Acetylation of cellulose in LiCl-N,N-dimethylacetamide: first report on the correlation between the reaction efficiency and the aggregation number of dissolved cellulose

The acylation of three cellulose samples by acetic anhydride, Ac(2)O, in the solvent system LiCl/N,N-dimethylacetamide, DMAc (4 h, 110 A degrees C), has been revisited in order to investigate the dependence of the reaction efficiency on the structural characteristics of cellulose, and its aggregation in solution. The cellulose samples employed included microcrystalline, MCC; mercerized cotton linters, M-cotton, and mercerized sisal, M-sisal. The reaction efficiency expresses the relationship between the degree of substitution, DS, of the ester obtained, and the molar ratio Ac(2)O/AGU (anhydroglucose unit of the biopolymer); 100% efficiency means obtaining DS = 3 at Ac(2)O/AGU = 3. For all celluloses, the dependence of DS on Ac(2)O/AGU is described by an exponential decay equation: DS = DS(o) - Ae(-[(Ac2O/AGU)/B]); (A) and (B) are regression coefficients, and DS(o) is the calculated maximum degree of substitution, achieved under the conditions of each experiment. Values of (B) are clearly dependent on the cellulose employed: B((M-cotton)) > B((M-sisal)) > B((MCC)); they correlate qualitatively with the degree of polymerization of cellulose, and linearly with the aggregation number, N(agg), of the dissolved biopolymer, as calculated from static light scattering measurements: (B) = 1.709 + 0.034 N(agg). To our knowledge, this is the first report on the latter correlation; it shows the importance of the physical state of dissolved cellulose, and serves to explain, in part, the need to use distinct reaction conditions for MCC and fibrous celluloses, in particular Ac(2)O/AGU, time, temperature.

Methylmercury localization in Danio rerio retina after trophic and subchronic exposure: A basis for neurotoxicology

Methylmercury is a known neurotoxic organometal which affects visual functions and few studies concerns to wild fish are available. The autometallography mercury distribution in the retina of Danio rerio was mapped using light and electron microscopy. Abundant mercury deposits were found in the photoreceptor layer (outer and inner segments of the photoreceptors) and in the inner and outer nuclear layers. Occasionally, the presence of mercury deposits in plexiform layers was observed and very rarely in the ganglion cell layer. Also the occurrence of mercury deposits in cells from the disc region was observed, but not in the nerve fiber layer. An interesting difference was found between mercury accumulation in the central and peripheral regions of the retina. These results demonstrate that mercury after trophic exposure to Danio rerio is able to cross the blood-retina barrier and accumulate in the cells of the retina even under subchronic exposure. (C) 2010 Elsevier Inc. All rights reserved.

Low levels of methylmercury induce DNA damage in rats: protective effects of selenium

In this study we examined the possible antigenotoxic effect of selenium (Se) in rats chronically exposed to low levels of methylmercury (MeHg) and the association between glutathione peroxidase (GSH-Px) activity and DNA lesions (via comet assay) in the same exposed animals. Rats were divided into six groups as follows: (Group I) received water; (Group II) received MeHg (100 mu g/day); (Group III) received Se (2 mg/L drinking water); (Group IV) received Se (6 mg/L drinking water); (Group V) received MeHg (100 mu g/day) and Se (2 mg/L drinking water); (Group VI) received MeHg (100 mu g/day) and Se (6 mg/L drinking water). Total treatment time was 100 days. GSH-Px activity was determined spectrophotometrically and DNA damage was determined by comet assay. Mean GSH-Px activity in groups I, II, III, IV, V and VI were, respectively: 40.19 +/- A 17.21; 23.63 +/- A 6.04; 42.64 +/- A 5.70; 38.50 +/- A 7.15; 34.54 +/- A 6.18 and 41.39 +/- A 11.67 nmolNADPH/min/gHb. DNA damage was represented by a mean score from 0 to 300; the results for groups I, II, III, IV, V and VI were, respectively: 6.87 +/- A 3.27; 124.12 +/- A 13.74; 10.62 +/- A 3.81; 13.25 +/- A 1.76; 86.87 +/- A 11.95 and 76.25 +/- A 7.48. There was a significant inhibition of GSH-Px activity in group II compared with group I (P < 0.05). Groups V and VI did not show a difference in enzyme activity compared with groups III and IV, showing the possible protective action of Se. Comet assay presented a significant difference in DNA migration between group II and group I (P < 0.0001). Groups V and VI showed a significant reduction in MeHg-induced genotoxicity (P < 0.001) when compared with group II. A negative correlation (r = -0.559, P < 0.05) was found between GSH-Px activity and DNA lesion, showing that the greater the DNA damage, the lower the GSH-Px activity. Our findings demonstrated the oxidative and genotoxic properties of MeHg, even at low doses. Moreover, Se co-administration reestablished GSH-Px activity and reduced DNA damage.

