A role for Cdc42 in macrophage chemotaxis

Three members of the Rho family, Cdc42, Rac, and Rho are known to regulate the organization of actin-based cytoskeletal structures. In Bac1.2F5 macrophages, we have shown that Rho regulates cell contraction, whereas Rac and Cdc42 regulate the formation of lamellipodia and filopodia, respectively. We have now tested the roles of Cdc42, Rac, and Rho in colony stimulating factor-1 (CSF-1)-induced macrophage migration and chemotaxis using the Dunn chemotaxis chamber. Microinjection of constitutively activated RhoA, Rac1, or Cdc42 inhibited cell migration, presumably because the cells were unable to polarize significantly in response to CSF-1. Both Rho and Rac were required for CSF-1-induced migration, since migration speed was reduced to background levels in cells injected with C3 transferase, an inhibitor of Rho, or with the dominant-negative Rac mutant, N17Rac1. In contrast, cells injected with the dominant-negative Cdc42 mutant, N17Cdc42, were able to migrate but did not polarize in the direction of the gradient, and chemotaxis towards CSF-1 was abolished.

Woodruff Family fonds, 1784 – 1983, (non-inclusive)

The Woodruff Family Collection: From the time the Woodruff Family came to Canada from the United States in 1795, they took an active role in the forming of their communities both in a civic and social manner. This is evident through the documents contained in this collection. The Woodruffs played an active role in the battles fought in Upper Canada and they were an integral part of the Village of St. Davids. They were educated, business-minded and socially engaged. They accumulated much of their fortune through land dealings. Much of this collection focuses on Samuel DeVeaux Woodruff who was principally a businessman. His dedication to his work is shown through his numerous undertakings. He made his mark on the Niagara Peninsula through his work on the railways, roads, marsh land revisions, canals and the paper industry. He was also involved with the founding of the Long Point Company and he took control of building DeVeaux Hall down to the last detail. His offspring inherited his work ethic and his business acumen. The people who married into the Woodruff Family also possessed key social, political and business ties. Anne and Margaret Clement were from a staunch Loyalist background. Samuel Zimmerman was instrumental to the founding of Niagara Falls and Judge Samuel DeVeaux left behind a legacy for poor and homeless boys in Niagara Falls, New York. The Woodruff Family undoubtedly left a mark on the Niagara Peninsula. This collection brings to light many endeavours of the family and their varied contributions.

Incidencia de la Reforma Agraria de 1936 en la creación de Autodefensas Campesinas en Colombia.

La presente monografía busca establecer una conexión argumentada entre la expedición de la ley 200 de 1936 y la creación de Autodefensas Campesinas en la primera mitad del siglo XX en Colombia. Se buscan las razones estructurales por las cuales la sociedad rural se vio abocada a impulsar agrupaciones armadas para defender sus derechos fundamentales, debido a que el Estado demostró ser incapaz de protegerlos mientras que el odio entre clases rurales aumentó conforme se implementaba el capitalismo agrario en el país. Desde la Teoría del Conflicto de Clases Rurales de Jeffery Paige, se explicará la forma en la que se articulan las variables que no permiten una revolución social, pero si propician la aparición de este tipo de grupos campesinos armados e ilegales; que luego se transformarían en “Guerrillas”.

Estrategias Populistas en Colombia: Las elecciones Presidenciales de 2014

La presente investigación analiza las estrategias populistas empleadas por los candidatos para las presidenciales colombianas de 2014. Se asume el populismo como discurso desde los planteamientos de Ernesto Laclau, considerando que el populismo actúa en forma de discurso movilizador, cuya lógica implica la construcción de una perspectiva antagónica de la realidad, la cual identifica positivamente a las mayorías frente un enemigo que encarna valores y prácticas negativas. Las estrategias populistas constituyen el medio para proponer una visión dicotómica de la realidad y una demanda hegemónica, donde el candidato aparece como parte positiva del antagonismo y constituye la solución de la demanda más importante en términos sociales. La tesis se concentra en responder a la pregunta: ¿Cómo se emplearon las estrategias populistas en las elecciones presidenciales de 2014? Para esto se construyó un índice de estrategias populistas en el cual se ubicó el discurso de cada candidato, donde un antagonismo adecuadamente estructurado y una demanda hegemónica representativa para la sociedad, representa beneficios electorales para el candidato. Se concluye que una adecuada articulación discursiva entre frontera antagónica (receptor positivo y contraparte negativa) y demanda hegemónica, puede significar para el candidato una mayor probabilidad de éxito, en la medida que los ciudadanos interioricen su discurso y se adhieran a él.

La Política Exterior colombiana: reflexiones en torno al Carácter Nacional a partir de la historia de Colombia durante los siglos XX y XXI

Durante los siglos XX y XXI, la política exterior colombiana ha reflejado ciertas tendencias que han repercutido en la realidad del país de manera favorable y desfavorable. Al ser la política exterior el reflejo de los intereses y necesidades de los ciudadanos de un Estados, es importante conocer cómo es el Carácter Nacional para entender por qué un Estado actúa de cierta manera, y cómo puede mejorar sus estrategias implementadas a nivel exterior. La presente investigación diagnóstica busca, mediante un recuento de la historia de Colombia durante estos dos siglos, vislumbrar los factores que han condicionado el carácter nacional, y por ende, han influenciado la política exterior colombiana. Al hacer un recuento de estos sucesos, se podrá comprender por qué el gobierno colombiano utiliza ciertas estrategias a nivel exterior, para así, recomendar su replanteamiento de tal manera que se adecúen favorablemente al carácter nacional colombiano.

The Goss-Udderzook tragedy : being a history of a strange case of deception and murder, including the great life insurance case, and the trial of William E. Udderzook for the murder of W. S. Goss.

Spine title: Trial of Udderzook.

Letters of Lady Rachel Russell : from the manuscript in the library at Woburn Abbey : with an introduction vindicating the character of Lord Russell against Sir John Dalrymple, &c., and the trial of Lord William Russell for high treason.

Mode of access: Internet.

The life of Sir William Wallace, the governor general of Scotland, and hero of the Scottish chiefs, Containing his parentage, adventures, heroic achievements, imprisonments and death; drawn from authentic materials of Scottish history.

Mode of access: Internet.

The Hord family of Virginia; a supplement to the Genealogy of the Hord family,

Photocopy.

William J. Browning (late a representative from New Jersey) : memorial addresses delivered in the House ... and Senate of the U.S., 66th Congress, 2nd session.

Mode of access: Internet.

The Armistead family. 1635-1910.

Mode of access: Internet.

Some of the descendants of Zaccheus Ballord : a private in the revolutionary war; also in the last French and Indian war.

Mode of access: Internet.

A chronicle of England during the reigns of the Tudors, from A.D. 1485 to 1559. By Charles Wriothesley, Windsor Herald. Ed., from a ms. in the possession of Lieut.-General Lord Henry H.M. Percy ...

Mode of access: Internet.

The register of John de Halton, bishop of Carlisle, A.D. 1292-1324.

Issued in 4 parts, 1906-13.