Triiodothyronine and breast cancer

The thyroid hormones (THs), triiodothyronine (T3) and thyroxine (T4), are essential for survival; they are involved in the processes of development, growth, and metabolism. In addition to hyperthyroidism or hypothyroidism, THs are involved in other diseases. The role of THs in the development and differentiation of mammary epithelium is well established; however, their specific role in the pathogenesis of breast cancer (BC) is controversial. Steroid hormones affect many human cancers and the abnormal responsiveness of the mammary epithelial cells to estradiol (E2) in particular is known to be an important cause for the development and progression of BC. The proliferative effect of T3 has been demonstrated in various types of cancer. In BC cell lines, T3 may foster the conditions for tumor proliferation and increase the effect of cell proliferation by E2; thus, T3 may play a role in the development and progression of BC. Studies show that T3 has effects similar to E2 in BC cell lines. Despite controversy regarding the relationship between thyroid disturbances and the incidence of BC, studies show that thyroid status may influence the development of tumor, proliferation and metastasis.

Effects of re-stripping on the seminal characteristics of pacu (Piaractus mesopotamicus) during the breeding season

Seminal characteristics in teleost fish with an annual reproductive period, such as pacu (Piaractus mesopotamicus), may vary during the breeding season. The sperm formed before the beginning of the spawning period may be stored for a long time, causing damage to the cells. Therefore, re-stripping may be an important way to eliminate the old and allow for the collection of new spermatozoids. In this study, we analyzed the seminal characteristics of hormonally induced pacu at the beginning, middle and end of the breeding season, and we analyzed samples from re-stripped males (stripped first at the beginning, re-stripped in the middle, and re-stripped again at the end of the season) during two breeding seasons. The sperm density, ionic composition, pH, and osmolality were similar among the groups. The semen volume, seminal plasma protein concentration and incidence of morphologically anomalous sperm increased over time. In addition, some parameters that are associated with good-quality semen decreased, such as sperm motility, viability and DNA integrity. Moreover, we observed a positive association among motility, viability and DNA integrity for sperm with elevated 11-ketotestosterone, but there was no such association for fshb or lhb mRNA levels in the pituitary. The semen that was obtained earlier (at the beginning) or from re-stripped males exhibited better characteristics than the other samples collected. In conclusion, collecting semen from pacu at the end of breeding season should be avoided; it is preferable to strip early and then re-strip later in the season, and this approach may be used for diverse aquaculture purposes.

Identification of the molecular sex-differentiation period in the siberian sturgeon

Sexual development prior to gonadal sex differentiation is regulated by various molecular mechanisms. In fish, a molecular sex-differentiation period has been identified in species for which sex can be ascertained prior to gonadal sex differentiation. The present study was designed to identify such a period in a species for which no genetic sex markers or monosex populations are available. Siberian sturgeons undergo a slow sex-differentiation process over several months, so gonad morphology and gene expression was tracked in fish from ages 3-27 months to identify the sex-differentiation period. The genes amh, sox9, and dmrt1 were selected as male gonad markers; cyp19a1a and foxl2a as female gonad markers; and cyp17a1 and ar as markers of steroid synthesis and steroid receptivity. Sex differentiation occurred at 8 months, and was preceded by a molecular sex-differentiation period at 3-4 months, at which time all of the genes except ar showed clear expression peaks. amh and sox9 expression seemed to be involved in male sexual development whereas dmrt1, a gene involved in testis development in metazoans, unexpectedly showed a pattern similar to those of the genes known to be involved in female gonadal sex differentiation (cyp19a1 and foxl2a). In conclusion, the timing of and gene candidates involved with molecular sex differentiation in the Siberian sturgeon were identified. Mol. Reprod. Dev. 2015. © 2015 Wiley Periodicals, Inc.

Níveis plasmáticos de nitrito/nitrato, GMPc e cortisol em mulheres normotensas e hipertensas após a menopausa: efeito crônico do exercício físico e exposição aguda à L-arginina

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Lombalgia equina: diagnóstico e tratamento

Low back pain is considered a major cause of lameness and performance decay, but identify the location of the lesions and quantify the intensity of pain is difficult because often the most obvious clinical sign, in some cases, is not the pain itself, but, low athletic performance. The diagnosis and treatment of this disease are associated with a high cost and have a strong impact on the equine industry, since it results in direct economic losses. The diagnosis of low back pain is made through physical examination and additional tests, including radiography, ultrasound, thermography and blockades. Major injuries causing back pain in horses is the contact or overlap of the spinous processes, supraspinous desmitis, osteoarthritis of the articular processes, vertebral body lesions and myositis. Therapeutic measures used in the treatment of these diseases are systemic inflammatory steroid, local infiltration, acupuncture, chiropractic, physical therapy, changes in training and surgeries.

Assistência cirúrgico-odontológica a pacientes imunodeprimidos por uso crônico de corticoides

Objective: The objective of this work, and review concepts on the physiology of hormones Adrenals to enhance pre, trans and post-operative care to dentists facing surgical, dental care of immunosuppressed patients. Literature review: The corticosteroids are among the most used drugs in medicine in recent times due to its anti-inflammatory and immunosuppressive activities, especially in transplant patients and patients with chronic autoimmune diseases. However, the continuing use of these drugs leads to a decrease in endogenous production of cortisol by the adrenal. Besides depressing the patient’s immune system, it may generate many parallel undesirable effects like blocking the production of the natural hormone of adrenal cortex, or steroid called cortisol, which may be the cause of a malfunctioning of the adrenal gland, causing hypofunction or hyperfunction of the gland. Final considerations: This fact will lead to changes in the planning of dental surgery, where it will be necessary special actions towards the patients who have this condition.

