Eocene to Quaternary benthic foraminifers from the Izu-Bonin Arc

The benthic foraminifer fauna at Sumisu Rift Sites 790 and 791 indicates that a deep open-ocean (>2300 m) or a basin with open-ocean access existed between 1.1 and 0.7 Ma at the time of the initiation of rifting. The appearance of a low- to medium-oxygen fauna (1600-2300 m) between 0.7 and 0.5 Ma suggests that the open-ocean access may have been terminated at this time because of the development of volcanoes and rift flank uplifts around the basin. The occurrence of low-oxygen faunas at 0.03 Ma suggests a secondary closing of the basin. The lower bathyal benthic faunas from lower Pliocene sediments of rift margin Site 788 suggest about 0.6-1.6 km of total basement uplift. This uplift may have led to the formation of the major hiatus between 2.3 and <0.3 Ma. The faunal changes of benthic foraminifers at Sites 792 and 793 in the forearc basin document a shallowing water depth from below the carbonate compensation depth (CCD) (about 3.5 km) in the late early Oligocene to the present depths of 1800 and 2975 m, respectively. These data suggest about 1 km of total basement uplift in the inner part of the forearc basin (Site 792) and about 0.6 km total basement subsidence in the central part of the forearc basin (Site 793) since about 31 Ma. The former uplift led to a thinner sediment accumulation (800 m) and the latter subsidence to a thicker sediment accumulation (1400 m) at these sites. Faunal changes of benthic foraminifers observed in Sites 782 and 786 sequences drilled at the outer-arc high document a deepening water depth from 1.3 to 2.1 km in late Eocene to the present depth of about 3 km. These data suggest about 1.1-1.9 and 1.3-2.1 km of total basement subsidence at Sites 786 and 782, respectively. These results indicate total basement uplift in the inner part of the Bonin arc-trench system since late Oligocene and total basement subsidence in the outer part of the system since late Eocene. The last occurrence (LO) of Stilostomella spp. and Pleurostomella spp. and the first occurrence (F0) of Bulimina aculeata d'Orbigny occurred consistently at 0.7 Ma at all three arc proximal sites (790,791, and 792). This fact is taken to suggest a change of water mass, from one originating from the central part of the ocean to that originating from ocean-margin areas at that time.

Radiolarians of the Izu-Bonin Region

Radiolarians occur at five Leg 126 sites. Well-preserved radiolarians were recovered from Miocene and Pliocene through Holocene sections. The results of this study may help to fill the informational gap on Quaternary radiolarian distribution at mid-latitudes in the western Pacific. Radiolarian preservation is discontinuous, and, although present in Oligocene sections, specimens are poorly preserved.

Geochemistry and radiogenic isotope ratios of the volcanic sequences from Izu-Bonin Arc, Japan

New radiogenic isotope and trace element data are presented for the volcanic sequences along 600 km of the active Izu-Bonin arc, the Oligocene Izu arc, and their associated rift basins. As with many intra-oceanic island arcs, the Pliocene-Recent Izu-Bonin frontal-arc lavas are highly depleted in Zr, Nb and the rare-earth elements relative to typical mid-ocean ridge basalt (MORB), indicating that the mantle wedge source has undergone a previous episode of melting. Ratios between these elements (such as Nb/Zr and La/Sm), as well as 143Nd/144Nd, do not vary significantly along the length of the frontal-arc. These parameters suggest that each of the arc volcanoes is derived from similar melt fractions of the mantle wedge. However, Ba/Zr, Ba/Rb and 87Sr/86Sr increase along the frontal-arc to the north. This leads us to propose that a variable enrichment in Ba and radiogenic Sr is superimposed on the mantle wedge. Sr-Nd and Pb-Nd isotope variation indicate that both Sr and Pb become more radiogenic after fluid addition. However, Pb isotope ratios do not correlate with increases in Pb concentration or ratios such as Ba/Zr and Nb/Pb. In other words, the Pb isotopic composition of the arc lavas appears to be independent of the amount of Pb introduced by subduction fluids into the mantle source. This buffering of Pb isotopes along the frontal-arc means that the isotopic composition of the lavas is indistinguishable from that of the fluid. Isotopic mixing models presented for the arc are only illustrative of the many plausible combinations of components and quantities. Despite this, we are able to determine that the mantle wedge has isotopic characteristics similar to Indian Ocean MORB, and that the subduction-fluid solute is primarily derived from subducted oceanic basalt with a <2% contribution from subducted sediment. Lavas in the Oligocene Izu arc and fore-arc basin were derived from a mantle wedge of similar composition to the active arc. Despite levels of Pb enrichment comparable to those of the modern arc, the Pb isotopes of the Oligocene volcanics indicate a lower sediment input into the melting region.

