Rehydroxylation Dating: Assessment for Archaeological Application

Investigations are carried out into the mass gain behaviour of fired clay ceramics following drying (130°C) and reheating (500°C), and the application of these mass gain properties to the dating of archaeological ceramics using a modified rehydroxylation dating (RHX) methodology, a component based approach. Gravimetric analysis is conducted using a temperature and humidity controlled glove box arrangement (featuring a top-loading balance) on eighteen samples of varied known ages and contexts; this occurs following transfer from environmentally controlled chambers where subsamples of these samples are aged at three temperatures (25°C, 35°C, 45°C) following drying and reheating. The sample set consists principally of post-medieval bricks, but also includes some post-medieval pottery as well as both Etruscan and Roman ceramics. A suite of techniques are applied to characterise these ceramics, including XRD, FTIR, p-XRF, thin-section petrography, BET analysis, TG-MS and permeametry.

Technology is Set to Change Real Estate Forever

Major developments in the technological environment can become commonplace very quickly. They are now impacting upon a broad range of information-based service sectors, as high growth Internet-based firms, such as Google, Amazon, Facebook and Airbnb, and financial technology (Fintech) start-ups expand their product portfolios into new markets. Real estate is one of the information-based service sectors that is currently being impacted by this new type of competitor and the broad range of disruptive digital technologies that have emerged. Due to the vast troves of data that these Internet firms have at their disposal and their asset-light (cloud-based) structures, they are able to offer highly-targeted products at much lower costs than conventional brick-and-mortar companies.

Relational and reproductive trajectories leading to adolescent pregnancy in Portugal: a national and regional characterization

INTRODUCTION: The current study aimed to describe the relational and reproductive trajectories leading to adolescent pregnancy in Portugal, and to explore whether there were differences in this process according to adolescents' place of residence. MATERIAL AND METHODS: Data were collected between 2008 and 2013 in 42 public health services using a self-report questionnaire developed by the researchers. The sample consisted of a nationally representative group of pregnant adolescents (n = 459). RESULTS: Regardless of having had one (59.91%) or multiple sexual partners (40.09%), the majority of adolescents became pregnant in a romantic relationship, using contraception at the time of the conception and knowing the contraceptive failure which led to pregnancy (39.22%). In some regions other trajectories were highly prevalent, reflecting options such as planning the pregnancy (Alentejo Region/ Azores Islands), not using contraception (Centro Region/Madeira Islands) or using it incorrectly, without identifying the contraceptive failure (Madeira Islands). On average, romantic relationships were longer than 19 months and adolescents' partners were older than themselves (> 4 years) and no longer in school (75.16%); these results were particularly significant when the pregnancy was planned. DISCUSSION: The knowledge gained in this study shows that prevention efforts must be targeted according to the adolescents' needs in each region and should include high-risk male groups. CONCLUSION: Our results may enable more efficient health policies to prevent adolescent pregnancy in different country regions and support educators and health care providers on sexual education and family planning efforts.

Modelo para la creación de un portal en internet que les facilite a los laboratorios farmaceúticos la promoción médica a través del uso de medios virtuales

La presente investigación se realizó con el propósito de desarrollar un modelo que fuera la base para que los laboratorios farmacéuticos puedan orientar su promoción médica hacia el uso de los recursos tecnológicos actuales como es el internet. Además de proveer un mapa conceptual de los pasos que deben seguir los laboratorios para pasar de los medios tradicionales de promoción médica (Brick) a los medios virtuales e interactivos (Click) a través de la red, es decir, actualmente la promociónmédica se hace a través de los canales tradicionales de comercialización; a esta forma la llamamos "Brick", pero nuestra propuesta permite crear una estrategia para que el laboratorio transforme la promoción médica a través de las tecnologías de comunicación, como el internet, creando un nuevo canal de comercialización, "Click", virtual, en línea. El modelo puede ser aplicado por cualquier laboratorio farmacéutico y no tiene ninguna exclusividad, puesto que es genérico; los principios aplicadosson de conocimiento público. Lo que haría la diferencia entre unportal y otro sería la forma como cada laboratorio enfrente el diseño y la implementación del mismo.

