Regional Advisory Committee on Cancer - Report on Skin Cancer (September 2004) (PDF 201 KB)

Skin cancer is the diagnosis for about a quarter of all patients with cancer and because most of the work is done on an outpatient basis the true extent of the disease has largely gone unrecognised. Skin cancers are related to ultraviolet radiation exposure. Geographic latitude as well as attitude affects the amount of ultraviolet exposure and the risk of skin cancer, with people from Northern Ireland exposing themselves to higher levels of ultraviolet radiation when on holiday abroad and artificially from sunbeds. Ozone depletion is known to increase the risk of ultraviolet exposure and skin cancer. The majority of people living in Northern Ireland have pale skin and are at increased risk of developing skin cancer, as are some patients with an increased genetic risk for cancer. Some pre-existing skin lesions are known to increase the risk of developing skin cancer. Data collection on the incidence of non melanoma skin cancer in Northern Ireland was not available before the establishment of the Cancer Registry in 1993. There is however good data on the incidence of melanoma before that period. In 1974 there were 39 cases in melanoma in Northern Ireland, by 2000 this had risen by almost 500% to 185 cases. åÊ

[8 phot. d'Islande prises en 1887 (expédition de l'Indre) par H. Labonne, donateur la même année (voir Wc 201)]

Donateur : Labonne, Henry (1853-1936?)

Friday Facts, January 31, 2014, Vol. 201

Bureau of Nutrition and Health Promotion part of the Iowa Department of Public Health produces of weekly newsletter about the Iowa WIC Program for the State of Iowa citizen.

Evaluation of Fly Ash in Portland Cement Concrete Paving in Woodbury County, Iowa, HR-201, Construction Report, 1979

The earliest overall comprehensive work on the use of fly ash in concrete was reported by Davis and Associates of the University of California in 1937. Since that time there have been numerous applications of the use and varying proportions of fly ash in portland cement concrete mixes. Fly ash is a pozzolanic powdery by-product of the coal combustion process which is recovered from flue gases and is generally associated with electric power generating plants. Environmental regulations enacted in recent years have required that fly ash be removed from the flue gases to maintain clean air standards. This has resulted in an increased volume of high quality fly ash that is considered a waste product or a by-product that can be utilized in products such as portland cement concrete. There are several sources of the high quality fly ash located in Iowa currently producing a combined total of 281,000 tons of material annually. Due to recent cement shortages and the rapidly increasing highway construction costs, the Iowa Department of Transportation has become interested in utilizing fly ash in portland cement concrete paving mixes. A preliminary review of the Iowa Department of Transportation Materials Laboratory study indicates that a substitution of fly ash for portland cement, within limits, is ·not detrimental to the overall concrete quality. Also the use of fly ash in concrete would reduce the cement consumption as well as provide a potential cost savings in areas where high quality fly ash is available without excessive transportation costs. The previously expressed concerns have shown the need for a research project to develop our knowledge of fly ash replacement in the Iowa Department of Transportation portland cement concrete paving mixes.

Evaluation of Fly Ash in Portland Cement Concrete Paving in Woodbury County, Iowa, Final Report, HR-201, 1980

The earliest overall comprehensive work on the use of fly ash in concrete was reported by Davis and Associates of the University of California in 1937. Since that time, there have been numerous applications of the use and varying propertions of fly ash in portland cement concrete mixes. Fly ash is a pozzolanic powdery by-product of the coal combustion process which is recovered from flue gases and is, generally associated with electric power generating plants. Environmental regulations enacted in recent years have required that fly ash be removed from the flue gases to maintain clean air standards. This has resulted in an increased volume of high quality fly ash that is considered a waste product or a by-product that can be utilized in products such as portland cement concrete. There are several sources of the high quality fly ash located in Iowa currently producing a combined total of 281,000 tons of material annually.

Heart Rate Variability (HRV) modifications in adult hemiplegic patients after botulinum toxin type A (nt-201) injection.

BACKGROUND: The most important adverse effect of BoNT-A is the systemic diffusion of the toxin. There is some evidence that the administration of high doses can increase the risk of systemic diffusion and the development of clinically evident adverse effects, however an international consensus does not exist about its maximum dose. AIM: The aim of this study was to evaluate changes in autonomic heart drive induced by high doses (higher than 600 units) of incobotulinumtoxinA injection in spastic stroke patients. Moreover, the treatment safety by monitoring adverse events occurrence was assessed. DESIGN: Case control study. POPULATION: Eleven stroke survivors with spastic hemiplegia. METHODS: Patients were treated with intramuscular focal injections of IncobotulinumtoxinA (NT 201; Xeomin®, Merz Pharmaceuticals GmbH, Frankfurt, Germany). Doses were below 12 units/Kg. Each patient underwent an ECG recording before injection and 10 days after treatment. Linear and non-linear Heart Rate variability (HRV) measures were derived from ECGs with a dedicated software. RESULTS: None of the variable considered showed statistically significant changes after BoNT-A injection. CONCLUSION: The use of incobotulinumtoxinA in adult patients at doses up to 12 units/kg seems to be safe regarding autonomic heart drive. CLINICAL REHABILITATION IMPACT: The use of IncobotulinumtoxinA up to 600 units could be a safe therapeutic option in spastic hemiplegic stroke survivors.

