Observation of Three-Quasiparticle Doublet Bands in I-123: Possible Evidence of Chirality

A new band in the odd proton nucleus I-123 is identified via in- beam gamma- ray spectroscopy using the N-14+Cd-116 reaction. This band shows up as doublets with the previously assigned pi g(7/2) circle times (nu h(11/2))(2) band. Possible configurations of the new band are discussed in the framework of the cranked shell model and the geometrical model. It is argued that the new band might be a chiral partner of the previously known pi g(7/2) circle times (nu h(11/2))(2) band.

Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials

Background Moderate di?erences in e?cacy between adjuvant chemotherapy regimens for breast cancer are plausible, and could a? ect treatment choices. We sought any such di?erences.

Methods We undertook individual-patient-data meta-analyses of the randomised trials comparing: any taxane-plusanthracycline-based regimen versus the same, or more, non-taxane chemotherapy (n=44 000); one anthracyclinebased regimen versus another (n=7000) or versus cyclo phosphamide, methotrexate, and ?uorouracil (CMF; n=18 000); and polychemotherapy versus no chemotherapy (n=32 000). The scheduled dosages of these three drugs and of the anthracyclines doxorubicin (A) and epirubicin (E) were used to de? ne standard CMF, standard 4AC, and CAF and CEF. Log-rank breast cancer mortality rate ratios (RRs) are reported.

Findings In trials adding four separate cycles of a taxane to a ?xed anthracycline-based control regimen, extending treatment duration, breast cancer mortality was reduced (RR 0·86, SE 0·04, two-sided signi?cance [2p]=0·0005). In trials with four such extra cycles of a taxane counterbalanced in controls by extra cycles of other cytotoxic drugs, roughly doubling non-taxane dosage, there was no signi?cant di?erence (RR 0·94, SE 0·06, 2p=0·33). Trials with CMF-treated controls showed that standard 4AC and standard CMF were equivalent (RR 0·98, SE 0·05, 2p=0·67), but that anthracycline-based regimens with substantially higher cumulative dosage than standard 4AC (eg, CAF or CEF) were superior to standard CMF (RR 0·78, SE 0·06, 2p=0·0004). Trials versus no chemotherapy also suggested greater mortality reductions with CAF (RR 0·64, SE 0·09, 2p<0·0001) than with standard 4AC (RR 0·78, SE 0·09, 2p=0·01) or
standard CMF (RR 0·76, SE 0·05, 2p<0·0001). In all meta-analyses involving taxane-based or anthracycline-based regimens, proportional risk reductions were little a? ected by age, nodal status, tumour diameter or di?erentiation (moderate or poor; few were well di?erentiated), oestrogen receptor status, or tamoxifen use. Hence, largely independently of age (up to at least 70 years) or the tumour characteristics currently available to us for the patients selected to be in these trials, some taxane-plus-anthracycline-based or higher-cumulative-dosage anthracycline-based regimens (not requiring stem cells) reduced breast cancer mortality by, on average, about one-third. 10-year overall mortality di?erences paralleled breast cancer mortality di?erences, despite taxane, anthracycline, and other toxicities.

Interpretation 10-year gains from a one-third breast cancer mortality reduction depend on absolute risks without chemotherapy (which, for oestrogen-receptor-positive disease, are the risks remaining with appropriate endocrine therapy). Low absolute risk implies low absolute bene?t, but information was lacking about tumour gene expression markers or quantitative immunohistochemistry that might help to predict risk, chemosensitivity, or both.

Grandeur et décadence de Monsieur Joseph Prudhomme : comédie en cinq actes et en prose. [suivi de] Le roman d'une heure ou La folle gageure : comédie en un acte et en prose. Livr. 123 / par MM. Henry Monnier et Gustave Vaez ; par Hoffmann

Collection : Théâtre contemporain illustré ; 123e-124e livraison

Grandeur et décadence de Monsieur Joseph Prudhomme : comédie en cinq actes et en prose. [suivi de] Le roman d'une heure ou La folle gageure : comédie en un acte et en prose. Livr. 123 / par MM. Henry Monnier et Gustave Vaez ; par Hoffmann