Chemical characterization and evaluation of biological activity of Cynara cardunculus extractable compounds

The Mediterranean species Cynara cardunculus L. is recognized in the traditional medicine, for their hepatoprotective and choleretic effects. Biomass of C. cardunculus L. var. altilis (DC), or cultivated cardoon, may be explored not only for the production of energy and pulp fibers, but also for the extraction of bioactive compounds. The chemical characterization of extractable components, namely terpenic and phenolic compounds, may valorize the cultivated cardoon plantation, due to their antioxidant, antitumoral and antimicrobial activities. In this study, the chemical composition of lipophilic and phenolic fractions of C. cardunculus L. var. altilis (DC), cultivated in the south of Portugal (Baixo Alentejo region) was characterized in detail, intending the integral valorization of its biomass. The biological activity of cultivated cardoon extracts was evaluated in terms of antioxidant, human tumor cell antiproliferative and antibacterial effects. Gas chromatography-mass spectrometry (GC-MS) was used for the chemical analysis of lipophilic compounds. Sixty-five lipophilic compounds were identified, from which 1 sesquiterpene lactone and 4 pentacyclic triterpenes were described, for the first time, as cultivated cardoon components, such as: deacylcynaropicrin, acetates of β- and α-amyrin, lupenyl acetate and ψ-taraxasteryl acetate. Sesquiterpene lactones were the major family of lipophilic components of leaves (≈94.5 g/kg), mostly represented by cynaropicrin (≈87.4 g/kg). Pentacyclic triterpenes were also detected, in considerably high contents, in the remaining parts of cultivated cardoon, especially in the florets (≈27.5 g/kg). Taraxasteryl acetate was the main pentacyclic triterpene (≈8.9 g/kg in florets). High pressure liquid chromatography-mass spectrometry (HPLC-MS) was utilized for the chemical analysis of phenolic compounds. Among the identified 28 phenolic compounds, eriodictyol hexoside was reported for the first time as C. cardunculus L. component, and 6 as cultivated cardoon components, namely 1,4-di-O-caffeoylquinic acid, naringenin 7-O-glucoside, naringenin rutinoside, naringenin, luteolin acetylhexoside and apigenin acetylhexoside. The highest content of the identified phenolic compounds was observed in the florets (≈12.6 g/kg). Stalks outer part contained the highest hydroxycinnamic acids abundance (≈10.3 g/kg), and florets presented the highest flavonoids content (≈10.3 g/kg). The antioxidant activity of phenolic fraction was examined through 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay. Stalks outer part, and receptacles and bracts extracts demonstrated the highest antioxidant effect on DPPH (IC50 of 34.35 μg/mL and 35.25 μg/mL, respectively). (cont.) abstract (cont.) The DPPH scavenging effect was linearly correlated with the total contents of hydroxycinnamic acids (r = -0.990). The in vitro antiproliferative activity of cultivated cardoon lipophilic and phenolic extracts was evaluated on a human tumor cells line of triple-negative breast cancer (MDA-MB-231), one of the most refractory human cancers to conventional therapeutics. After 48 h of exposition, leaves lipophilic extract showed higher inhibitory effect (IC50 = 10.39 μg/mL) than florets lipophilic extract (IC50 = 315.22 μg/mL), upon MDA-MB-231 cellular viability. Pure compound of cynaropicrin, representative of the main compound identified in leaves lipophilic extract, also prevented the cell proliferation of MDA-MB-231 (IC50 = 17.86 μM). MDA-MB-231 cells were much more resistant to the 48 h- treatment with phenolic extracts of stalks outer part (IC50 = 3341.20 μg/mL) and florets (IC50 > 4500 μg/mL), and also with the pure compound of 1,5-di-O-caffeoylquinic acid (IC50 = 1741.69 μM). MDA-MB-231 cells were exposed, for 48 h, to the respective IC50 concentrations of leaves lipophilic extract and pure compound of cynaropicrin, in order to understand their ability in modelling cellular responses, and consequently important potentially signaling pathways for the cellular viability decrease. Leaves lipophilic extract increased the caspase-3 enzymatic activity, contrarily to pure compound of cynaropicrin. Additionally, leaves lipophilic extract and pure compound of cynaropicrin caused G2 cell cycle arrest, possibly by upregulating the p21Waf1/Cip1 and the accumulation of phospho-Tyr15-CDK1 and cyclin B1. The inhibitory effects of leaves lipophilic extract and cynaropicrin pure compound, against the MDA-MB-231 cell proliferation, may also be related to the downregulation of phospho-Ser473-Akt. The antibacterial activity of cultivated cardoon lipophilic and phenolic extracts was assessed, for the first time, on two multidrug-resistant bacteria, such as the Gram-negative Pseudomonas aeruginosa PAO1 and the Gram-positive methicillin-resistant Staphylococcus aureus (MRSA), two of the main bacteria responsible for health care-associated infections. Accordingly, the minimum inhibitory concentrations (MIC) were determined. Lipophilic and phenolic extracts of florets did not have antibacterial activity on P. aeruginosa PAO1 and MRSA (MIC > 2048 μg/mL). Leaves lipophilic extract did not prevent the P. aeruginosa PAO1 growth, but pure compound of cynaropicrin was slightly active (MIC = 2048 μg/mL). Leaves lipophilic extract and pure compound of cynaropicrin blocked MRSA growth (MIC of 1024 and 256 μg/mL, respectively). The scientific knowledge revealed in this thesis, either by the chemical viewpoint, or by the biological viewpoint, contributes for the valorization of C. cardunculus L. var. altilis (DC) biomass. Cultivated cardoon has potential to be exploited as source of bioactive compounds, in conciliation with other valorization pathways, and Portuguese traditional cheeses manufacturing.

