Holocene changes in atmospheric circulation patterns as shown by lake status changes in northern Europe

Changes in lake status, a measure of relative water depth or lake level, have been reconstructed from geological and biological evidence for 87 sites in northern Europe. During the early Holocene. the lakes show conditions similar to or drier than present in a broad band across southern Britain, southern Scandinavia and into the eastern Baltic and wetter conditions along the west coast and in central Europe. This pattern is consistent with the effects of a glacial anticyclone over the Scandinavian Ice Sheet, namely enhanced southwesterly flow along the west coast and strengthened easterlies south of the ice. After c, 8000 BP a different lake status pattern was established. with conditions drier than present over much of northern Europe. Lakes higher than today were confined to the far north, the west coast, eastern Finland and western Russia. This pattern gradually attenuated after 4000 BP. Differences in lake status during the mid- to late Holocene are consistent with a strengthening of the blocking anticyclone over the Baltic Sea in summer. resulting in more meridional circulation than today. This strengthening of the blocking anticyclone during the mid-Holocene is interpreted as a consequence of insolation changes, enhanced by the fact that the Baltic Sea was larger than present.

Effects of voluntary running on spatial memory and mature brain-derived neurotrophic factor expression in mice hippocampus after status epilepticus

Voluntary physical activity improves memory and learning ability in rodents, whereas status epilepticus has been associated with memory impairment. Physical activity and seizures have been associated with enhanced hippocampal expression of BDNF, indicating that this protein may have a dual role in epilepsy. The influence of voluntary physical activity on memory and BDNF expression has been poorly studied in experimental models of epilepsy. In this paper, we have investigated the effect of voluntary physical activity on memory and BDNF expression in mice with pilocarpine-incluced epilepsy. Male Swiss mice were assigned to four experimental groups: pilocarpine sedentary (PS), pilocarpine runners (PRs), saline sedentary (SS) and saline runners (SRs). Two days after pilocarpine-induced status epilepticus, the affected mice (PR) and their running controls (SR) were housed with access to a running wheel for 28 days. After that, the spatial memory and the expression of the precursor and mature forms of hippocampal BDNF were assessed. PR mice performed better than PS mice in the water maze test. In addition, PR mice had a higher amount of mature BDNF (14 kDa) relative to the total BDNF (14 kDa + 28 kDa + 32 kDa forms) content when compared with PS mice. These results show that voluntary physical activity improved the spatial memory and increased the hippocampal content of mature BDNF of mice with pilocarpine-induced status epilepticus. (C) 2009 Elsevier B.V. All rights reserved.

Ovarian structure and hormonal status of the UChA and UChB adult rats in response to ethanol

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Effect of aerobic training status on both maximal lactate steady state and critical power

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Effects of inhibition gastric acid secretion on arterial acid-base status during digestion in the toad Bufo marinus

Digestion affects acid-base status, because the net transfer of HCl from the blood to the stomach lumen leads to an increase in HCO3- levels in both extra- and intracellular compartments. The increase in plasma [HCO3-], the alkaline tide, is particularly pronounced in amphibians and reptiles, but is not associated with an increased arterial pH, because of a concomitant rise in arterial Pco(2) caused by a relative hypoventilation. In this study, we investigate whether the postprandial increase in Paco(2) of the toad Bufo marinus represents a compensatory response to the increased plasma [HCO3-] or a state-dependent change in the control of pulmonary ventilation. To this end, we successfully prevented the alkaline tide, by inhibiting gastric acid secretion with omeprazole, and compared the response to that of untreated toads determined in our laboratory during the same period. In addition, we used vascular infusions of bicarbonate to mimic the alkaline tide in fasting animals. Omeprazole did not affect blood gases, acid-base and haematological parameters in fasting toads, but abolished the postprandial increase in plasma [HCO3-] and the rise in arterial Pco(2) that normally peaks 48 h into the digestive period. Vascular infusion of HCO3-, that mimicked the postprandial rise in plasma [HCO3-], led to a progressive respiratory compensation of arterial pH through increased arterial Pco(2) Thus, irrespective of whether the metabolic alkalosis is caused by gastric acid secretion in response to a meal or experimental infusion of bicarbonate, arterial pH is being maintained by an increased arterial Pco(2). It seems, therefore, that the elevated Pco(2), occuring during the postprandial period, constitutes of a regulated response to maintain pH rather than a state-dependent change in ventilatory control. (C) 2003 Elsevier B.V. All rights reserved.

