Antonio Moro, son œuvre et son temps,

Part of the plates accompanied by guard sheets with descriptive letterpress.

Otello : o, Il moro di Venezia. Tragedia /

Tr. of: Othello.

I. The present status of the leprosy problem in Hawaii. II. The reaction of lepers to Moro's "percutaneous" test. III. A note upon the possibility of the mosquito acting in the transmission of leprosy.

At head of title: Treasury department. Public health and marine-hospital service of the United States.

La función de la cosmovisión del moro en el Poema de Alfonso Onceno

Existe en el Poema de Alfonso Onceno una intencionalidad manifiesta de exaltar la figura del rey, mostrando su poder para pacificar las revueltas internas de Castilla y para poder hacerle la guerra al infiel: el moro. El trabajo que nos ocupa tiende a evidenciar de qué manera el autor del Poema de Alfonso Onceno realiza una construcción de la cosmovisión del moro como enemigo externo en vistas de exaltar las virtudes de un rey hasta convertirlo en ?espejo y escudo de la cristiandad?, permitiéndole a través de éste procedimiento, juzgar con la misma vara a todo aquél que impida a Alfonso XI luchar contra el enemigo de la fe verdadera.

Moro em edifício histórico, e agora?: avaliação pós-ocupação de habitações multifamiliares no Centro Histórico de São Luís -MA

The central question of the research if inserts in thematic current and of relevance for the studies in Preservation and a Conservation of Historical Centers. It analyzes the relations between habitacional use, satisfaction of the inhabitants and preservation of the patrimony constructed in the Historical Center of São Luis-MA It considers that the use is factor that makes possible the transformation of spaces in places , prioritizing the point of view of the user as essential element to the analysis of the reality and that enriches the evaluation technique of the functional and formal aspects of the constructed environment. It is looked to understand the relation man-environment, and mainly, to verify as it happens throughout the process of the occupation and of appropriation of historical buildings destined to habitacional reuse, and still if this appropriation favors the preservation of the Historical Center of São Luís

Paula Morão & Cristina Pimentel (Coords.) (2014). Matrizes Clássicas da Literatura Portuguesa: uma (re)visão da literatura portuguesa das origens à contemporaneidade. Lisboa; Campo da Comunicação, 550 págs. ISBN: 978-989-8465-24-5

Sem resumo disponível.

Moro em edifício histórico, e agora?: avaliação pós-ocupação de habitações multifamiliares no Centro Histórico de São Luís -MA

The central question of the research if inserts in thematic current and of relevance for the studies in Preservation and a Conservation of Historical Centers. It analyzes the relations between habitacional use, satisfaction of the inhabitants and preservation of the patrimony constructed in the Historical Center of São Luis-MA It considers that the use is factor that makes possible the transformation of spaces in places , prioritizing the point of view of the user as essential element to the analysis of the reality and that enriches the evaluation technique of the functional and formal aspects of the constructed environment. It is looked to understand the relation man-environment, and mainly, to verify as it happens throughout the process of the occupation and of appropriation of historical buildings destined to habitacional reuse, and still if this appropriation favors the preservation of the Historical Center of São Luís

La función de la cosmovisión del moro en el Poema de Alfonso Onceno

Existe en el Poema de Alfonso Onceno una intencionalidad manifiesta de exaltar la figura del rey, mostrando su poder para pacificar las revueltas internas de Castilla y para poder hacerle la guerra al infiel: el moro. El trabajo que nos ocupa tiende a evidenciar de qué manera el autor del Poema de Alfonso Onceno realiza una construcción de la cosmovisión del moro como enemigo externo en vistas de exaltar las virtudes de un rey hasta convertirlo en ?espejo y escudo de la cristiandad?, permitiéndole a través de éste procedimiento, juzgar con la misma vara a todo aquél que impida a Alfonso XI luchar contra el enemigo de la fe verdadera.

La función de la cosmovisión del moro en el Poema de Alfonso Onceno

Existe en el Poema de Alfonso Onceno una intencionalidad manifiesta de exaltar la figura del rey, mostrando su poder para pacificar las revueltas internas de Castilla y para poder hacerle la guerra al infiel: el moro. El trabajo que nos ocupa tiende a evidenciar de qué manera el autor del Poema de Alfonso Onceno realiza una construcción de la cosmovisión del moro como enemigo externo en vistas de exaltar las virtudes de un rey hasta convertirlo en ?espejo y escudo de la cristiandad?, permitiéndole a través de éste procedimiento, juzgar con la misma vara a todo aquél que impida a Alfonso XI luchar contra el enemigo de la fe verdadera.