Kvinnlig Könsstympning : Litteraturstudie om praktisk handläggning och komplikationsrisker vid förlossning

Today around 28 000 women originally from countries where FGM is practised, are living in Sweden. Many of them are at childbearing age which means that knowledge about FGM and its consequences is of outmost importance during delivery. The aim of this study is to describe current research on how to manage the delivery, regarding deinfibulation and the following stitching as well as the risk of complications when the labouring woman is mutilated. This review of literature is based on 12 scientific articles published between years 1989 – 2005. Five different databases have been searched with use of a large number of keywords.The review found that no scientific research has been carried out that describes how deinfibulation and following stitching should be managed when the woman is mutilated. All available articles within this area are referring to best practice only. The review also found that the conclusions of the studies are contradictory. The majority, however, show an increased frequency for prolonged labour that could be related to FGM. The three largest studies also show an increased rate of caesarean section among mutilated women. In the few studies that examine haemorrhage, the majorities show an increased tendency to bleed, that could be related to FGM. Several articles emphasize the importance of good routines for deinfibulation to reduce the risk for complications.In summary it can be established that due to methodological problems in many studies, no reliable conclusion can be made that the researched complications exists to a greater extent when the woman is mutilated

Quality management for vital forest tree seedlings : Final report, Project no: P33854-1

The work concerns development of a prototype molecular tests to identify vitality status of conifer seedlings. The work is done by NSure, Holland, Dalarna University and SUAS. In case for spruce, a successful validation experiment has been performed to validate the identified frost tolerance and vitality genes. Multiple indicators were identified that can be used to either reinforce the existing ColdnSure test, but also for development of a vitality test. The identified frost tolerance and vitality genes for pine still need to be validated. NSure together with Dalarna University aim to perform a validation next season. Multiple LN indicators were identified in spruce that can be used to determine the effectiveness of a LN treatment, but they are not yet validated. In spruce and pine hardly any scientific research is performed to study the effect of a LN treatment, particularly not at molecular level. Therefore NSure together with Dalarna Research Station want to apply for a project. Within this project, we would be able to develop the tests further.

Gli studi italiani sulla regina Cristina di Svezia negli ultimi cinquant'anni

Queen Christina of Sweden (1626-1689)) is probably the most important individual to directly link the cultures of Sweden and Italy, and thus fascinate scholars over the last four centuries. In the last fifty years, research on and interest in this monarch has been particularly intense. This has led to current international scientific debate concerning all the different cultural expressions in which Queen Cristina was particularly involved. However, until now there has been lacking a comprehensive work to illustrate the development of scientific research in Italian on Queen Christina. This article, therefore, without claiming to be exhaustive, aims to fill this gap by identifying the main direction of current research. The article, after briefly introducing previous works (both Italian and Swedish), demonstrates how the first major renaissance of international studies on Queen Cristina took place in Sweden in the early 1960s. Even more important was the subsequent turning point in 1989, when the tercentenary of the death of Queen Christina was celebrated and the Azzolino Collection at the Biblioteca Comunale in Jesi was opened. The article focuses on the studies in Italian during this latter period. To make the exposition more organic and, importantly, more accessible to those readers interested in only one particular aspect of the scientific studies about Queen Christina, the studies in Italian since 1689 are divided into different subject areas.