Socio-economic aspects of the fisheries of Nabugabo lakes and implications for management

Fisheries are very important to Uganda's economy. The sector provides a vital source of food, recreation, trade and socioeconomic well being for the people and community globally. The fisheries of small lakes are important for producing fish for local populations who are not near the large lakes. These satellite lakes support important fisheries and other economic activities like fishing, water for domestic purposes and tourism, besides socio-cultural values. A number-of fish;- species, some of which were found only in Lake Victoria have been depleted through over-exploitation, introduction of exotics especiaily Nile perch and environmental degradation. Some of these fishes have been observed to survive in satellite lakes in the Victoria and Kyoga Lake basins. The Nabugabo satellite lakes (Manywa, Kayugi and Kayanja) contain endemic Cichlid fish species acting as reservoirs and therefore very important for conservation of fish biodiversity. Despite the socio-economic importance and uniqueness of these satellite lakes little research on socio-economic studies has been carried out. The sustainability of the lake is being threatened by increasing human activities. The fish stocks and species diversity are declining and this poses a threat to the livelihood of the people who depend on fish for food and income. Arising from this need a study was carried out to establish the socio-economic aspects of Nabugabo fisheries and implications for management, on which basis resource users would be made aware of the impacts of their activities. It was hoped that this would go further to ensure wise use and management of the resources by the users. The specific objectives were identifying activities around the lake, establishing socioeconomic values attached to the lake, identifying problems of the lake and resource users and examining existing local based management institutions. Results show that the activities taking place around the lakes include fishing, farming, watering of animals, deforestation and charcoal burning, brick making, resort beach development and food and refreshment. The major problem facing the lake was found to be encroachment of Hippo grass (Vossia) on the lake, which is decreasing the size of the lake, and limiting open waters for fishing (this only applied to Lake Nabugabo). Other important problems include use of illegal fishing methods, declining fish stocks and loss of cultural identity. The resource users are most pressed by the low incomes resulting from poor fish catches, theft of gears and lack of market. On examining the resource base for the lakes, it was only Lake Nabugabo that had a Landing Management Committee. The other three lakes did not have leadership institutions in place except the local councils for the respective villages. This was probably due to observed limited fisheries activities. Majority of the respondents agreed that Government and other service providers should work jointly to supplement local beach management committees in the management of the lakes resources. This is a good gesture because with increase in fishing effort and rampant use of illegal fishing methods, there is need to strengthen management institutions present on the lake. This would require Government, local community and other service providers to work together in a participatory way to control environment-degrading activities and stop the use of illegal fishing methods. Burning of vegetation on the lake should be stopped since it enhances growth of this grass. Finally, traditional taboos; which are present on some of the Nabugabo lakes, should be enhanced, as away of preserving them.

