Manual compendio de el regio patronato indiano para fu mas facil ufo en las materias conducentes a la practica.

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Pastoral del ilustrísimo Señor Doctor D. Juan Cayetano G. de Portugal, dignísimo Obispo que fué de Michoacán : obra póstuma que dejó para instrucción de los fieles.

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Come fu fatta L'italia (1856-1870)

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Instrucción reservada que el conde de Revilla Gigedo dió a su sucesor en el mando, marqués de Branciforte sobre el gobierno de este continente en el tiempo que fué su virey : con un prontuario esacto de las materias que se tocan en ella ; y el retrato de su autor

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Cuestiones constitucionales : Votos del Sr. Lic. D. Ignacio L. Vallarta, Presidente que fué de la Suprema Corte de Justicia Nacional, en los negocios más notables resueltos por este tribunal desde mayo de1878 hasta noviembre de 1882.

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Noticias históricas de la instrucción por el clero en León, desde el año de 1576 en que se fundó la ciudad hasta el de 1862 en que fué ergida capital del obispado

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Arte de lengua mexicana que fué usual entre los indios del obispado de Guadalajara y de parte de los de Durango y Michoacán, escrito en 1692

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Exposición de motivos con que fué presentado a la Secretaría de Justicia el proyecto de reformas al Código de procedimientos penales del Distrito y Territorios Federales.

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Manifiesto que haze el Lic.do D. Joseph Méndez, abogado de esta real audiencia, de los fundamentos que tuvo (que oy se hallan mas instruidos, en la segunda, y tercera instancia) para el parecer que dió, y con el que se pronunció, por la Justicia ordinaria de Oaxaca, la sentencia de onze de Julio del año passado de mil setecientos y veinte y quatro: En los autos que siguen los herederos del Alferez D. Gaspar de Somoza, contra los albaceas del Cappn. D. Juan Gomez Márquez, quien lo fué de D. Francisco de Somoza, sobre la subsistencia del testamento otorgado en virtud de su poder, y sus disposiciones.

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What for? : I went to school this morning. '¿Para qué? : fuí a la escuela esta mañana'.

Forma parte de un programa de lectura para niños de hasta cinco años y cumple con los requisitos del currículo de Inglaterra, Gales y Escocia. Durante esta etapa, el niño se acerca a la lectura sobre la base de la comprensión de la relación entre imágenes y texto, y debe familiarse con el sentido de izquierda a derecha en que se efectua áquella. El profesor hace la lectura en voz alta para que los alumnos se familiaricen con los textos y tengan confianza en lo que leen. Son dos breves historias, una con más texto que la otra, que se apoyan sobre todo en las ilustraciones.

[Ressenya del llibre] Tuan, Yi-Fu . Escapismo: formas de evasión en el mundo actual

Comentari al llibre de Yi-Fu Tuan, 'Escapismo : formas de evasión en el mundo actual', publicat l'any 2003 per Península. Obra on es reflexiona i es planteja les relacions entre Natura i Cultura

Kung slår dam : våldsforskningsmetodologi i ett våldsamt jämställt Sverige

King captures queen. Methodology in research on violence in violently equal Sweden Research and debate on violence against women in a Swedish context is here discussed from a perspective that focuses on the different understandings and epistemological claims behind existing positions. I crystallize a dominant perspective on violence, centred around fragmentation/deviance, and a challenging feminist understanding, centred around coherence/normality. I relate these understandings to a wider set of methodological choices and epistemological claims within research on violence against women, captured in what I call a discourse on partner violence (fragmentation) and a feminist discourse on men’s violence against women (coherence). The article also examines the reactions, in media and academic life, that a quantitative study on men’s violence against women in Sweden provoked, Captured queen, men’s violence against women in equal Sweden. A prevalence study (Lundgren et al 2001). By applying a coherent methodological approach, stemming from the feminist discourse on violence against women, the study seems to have placed itself outside what was comprehensible for many voices in the debate (from media and the academic field). I discuss the hostile reactions the study aroused, in relation to its methodology and the above presented conflicting understandings that occupy the research field “violence against women”.

Functionalization of hollow mesoporous silica nanoparticles for improved 5-fu loading

 Hollow mesoporous silica nanoparticles were successfully fabricated and functionalized with appropriate silanes. After modifications, amine, carboxyl, cyano, and methyl groups were grafted onto the nanoparticles and all functionalized hollow mesoporous silica nanoparticles maintained a spherical and hollow structure with a mean diameter of ~120 nm and a shell thickness of ~10 nm. The loading capacity of the hollow mesoporous silica nanoaprticles to the anticancer drug, 5-fluorouracil, can be controlled via precise functionalization. The presence of amine groups on the surface of nanoparticles resulted in the highest loading capacity of 28.89%, due to the amine functionalized nanoparticles having a similar hydrophilicity but reverse charge to the drug. In addition, the change in pH leads to the variation of the intensity of electrostatic force between nanoparticles and the drug, which finally affects the loading capacity of amine functionalized hollow mesoporous silica nanoparticles to some extent. Higher drug loading was observed at pH of 7.4 and 8.5 as 5-fluorouracil becomes more deprotonated in alkaline conditions. The improved drug loading capacity by amine functionalized hollow mesoporous silica nanoparticles has demonstrated that they can become potential intracellular 5-fluorouracil delivery vehicles for cancers.

Overcoming acquired drug resistance in colorectal cancer cells by targeted delivery of 5-FU with EGF grafted hollow mesoporous silica nanoparticles

Acquired drug resistance (ADR) can be developed in colorectal cancer cells after 5-fluorouracil (5-FU) treatment and diminish the effectiveness of chemotherapy. In this work, acquired 5-FU resistance in the colorectal cancer cell line SW480 was obtained with the up-regulation of dihydropyrimidine dehydrogenase (DPYD) gene expression which can convert 5-FU to its inactive metabolite. To overcome ADR in colorectal cancer, hollow mesoporous silica nanoparticles (HMSNs) grafted with epidermal growth factor (EGF) were used as nanocarriers to deliver 5-FU to colorectal cancer cells with acquired drug resistance. The effect and mechanism of 5-FU loaded EGF grafted HMSNs (EGF-HMSNs-5-FU) in overcoming acquired drug resistance in SW480/ADR cells were studied. The EGF-HMSNs were demonstrated to be specifically internalized in EGFR overexpressed SW480/ADR cells via a receptor-mediated endocytosis and can escape from endo-lysosomes. The EGF-HMSNs-5-FU exhibited much higher cytotoxicity on SW480/ADR cells than HMSNs-5-FU and free 5-FU while the plain HMSNs did not show significant cytotoxicity. The mechanism of EGF-HMSNs-5-FU in overcoming drug resistance in SW480/ADR cells could be attributed to the specific internalization of EGF-HMSNs-5-FU in EGFR overexpressed cells which can lead to high intracellular drug accumulation and cause cell death through S phase arrest.