Kritisk diskursanalys av Gy2011 med fokus på kulturkontexten : Politiska diskursers relation till svensk läroplansutveckling

This research aims to relate the modern Swedish curriculum development to the political discourses liberalization and European integration through a critical discourse analysis of the Swedish curriculum Gy2011. These political discourses constitute the cultural context of Gy2011, which according to critical discourse theory is synonymous with the terms social sphere or praxis. The term cultural context includes the environment in which the text has been created as well as its intertextuality – in this case its relations to earlier curricula. The analysis of Gy2011 exhumes scientific research done in the field of curriculum studies, which enables future research. The Gy2011 analysis shows that the political discourses liberalization and European integration stands out within the texts cultural context, and have done so for more than 70 years, a fact that is illustrated by an overview of Swedish curricula history. This research also illuminates how the liberalization discourse accelerated during the 1980’s, by both social democrats and the political right, and that the European integration process has gained momentum in recent years.

Recording and Using Provenance in a Protein Compressibility Experiment

Very large scale computations are now becoming routinely used as a methodology to undertake scientific research. In this context, `provenance systems' are regarded as the equivalent of the scientist's logbook for in silico experimentation: provenance captures the documentation of the process that led to some result. Using a protein compressibility analysis application, we derive a set of generic use cases for a provenance system. In order to support these, we address the following fundamental questions: what is provenance? how to record it? what is the performance impact for grid execution? what is the performance of reasoning? In doing so, we define a technologyindependent notion of provenance that captures interactions between components, internal component information and grouping of interactions, so as to allow us to analyse and reason about the execution of scientific processes. In order to support persistent provenance in heterogeneous applications, we introduce a separate provenance store, in which provenance documentation can be stored, archived and queried independently of the technology used to run the application. Through a series of practical tests, we evaluate the performance impact of such a provenance system. In summary, we demonstrate that provenance recording overhead of our prototype system remains under 10% of execution time, and we show that the recorded information successfully supports our use cases in a performant manner.

Evidence Algorithm and Processing Formalized Mathematical Texts

The goal of a research programme Evidence Algorithm is a development of an open system of automated proving that is able to accumulate mathematical knowledge and to prove theorems in a context of a self-contained mathematical text. By now, the first version of such a system called a System for Automated Deduction, SAD, is implemented in software. The system SAD possesses the following main features: mathematical texts are formalized using a specific formal language that is close to a natural language of mathematical publications; a proof search is based on special sequent-type calculi formalizing natural reasoning style, such as application of definitions and auxiliary propositions. These calculi also admit a separation of equality handling from deduction that gives an opportunity to integrate logical reasoning with symbolic calculation.

Choreographic exploration of physical duress: motivation for and responses to exhaustion (a project in performance)

What motivates someone to dance until they are exhausted, sweaty, boiling hot and out of breath? I myself, recalling experiences when I have danced so hard I've nearly fainted, remember how exhilarating that motivation can be. But why? Why is that at all pleasant? Of course, I had several of my own explanations, but I was also interested in doing some scientific research on exhaustion. This question was of ample depth to become the basis of my project.

Experiências de interação do Instituto de Biotecnologia da Universidade de Caxias do Sul com a comunidade

Este estudo tem a finalidade de analisar experiências de interação Universidade – Empresa, em projetos do Instituto de Biotecnologia - ( IB ) da Universidade de Caxias do Sul – ( UCS ), a qual, como Instituição produtora e disseminadora de conhecimentos, busca atuar ativamente na transformação tecnológica da Região Nordeste do Estado do RS. Procura-se analisar as experiências de interação entre os pesquisadores da área de biotecnologia da UCS, as empresas do setor produtivo e a comunidade, identificando possíveis mecanismos e problemas. O IB foi criado para que, através dos resultados de suas pesquisas, possa contribuir efetivamente com os anseios da Comunidade a qual está inserida. Este estudo se constitui na análise de múltiplos casos de interação em oito projetos desenvolvidos no IB. Os dados foram coletados através de entrevistas com os coordenadores dos projetos no IB e com os responsáveis pela interação nas organizações parceiras, num total de 16 entrevistas.O estudo evidencia que as interações ocorrem a partir de contatos informais, baseadas na amizade entre os parceiros e oriundas, principalmente, do esforço do pesquisador. Os entrevistados acentuam a necessidade de uso de mecanismos formais de interação para agilizar e viabilizar projetos conjuntos do IB com empresas do setor produtivo e a comunidade, através de parcerias consolidadas. Finalmente, considera-se que, para assegurar o crescimento da interação com a comunidade, é urgente possibilitar, através de mecanismos formais, que a pesquisa científica desenvolvida no Instituto de biotecnologia da UCS volte-se prioritariamente para a identificação de problemas regionais, buscando as respectivas soluções, na perspectiva do desenvolvimento integrado da Região.