Crizotinib versus chemotherapy in advanced ALK-positive lung cancer

BACKGROUND: In single-group studies, chromosomal rearrangements of the anaplastic lymphoma kinase gene (ALK ) have been associated with marked clinical responses to crizotinib, an oral tyrosine kinase inhibitor targeting ALK. Whether crizotinib is superior to standard chemotherapy with respect to efficacy is unknown. METHODS: We conducted a phase 3, open-label trial comparing crizotinib with chemotherapy in 347 patients with locally advanced or metastatic ALK-positive lung cancer who had received one prior platinum-based regimen. Patients were randomly assigned to receive oral treatment with crizotinib (250 mg) twice daily or intravenous chemotherapy with either pemetrexed (500 mg per square meter of body-surface area) or docetaxel (75 mg per square meter) every 3 weeks. Patients in the chemotherapy group who had disease progression were permitted to cross over to crizotinib as part of a separate study. The primary end point was progression-free survival. RESULTS: The median progression-free survival was 7.7 months in the crizotinib group and 3.0 months in the chemotherapy group (hazard ratio for progression or death with crizotinib, 0.49; 95% confidence interval [CI], 0.37 to 0.64; P<0.001). The response rates were 65% (95% CI, 58 to 72) with crizotinib, as compared with 20% (95% CI, 14 to 26) with chemotherapy (P<0.001). An interim analysis of overall survival showed no significant improvement with crizotinib as compared with chemotherapy (hazard ratio for death in the crizotinib group, 1.02; 95% CI, 0.68 to 1.54; P=0.54). Common adverse events associated with crizotinib were visual disorder, gastrointestinal side effects, and elevated liver aminotransferase levels, whereas common adverse events with chemotherapy were fatigue, alopecia, and dyspnea. Patients reported greater reductions in symptoms of lung cancer and greater improvement in global quality of life with crizotinib than with chemotherapy. CONCLUSIONS: Crizotinib is superior to standard chemotherapy in patients with previously treated, advanced non-small-cell lung cancer with ALK rearrangement. (Funded by Pfizer; ClinicalTrials.gov number, NCT00932893.) Copyright © 2013 Massachusetts Medical Society.

Estrogen receptor β activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo

Estrogen receptor (ER)-β has been shown to possess a tumor suppressive effect, and is a potential target for cancer therapy. Using gene-expression meta-analysis of human malignant pleural mesothelioma, we identified an ESR2 (ERβ coding gene) signature. High ESR2 expression was strongly associated with low succinate dehydrogenase B (SDHB) (which encodes a mitochondrial respiratory chain complex II subunit) expression. We demonstrate that SDHB loss induced ESR2 expression, and that activated ERβ, by over-expression or by selective agonist stimulation, negatively affected oxidative phosphorylation compromising mitochondrial complex II and IV activity. This resulted in reduced mitochondrial ATP production, increased glycolysis dependence and impaired cell proliferation. The observed in vitro effects were phenocopied in vivo using a selective ERβ agonist in a mesothelioma mouse model. On the whole, our data highlight an unforeseen interaction between ERβ-mediated tumor suppression and energy metabolism that may be exploited to improve on the therapy for clinical management of malignant mesothelioma.

Practical guidelines for planning and implementing fauna translocations

A successful translocation involves many complex factors, including a genetically appropriate source population that can sustain harvest, social and governmental support, assessment of disease transmission risk and a release site with appropriately secure habitat that can support population establishment and persistance. This information is typically discussed during staturory approval processes and can take considerable time. However, following approval, for translocations of most fauna, the initial critical step involves the inherently stressful process of capture, holding, transportation and release. This process is unpredictable and novel, and is especially challenging for wild animals when they are confined in close proximity to conspecifics and humans. In contrast, captive-reared animals have to cope with the unfamiliar challenges of finding food and shelter, along with coping with competition and predation. Little has been written in the scientific literature about the translocation process. This is unsurprising because this process has usually been the realm of skilled practioners, often with animal husbandry backgrounds, rather than research scientists. Highly skilled intuition, observation and the translocation practioner's equivalent of a 'green thumb' often guides the way. However, theory and experimentation, particularly on the effects of stress, is available and this work is invaluable for a successful translocation. Here, we provide a brief description of the translocation process, and discussion of what stress is and how it can be managed. We then provide practical guidelines for the successful translocation of invertebrates, lizards, turtles, passerine birds, marsupials and bats, using examples from Australia and New Zealand.