Chemistry of Pliocene-Pleistocene pumice from the Izu-Bonin Arc

Thick pumice deposits were found in the cored sequences of forearc, arc, and backarc sites of Leg 126 in the Izu-Bonin Arc. These deposits, composed of fragmental rhyolite pumice with the chemical composition of low-alkali tholeiites, are products of arc volcanism. Pumice deposits constitute more than half of the thickness of the sediment fill of the Sumisu Rift, a backarc rift of the Izu-Bonin Arc. They comprise five thick pumiceous beds separated by thin hemipelagic units; as such, they record four major episodes or pulses of explosive, rhyolitic volcanism during the last 0.15 Ma, separated by quiescent intervals that each lasted about 30-60 k.y. The thick pumiceous beds were deposited in the rift mainly by sediment gravity flows during and immediately after the eruption of arc volcanos, which were probably submarine. Initiation of rifting was also preceded in the Pliocene by submarine rhyolitic volcanism, as seen in samples from the top of the eastern rift flank. Thick pumice beds correlative with those in the backarc also occur in the forearc basin to the east.

miR-126 in human cancers : clinical roles and current perspectives

miR-126 has been implicated in the processes of inflammation and angiogenesis. Through these processes, miR-126 is implicated in cancer biology, but its role there has not been well reviewed. The aim of this review is to examine the molecular mechanisms and clinicopathological significance of miR-126 in human cancers. miR-126 was shown to have roles in cancers of the gastrointestinal tract, genital tracts, breast, thyroid, lung and some other cancers. Its expression was suppressed in most of the cancers studied. The molecular mechanisms that are known to cause aberrant expression of miR-126 include alterations in gene sequence, epigenetic modification and alteration of dicer abundance. miR-126 can inhibit progression of some cancers via negative control of proliferation, migration, invasion, and cell survival. In some instances, however, miR-126 supports cancer progression via promotion of blood vessel formation. Downregulation of miR-126 induces cancer cell proliferation, migration, and invasion via targeting specific oncogenes. Also, reduced levels of miR-126 are a significant predictor of poor survival of patients in many cancers. In addition, miR-126 can alter a multitude of cellular mechanisms in cancer pathogenesis via suppressing gene translation of numerous validated targets such as PI3K, KRAS, EGFL7, CRK, ADAM9, HOXA9, IRS-1, SOX-2, SLC7A5 and VEGF. To conclude, miR-126 is commonly down-regulated in cancer, most likely due to its ability to inhibit cancer cell growth, adhesion, migration, and invasion through suppressing a range of important gene targets. Understanding these mechanisms by which miR-126 is involved with cancer pathogenesis will be useful in the development of therapeutic targets for the management of patients with cancer.

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R(2) approximately 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for approximately 2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.

Deregulation of miR-126 expression in colorectal cancer pathogenesis and its clinical significance

In this study, we investigated the expression profiles and clinicopathological significance of miR-126 in large cohort of patients with colorectal cancers as well the cellular repercussions of miR-126 in colon cancer cells along with its targets in-vitro. Down regulation of miR-126 expression was associated with histological subtypes, peri-neural tumour infiltration, microsatellite instability and pathological staging of colorectal cancers (p<0.05). Low miR-126 expression was also associated with poorer survival in patients with colorectal cancer. Analysis of matched tissues from the same patient revealed that approximately 70% of the tested patients had similar levels of expression of miR-126 in primary cancer and cancer metastases in both lymph node and distant metastases. In addition, induced overexpression of miR-126 showed reduced cell proliferation, increased apoptosis and decreased accumulation of cells in the G0-G1 phase of the colon cancer cells. Furthermore, SW480(+miR-126) cells showed reduced BCL-2 and increased P53 protein expression. To conclude, deregulation of miR-126 in colorectal cancer at the tissue and cellular levels as well as its correlation with various clinicopathological parameters confirm the cancer suppressive role of miR-126 in colorectal cancer.

