Assessment of vitamin A status in chronic obstructive pulmonary disease patients and healthy smokers
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
27/05/2014
27/05/2014
01/12/1996
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Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) The relation between vitamin A status and the degree of lung airway obstruction was examined in a cross-sectional study of 36 male subjects aged 43-74 y who were assigned to five groups as follows: healthy nonsmokers (n = 7), healthy smokers (n = 7), mild chronic obstructive pulmonary disease (COPD-mild) patients (n = 9), COPD-moderate-severe patients (n = 7), and COPD-moderate-severe patients with exacerbation (+ex; n = 6). Smoking habits, pulmonary function tests, and energy-protein status were assessed; serum concentrations of retinyl esters, retinol, retinol binding protein, and transthyretin and relative dose responses were measured. In addition, 12 male smokers aged 45-61 y with mild COPD were randomly assigned to two groups for a longitudinal study: six subjects consumed vitamin A (1000 RE/d; COPD- vitamin A) and six subjects received placebo for 30 d. Lowered serum retinol concentrations were found in the COPD-moderate-severe and COPD-moderate- severe+ex groups. Measurements of vitamin A status in healthy smokers and in COPD-mild patients were not different from those in healthy nonsmokers. The improvement of pulmonary function test results after vitamin A supplementation [mean increase for 1-s forced expiratory volume (FEV1) = 22.9% in the COPD-vitamin A group] may support the assumption of a local (respiratory) vitamin A deficiency in patients with this disease. |
Formato |
928-934 |
Identificador |
http://ajcn.nutrition.org/content/64/6/928.abstract American Journal of Clinical Nutrition, v. 64, n. 6, p. 928-934, 1996. 0002-9165 http://hdl.handle.net/11449/64880 WOS:A1996VU81400016 2-s2.0-0029850635 |
Idioma(s) |
eng |
Relação |
American Journal of Clinical Nutrition |
Direitos |
closedAccess |
Palavras-Chave | #chronic obstructive pulmonary disease #pulmonary function tests #retinol circulating complex #Vitamin A status assessment #acute phase protein #albumin #alpha carotene #beta carotene #c reactive protein #ceruloplasmin #placebo #prealbumin #retinol binding protein #retinol ester #retinol palmitate #airway obstruction #chronic obstructive lung disease #cigarette smoking #clinical protocol #clinical trial #controlled clinical trial #controlled study #diet supplementation #disease severity #forced expiratory volume #lung function test #nutritional status #oral drug administration #randomized controlled trial #retinol deficiency #vitamin blood level #Analysis of Variance #Carotenoids #Cross-Sectional Studies #Diet #Intestinal Absorption #Liver #Longitudinal Studies #Lung #Lung Diseases, Obstructive #Middle Aged #Nutritional Status #Respiratory Function Tests #Smoking #Vitamin A #Vitamin A Deficiency |
Tipo |
info:eu-repo/semantics/article |