Vyra enie obob čёnno-ličnogo značenija v russkom jazyke

Expressing generalized-personal meaning in Russian Based on data from Russian, this doctoral dissertation examines generalized-personal meaning that is, generic expressions referring to all human beings, people in general, each or any person (e.g. S vozrastom načinae cenit prostye ve či With age you start to appreciate simple things ). The study shares its basic theoretical orientation with functional approaches going from meaning to form . The objective of the thesis is to determine and describe the various linguistic means which can be used by the speaker to express generalized-personal meaning. The main material of the study consists of 2,000 examples collected from modern Russian literature, newspapers, and magazines. The linguistic means of expressing generalized-personal meaning are divided into three main classes. Morphological and lexico-grammatical means (22% of the material) include the use of personal pronouns and personal verbal endings. In Russian, all personal forms except the 3rd person singular can be used in a generalized-personal meaning. Lexical means (14% of the material) involve, above all, pronouns like vse all , ka dyj everyone , nikto no one , as well as the nouns čelovek man and ljudi people . In emotional speech, generalized-personal meaning can also be conveyed lexically by using utterances like da e idiot znaet even an idiot knows . In rhetorical questions the pronoun kto who can appear in this meaning (cf. Kto ne ljubit moro enoe?! Who doesn t like ice cream?! ). The third main class, syntactic means (64% of the material), consists of constructions in which the generic person is not expressed at the surface level. This class mainly includes two-component structures in which the infinitive relates to a modal predicative adverb (e.g. mo no can, be allowed to , nado must ), modal verb (e.g. stoit be worth(while) , sleduet must, be obliged to ), or predicative adverb ending in -о (e.g. trudno it is hard to , neprilično is not appropriate ). Other syntactic means are: one-component infinitive structures, so-called embedded structures, structures with a processual noun, passive constructions, and gerund constructions. The different forms of expression available in Russian are not interchangeable in all contexts. Even if a given context tolerates the substitution of one construction for another, the two expressions are never entirely synonymous. In addition to determining the range of forms which can express generalized-personal meaning, the study aims to compare these forms and to specify the conditions and possible restrictions (contextual, semantic, syntactic, stylistic, etc.) associated with the use of each construction. In Russian linguistics, the generalized-personal meaning has not been extensively studied from a functional perspective. The advantage of a meaning-based functional approach is that it gives a comprehensive picture of the diversity and distribution of the phenomenon.

A promoter-level mammalian expression atlas

Regulated transcription controls the diversity, developmental pathways and spatial organization of the hundreds of cell types that make up a mammal. Using single-molecule cDNA sequencing, we mapped transcription start sites (TSSs) and their usage in human and mouse primary cells, cell lines and tissues to produce a comprehensive overview of mammalian gene expression across the human body. We find that few genes are truly 'housekeeping', whereas many mammalian promoters are composite entities composed of several closely separated TSSs, with independent cell-type-specific expression profiles. TSSs specific to different cell types evolve at different rates, whereas promoters of broadly expressed genes are the most conserved. Promoter-based expression analysis reveals key transcription factors defining cell states and links them to binding-site motifs. The functions of identified novel transcripts can be predicted by coexpression and sample ontology enrichment analyses. The functional annotation of the mammalian genome 5 (FANTOM5) project provides comprehensive expression profiles and functional annotation of mammalian cell-type-specific transcriptomes with wide applications in biomedical research.

Letras, 2000-2001, nº 42-43 (número completo)

Contenido: Garcilaso de la Vega: 1501?-2001 -- El concepto de "transformación" y sus aplicaciones al análisis de la poesía de Garcilaso / Sofía M. Carrizo Rueda – Algunas observaciones, a principios de un nuevo milenio, en torno a las comedias de Calderón de la Barca / Lilia E. Ferrario de Orduna – Palomeque, don Quijote, Cervantes: tres lectores de Cirongilio de Tracia de Bernardo de Vargas / Javier Roberto González – Cervantes: riesgo del vivir, azar y Providencia. Una lectura en clave bíblica y patrística / Teresa Herráiz de Tresca –La justicia divina o el orlo Amoris en el Amadis de Gaula / Silivia C. Lastra Paz -- Catálogo descriptivo de libros de caballerías castellanos, XIV. Otro Palmerín de Olivia recuperado: Sevilla, Jácome Cromberger, 1547 (Con algunas reflexiones sobre el arte de editar textos impresos) / José Manuel Lucía Megías – La defensa de la poesía en el Perú colonial: El Discurso en Loor de la Poesía / Graciela Maturo – Sobre la evolución de -nn-, -nw- y -w- interiores intervocálicos en la onomástica geográfica del Amadís de Gaula / Aquilino Suárez Pallasá – Reforma y Contrarreforma en las artes plásticas / Carmen Balzer – Tomás Moro y el Humanismo cristiano / Inés de Cassagne – Algunos poetas latinos del Humanismo / Raúl Lavalle – Reseñas bibliográficas