Transmissão sexual e tratamento na hepatite C aguda : dois casos clinicos

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014

Dually Active HIV/HBV Antiretrovirals Protect Against Incident Hepatitis B Infections: Potential for Prophylaxis.

BACKGROUND  Hepatitis-B virus (HBV) has a detrimental effect on HIV natural course, and HBV vaccination is less effective in the HIV infected. We examine the protective effect of dually active antiretroviral therapy (DAART) for HIV/HBV (Tenofovir/Lamivudine/Emtricitabine) in a large cohort encompassing heterosexuals, men-who-have-sex-with-men (MSM), and intravenous drug users (IDU), who are HIV-infected yet susceptible to HBV, with comprehensive follow-up data about risky behavior and immunological profile. METHODS  We defined an incident HBV infection as the presence of any of HBV serological markers (HBsAg/AntiHBc/HBV-DNA) following a negative baseline AntiHBc test. Patients with positive AntiHBs were excluded. Cox proportional hazard models were utilized, with an incident case of HBV infection as the outcome variable. RESULTS  We analyzed 1,716 eligible patients from the Swiss HIV Cohort Study with 177 incident HBV cases. DAART was negatively associated with incident HBV infection (hazard ratio 0.4, 95%CI 0.2-0.6). This protective association was robust to adjustment (0.3, 0.2-0.5) for condomless sex, √CD4 count, drug use, and patients' demographics. Condomless sex (1.9,1.4-2.6), belonging to MSM (2.7,1.7-4.2) or IDU (3.8,2.4-6.1) were all associated with higher HBV hazard. CONCLUSIONS  Our study suggests that DAART, independently of CD4 count and risky behavior, has a potentially strong public health impact including pre-exposure prophylaxis of HBV co-infection.

Methods for integrating alcohol education into existing curriculum. Volume II. Part 7. Final report.

National Highway Traffic Safety Administration, Office of Alcohol Countermeasures, Washington, D.C.

Sentencing and dispositions of youth DUI and other alcohol offenses: a guide for judges and prosecutors.

Mode of access: Internet.

Marijuana, other drugs and their relation to highway safety: a report to the Congress.

Mode of access: Internet.

Summary of work performed pursuant to the development of K-12 alcohol and alcohol safety curriculum materials. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Training materials for traffic court judges. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Youth driving without impairment: report on the youth impaired driving public hearings - a community challenge.

Mode of access: Internet.

Using trigger films: a guide for discussion leaders.

National Highway Traffic Safety Administration, Washington, D.C.

Youth alcohol safety education criteria development. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Alcohol and alcohol safety. A curriculum manual for senior high level. Volume II of II. A teacher's activities guide.

National Highway Traffic Safety Administration, Washington, D.C.

Alcohol and alcohol safety. A curriculum manual for elementary level. Volume II of II. A teacher's activities guide.

National Highway Traffic Safety Administration, Washington, D.C.

The incidence of drugs in fatally injured drivers. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Youth alcohol education material dissemination and promotion. Final report.

National Highway Traffic Safety Administration, Office of Driver and Pedestrian Programs, Washington, D.C.

Comparison of recovered alcoholic and non-alcoholic communicator in alcohol education. Final report.

National Highway Traffic Safety Administration, Washington, D.C.