Critérios de avaliação de produção científica em administração no Brasil

Esta pesquisa pretende investigar critérios de avaliação da produção científica em periódicos e congressos em Administração no Brasil. A primeira parte da pesquisa consiste de um estudo exploratório sobre que critérios que deveriam ser utilizados para definir a qualidade de uma contribuição científica. A segunda parte da pesquisa consiste de uma avaliação sobre que critérios são efetivamente utilizados na avaliação de pesquisa científica brasileira nesse campo. O objetivo final é propor um modelo de requisitos para a avaliação de trabalhos científicos no campo da Administração no Brasil.

As organizações sociais no contexto da reforma do Estado: o caso da associação de Comunicação Educativa Roquete Pinto

Diante da incapacidade do Estado em atender às demandas que lhe são exigidas, o governo federal propôs alterações na máquina pública, através do Plano Diretor da Reforma do Aparelho do Estado, de forma a estabelecer novas formas de gestão e novos modelos para as instituições. O objetivo é possibilitar maior interação entre Estado e Sociedade e ao mesmo tempo atingir níveis maiores de eficiência. Em especial, o projeto das Organizações Sociais (OS) pode representar a primeira tentativa de fomentar uma nova espécie de parceria entre o Estado e a Sociedade. Não obstante, existem defeitos na implementação das OS, pois surgiram na prática por iniciativa do governo e não da sociedade civil; o processo de qualificação mostrou-se extremamente centralizador e a composição do Conselho de Administração fortemente comandada pelo poder público. Portanto, as OS devem ser analisadas como um processo em curso, uma possibilidade de vir ainda a se constituir em alternativa eficiente nas áreas de produção e veiculação de radiofusão educativa e cultural, de saúde, de pesquisa científica, de educação e de cultura. Para que atinja os seus objetivos, não se limitando à maior flexibilidade administrativa conquistada, terão de ser revistas e corrigidas as falhas iniciais e introduzidos mecanismos que possibilitem maior controle social da gestão pública. Esta dissertação está voltada para a experiência piloto das OS: a transformação da extinta Fundação Roquette Pinto em ACERP (Associação de Comunicação Educativa Roquette Pinto), I apontando desafios e dificuldades da mudança organizacional, os objetivos e as metas fixados no contrato de gestão e a busca da concretização da implementação de novos valores de direcionamento ao cliente com qualidade. Há críticas em relação ao processo de mudanças adotado, em especial à ausência de planejamento e à dificuldade de diálogo manifestadas pelos dirigentes da ACERP. A mudança organizacional tem importado valores culturais e buscado, a curtíssimo prazo, a modificação de traços de cultura e de comportamento predominantes na organização, provocando o êxodo dos servidores públicos.

