Sendschreiben eines verdeibelten Reharbeiters an den Arbeits-Minister Milde: Ex-Silenz-ia! Da't nanu nich anders is, das des Volk sufferen wurde, wie uns die Rehberger-Nazional-Zeitung gemöldet hat ...

Welsch (Projektbearbeiter): Heftige Kritik an der Politik des preußischen Arbeits- und Handelsministers Milde

Execution der An̄a Maria Karpffin : ihres Alters 28 Jahr, v. Unterdencken gebürtig, welche Zu Dahlhoffen ein Kind jämerl. ermordet und noch ein anders WochenKind gestohlen ...

Thomas Bäck sc. exc.

Erich Anders, Hüftbild

Signatur des Originals: S 36/F02582

Life-like forms in meteorites and the problems of environmental control on the morphology of fossil and recent protobionta / consulting editor, Bartholomew Nagy ; conference chairman, J. Joseph Lynch ; authors, E. Anders [et al.]

108

Geschiedenis van het patronaatregt : anders genoemd kollatieregt, in verband met het Christelijk Kerkbestuur sinds de vroegste tijden tot op den tegenwoordigen tijd /

Mode of access: Internet.

De historie van den Waldensen : ghedeelt in drie deelen där van het eerste handelt van hunnen oorspronck suyver Gheloove ende vervolgingen die sy door geheel Europa, gedürende den tijt van meer als 450. jaren hebben gheleden. Het tweede vervat de historie van de Waldensen, anders genämt de Albigensen. Het derde begrijpt de leere ende discipline welcke sy onderlinghe ghemeyn ghehadt hebben Midsgaders de wederlegginghe vande leere van ... nne weder-partije. ... Vergadert wt d'autheuren, der welcker namen hier nä ghestelt worden, ende in de Fransoysche tale beschreven,

Mode of access: Internet.

Drey curieuse chymische tractätlein, das erste, betitult: Güldene rose, [das ist, einfältige beschreibung des allergrössesten, von dem allmächtigsten schopffer himmels und der erden Jehovah in die natur gelegten, und dessen freunden unhd auserwählten zugetheilten geheimnisses, als speigels der göttlichen und natürlichen weissheit.] Das andere Brunn der weisheit und erkänntnis der natur, von einem unvergleichlichen philosopho gegraben. Das dritte Blut der natur, [oder: Entdeckung des allergeheimsten schatzes derer weisen, seyende nichts anders, als der rothe lebens-safft davon alle geschöpfe nach dem willen des Allmächtigen herstammen, erhalten und fortgepflanzet werden.]

[Each tract has special t.-p.: Güldene rose ... ans licht gebracht durch J.R.V.M.D.--Brunnen der weissheit ... geöffnet durch Anonymum von Schwartzfuss.--Das blut der natur ... hervorgegeben von Anonymus von Schwarzfuss.]

Hans-Christoph Koller: Bildung anders denken, Einführung in die Theorie transformatorischer Bildungsprozesse. Stuttgart: Kohlhammer 2012 [Rezension]

Rezension von: Hans-Christoph Koller: Bildung anders denken, Einführung in die Theorie transformatorischer Bildungsprozesse, Stuttgart: Kohlhammer 2012 (194 S.; ISBN 978-3-17-021980-9)

Convergence Of Soil Nitrogen Isotopes Across Global Climate Gradients.

Quantifying global patterns of terrestrial nitrogen (N) cycling is central to predicting future patterns of primary productivity, carbon sequestration, nutrient fluxes to aquatic systems, and climate forcing. With limited direct measures of soil N cycling at the global scale, syntheses of the (15)N:(14)N ratio of soil organic matter across climate gradients provide key insights into understanding global patterns of N cycling. In synthesizing data from over 6000 soil samples, we show strong global relationships among soil N isotopes, mean annual temperature (MAT), mean annual precipitation (MAP), and the concentrations of organic carbon and clay in soil. In both hot ecosystems and dry ecosystems, soil organic matter was more enriched in (15)N than in corresponding cold ecosystems or wet ecosystems. Below a MAT of 9.8°C, soil δ(15)N was invariant with MAT. At the global scale, soil organic C concentrations also declined with increasing MAT and decreasing MAP. After standardizing for variation among mineral soils in soil C and clay concentrations, soil δ(15)N showed no consistent trends across global climate and latitudinal gradients. Our analyses could place new constraints on interpretations of patterns of ecosystem N cycling and global budgets of gaseous N loss.