Arterial acid-base status during digestion and following vascular infusion of NaHCO3 and HCl in the South American rattlesnake, Crotalus durissus

Digestion is associated with gastric secretion that leads to an alkalinisation of the blood, termed the alkaline tide. Numerous studies on different reptiles and amphibians show that while plasma bicarbonate concentration ([HCO3-](pl)) increases substantially during digestion, arterial pH (pHa) remains virtually unchanged, due to a concurrent rise in arterial PCO2 (PaCO2) caused by a relative hypoventilation. This has led to the suggestion that postprandial amphibians and reptiles regulate pHa rather than PaCO2.Here we characterize blood gases in the South American rattlesnake (Crotalus durissus) during digestion and following systemic infusions of NaHCO3 and HCl in fasting animals to induce a metabolic alkalosis or acidosis in fasting animals. The magnitude of these acid-base disturbances were similar in magnitude to that mediated by digestion and exercise. Plasma [HCOT] increased from 18.4+/-1.5 to 23.7+/-1.0 mmol L-1 during digestion and was accompanied by a respiratory compensation where PaCO2 increased from 13.0+/-0.7 to 19.1+/-1.4 mm Hg at 24 h. As a result, pHa decreased slightly, but were significantly below fasting levels 36 h into digestion. Infusion of NaHCO3 (7 mmol kg(-1)) resulted in a 10 mmol L-1 increase in plasma [HCO3-] within 1 h and was accompanied by a rapid elevation of pHa (from 7.58+/-0.01 to 7.78+/-0.02). PaCO2, however, did not change following HCO3- infusion, which indicates a lack of respiratory compensation. Following infusion of HCl (4 mmol kg(-1)), plasma pHa decreased by 0.07 units and [HCO3-](pl) was reduced by 4.6 mmol L-1 within the first 3 h. PaCO2, however, was not affected and there was no evidence for respiratory compensation.Our data show that digesting rattlesnakes exhibit respiratory compensations to the alkaline tide, whereas artificially induced metabolic acid-base disturbances of same magnitude remain uncompensated. It seems difficult to envision that the central and peripheral chemoreceptors would experience different stimuli during these conditions. One explanation for the different ventilatory responses could be that digestion induces a more relaxed state with low responsiveness to ventilatory stimuli. (C) 2005 Elsevier B.V. All rights reserved.

Assessment of vitamin A status in chronic obstructive pulmonary disease patients and healthy smokers

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Unbiased approach to diagnose the nutrient status of red guava (Psidium guajava)

Fertilization of guava relies on soil and tissue testing. The interpretation of tissue test is currently conducted by comparing nutrient concentrations or dual ratios with critical values or ranges. The critical value approach is affected by nutrient interactions. Nutrient interactions can be described by dual ratios where two nutrients are compressed into a single expression or a ternary diagrams where one redundant proportion can be computed by difference between 100% and the sum of the other two. There are D(D-1) possible dual ratios in a D-parts composition and most of them are thus redundant. Nutrients are components of a mixture that convey relative, not absolute information on the composition. There are D-1 balances between components or ingredients in any mixture. Compositional data are intrinsically redundant, scale dependent and non-normally distributed. Based on the principles of equilibrium and orthogonality, the nutrient balance concept projects D-1 isometric log ratio (ilr) coordinates into the Euclidean space. The D-1 balances between groups of nutrients are ordered to reflect knowledge in plant physiology, soil fertility and crop management. Our objective was to evaluate the ilr approach using nutrient data from a guava orchard survey and fertilizer trials across the state of São Paulo, Brazil. Cationic balances varied widely between orchards. We found that the Redfield N/P ratio of 13 was critical for high guava yield. We present guava yield maps in ternary diagrams. Although the ratio between nutrients changing in the same direction with time is often assumed to be stationary, most guava nutrient balances and dual ratios were found to be non-stationary. The ilr model provided an unbiased nutrient diagnosis of guava. © ISHS.

