Greece with part of Anatolia / Barnard Randolph Author

Échelle(s) : [1:2 581 000 environ] A Scale of English Miles 100 [= 7,2 cm]

Carte statistique de la France électorale : (Chambre de 1839) / par A. Frère de Montizon ; Dédiée à M.Mrs les électeurs

Échelle(s) : [ca 1:2 145 000]

El batalló dels esperitats. Barry Hannah

Aquest treball presenta una traducció al català d’un conte de l’obra Bats out of hell de Barry Hannah, un escriptor nascut al Sud dels Estats Units. L’interès d’aquest treball és la inexistència de traduccions de l’obra de Hannah al català i la denúncia que fa l’autor dels estereotips tan marcats de la societat de la seva regió natal.

Mrs. Katri Ratia 7/8 1969

Kirje 7.8.1969

Mrs. Hemming Hartikka 18/4 1961

Kirje 18.4.1961

An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker.

The detection of Parkinson's disease (PD) in its preclinical stages prior to outright neurodegeneration is essential to the development of neuroprotective therapies and could reduce the number of misdiagnosed patients. However, early diagnosis is currently hampered by lack of reliable biomarkers. (1) H magnetic resonance spectroscopy (MRS) offers a noninvasive measure of brain metabolite levels that allows the identification of such potential biomarkers. This study aimed at using MRS on an ultrahigh field 14.1 T magnet to explore the striatal metabolic changes occurring in two different rat models of the disease. Rats lesioned by the injection of 6-hydroxydopamine (6-OHDA) in the medial-forebrain bundle were used to model a complete nigrostriatal lesion while a genetic model based on the nigral injection of an adeno-associated viral (AAV) vector coding for the human α-synuclein was used to model a progressive neurodegeneration and dopaminergic neuron dysfunction, thereby replicating conditions closer to early pathological stages of PD. MRS measurements in the striatum of the 6-OHDA rats revealed significant decreases in glutamate and N-acetyl-aspartate levels and a significant increase in GABA level in the ipsilateral hemisphere compared with the contralateral one, while the αSyn overexpressing rats showed a significant increase in the GABA striatal level only. Therefore, we conclude that MRS measurements of striatal GABA levels could allow for the detection of early nigrostriatal defects prior to outright neurodegeneration and, as such, offers great potential as a sensitive biomarker of presymptomatic PD.

Carte de la France / dressée par Mrs Charle et L. Badré,... ; sous la direction de Mr Letronne,...

Échelle(s) : 1:800 000