacios : un físico español de categoría universal.

Se trata de la biografía de uno de los científicos españoles de mayor proyección internacional: Julio Palacios. Fue licenciado en Ciencias Físicas y en Ciencias Exactas en la Universidad de Barcelona, y catedrático de Termología de la Universidad Central. En la Universidad de Leiden (Países Bajos) trabajó con el profesor Kamerlingh Onnes en el estudio del comportamiento de los gases nobles a baja temperatura. Colaboró también con la Universidad de Madrid y con el Laboratorio de Investigaciones Físicas de la Junta de Ampliación de Estudios e Investigaciones Científicas (JAE), en el que investigan también los mejores físicos de la época, como Miguel Catalán, Arturo Duperier, etc. Sus trabajos tuvieron repercusión internacional y, a raíz de ello, la Fundación Rockefeller donó un edificio dotado de instalaciones para la investigación científica del más alto nivel: el Instituto Nacional de Física y Química. En él, Palacios dirigió la sección de rayos X, creando una auténtica escuela española en ese campo. A lo largo de su vida también trabaja en termodinámica de gases a muy bajas temperaturas, electroquímica, óptica fisiológica, magnetismo, física nuclear, biofísica, relatividad, etc. Escribió 186 artículos de investigación y más de una docena de monografías y textos universitarios. A los 65 años publicó su Análisis Dimensional que tuvo un gran impacto en Europa y en los últimos años de su vida puso en duda la teoría de la relatividad de Einstein. Palacios fue vicerrector de la Universidad de Madrid y vicepresidente del Instituto de España. Entonces, la figura científica con más autoridad en España. Desde su puesto preeminente impulsó la reorganización de las Reales Academias y de la Real Sociedad Española de Física y Química; así como la transformación de la JAE en el Consejo Superior de Investigaciones Científicas.

Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins

Although cell surface metalloendopeptidases degrade neuropeptides in the extracellular fluid to terminate signaling, the function of peptidases in endosomes is unclear. We report that isoforms of endothelin-converting enzyme-1 (ECE-1a-d) are present in early endosomes, where they degrade neuropeptides and regulate post-endocytic sorting of receptors. Calcitonin gene-related peptide (CGRP) co-internalizes with calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), beta-arrestin2, and ECE-1 to early endosomes, where ECE-1 degrades CGRP. CGRP degradation promotes CLR/RAMP1 recycling and beta-arrestin2 redistribution to the cytosol. ECE-1 inhibition or knockdown traps CLR/RAMP1 and beta-arrestin2 in endosomes and inhibits CLR/RAMP1 recycling and resensitization, whereas ECE-1 overexpression has the opposite effect. ECE-1 does not regulate either the resensitization of receptors for peptides that are not ECE-1 substrates (e.g., angiotensin II), or the recycling of the bradykinin B(2) receptor, which transiently interacts with beta-arrestins. We propose a mechanism by which endosomal ECE-1 degrades neuropeptides in endosomes to disrupt the peptide/receptor/beta-arrestin complex, freeing internalized receptors from beta-arrestins and promoting recycling and resensitization.

Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators

Nucleotide-based drug candidates such as antisense oligonucleotides, aptamers, immunoreceptor-activating nucleotides, or (anti)microRNAs hold great therapeutic promise for many human diseases. Phosphorothioate (PS) backbone modification of nucleotide-based drugs is common practice to protect these promising drug candidates from rapid degradation by plasma and intracellular nucleases. Effects of the changes in physicochemical properties associated with PS modification on platelets have not been elucidated so far. Here we report the unexpected binding of PS-modified oligonucleotides to platelets eliciting strong platelet activation, signaling, reactive oxygen species generation, adhesion, spreading, aggregation, and thrombus formation in vitro and in vivo. Mechanistically, the platelet-specific receptor glycoprotein VI (GPVI) mediates these platelet-activating effects. Notably, platelets from GPVI function-deficient patients do not exhibit binding of PS-modified oligonucleotides, and platelet activation is fully abolished. Our data demonstrate a novel, unexpected, PS backbone-dependent, platelet-activating effect of nucleotide-based drug candidates mediated by GPVI. This unforeseen effect should be considered in the ongoing development programs for the broad range of upcoming and promising DNA/RNA therapeutics.