The status of biodiversity and bioprospecting efforts in the Caribbean subregion

Includes bibliography

The seasonal and ovarian status effects on in vitro production of domestic cat embryos between Equator and Tropic of Capricorn

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

THE CURRENT STATUS OF PLAGUE IN CALIFORNIA

At the first Vertebrate Pest Control Conference in 1964, I traced the history of plague control in California and outlined a revised approach, based on newer concepts of plague ecology. In our state of relative ignorance, this required a number of unproved assumptions about plague occurrence in California that verged on crystal ball gazing. These were principally that (1) plague persists in relatively resistant rodent species in certain favorable locations, (2) ground squirrels and chipmunks experience periodic epizootics, but are not permanent reservoirs, (3) plague "foci" of the past were merely sites of conspicuous epizootics, they did not necessarily correspond to permanent foci, and could result from epizootic migrations over considerable distances, and (4) a number of assumptions about areas of greatest epizootic potential can be made by analyzing the pattern of recurrent plague outbreaks in the past. Since then the validity of these assumptions has been tested by the largest outbreak of plague since the early 1940's. We believe that the results have proved the crystal ball largely correct, resulting in much more precise and efficient epizootic surveillance and deployment of control measures than in the past. The outbreak was for us an administrative emergency that exceeded the capacities of the State Health Department. We greatly appreciated the vital help and cooperation of other agencies and individuals. The U.S, Public Health Service accepted a heavy burden of laboratory testing through its San Francisco Field Station, and provided emergency field personnel. The contributions of State Department of Agriculture, Bureau of Weed and Vertebrate Pest Control; U.S. Parks, Forest Service and Bureau of Land Management; local health and agriculture department; and State Division of Parks personnel were essential in accomplishing control work, as well as epizootic surveillance.

Dental caries-related quality of life and socioeconomic status of preschool children, Bauru, SP

AIM: To evaluate oral health-related quality of life of preschool children of Bauru, State of São Paulo, Brazil, and associate it with socioeconomic profile of households. METHODS: The sample consisted of 229 preschool children between 3 and 5 years and the dmft (decayed, missing due to caries, filled teeth) index was adopted for assessment children's dental caries in accordance with the standards recommended by the World Health Organization. Questionnaires were used for evaluation oral health-related quality of life (Early Childhood Oral Health Impact Scale) and socioeconomic profile of parents or guardians of the preschool children. Statistical analysis was performed descriptively by relative and absolute frequencies and by Spearman's correlation and Kruskal-Wallis test (p <0.05). RESULTS: A dmft of 1.65 (± 2.87) and a Sic Index 4.88 (± 3.20) were found, indicating the polarization of dental caries in the studied group. It was verified low influence of oral health on quality of life of the children examined. With respect to socioeconomic classification, 66.38% of families were in the lower middle class. Linear and statistically significant correlation was found between dmft and oral health-related quality of life for the overall score and domains of the questionnaire (p<0.001). CONCLUSIONS: It was found low influence of oral health on quality of life of the preschool children and the assessment of socioeconomic conditions of the children's families may guide practices aiming to reducing inequalities in the distribution of dental caries in the population.

L'impatto delle politiche e dei programmi europei sullo sviluppo della società multiculturale e dello status sociale delle comunità minoritarie in Repubblica di Macedonia