Relational and reproductive trajectories leading to adolescent pregnancy in Portugal: a national and regional characterization

INTRODUCTION: The current study aimed to describe the relational and reproductive trajectories leading to adolescent pregnancy in Portugal, and to explore whether there were differences in this process according to adolescents' place of residence. MATERIAL AND METHODS: Data were collected between 2008 and 2013 in 42 public health services using a self-report questionnaire developed by the researchers. The sample consisted of a nationally representative group of pregnant adolescents (n = 459). RESULTS: Regardless of having had one (59.91%) or multiple sexual partners (40.09%), the majority of adolescents became pregnant in a romantic relationship, using contraception at the time of the conception and knowing the contraceptive failure which led to pregnancy (39.22%). In some regions other trajectories were highly prevalent, reflecting options such as planning the pregnancy (Alentejo Region/ Azores Islands), not using contraception (Centro Region/Madeira Islands) or using it incorrectly, without identifying the contraceptive failure (Madeira Islands). On average, romantic relationships were longer than 19 months and adolescents' partners were older than themselves (> 4 years) and no longer in school (75.16%); these results were particularly significant when the pregnancy was planned. DISCUSSION: The knowledge gained in this study shows that prevention efforts must be targeted according to the adolescents' needs in each region and should include high-risk male groups. CONCLUSION: Our results may enable more efficient health policies to prevent adolescent pregnancy in different country regions and support educators and health care providers on sexual education and family planning efforts.

Effects of incomplete combustion on atmospheric chemistry: Black carbon climate forcing and global carbon monoxide emissions

This thesis is actually the composition of two separate studies aimed at further understanding the role of incomplete combustion products on atmospheric chemistry. The first explores the sensitivity of black carbon (BC) forcing to aerosol vertical location since BC has an increased forcing per unit mass when it is located above reflective clouds. We used a column radiative transfer model to produce globally-averaged values of normalized direct radiative forcing (NDRF) for BC over and under different types of clouds. We developed a simple column-weighting scheme based on the mass fractions of BC that are over and under clouds in measured vertical profiles. The resulting NDRF is in good agreement with global 3-D model estimates, supporting the column-weighted model as a tool for exploring uncertainties due to diversity in vertical distribution. BC above low clouds accounts for about 20% of the global burden but 50% of the forcing. We estimate maximum-minimum spread in NDRF due to modeled profiles as about 40% and uncertainty as about 25%. Models overestimate BC in the upper troposphere compared with measurements; modeled NDRF might need to be reduced by about 15%. Redistributing BC within the lowest 4 km of the atmosphere affects modeled NDRF by only about 5% and cannot account for very high forcing estimates. The second study estimated global year 2000 carbon monoxide (CO) emissions using a traditional bottom-up inventory. We applied literature-derived emission factors to a variety of fuel and technology combinations. Combining these with regional fuel use and production data we produced CO emissions estimates that were separable by sector, fuel type, technology, and region. We estimated year 2000 stationary source emissions of 685.9 Tg/yr and 885 Tg/yr if we included adopted mobile sources from EDGAR v3.2FT2000. Open/biomass burning contributed most significantly to global CO burden, while the residential sector, primarily in Asia and Africa, were the largest contributors with respect to contained combustion sources. Industry production in Asia, including brick, cement, iron and steel-making, also contributed significantly to CO emissions. Our estimates of biofuel emissions are lower than most previously published bottom-up estimates while our other fuel emissions are generally in good agreement. Our values are also universally lower than recently estimated CO emissions from models using top-down methods.

