Increased CNS levels of apolipoprotein D in schizophrenic and bipolar subjects: Implications for the pathophysiology of psychiatric disorders

Chronic administration of the atypical antipsychotic drug, clozapine, to rodents has been shown to increase the concentration of apolipoprotein D (apoD) in several area of the brain, suggesting that apoD could be involved in the therapeutic effects of antipsychotic drugs and/or the pathology of psychotic illnesses. Here, we measured a significant decrease in the concentration of apoD in serum samples from schizophrenic patients. In contrast, apoD levels were significantly increased (92–287%) in dorsolateral prefrontal cortex (Brodmann's area 9) of schizophrenic and bipolar subjects. Elevated levels of apoD expression were also observed in the caudate of schizophrenic and bipolar subjects (68–89%). No differences in apoD immunoreactivity were detected in occipital cortex (Brodmann's area 18) in either group, or in the hippocampus, substantia nigra, or cerebellum of the schizophrenic group. The low serum concentrations of apoD observed in these patients supports recent hypotheses involving systemic insufficiencies in lipid metabolism/signaling in schizophrenia. Elevation of apoD expression selectively within central nervous system regions implicated in the pathology of these neuropsychiatric disorders suggests a focal compensatory response that neuroleptic drug regimens may augment.

Les devins, ou, Commentaire des principales sortes de devinations : distingúe en quinze liures, esquels les ruses & impostures de Satan sont descouuertes, solidement refutees, & separees d'auec les sainctes propheties & d'auec les predictions naturelles /

Mode of access: Internet.

Die sagenpoesie d. Griechen kritisch dargestellt.

Mode of access: Internet.

The trials of James, Duncan and Robert M'Gregor, three sons of the celebrated Rob Roy, before the High court of justiciary, in the years 1752, 1753, and 1754. To which is prefixed a memoir relating to the Highlands, with anecdotes of Rob Roy and his family.

Trials for the abduction of Jean Key Wright.

Les Della Robbia : leur vie et leur œuvre, d'après des documents inédits, suivi d'un catalogue de l'œuvre des Della Robbia en Italie et dans les principaux musée de l'Europe /

Mode of access: Internet.

Martin Luther on the bondage of the will : Written in answer to the diatribe of Erasmus on free-will. First pub. in the year of Our Lord 1525 /

Mode of access: Internet.

De Sadowa à Sedan; mémoires d'un ambassadeur secret aux Tuileries,

Mode of access: Internet.

Denkmäler mittelalterlicher Meteorologie. Mit einer Einleitung und einem Anhang,

(cont.)--Thomas de Cantimpré, De naturis rerum (XIII. Jahrhundert)--El Kazwini, Kosmographie, deutsche Übersetzung aus dem Arabischen (XIII. Jahrhundert)--Image du monde (XIII. Jahrhundert)--Roger Bacon, Opus majus (XIII. Jahrhundert)--Konungs skuggsjá (Königsspiegel), deutsche Übersetzung aus dem Norwegischen (XIII. Jahrhundert)--Ristoro d'Arezzo, La composizione del mondo (XIII. Jahrhundert)--Brunetto Latini, Li livres dou tresor (XIII. Jahrhundert)--Gereimtes Altenglisches "Heiligenleben," Altenglisch mit deutscher Übersetzung (XIII./XIV. Jahrhundert)--Broeder Gheraert, Natuurkunde van het Geheel-al (XIII./XIV. Jahrhundert)--Bartholomaeus Anglicus, De proprietatibus rerum (XIV. Jahrhundert)--Konrad von Megenberg, Das Buch der Natur (XIV. Jahrhundert)--Leonardo Dati, La sfera (XIV. Jahrhundert)--Gregor Reisch, Margarita philosophica (XIV. Jahrhundert)--Anhang.