Collection : Théâtre contemporain illustré ; 123e-124e livraison

Livre des Morts de Nésyménou. Egyptien 123

Fragment 3 :Col. 1 + vignette (très fragmentaires) : ?Col. 2 + vignette : chapitre 86 (formule pour prendre l'aspect d'une hirondelle). La vignette contient une hirondelle sur une butte.Col. 3 + vignette : chapitre 87 (formule pour prendre l'aspect d'un serpent-sata). La vignette montre un serpent à tête humaine. Col. 4 + vignette : chapitre 88 (formule pour faire une transformation en crocodile Sobek). La vignette montre une crocodile momiforme.Col. 5 + vignette : chapitre 89 (formule pour permettre que la ba atteigne son cadavre dans la nécropole). La vignette montre l'oiseau-ba volant au-dessus du cadavre allongé sur le lit funéraire.Col. 6 + vignette (fragmentaires) : chapitre 90 (?). La vignette montre le défunt debout les bras en avant.Fragment 2 :Col. 1 + vignette (fragmentaires) : ? Seul un morceau de la vignette est conservé où l'on voit une divinité debout.Col. 2 + vignette : chapitre 91 (formule pour ne pas retenir le ba du défunt dans la nécropole). La vignette montre le défunt debout devant son oiseau-ba.Col. 3 + vignette : chapitre 92 (formule pour ouvrir la tombe pour le ba et pour l'ombre du défunt pour sa sortie pendant le jour). La vignette représente le défunt devant une chapelle où l'on voit l'oiseau-ba.Col. 4 + vignette : chapitre 93 (formule pour ne pas permettre que le défunt ne traverse vers l'Orient dans la nécropole). La vignette représente une divinité assise sur une barque avec le signe de l'Orient.Col. 5 + vignette (voir cadre suivant) : début du chapitre 98 (formule pour aller chercher le bac dans le ciel). La vignette montre la proue de la barque.Fragment 1 (prend place au sein des fragments du cadre suivant Egyptien 122) :Col. 1 + vignette : chapitre 102 (formule pour descendre dans la barque). La vignette représente Rê assis sur sa barque.Col. 2 + vignette (fragmentaires) : ? La vignette laisse deviner une barque.

Resolución No. 123: Por la cual se resuelve un recurso de reposición

Servicios registrales

Resolución N° 83 del 123 de mayo de 2010 ¿Escapa a la competencia de la Cámara de Comercio revisar asuntos sustanciales de los actos sometidos a registro? ¿Puede la Cámara de Comercio oficiar a autoridades jurisdiccionales para que adelanten investigaciones? Elementos para la viabilidad de las reuniones por derecho propio del articulo 422 del Código Comercio?

Servicios registrales

Proteases from an Environmental Isolate of Pseudomonas Aeruginosa MCCB 123 and Their Applications

In the present study,heterotrophic protease producing bacterial isolates were screened for protease activity and a potent protease producing bacterial isolate was selected,identified and coded as Pseudomonas aeruginosa MCCB 123.The organism was capable of producing three different types of enzymes each having potential industrial applications.The non-toxic nature of the bacterial strain and the relatively non-toxic nature of three enzymes suggested their poetential application in various industries.Application of LasA protease and beta-1,3 glucanase in DNA extraction is a promising area for commercial utilization. LasB protease can find its potential application in detergent and tanning industries.As on today Bacillus sp.has been the source of commercial proteases,and the ones produced form P.aeruginosa 123 can pave way for making the industrial and biomedical processes more cost effective and refined.

Potential application of β-1, 3 glucanase from an environmental isolate of Pseudomonas aeruginosa MCCB 123 in fungal DNA extraction

Pseudomonas aeruginosa MCCB 123 was grown in a synthetic medium for β-1,3 glucanase production. From the culture filtrate, β-1,3 glucanase was purified with a molecular mass of 45 kDa. The enzyme was a metallozyme as its β-1,3 glucanase activity got inhibited by the metal chelator EDTA. Optimum pH and temperature for β-1,3 glucanase activity on laminarin was found to be 7 and 50 °C respectively. The MCCB 123 β-1,3 glucanase was found to have good lytic action on a wide range of fungal isolates, and hence its application in fungal DNA extraction was evaluated. β-1,3 glucanase purified from the culture supernatant of P. aeruginosa MCCB 123 could be used for the extraction of fungal DNA without the addition of any other reagents generally used. Optimum pH and temperature of enzyme for fungal DNA extraction was found to be 7 and 65 °C respectively. This is the first report on β-1,3 glucanase employed in fungal DNA extraction

testing 123

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Ooey-gooey : animals 123.

Se describen las características físicas y el hábitat de animales invertebrados y pegajosos como las anémonas de mar, babosas, lombrices de tierra, medusas, salamandras, y sanguijuelas. Ayuda a contar y clasificar. Para niños entre tres y siete años.