Telesia Archaeological Project: Indagini nella basilica e nel foro (2014-2015)

The Telesia Archaeological Project is an initiative that will make a significant contribution to thi historical and archaeological knowledge of the urban area of the Roman city of Telesia, located near Benevento (S. Salvatore Telesino). The first and second season of the Telesia Archaeological Project (2014-2015), conducted under the supervision of the Archaeological Superintendence, and thanks to the indispensable collaboration of a private landowner, provided results of great scientific interest. There was the possibility to investigate part of a significant building of imperial age, richly decorated, identified with the basilica of the city. It was possible to establish, in addition, that this large building (36 by 21 m ca) was opened, through a great brick colonnade, to the forum, localized in summer 2015 with certainty for the first time. The extraordinary large double colonnade (porticus duplex), 9 meters wide, covering the entire façade of that public building, was erased in the fifth century AD, probably after two earthquakes that seriously damaged the city in 346 and 375 AD.

Tectonoestratigrafia do Terreno Ibérico no sector Tomar- Sardoal-Ferreira do Zêzere e relações com o Terreno Finisterra

A cartografia geológica da região Tomar-Sardoal-Ferreira do Zêzere permitiu individualizar sucessões tectono-estratigráficas em domíníos da Zona Centro-Ibérica (ZCI) e da Zona Ossa Morena (ZOM) que anteriormente eram considerados apenas como ZOM, separadas entre si pelo carreamento de Ortiga-Torrão. A sucessão centro-ibérica monometamórfica, datada do Neoproterozóico ao Silúrico (?), encontra-se numa estrutura triangular e é constituída por unidades típicas do Paleozóico/Neoproterozóico da ZCI. Na ZOM foram estabelecidas duas sucessões polimetamórficas nas regiões do Sardoal e de Serra (Tomar), ambas datadas no geral do Neoproterozóico. A primeira constitui um autóctone relativo e a outra, alóctone; ambas são compostas por unidades deformadas da crosta cadomiana. A continuidade das sucessões tectono-estratigráficas antecedentes do Terreno Ibérico e do carreamento que as limita é interrompida a E pela Zona de Cisalhamento Porto-Tomar-Ferreira do Alentejo (N-S e cinemática direita), a ocidente da qual se encontra o Terreno Finisterra.

Effect of different doses of post-emergence-applied iodosulfuron on weed control and grain yield of malt barley (Hordeum distichum L.), under Mediterranean conditions

A study was carried out over a two year period (2009/2010 and 2012/2013) on an experimental farm in the Alentejo region (Beja), in southern Portugal where rainfed malt barley (Hordeum distichum L.) is sown at the end of autumn or beginning of winter (November– December). The aim of this experiment was to study the efficiency of the herbicide iodosulfuron-methyl-sodium to control post-emergence broadleaved weeds in this cereal crop. The malt barley crop was established using no-till farming. This technology provides the necessary machine bearing capacity of the soil to assure the post-emergence application of herbicides at two diferente weed development stages. The herbicide iodosulfuron-methyl-sodium was applied at three doses (5.0, 7.5, and 10.0 g a. i. · ha–1) and at two different broadleaved weed development stages (3 to 4 and 6 to 7 pairs of leaves), that also corresponded to two diferente crop development stages (beginning of tillering and complete tillering). The results indicated that early herbicide application timing provided a significantly higher efficiency for all the applied herbicide doses, but this better weed control was not reflected in a higher crop grain yield. The lack of a higher crop grain yield was probably due to a crop phytotoxicity of the herbicide, when used at an early application timing.

Salted-Fish industry in Roman Lusitania: Trade Memories between Oceanus and Mare Nostrum

Initiated by Augustus, Rome’s Atlantic policy seems to have been consolidated in the age of Claudius, with the acknowledgement of the economic potential offered by the Atlantic region. It is in this context that we must understand the development of the salted-fish industry in Lusitania. In the same geographical contexts, and in close relationship with fish-processing factories, are known about 20 pottery centres producing amphorae, located in the regions of Peniche, Sado and Tejo valleys, and the coasts of Alentejo and Algarve. This production extended in time beyond the end of the Western Roman Empire and up to the end of the 5th and 6th centuries, according to the archaeological data of some amphora kilns and fish-processing sites. The identification of Lusitanian amphorae in distant consuming centres and several shipwrecks in the Mediterranean basin confirm the long-distance commerce and the total integration of this “peripheral” region into the trade routes of the Roman Empire.

