Nouus orbis seu Descriptionis Indiae occidentalis : libri XVIII /

Datos tomados de ICCU y COPAC.

Utriusque Hollandiae, Zelandiae, Frisiaeque Curiae decisiones ; item Tractatus de feudi Hollandici Frisicique Occidentalis origine & successione, nec non Curiae Feudalis ejusdem provinciae observationum feudisticarum decades sex, quarum quinque posthumae nunquam ante-hac editae ; accedunt De pactis antenuptialibus observationes & decisiones /

Signatures: (*)² 2[cross]² A-2Z⁴, ²[cross]⁴ A-2B⁴ a-m⁴.

Safety and efficacy of ledipasvir-sofosbuvir in black patients with hepatitis C virus infection: A retrospective analysis of phase 3 data.

UNLABELLED: Black patients chronically infected with genotype 1 hepatitis C virus (HCV) have historically had lower rates of response to interferon-based treatment than patients of other races. In the phase 3 ION program, the single-tablet regimen of the NS5A inhibitor ledipasvir and NS5B nucleotide polymerase inhibitor sofosbuvir was shown to be safe and highly effective in the general population. The aim of this study was to evaluate the safety and efficacy of ledipasvir/sofosbuvir in black patients using data from the three open-label ION clinical trials, which evaluated the safety and efficacy of 8, 12, and 24 weeks of ledipasvir/sofosbuvir with or without ribavirin for the treatment of treatment-naïve and treatment-experienced patients with genotype 1 HCV, including those with compensated cirrhosis. The primary endpoint was sustained virologic response at 12 weeks after the end of therapy (SVR12). For our analysis, rates of SVR12, treatment-emergent adverse events, and graded laboratory abnormalities were analyzed in black versus non-black patients. Of the 1949 patients evaluated, 308 (16%) were black. On average, black patients were older, had higher body mass index, were more likely to be IL28B non-CC, and had a lower serum alanine aminotransferase at baseline than non-black patients. Overall, 95% of black and 97% of non-black patients achieved SVR12. The rate of relapse was 3% in black patients as compared with 2% in non-black patients. The most common adverse events included fatigue, headache, nausea, and insomnia. The majority of adverse events occurred more frequently in the ribavirin-containing arms of the studies. No differences were observed in overall safety by race. CONCLUSION: A once-daily dosage of ledipasvir/sofosbuvir was similarly effective in black and non-black patients with genotype 1 HCV infection. The addition of ribavirin did not appear to increase SVR12 but was associated with higher rates of adverse events.

A vueltas con la naturaleza del cambio fonético-fonológico: los casos de Nj y Lj

Las etapas del cambio fonético-fonológico han sido descritas desde hace décadas, especialmente desde un punto de vista articulatorio y casi siempre partiendo de los testimonios escritos de que se podía disponer. No obstante, recientemente han ido surgiendo nuevas teorías que defienden que el cambio puede ser explicado a través del estudio de la variación y los procesos fonéticos propios del habla actual, puesto que ambos están relacionados con fenómenos de hipo (e hiper) articulación y, a la postre, de coarticulación. Una de ellas es la Fonología Evolutiva (Blevins 2004), aun cuando no ofrece una explicación satisfactoria para la difusión del cambio. En este estudio, se ha recurrido a estas teorías para esclarecer las causas de la evolución de dos contextos de yod segunda: /nj/ y /lj/, que llevaron a la fonologización de // y //, en un primer estadio de la historia del español.