L’oggetto della mia ricerca è la società multiculturale e il livello di sviluppo sociale delle comunità minoritarie in Macedonia, rispetto all’attuazione delle politiche e i programmi europei per la stabilizzazione democratica. L’indagine condotta nella mia tesi si è sviluppata esaminando i risultati ottenuti dai programmi CARDS, attuati per soddisfare gli obblighi stabiliti nell’Accordo di Stabilizzazione e Associazione e per l’implementazione dell’Accordo Quadro di Ohrid. Uno dei valori democratici, su cui l’UE è particolarmente attenta, ed al quale ha riservato un posto primario nei programmi CARDS, è la tutela dei diritti delle minoranze ossia il rispetto delle differenze culturali, linguistiche e religiose. L’obiettivo della mia indagine è stato quello di valutare l’impatto delle politiche europee sulla normativa macedone, concernente i diritti delle comunità minoritarie, ovvero il loro effetto sul consolidamento della società multiculturale e sullo status sociale delle comunità minoritarie in Macedonia. A tale scopo, in primo luogo sono stati esaminati gli emendamenti costituzionali e le modifiche legislative introdotti in seguito alla stipulazione dell’Accordo Quadro di Ohrid. L’analisi è stata incentrata nel verificare se la normativa macedone rientra nei parametri della normativa europea. I risultati ottenuti dimostrano quale è il tipo di multiculturalismo che promuove e garantisce la costituzione macedone. Attraverso l’analisi dei rapporti preparati dalla Commissione europea, relativi all’implementazione del Processo di Stabilizzazione e Associazione, è stato dimostrato come le politiche e i programmi europei hanno inciso sul consolidamento della società multiculturale. Analizzando invece i risultati dai rapporti relativi all’implementazione delle disposizioni dell’Accordo Quadro di Ohrid è stato valutato l’impatto che le politiche europee hanno avuto sullo sviluppo sociale delle comunità minoritarie in Macedonia. Per la valutazione di questo ultimo, sono state prese in considerazione il livello di partecipazione politica delle comunità minoritarie, la realizzazione delle richieste e delle questioni legate alla loro particolarità, l’ambito normativo regolato dal diritto di con-decisione, la rappresentanza delle comunità minoritarie nella sfera pubblica, il livello dell’accesso di istruirsi nella propria lingua e quindi il livello di istruzione e l’ambito e la libertà di usare la propria lingua nel settore pubblico. I concetti principali di questa ricerca sono: cooperazione, democrazia, multiculturalismo e sviluppo. Il termine cooperazione usato in questa ricerca si riferisce ai rapporti di cooperazione instaurati tra l’Unione Europea e la Macedonia nell’ambito dell’Accordo di Stabilizzazione e Associazione e dell’Accordo Quadro di Ohrid, ossia il sostegno dell’UE per la stabilizzazione democratica della Macedonia. Riferendosi a questa ultima, si fa riferimento al livello di garanzia di libera partecipazione dei cittadini, in ogni segmento della vita politica, sociale ed economica, senza discriminazioni etniche, linguistiche e religiose. Il termine multiculturalismo si riferisce alla società multiculturale ed è legato alla questione della politica della differenza, ossia del riconoscimento delle differenze culturali, che discendono dall’appartenenza ad una minoranza etnica e linguistica. Il multiculturalismo in questa ricerca viene analizzato, riferendosi alla multiculturalità della società macedone e ai diritti che la Costituzione macedone garantisce alle comunità minoritarie in Macedonia. Infine, per lo sviluppo in questa ricerca si fa riferimento allo sviluppo sociale delle comunità minoritarie, inteso e misurato tramite una seri di indicatori relativi all’occupazione (crescita di capitale sociale), all’educazione (capitale umano e qualifica di alta istruzione), alla partecipazione politica (occupazione dei posti principali nelle istituzione governative e della amministrazione pubblica), alla diffusione della cultura (uso e mantenimento della lingua e delle tradizioni) ecc. Prendendo in considerazione i principali concetti di questa tesi, il quadro teorico della ricerca sviluppa i nodi cruciali del dibattito sullo sviluppo e la democrazia, sul nesso tra democrazia e multiculturalismo e tra multiculturalismo e sviluppo. Attenendosi alle varie tesi, la ricerca avrà lo scopo di rilevare come si conciliano la società multiculturale macedone ed il modello democratico vigente. In questo contesto sarà fatto riferimento alle tesi fanno favoriscono la necessità di iniziare con la democrazia per poter innescare e sostenere il processo di sviluppo, alla tesi che sostiene la necessità di riconoscimento obbligatorio dei diritti collettivi nella società multiculturale, ossia dell’etnosviluppo delle comunità minoritarie. La ricerca è stata condotta tramite i seguenti metodi: - Il metodo descrittivo sarà usato per descrivere cosa è accaduto nel periodo di interesse di ricerca, riguardo i cambiamenti di natura sociale e politica delle minoranze in Macedonia. - Il metodo comparativo sarà applicato nella comparazione dell'efficacia delle leggi relative ai diritti delle minoranze e del loro status di sviluppo sociale e politico, prima e dopo l'attuazione e implementazione delle riforme europee. - Il metodo qualitativo sarà applicato per l’analisi di documenti, della legislatura e dei rapporti europei e nazionali. Le fonti usate in questa ricerca principalmente si basano su: - analisi di documenti e rapporti governativi, rapporti elaborati dalla Commissione Europea, dall’OSCE, dagli organi governativi e dalle organizzazioni non governative. - analisi di letteratura accademica, focalizzata sui problemi che sono oggetto di questa ricerca. - analisi di documenti pubblicati, come la gazzetta ufficiale, leggi costituzionali e atti legislativi, strategie nazionali e statistiche ufficiali. - analisi dei dati ottenuti da interviste e questionari.