A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function

Filamin A (FlnA) cross-links actin filaments and connects the Von Willebrand factor receptor GPIb-IX-V to the underlying cytoskeleton in platelets. Because FlnA deficiency is embryonic lethal, mice lacking FlnA in platelets were generated by breeding FlnA(loxP/loxP) females with GATA1-Cre males. FlnA(loxP/y) GATA1-Cre males have a macrothrombocytopenia and increased tail bleeding times. FlnA-null platelets have decreased expression and altered surface distribution of GPIbalpha because they lack the normal cytoskeletal linkage of GPIbalpha to underlying actin filaments. This results in approximately 70% less platelet coverage on collagen-coated surfaces at shear rates of 1,500/s, compared with wild-type platelets. Unexpectedly, however, immunoreceptor tyrosine-based activation motif (ITAM)- and ITAM-like-mediated signals are severely compromised in FlnA-null platelets. FlnA-null platelets fail to spread and have decreased alpha-granule secretion, integrin alphaIIbbeta3 activation, and protein tyrosine phosphorylation, particularly that of the protein tyrosine kinase Syk and phospholipase C-gamma2, in response to stimulation through the collagen receptor GPVI and the C-type lectin-like receptor 2. This signaling defect was traced to the loss of a novel FlnA-Syk interaction, as Syk binds to FlnA at immunoglobulin-like repeat 5. Our findings reveal that the interaction between FlnA and Syk regulates ITAM- and ITAM-like-containing receptor signaling and platelet function.

Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease

Germline mutations in CYBB, the human gene encoding the gp91(phox) subunit of the phagocyte NADPH oxidase, impair the respiratory burst of all types of phagocytes and result in X-linked chronic granulomatous disease (CGD). We report here two kindreds in which otherwise healthy male adults developed X-linked recessive Mendelian susceptibility to mycobacterial disease (MSMD) syndromes. These patients had previously unknown mutations in CYBB that resulted in an impaired respiratory burst in monocyte-derived macrophages but not in monocytes or granulocytes. The macrophage-specific functional consequences of the germline mutation resulted from cell-specific impairment in the assembly of the NADPH oxidase. This `experiment of nature` indicates that CYBB is associated with MSMD and demonstrates that the respiratory burst in human macrophages is a crucial mechanism for protective immunity to tuberculous mycobacteria.

Maus ares e malária: entre os pântanos de Natal e o feroz mosquito africano (1892-1932)

The development of epidemiological practices in the last years of the nineteenth and early twentieth century was characterized by both an influence of medical geography and the emergence of microbes and vectors of diseases. Both theories were used to explain outbreaks in Rio Grande do Norte specially in Natal. In this process were organized new institutions linked to public health, unhealthy spaces and prescribed hygiene measures. The redefinitions of the spaces were linked to updated elements of Hippocratic medicine such as aerism and emphasis on medical topography. How the physicians of the town were organized in the face of new meanings and fields of expertise in the demarcation of diseases and regulation of their own practices against the illegal medical practitioners? Likewise, the very occurrence of epidemics mobilized people, urban institutions and apparatuses. But how the Hippocratic legacy that leads to the idea of bad air originated by swamps from the eighteenth and nineteenth century has been linked to new microbial assumptions and disease vectors in the early twentieth century? How an invader from Africa, (the mosquito A. gambiae) mobilized transnational efforts to combat malaria and redefined the epidemiological practices? The aim of this work is to understand how epidemiological practices redefine the way we define spaces, practices and disease from both an approach influenced by a relational history of spaces and a theoretical synergy which includes topics in Science Studies, Post Structuralist Geography and some elements of Feminist Studies. Documentary research were surveyed in the reports of the provincial presidents, government posts to the Provincial Assembly, specialized medical articles and theses, and documents from the Rockefeller Foundation and national and international journals. In this regard shall be given to both material and discursive aspects of space-related practical epidemiological that Natal as much (in general) Rio Grande do Norte between bad air and malaria.

Mujeres inmigrantes y mercado de trabajo en Santiago

Incluye Bibliografía

Eficácia e período residual do diflubenzuron para o controle de larvas de Aedes aegypti resistentes ao temefós

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo da variabilidade genética de populações de Aedes aegypti (Diptera,Culicidae), resistente e suscetíveis a inseticidas

Pós-graduação em Genética - IBILCE

A construção do pan-americanismo na revista Em Guarda: o olhar americano pela defesa das Américas (1941-1946)

Pós-graduação em História - FCLAS

Effects of declining fertility on infant mortality levels: a study based on data from five Latin American countries

Includes bibliography