Patentes e etanol lignocelulósico

Produção intelectual e desenvolvimento tecnológico podem diferenciar países e regiões no processo de desenvolvimento socioeconômico. No caso do Brasil, observa-se o papel energético do etanol combustível para veículos motorizados leves como um resultado importante do avanço tecnológico do país, que vai além da aptidão agroclimática. A contínua busca pela especialização tecnológica verticalizada do setor sucroenergético poderia levar o Brasil a uma posição, se não autônoma, mais confortável, não só de produtor de matéria-prima, mas de processos agregadores de valor no que diz respeito aos processos de produção de etanol de segunda geração, produzido a partir de biomassa lignocelulósica. O objetivo desta dissertação é analisar os esforços de P&D que resultaram em Depósitos e Publicações de patentes em órgãos oficiais como o United States Patent and Trademark Office (USPTO), o European Patent Office (EPO), e o Instituto Nacional de Propriedade Industrial (INPI), no tema etanol de segunda geração. Ainda, verifica-se se esses esforços impactam no poder concorrencial de países e firmas depositantes de patentes. Além das coletas e observações dos dados dos órgãos acima mencionados, foram calculados para os dados de depósitos e publicações de patentes no tema bioetanol lignocelulósico os índices de Herfindahl Hirschman (HHI) e a razão de concentração (Concentration Ratio) CR4, tradicionalmente utilizados para que órgãos reguladores de defesa do consumidor autorizem fusões e aquisições entre participantes de um determinado mercado. Esse método permite a observação do grau de competitividade entre as firmas depositantes de patentes no tema e a possível tendência sobre a detenção do controle em futuro próximo e a corrida para venda de royalties dos processos desenvolvidos em diferentes áreas tecnológicas para incrementar a produção industrial de etanol avançado. Os resultados indicam uma concentração elevada dos esforços de pesquisa, medidos pelos depósitos de patentes, referentes a etanol de segunda geração, em um número muito reduzido de empresas norte-americanas, quando analisada a base de dados dos EUA. O sucesso desses esforços, mensurados pela publicação de patentes, contudo, não se mostra concentrado nem nos EUA nem na União Europeia. No caso do Brasil, ainda não são encontradas publicações de patentes no tema Lignocellulosic Bioethanol, bem como apenas uma empresa brasileira possui uma patente publicada nos Estados Unidos. Esses resultados sugerem que investimentos em pesquisa científica no Brasil podem produzir mais artigos publicados e titulação acadêmica/científica que propriamente o registro de patentes em órgãos especializados em qualificar a invenção de métodos, processos ou fórmulas, dentro e fora do país. Isso pode significar tanto baixo esforço em pesquisa no assunto quanto à perda pelo autor e/ou sua instituição da oportunidade de ter seu esforço de pesquisa recompensado por meio de royalties, como compensação pela criatividade, dedicação intelectual e de recursos econômicos. Os resultados deste estudo contribuem para o debate a respeito da crescente necessidade de produção e abastecimento de fontes renováveis de energia, como o biocombustível etanol avançado à base do derivado bagaço de cana-de-açúcar, a custos mais competitivos como matéria-prima adicional e para produção incremental de etanol em futuro próximo. As conclusões do estudo indicam a necessidade do aumento na produção de conhecimento aplicado e em esforços para garantir sua propriedade intelectual, permitindo o retorno patrimonial com royalties.

Ética na pesquisa em Administração

Ethics on scientific research is approached and often discussed in several areas of knowledge connected to health. In the Administration area there are very few studies which approach the topic of ethics on research. The present paper tried to fill in this gap in the production of knowledge about the topic, investigating how the ethical principles found in the literature and in the codes of conduct are noticed and taken into account in Administration research activities developed by acting researchers in Administration Post Graduation Programs. Theoretically speaking, the study was based mainly on the approaches by Creswell (2007) and Bell and Bryman (2007), which discuss the research ethical principles. Methodologically speaking it was all about an exploratory kind of study, with qualitative research approach. Upon data collection, personal interviews were made aiming at its depth and focus groups were formed. The first stage had interviews with four experienced researchers who took part on a teaching and researching event and on the second stage we used the focus group technique. The focus groups were done in four college institutions along with the post graduation programs in Administration in the states of Rio Grande do Norte, Paraíba and Pernambuco, in Brazil. The results suggest the existence of general principles and parameters for the scientific research recommended in the literature and on official resolution. However, in the Administration area, there are only a few recommendations of good practices when it comes to submitting articles for scientific publications but we found no guidance with ethical principles and parameters which cover all the activities in the scientific research and which specifically meet the research particularities in Administration. The main ethical dilemma pointed by the researchers refers to ethical questions which arise at the time of data collection and on disclosing the results. Most researchers do not know the guidelines and the ethical norms on ethics about research that we have in our country neither do they send in their projects to the research ethics committee. When dilemma arises, they decide the ethical question based on their values and common sense. These elements confirm the thesis that the researcher s procedure in the research activities in Administration is predominantly signed by personal values or by common sense and less by ethical principles, whether by not knowing the normative instruments related to ethics or by disagreeing with any disciplining rules on ethical behavior in the research