Comparative Study of Informal Health Care Networks and Elderly Health Status in Argentina and Cuba

The objective of this study is to evaluate the impact of informal care support networks on the health status, life satisfaction, happiness and anxiety of elderly individuals in Argentina and Cuba. Recent economic changes, demographic changes, the structure of families and changes in women?s labor participation have affected the availability of informal care. Additionally, the growing number of elderly as a percentage of total population has significant implications for both formal and informal care in Argentina and Cuba. Methods: The SABE - Survey on Health, Well-Being, and Aging in Latin America and the Caribbean, 2000 was used as the data source. The survey has a sample of 10,656 individuals aged 60 years and older residing in private households occupied by permanent dwellers in 7 cities in the Latin American and Caribbean region. My study will focus on the Buenos Aires and Havana samples in which there were 1043 individuals and 1905 individuals respectively. General sampling design was used to establish comparability between countries. Individuals requiring assistance are surveyed on their source of help and the relative impact of informal versus paid help is measured for this group. Other measures of social support (number of living children, companionship and number of individuals living in the same dwelling) are used to measure networks for the full sample. Multivariate probit regression analyses were run separately for Cuba and for Argentina to evaluate the marginal impacts of the types of social support on health status, life satisfaction, happiness and anxiety. Results: For Argentina, almost all of the family help variables positively impact good health. Getting help from most other members of the family negatively impacts satisfaction with life. Happiness is affected differently by each of the family help variables but community support increases the likelihood of being happy. Although none of the family or community help variables show statistical significance, most negatively affect anxiety levels. In Cuba, all of the social support variables have a positive marginal impact on the health status of the elderly. In this case, some of the family and community help variables have a negative marginal impact on life satisfaction; however, it appears that having those closest to the elderly, children, spouse, or other family, positively impacts life satisfaction. Most of the support variables negatively impact happiness. Receiving help from a child, spouse or parent is associated with a marginal increase in anxiety, whereas receiving help from a grandchild, another family member or a friend actually reduces anxiety. Discussion: The study highlights the necessity for enhancing the coordination of various care networks in order to provide adequate care and reduce the burdens of old age on the individual, family and society and the need for consistent support for the caregivers. More qualitative work should be done to identify how support is given and what comprises the support. The constant change and advancement of the world, and the growth of the Latin American and Caribbean region, suggests that more updates studies need to be done.

Developing European conservation and mitigation tools for pollination services: approaches of the STEP (Status and Trends of European Pollinators) project

Pollinating insects form a key component of European biodiversity, and provide a vital ecosystem service to crops and wild plants. There is growing evidence of declines in both wild and domesticated pollinators, and parallel declines in plants relying upon them. The STEP project (Status and Trends of European Pollinators, 2010-2015, www.step-project.net) is documenting critical elements in the nature and extent of these declines, examining key functional traits associated with pollination deficits, and developing a Red List for some European pollinator groups. Together these activities are laying the groundwork for future pollinator monitoring programmes. STEP is also assessing the relative importance of potential drivers of pollinator declines, including climate change, habitat loss and fragmentation, agrochemicals, pathogens, alien species, light pollution, and their interactions. We are measuring the ecological and economic impacts of declining pollinator services and floral resources, including effects on wild plant populations, crop production and human nutrition. STEP is reviewing existing and potential mitigation options, and providing novel tests of their effectiveness across Europe. Our work is building upon existing and newly developed datasets and models, complemented by spatially-replicated campaigns of field research to fill gaps in current knowledge. Findings are being integrated into a policy-relevant framework to create evidence-based decision support tools. STEP is establishing communication links to a wide range of stakeholders across Europe and beyond, including policy makers, beekeepers, farmers, academics and the general public. Taken together, the STEP research programme aims to improve our understanding of the nature, causes, consequences and potential mitigation of declines in pollination services at local, national, continental and global scales.