Sapientia, 1977, Vol. XXXII, nº 126 (número completo)

Contenido: Bien común, justicia y paz / Octavio N. Derisi – La lógica-metafísica del P. José Angulo S. J. / Alberto Caturelli – Dante : aportación escolástica y peculiaridades de su pensar poético-filosófico / G. H. M. Terán – Notas y comentarios -- Bibliografía

Comentários acerca do Projeto de Lei nº 2.126/11, que “[e]stabelece princípios, garantias, direitos e deveres para o uso da Internet no Brasil”, o chamado Marco Civil da Internet

Trata dos princípios, garantias, direitos e deveres para usuários, provedores de serviço e demais agentes envolvidos com o uso da Internet.

Diário da Constituinte [gravação de vídeo] : [programa n. 126]

Comissão de tribos indígenas do Alto Rio Negro entrega um documento aos representantes da Fundação Nacional do Índio (FUNAI) comunicando a intenção de liberar suas terras para a exploração de minérios. As lideranças indígenas querem negociar essa exploração com a Assembleia Nacional Constituinte (ANC). Romero Jucá, Presidente da FUNAI, esclarece que essa exploração é uma espécie de autogestão das terras indígenas. João Menezes (PFL-BA) afirma ser necessária a regulamentação urgente da exploração das reservas indígenas, ou proibi-la definitivamente. Antonio Perosa (PMDB-SP) esclarece que a comissão temática votou contra a exploração de minérios em terras indígenas e entende que o setor público tem o direito de detectar a presença de jazidas, mas que a posterior exploração deverá respeitar todo o patrimônio cultural das várias nações indígenas. Será entregue por Bernardo Cabral (PMDN-AM) a segunda versão do anteprojeto de Constituição, feito a partir das propostas das comissões e emendas apresentadas pelos constituintes. Bernardo Cabral (PMDB-AM) comenta o trabalho de compatibilizar as emendas apresentadas e o prazo de entrega da segunda versão do anteprojeto. Os constituintes trabalham na Comissão de Sistematização no sentido de que a nova Constituição modifique alguns pontos na lei do casamento e do planejamento familiar. Israel Pinheiro Filho (PMDB-MG) acha que os casais, principalmente do campo, precisam de orientação para

'Fa Tsai', a Chinese edible Nostoc in market. [Translation from: Bulletin of the Japanese Society of Phycology 8 124-126, 1960. ]

The Nostoc 'Fa Tsai' is sometimes seen in Chinese cooking materials stores. It is investigated what 'Fa Tsai' consists of and where it originates.

Comment on "Acoustic chaos in a duct with two separate sound sources" [J. Acoust. Soc. Am. 110, 120-126 (2001)] (L)

In a paper published in this journal in 2001 by Dong [W. G. Dong, X. Y. Huang, and Q. L. Wo, J. Acoust. Soc. Am. 110, 120-126 (2001)] it was claimed that acoustic chaos was obtained experimentally by the nonlinear interaction of two acoustic waves in a duct. In this comment a simple experimental setup and an analytical model is used to show that the dynamics of such systems corresponds to a quasiperiodic motion, and not to a chaotic one. © 2008 Acoustical Society of America.

~(126)I高自旋态的识别

利用重离子融合蒸发反应12 2 Sn(11B ,5n2p)布居了双奇核12 6 I的激发态 ,首次建立了具有集体带结构特征的能级纲图 ,其中包括 2 0条新γ跃迁 .所建能级纲图的核素归属指定得到了核反应12 4 Sn(7Li,5n)的交叉支持 .简单讨论了所建带结构的可能组态 .