Future prospects for SPECT imaging using the radiolanthanide terbium-155 — production and preclinical evaluation in tumor-bearing mice

We assessed the suitability of the radiolanthanide 155 Tb (t1/2 = 5.32 days, Eγ = 87 keV (32%), 105 keV (25%)) in combination with variable tumor targeted biomolecules using preclinical SPECT imaging. Methods 155Tb was produced at ISOLDE (CERN, Geneva, Switzerland) by high-energy (~ 1.4 GeV) proton irradiation of a tantalum target followed by ionization and on-line mass separation. 155 Tb was separated from isobar and pseudo-isobar impurities by cation exchange chromatography. Four tumor targeting molecules – a somatostatin analog (DOTATATE), a minigastrin analog (MD), a folate derivative (cm09) and an anti-L1-CAM antibody (chCE7) – were radiolabeled with 155 Tb. Imaging studies were performed in nude mice bearing AR42J, cholecystokinin-2 receptor expressing A431, KB, IGROV-1 and SKOV-3ip tumor xenografts using a dedicated small-animal SPECT/CT scanner. Results The total yield of the two-step separation process of 155 Tb was 86%. 155 Tb was obtained in a physiological l-lactate solution suitable for direct labeling processes. The 155 Tb-labeled tumor targeted biomolecules were obtained at a reasonable specific activity and high purity (> 95%). 155 Tb gave high quality, high resolution tomographic images. SPECT/CT experiments allowed excellent visualization of AR42J and CCK-2 receptor-expressing A431 tumors xenografts in mice after injection of 155 Tb-DOTATATE and 155 Tb-MD, respectively. The relatively long physical half-life of 155 Tb matched in particular the biological half-lives of 155 Tb-cm09 and 155 Tb-DTPA-chCE7 allowing SPECT imaging of KB tumors, IGROV-1 and SKOV-3ip tumors even several days after administration. Conclusions The radiolanthanide 155 Tb may be of particular interest for low-dose SPECT prior to therapy with a therapeutic match such as the β--emitting radiolanthanides 177Lu, 161 Tb, 166Ho, and the pseudo-radiolanthanide 90Y.

Ms. hebr. oct. 155 - [Sammelband in 2 Teilen: Handschriftenkonvolut]

Vorbesitzer: Gerschon ben Man Schaz;; Eljāqīm Carmoly; Abraham Merzbacher; Abraham Levi Segal

Aspiration Thrombectomy for Treatment of ST-segment Elevation Myocardial Infarction: a Meta-analysis of 26 Randomized Trials in 11 943 Patients.

INTRODUCTION AND OBJECTIVES There is continued debate about the routine use of aspiration thrombectomy in patients with ST-segment elevation myocardial infarction. Our aim was to evaluate clinical and procedural outcomes of aspiration thrombectomy-assisted primary percutaneous coronary intervention compared with conventional primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction. METHODS We performed a meta-analysis of 26 randomized controlled trials with a total of 11 943 patients. Clinical outcomes were extracted up to maximum follow-up and random effect models were used to assess differences in outcomes. RESULTS We observed no difference in the risk of all-cause death (pooled risk ratio = 0.88; 95% confidence interval, 0.74-1.04; P = .124), reinfarction (pooled risk ratio = 0.85; 95% confidence interval, 0.67-1.08; P = .176), target vessel revascularization (pooled risk ratio = 0.86; 95% confidence interval, 0.73-1.00; P = .052), or definite stent thrombosis (pooled risk ratio = 0.76; 95% confidence interval, 0.49-1.16; P = .202) between the 2 groups at a mean weighted follow-up time of 10.4 months. There were significant reductions in failure to reach Thrombolysis In Myocardial Infarction 3 flow (pooled risk ratio = 0.70; 95% confidence interval, 0.60-0.81; P < .001) or myocardial blush grade 3 (pooled risk ratio = 0.76; 95% confidence interval, 0.65-0.89; P = .001), incomplete ST-segment resolution (pooled risk ratio = 0.72; 95% confidence interval, 0.62-0.84; P < .001), and evidence of distal embolization (pooled risk ratio = 0.61; 95% confidence interval, 0.46-0.81; P = .001) with aspiration thrombectomy but estimates were heterogeneous between trials. CONCLUSIONS Among unselected patients with ST-segment elevation myocardial infarction, aspiration thrombectomy-assisted primary percutaneous coronary intervention does not improve clinical outcomes, despite improved epicardial and myocardial parameters of reperfusion. Full English text available from:www.revespcardiol.org/en.

Bericht der Fach-Kommission für Justiz und Gesetzgebung über den Gesetz-Entwurf betreffend die Aufhebung der §§. 151. bis 155. Tit. 20. Thl. II. des allgemeinen Landrechts ...

Welsch (Projektarbeiter): Gesetzentwurf auf Aufhebung der Paragraphen 151 bis 155 des Preußischen Allgemeinen Landrechts ('Erweckung von Unzufriedenheit gegen die Regierung durch frechen Tadel oder Verspottung der Landesgesetze') und Vorschlag ihrer Neufassung in folgender Form: Wer durch Reden oder Schriften wissentlich Unwahrheiten verbreitet, welche geeignet sind, Haß oder Verachtung dem Staat gegenüber hervorzurufen, wird mit Freiheitsstrafe bis zu sechs Monaten bestraft

Haus Jacob Emdens [Illustration] : Altona, Breitestraße 155, mit dem Dachschutz nach biblischer Vorschrift

Scan von Monochrom-Mikroform

Ms. Barth. 155 - Ordo iudiciarius

Vorbesitzer: Bartholomaeusstift Frankfurt am Main

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 155 - Rechnung der Fürstlichen privaten Hofbuchhandlung Rudolstadt

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Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 943 - Mitteilung zur Versendung des veröffentlichten Briefwechsels mit Schopenhauer in der Österreichischen Zeitung "Deutsche Zeitung"

Abschrift vorhanden

Ms.Ff.F.Stoltze 3. 155 - Brief von Otto Kanngießer an Lyda Stoltze

Dank für ein Geschenk (Stoltze: Nachgelassene Gedichte), Bürstenabzug eines nicht erschienenen Feuilletons über Stoltze

Ms. Praed. 155 - Orationes et meditationes

Vorbesitzer: Dominikanerkloster Frankfurt am Main

Ms. lat. oct. 155 - In Thomae de Aquino Summam theologiae, P. II. 1

Vorbesitzer: Bernhard Diell;