Increase of leishmanicidal and tubercular activities using steroids linked to aminoquinoline

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Fontes lipídicas e ácidos graxos essenciais no desenvolvimento ovariano e desempenho reprodutivo de jundiás Rhamdia quelen

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Atividade dos neurônios do núcleo anterovental periventricular e sua participação no envelhecimento reprodutivo de ratas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Análise hormonal, imunolocalização e quantificação dos receptores de andrógenos (AR) e estrógenos (ER-α E ER-β) em ovário e útero de ratas submetidas a diferentes doses de decanoato de nandrolona: avaliação nos períodos pós-tratamento e pós-recuperação

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Association between neuropathic pain and A-Waves in Leprosy patients with type 1 and 2 reactions

Summary: Neuropathic pain (NP) is a well-recognized feature of leprosy neuropathy. However, the diagnosis of NP is difficult using only clinical criteria. In the study reported here, by means of conventional nerve conduction studies, the authors sought for an association between long-latency responses and NP complaints in leprosy patients with type 1 and 2 reactions. Of the 27 ulnar nerves of leprosy patients, 18 with type 1 reaction (T1R) and 9 with type 2 reaction (T2R) were followed-up for 6 months before and after steroid treatment. Clinical characteristics of pain complaints and clinical function were assessed, as well as the presence of F- and A-waves of the ulnar nerve using nerve conduction studies. The clinical and the neurophysiologic findings were compared to note positive concordances (presence of NP and A-waves together) and negative concordances (absence of NP and A-waves together) before and after treatment. Both reactions presented a high frequency of A-waves (61.1% in T1R and 66.7% in T2R, P < 0.05) and prolonged F-waves (69.4% in T1R and 65.8% in T2R, P = 0.4). No concordances were seen between pain complaints and F-waves. However, significant concordances between NP and A-waves were observed, although restricted to the T2R group ([chi]2 = 5.65, P = 0.04). After treatment, there was a significant reduction in pain complaints, as well as the presence of F- and A-waves in both groups (P < 0.05 for all comparisons). In conclusion, the presence of A-waves correlates well with pain complaints of neuropathic characteristics in leprosy patients, especially in those with type 2 reaction. Probably, such response shares similar mechanisms with the small-fiber dysfunction seen in these patients with NP, such as demyelination, intraneural edema, and axonal sprouting. Further studies using specific tools for small-fiber assessment are warranted to confirm our findings.

Efeitos do treinamento resistido sobre secreação de testosterona e cortisol: uma revisão bibliográfica

You can set the resistance training such as making a move against a resistance by performing a muscle contraction and generating a muscular adaptation. This form of training, was initially used only in training athletes aiming to strengthen and improve fitness. Some coaches did not give proper focus, as the increase in muscle mass would cause loss of flexibility and agility. But over time a huge evolution occurred within this area and the practitioners of resistance training are no longer just athletes, and reached the whole community, from young to elderly, being a physical activity that generates a large caloric expenditure and has several health benefits, improve the cardiovascular system and decreasing the amount of body fat in the body. Cortisol is a hormone secreted from a stressful stimulus to the body, secretion undergoes control of the hypothalamic-pituitary axis, which releases the hormone into the bloodstream andrenocorticotrópico, going to the adrenal cortex responsible for their release. This has catabolic function, acting in the metabolism of carbohydrates, proteins and lipids, as well as having an important effect antiflamatório. Testosterone is a steroid hormone cholesterol from being produced by the testicles in men, as in women is produced to a lesser extent in ovary and adrenal glands, has functions androgenic and anabolic. Androgen function is responsible for the development of male sexual characteristics, while on anabolic function operates in the growth of muscles and bones, influencing the development of the human body organs. Within the metabolic changes that occur in the resistance training testosterone plays an important role in protein synthesis, influencing the production of strength and / or power during exercise. The objective of this work is through a literature review to assess the effects of resistance training on the production of these hormones and the relationship between them

Doping e suplementação no MMA: um estudo documental de caso

The first records of the use of substances that enhance athletic performance began in antiquity. The objective of this study is to analyze the use of doping methods and supplements by amateur athletes and MMA professionals and what motivates usage. The work consisted of desk research in which use of work carried out at fifteen amateur and professional athletes, which underwent a data collection; these athletes are all over eighteen years old, male and practicing MMA for at least two years. The questionnaire that they were submitted corresponded to ten multiple-choice questions, which are: Age, what type of fight practiced as a basis for MMA, how long practices martial arts, sees the sport of competitive or recreational way, has already made use dietary supplements, have made use of banned substances (steroids) in the sport, it has already made use of steroids which the substance used and to what end was done using, know the side effects of anabolic steroids, know one or more people who have already made use of steroids in order to increase their performance in the fight, he believes it is possible an athlete achieve success in modern MMA without the use of anabolic steroids. The results showed that, of the fifteen athletes interviewed, only two said they never made use of dietary supplements, and four said they have already made use of anabolic steroids. All fifteen athletes claim to know the side effects of steroid use, and 14 of them say they know one or more sport-mates who have already made use of steroids. Given the results, it can be concluded that the use of steroids is common in MMA

Variações sazonais dos níveis plasmáticos do esteroide sexual 17β-estradiol (e2) em fêmeas de matrinxã (brycon amazonicus)

Pós-graduação em Ciência e Tecnologia Animal - FEIS

Comportamento materno e câncer de bexiga urinária: implicações da modulação de eixos hormonais e receptores de esteroides na fisiopatologia de lesões neoplásicas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)