Museus e Paisagens Culturais: Editorial

Este boletim é dedicado às paisagens culturais, tema do Dia Internacional de Museus de 2016. Lançado o repto, como podem os museus articular-se de forma mais efectiva com o território, com a sua compreensão e interpretação? Merece destaque o artigo sobre a Rota Histórica das Linhas de Torres, um projecto de patrimonialização da paisagem em curso desde 2007 (Florbela Estevao), a reflexão em torno da Carta de Siena (Joana Sousa Monteiro e Dália Paulo), a entrevista com Ana Paula Amendoeira (Directora Regional de Cultura do Alentejo) e o texto de perfil sobre Pedro Gadanho, director do novo Museu de Arte, Arquitectura e Tecnologia (Belém).

Entrevista com Ana Paula Amendoeira

A paisagem cultural foi o tema condutor desta entrevista com Ana Paula Amendoeira, que nos apresenta a sua perspectiva sobre os problemas e os desafios presentes na discussão sobre políticas públicas para a protecção e valorização das paisagens culturais em Portugal. Directora Regional de Cultura do Alentejo desde 2013, Ana Paula Amendoeira é especialista em património histórico e paisagístico. O seu percurso é marcado pela experiência na administração pública local e regional, pela investigação no âmbito da reflexão sobre património mundial e pelo activismo associativo, nomeadamente na Comissão Nacional Portuguesa do Conselho Internacional de Monumentos e Sítios (ICOMOS Portugal). De que falamos quando nos referimos à patrimonialização da paisagem? Que constrangimentos, balanços e desafios futuros? Que contributos dos museus?

Conservação de frutos secos: resultados de ensaios experimentais

A qualidade dos alimentos é um conceito que tem vindo a despertar o interesse das indústrias e dos consumidores, daí a preocupação em conservar os produtos sob condições adequadas, evitando alterações físicas e químicas que ponham em causa a integridade dos alimentos, bem como as suas propriedades nutricionais e sensoriais. Deste modo, foi realizado um estudo para avaliar os efeitos do armazenamento sob certas condições de temperatura e diferentes tipos de embalagens sobre as propriedades dos miolos de nozes, avelãs e amêndoas com pele, embora no caso das amêndoas também se tenha estudoa do uma amostra sem pele. As amostras utilizadas eram originárias de Portugal, mas também de outros países, Chile, Espanha, Turquia, Roménia e Estados Unidos. O armazenamento das nozes durou 90 dias, e as condições testadas foram: temperatura ambiente; estufa a 30 e 50 °C, refrigeração (2 °C) e congelamento(15 °C). Os dois tipos de embalagem de plástico utilizados foram o polietileno de baixa densidade (PEBD) e polietileno de baixa densidade linear (PEBDL), comparando com as amostras armazenadas sem qualquer embalagem. No caso das amêndoas, uma das amostras apresentava-se sem pelicula. Foram avaliadas várias características dos frutos: a atividade de água (medida por um higrómetro), o teor de humidade (secagem em estufa até massa constante), a cor (com um colorímetro) e a textura (utilizando-se um texturómetro). A partir dos resultados obtidos concluiu-se que as amostras de diferentes origens são diferentes no que diz respeito ao teor de humidade, atividade de água e cor, independentemente das condições de armazenamento e tipo de embalagem. Os resultaram mostraram que as condições de armazenagem que melhor preservam as características estudadas dos frutos secos foram os de baixa temperatura, sendo observadas maiores alterações nos frutos armazenados a temperaturas elevadas, nomeadamente na cor. Assim verificou-se que os processos de refrigeração e congelação têm uma influência mínima nas características dos frutos, particularmente na humidade, na actividade da água, na dureza e friabilidade. Os resultados indicaram também que os frutos apresentam valores de aw inferiores a 0,6, para todas condições testadas, garantindo alguma estabilidade a nível das estabilidade microbiana e enzimática. A presença da pele no miolo de amêndoa, para todos os tratamentos, tem uma influência significativa na textura e cor. Finalmente, em relação ao tipo de embalagem, foi observado que o uso de sacos de plástico testados não parece contribuir para a melhoria das características dos produtos em relação às amostras não embaladas.