A Randomized, Double-Blind, Placebo-Controlled Phase II Study of Vandetanib Plus Docetaxel/Prednisolone in Patients with Hormone-Refractory Prostate Cancer

Vandetanib (ZACTIMA(TM)) is a once-daily oral anticancer drug that selectively inhibits vascular endothelial growth factor receptor, epidermal growth factor receptor, and rearranged during transfection signaling. This randomized (1: 1), double-blind study evaluated vandetanib (100mg/day) or placebo in combination with docetaxel (D; 75mg/m(2) every 3 weeks) and prednisolone (P; 2 x 5 mg/day) in 86 patients with metastatic hormone-refractory prostate cancer (mHRPC). The primary assessment was prostate-specific antigen (PSA) response (confirmed reduction of >= 50% from baseline) and a greater number of patients showed a PSA response with placebo + DP (67%) versus vandetanib + DP (40%); hazard ratio = 2.23 (one-sided 80% confidence limit = 2.90; one-sided p = 0.99). More patients experienced progression events (disease progression or death from any cause) with vandetanib + DP (65%) versus placebo + DP (60%); hazard ratio = 1.13 (one-sided 80% confidence limit = 1.44; one-sided p = 0.67). The overall incidence of adverse events was similar in both groups, although more patients experienced adverse events, leading to permanent discontinuation with vandetanib + DP (28%) versus placebo + DP (12%). However, the safety and tolerability profile for vandetanib was similar to that previously reported; adverse events that occurred more frequently in the vandetanib + DP arm were hypertension (14% vs. 2%), erythematous rash (14% vs. 2%), and exfoliative rash (12% vs. 2%). In this study of patients with mHRPC, vandetanib + DP did not demonstrate any efficacy benefit, compared with placebo + DP.

A new approach to heart valve tissue engineering: mimicking the heart ventricle with a ventricular assist device in a novel bioreactor

The `biomimetic` approach to tissue engineering usually involves the use of a bioreactor mimicking physiological parameters whilst supplying nutrients to the developing tissue. Here we present a new heart valve bioreactor, having as its centrepiece a ventricular assist device (VAD), which exposes the cell-scaffold constructs to a wider array of mechanical forces. The pump of the VAD has two chambers: a blood and a pneumatic chamber, separated by an elastic membrane. Pulsatile air-pressure is generated by a piston-type actuator and delivered to the pneumatic chamber, ejecting the fluid in the blood chamber. Subsequently, applied vacuum to the pneumatic chamber causes the blood chamber to fill. A mechanical heart valve was placed in the VAD`s inflow position. The tissue engineered (TE) valve was placed in the outflow position. The VAD was coupled in series with a Windkessel compliance chamber, variable throttle and reservoir, connected by silicone tubings. The reservoir sat on an elevated platform, allowing adjustment of ventricular preload between 0 and 11 mmHg. To allow for sterile gaseous exchange between the circuit interior and exterior, a 0.2 mu m filter was placed at the reservoir. Pressure and flow were registered downstream of the TE valve. The circuit was filled with culture medium and fitted in a standard 5% CO(2) incubator set at 37 degrees C. Pressure and flow waveforms were similar to those obtained under physiological conditions for the pulmonary circulation. The `cardiomimetic` approach presented here represents a new perspective to conventional biomimetic approaches in TE, with potential advantages. Copyright (C) 2010 John Wiley & Sons, Ltd.

Genetic analysis of complement C1s deficiency associated with systemic lupus erythernatosus highlights alternative splicing of normal C1s gene

Deficiencies of complement proteins of the classical pathway are strongly associated with the development of autoimmune diseases. Deficiency of Clr has been observed to occur concomitantly with deficiency in Cls and 9 out of 15 reported cases presented systemic lupus erythernatosus (SLE). Here, we describe a family in which all four children are deficient in Cls but only two of them developed SLE. Hemolytic activity mediated by the alternative and the lectin pathways were normal, but classical pathway activation was absent in all children`s sera. Cls was undetectable, while in the parents` sera it was lower than in the normal controls. The levels of Clr observed in the siblings and parents sera were lower than in the control, while the concentrations of other complement proteins (C3, C4, MBL and MASP-2) were normal in all family members. Impairment of Cls synthesis was observed in the patients` fibroblasts when analyzed by confocal microscopy. We show that all four siblings are homozygous for a mutation at position 938 in exon 6 of the Cls cDNA that creates a premature stop codon. Our investigations led us to reveal the presence of previously uncharacterized splice variants of Cls mRNA transcripts in normal human cells. These variants are derived from the skipping of exon 3 and from the use of an alternative 3` splice site within intron I which increases the size of exon 2 by 87 nucleotides. (c) 2007 Elsevier Ltd. All rights reserved.

pH dependence of the progression in NMR T-2 relaxation times in post-mortem muscle

Continuous NMR T-2 relaxation measurements were carried out on seven rabbit longissimus muscle samples in the period from 25 min to 28 h post-mortem at 200 MHz for H-1. To display differences in post-mortern pH progress and extent of changes in water characteristics during conversion of muscle to meat, three of the seven animals were pre-slaughter injected with adrenaline (0.5 mg/kg live weight 4 h before sacrifice) to differentiate muscle glycogen stores at the time of slaughter. Distributed analysis of T-2 data displayed clear differences in the characteristics of the various transverse relaxation components dependent on progress in pH, as did the water-holding capacity of samples 24 h postmortem. This reveals a pronounced effect of the progressive change in pH on the subsequent development in physical/chemical states of water during the conversion of muscle to meat. Finally, the relaxation characteristics are discussed in relation to supposed post-mortem processes of protein denaturation.