Overview of literature and information on "khat-related" mortality: a call for recognition of the issue and further research

During the past 20 years or so, more has become known about the properties of khat, its pharmacology, physiological and psychological effects on humans. However, at the same time its reputation of social and recreational use in traditional contexts has hindered the dissemination of knowledge about its detrimental effects in terms of mortality. This paper focuses on this particular deficit and adds to the knowledge-base by reviewing the scant literature that does exist on mortality associated with the trade and use of khat. We sought all peer-reviewed papers relating to deaths associated with khat. From an initial list of 111, we identified 15 items meeting our selection criteria. Examination of these revealed 61 further relevant items. These were supplemented with published reports, newspaper and other media reports. A conceptual framework was then developed for classifying mortality associated with each stage of the plant's journey from its cultivation, transportation, consumption, to its effects on the human body. The model is demonstrated with concrete examples drawn from the above sources. These highlight a number of issues for which more substantive statistical data are needed, including population-based studies of the physiological and psychological determinants of khat-related fatalities. Khat-consuming communities, and health professionals charged with their care should be more aware of the physiological and psychological effects of khat, together with the risks for morbidity and mortality associated with its use. There is also a need for information to be collected at international and national levels on other causes of death associated with khat cultivation, transportation, and trade. Both these dimensions need to be understood.

A Call for Systematic Research on Solute Carriers

Solute carrier (SLC) membrane transport proteins control essential physiological functions, including nutrient uptake, ion transport, and waste removal. SLCs interact with several important drugs, and a quarter of the more than 400 SLC genes are associated with human diseases. Yet, compared to other gene families of similar stature, SLCs are relatively understudied. The time is right for a systematic attack on SLC structure, specificity, and function, taking into account kinship and expression, as well as the dependencies that arise from the common metabolic space.

Non-metastatic castrate-resistant prostate cancer: a call for improved guidance on clinical management.

BACKGROUND Guidelines on the clinical management of non-metastatic castrate-resistant prostate cancer (nmCRPC) generally focus on the need to continue androgen deprivation therapy and enrol patients into clinical trials of investigational agents. This guidance reflects the lack of clinical trial data with established agents in the nmCRPC patient population and the need for trials of new agents. AIM To review the evidence base and consider ways of improving the management of nmCRPC. CONCLUSION Upon the development of castrate resistance, it is essential to rule out the presence of metastases or micrometastases by optimising the use of bone scans and possibly newer procedures and techniques. When nmCRPC is established, management decisions should be individualised according to risk, but risk stratification in this diverse population is poorly defined. Currently, prostate-specific antigen (PSA) levels and PSA doubling time remain the best method of assessing the risk of progression and response to treatment in nmCRPC. However, optimising imaging protocols can also help assess the changing metastatic burden in patients with CRPC. Clinical trials of novel agents in nmCRPC are limited and have problems with enrolment, and therefore, improved risk stratification and imaging may be crucial to the improved management. The statements presented in this paper, reflecting the views of the authors, provide a discussion of the most recent evidence in nmCRPC and provide some advice on how to ensure these patients receive the best management available. However, there is an urgent need for more data on the management of nmCRPC.

Mental health and aging [microform] : call for federal action : hearing before the Select Committee on Aging, House of Representatives, One Hundredth Congress, second session, March 2, 1988.

"Comm. pub. no. 100-678."

A national conversation on American pluralism and identity : endowment, wide call for proposals.

Mode of access: Internet.

Sermons preached on public occasions : with fifteen addresses to the people of Otaheite, and a serious call respecting a mission to the River Indus /

"Memoir of Dr. John Love": (p. [v]-xvii).

The friendly call of truth and reason to a new species of dissenters : to which are prefixed a few observations on the expediency of parliamentary interposition, duly to explain, and if necessary to amend the act of William and Mary commonly called The Toleration Act."

Mode of access: Internet.

The right-aim school testament, comprising the New Testament of our Lord and Saviour Jesus Christ : and an annexment of the preliminary brief of the right-aim school, the declaration of freedebtism, and the free-debt-rules, with some appurtenances, in view of a humble and earnest call on all people to "search the scriptures" and to heed the analogy and application of Freedebtism to religious principle and scripture text : especially to this- "Forgive us our Debts as we forgive our debtors" distinguisched in the Lord's Prayer.

"Entered according to Act of Congress, in the year 1834, by Rufus Davenport, in the Clerk's Office of the District of Massachusetts."

Call to professing Christians on temperance /

Extracted from The National Preacher. v. 5, no. 8.

The History of the life and reign of the valiant Prince Edward, afterwards King Edward the first of England, son to King Henry the third; and his Princess Eleonora. On which history is founded a play written by Mr. Thomson, call'd Edward and Eleonora; now in rehearsal at the Theatre in Covent-Garden. Extracted from the best historians. With a geographical description of that Prince's expedition to the Holy Land.

Mode of access: Internet.

Legislative record of California congressmen on measures of interest to labor as expressed by roll-call vote.

Cover title.

Brewing and liquor interests and German propaganda : hearings before a subcommittee of the Committee on the Judiciary, United States Senate, Sixty-fifth Congress, second and third sessions, pursuant to S. res. 307, a resolution authorizing and directing the Committee on the Judiciary to call for certain evidence and documents relating to charges made against the United States Brewers' Association and allied interests and to submit a report of their investigation to the Senate.

Charles A. Culberson, chairman.