Zero-day malware detection based on supervised learning algorithms of API call signatures

Zero-day or unknown malware are created using code obfuscation techniques that can modify the parent code to produce offspring copies which have the same functionality but with different signatures. Current techniques reported in literature lack the capability of detecting zero-day malware with the required accuracy and efficiency. In this paper, we have proposed and evaluated a novel method of employing several data mining techniques to detect and classify zero-day malware with high levels of accuracy and efficiency based on the frequency of Windows API calls. This paper describes the methodology employed for the collection of large data sets to train the classifiers, and analyses the performance results of the various data mining algorithms adopted for the study using a fully automated tool developed in this research to conduct the various experimental investigations and evaluation. Through the performance results of these algorithms from our experimental analysis, we are able to evaluate and discuss the advantages of one data mining algorithm over the other for accurately detecting zero-day malware successfully. The data mining framework employed in this research learns through analysing the behavior of existing malicious and benign codes in large datasets. We have employed robust classifiers, namely Naïve Bayes (NB) Algorithm, k−Nearest Neighbor (kNN) Algorithm, Sequential Minimal Optimization (SMO) Algorithm with 4 differents kernels (SMO - Normalized PolyKernel, SMO – PolyKernel, SMO – Puk, and SMO- Radial Basis Function (RBF)), Backpropagation Neural Networks Algorithm, and J48 decision tree and have evaluated their performance. Overall, the automated data mining system implemented for this study has achieved high true positive (TP) rate of more than 98.5%, and low false positive (FP) rate of less than 0.025, which has not been achieved in literature so far. This is much higher than the required commercial acceptance level indicating that our novel technique is a major leap forward in detecting zero-day malware. This paper also offers future directions for researchers in exploring different aspects of obfuscations that are affecting the IT world today.

Advertisement call of Scinax littoralis and S. angrensis (Amphibia: Anura: Hylidae), with notes on the reproductive activity of S. littoralis

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Overview of literature and information on "khat-related" mortality: a call for recognition of the issue and further research

During the past 20 years or so, more has become known about the properties of khat, its pharmacology, physiological and psychological effects on humans. However, at the same time its reputation of social and recreational use in traditional contexts has hindered the dissemination of knowledge about its detrimental effects in terms of mortality. This paper focuses on this particular deficit and adds to the knowledge-base by reviewing the scant literature that does exist on mortality associated with the trade and use of khat. We sought all peer-reviewed papers relating to deaths associated with khat. From an initial list of 111, we identified 15 items meeting our selection criteria. Examination of these revealed 61 further relevant items. These were supplemented with published reports, newspaper and other media reports. A conceptual framework was then developed for classifying mortality associated with each stage of the plant's journey from its cultivation, transportation, consumption, to its effects on the human body. The model is demonstrated with concrete examples drawn from the above sources. These highlight a number of issues for which more substantive statistical data are needed, including population-based studies of the physiological and psychological determinants of khat-related fatalities. Khat-consuming communities, and health professionals charged with their care should be more aware of the physiological and psychological effects of khat, together with the risks for morbidity and mortality associated with its use. There is also a need for information to be collected at international and national levels on other causes of death associated with khat cultivation, transportation, and trade. Both these dimensions need to be understood.

A Call for Systematic Research on Solute Carriers

Solute carrier (SLC) membrane transport proteins control essential physiological functions, including nutrient uptake, ion transport, and waste removal. SLCs interact with several important drugs, and a quarter of the more than 400 SLC genes are associated with human diseases. Yet, compared to other gene families of similar stature, SLCs are relatively understudied. The time is right for a systematic attack on SLC structure, specificity, and function, taking into account kinship and expression, as well as the dependencies that arise from the common metabolic space.

Non-metastatic castrate-resistant prostate cancer: a call for improved guidance on clinical management.

BACKGROUND Guidelines on the clinical management of non-metastatic castrate-resistant prostate cancer (nmCRPC) generally focus on the need to continue androgen deprivation therapy and enrol patients into clinical trials of investigational agents. This guidance reflects the lack of clinical trial data with established agents in the nmCRPC patient population and the need for trials of new agents. AIM To review the evidence base and consider ways of improving the management of nmCRPC. CONCLUSION Upon the development of castrate resistance, it is essential to rule out the presence of metastases or micrometastases by optimising the use of bone scans and possibly newer procedures and techniques. When nmCRPC is established, management decisions should be individualised according to risk, but risk stratification in this diverse population is poorly defined. Currently, prostate-specific antigen (PSA) levels and PSA doubling time remain the best method of assessing the risk of progression and response to treatment in nmCRPC. However, optimising imaging protocols can also help assess the changing metastatic burden in patients with CRPC. Clinical trials of novel agents in nmCRPC are limited and have problems with enrolment, and therefore, improved risk stratification and imaging may be crucial to the improved management. The statements presented in this paper, reflecting the views of the authors, provide a discussion of the most recent evidence in nmCRPC and provide some advice on how to ensure these patients receive the best management available. However, there is an urgent need for more data on the management of nmCRPC.