Ecclesiae militantis trivmphi, sive, Deo amabilium martyrvm gloriosa pro Christi fide certamina : prout opera RR Patrum Societatis Iesv Collegij Germanici et Hungarici moderator impensa S.D.N. Gregorii PP XIII in ecclesia S. Stephani Rotundi Romae Nicolai Circiniani pictoris manu uisuntur depicta, ad exictandam pior deuotionem /

Cavalieri has engraved reproductions of Circignano's frescoes in S. Stefano Rotondo in Rome.

Die Schriften Hartmuths von Cronberg [1521-1525]

I. Sendbrief an Kaiser Karl v. (1521)--II. Sendbrief an Franz v. Sickingen (1521)--III. Sendbrief an Walther von Cronberg (1521)--IV. Drei (vier) christliche Schriften: A. An Papst Leo X. (1521) B. An die Einwohner von Cronberg (1522) C. An die Bettelorden (1522) D. An Jakob Köbel in Oppenheim (1522)--V. Antwort auf Luthers Missive und die Bestallung. (1522)--VI. Statuten der Himmlischen (Cronbergischen) brüderschaft (1522)--VII. Die schriftstücke aus Cronbergs streit mit Peter Meyer (1522)--VIII. Treue vermahnung an alle stände und gesandten auf dem Reichstag zu Nürnberg (1522)--IX. Vermahnung an die Eldgenossen (1522)--X. An meister und rat zu Strassburg (1523)--XI. Sendbrief an Hadrian VI. (1523)--XII. Sendbrief an die Böhmen (1523)--XIII. Christliche schrift und vermahnung an alle stände (1523)--XIV. Persönliches vorbringen vor dem kaiserlichen regiment zu Nürnberg (1523)--XV. Ernstliche schrift an alle stände (1524)--XVI. Sendbrief an Spalatin (1525).

Bailando con Dioniso: el mito de Leucipo y Daphne de Richard Strauss y Joseph Gregor

Primera parte de un artículo dividido en dos que analiza la profunda reinterpretación que del mito de Dafne llevaron a cabo, a partir del relato alternativo de Partenio de Nicea más que del célebre relato de Ovidio, Richard Strauss y su libretista Joseph Gregor en su versión operística Daphne (1938). El objetivo final es someter a examen la declaración expresa de Strauss sobre el significado de su nueva ópera y si a través de la manipulación del argumento mítico los autores lograron alcanzar su objetivo.

Large scale laboratory cultures of Ankistrodesmus gracilis (Reisch) Korsikov (Chlorophyta) and Diaphanosoma biergei Korinek, 1981 (Cladocera)

O objetivo deste trabalho foi avaliar o cultivo em larga escala de Ankistrodesmus gracilis e Diaphanososma birgei em laboratório através do estudo da biologia das espécies, composição bioquímica e custo operacional de produção. A. gracilis apresentou um crescimento exponencial até o sexto dia, ao redor de 144 x 10(4) células mL-1. Logo em seguida, sofreu um brusco decréscimo apresentando 90 x 10(4) células mL-1 (oitavo dia). A partir do d��cimo primeiro dia, as células algais tenderam a crescer novamente, apresentando um máximo de 135 x 10(4) células mL-1 no 17º dia. No cultivo de D. birgei, foi observado o primeiro pico de crescimento no nono dia com 140 x 10² indivíduos L-1, aumentando novamente a partir do d��cimo segundo dia. A alga clorofícea A. gracilis e o zooplâncton D. birgei possuem aproximadamente 50 e 70% de proteína (PS), respectivamente, com teor de carboidrato acima de 5%. A eletricidade e mão de obra foram os itens mais dispendiosos e, de acordo com os dados obtidos, a temperatura, nutrientes, disponibilidade de luz e manejo do cultivo, foram fatores determinantes sobre a produtividade. Os resultados indicam que o meio NPK (20-5-20) pode ser utilizado diretamente como uma alternativa de cultivo em larga escala, considerando o baixo custo de produção, promovendo adequado crescimento e valor nutricional para A. gracilis e D. birgei.