TRIAGEM METABÓLICA POR PKS E NRPS EM ACTINOBACTÉRIAS ENDOFÍTICAS DE Citrus reticulata

Polyketides and non-ribosomal peptides are natural products widely found in bacteria, fungi and plants. The biological activities associated with these metabolites have attracted special attention in biopharmaceutical studies. Polyketide synthases act similarly to fatty acids synthetases and the whole multi-enzymatic set coordinating precursor and extending unit selection and reduction levels during chain growth. Acting in a similarly orchestrated model, non-ribosomal peptide synthetases biosynthesize NRPs. PKSs-I and NRPSs enzymatic modules and domains are collinearly organized with the parent gene sequence. This arrangement allows the use of degenerated PCR primers to amplify targeted regions in the genes corresponding to specific enzymatic domains such as ketosynthases and acyltransferases in PKSs and adenilation domains in NRPSs. Careful analysis of these short regions allows the classifying of a set of organisms according to their potential to biosynthesize PKs and NRPs. In this work, the biosynthetic potential of a set of 13 endophytic actinobacteria from Citrus reticulata for producing PKs and NRP metabolites was evaluated. The biosynthetic profile was compared to antimicrobial activity. Based on the inhibition promoted, 4 strains were considered for cluster analysis. A PKS/NRPS phylogeny was generated in order to classify some of the representative sequences throughout comparison with homologous genes. Using this approach, a molecular fingerprint was generated to help guide future studies on the most promising strains.

DUNS SCOTUS, ESCOTISTAS E O DEBATE EM TORNO À EXTENSÃO PREDICATIVA IN QUID DA NOÇÃO DE ENTE NO SÉCULO XIV

O objetivo de meu texto consiste em reconstruir um aspecto da recepção da compreensão de Duns Scotus sobre a noção de ente em dois autores pertencentes à geração que imediatamente o sucedeu: no franciscano Guilherme de Alnwick e em seu confrade Francisco de Meyronnes. O problema que surge nessa primeira recepção de Scotus pode ser assim resumido: uma vez que tenhamos aceitado que a noção de ente é simultaneamente unívoca, primeira, a mais geral e a mais simples das noções, como podemos evitar a ameaça de se ter de conceder que a ciência de tal noção – que a metafísica, noutras palavras – não seja capaz de se distinguir claramente de uma investigação que não lida necessariamente com realidades extramentais? Ou, pondo a questão em outros termos: não nos vemos depois de Scotus condenados a ter de escolher entre uma noção de ente como uma noção real ou como uma noção perfeitamente geral? Veremos que, tratando da mesma questão, Alnwick e Meyronnes seguem diferentes caminhos, cada um deles com seus custos e méritos.

Tolerância da cultivar de soja coodetec 201 aos herbicidas inibidores de als

A obtenção de cultivares resistentes aos herbicidas possibilita o aumento da diversidade dos herbicidas utilizados seletivamente para o controle de plantas daninhas em uma determinada cultura. O aumento da disponibilidade destes herbicidas na cultura da soja pode proporcionar maior facilidade no controle de plantas daninhas de difícil eliminação, de espécies com características biológicas semelhantes à cultura e de plantas daninhas resistentes aos herbicidas. O objetivo deste trabalho foi avaliar a resistência cruzada da cultivar COODETEC 201 a três herbicidas inibidores da ALS, não seletivos para a cultura da soja. O experimento foi realizado em casa de vegetação através da semeadura em vasos, o qual foi disposto em delineamento completamente casualizado em arranjo fatorial. Os tratamentos constaram das cultivares de soja COODETEC 201 e OCEPAR 14 e dos herbicidas imazapyr, metsulfuron e nicosulfuron, aplicados em cinco doses. A aplicação destes produtos foi realizada 30 dias após a emergência, quando as plantas de soja estavam no estádio V4. A área foliar e a fitoxicidade aos 14 e 35 dias após a aplicação do herbicida metsulfuron foram menos afetadas na cultivar COODETEC 201 do que na OCEPAR 14. A determinação da restrição do crescimento das plantas em função da matéria seca das plantas demonstrou que as duas cultivares são igualmente sensíveis ao herbicida imazapyr. A cultivar COODETEC 201 apresentou maior tolerância aos herbicidas metsulfuron e nicosulfuron, sendo 10,25 e 3,25 vezes, respectivamente, mais resistente do que a cultivar OCEPAR 14.