Triiodothyronine and breast cancer


Autoria(s): Sibio, Maria Teresa de; Oliveira, Miriane de; Moretto, Fernanda Cristina Fontes; Olimpio, Regiane Marques Castro; Conde, Sandro José; Luvizon, Aline Carbonera; Nogueira, Célia Regina
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

07/12/2015

07/12/2015

10/08/2014

Resumo

The thyroid hormones (THs), triiodothyronine (T3) and thyroxine (T4), are essential for survival; they are involved in the processes of development, growth, and metabolism. In addition to hyperthyroidism or hypothyroidism, THs are involved in other diseases. The role of THs in the development and differentiation of mammary epithelium is well established; however, their specific role in the pathogenesis of breast cancer (BC) is controversial. Steroid hormones affect many human cancers and the abnormal responsiveness of the mammary epithelial cells to estradiol (E2) in particular is known to be an important cause for the development and progression of BC. The proliferative effect of T3 has been demonstrated in various types of cancer. In BC cell lines, T3 may foster the conditions for tumor proliferation and increase the effect of cell proliferation by E2; thus, T3 may play a role in the development and progression of BC. Studies show that T3 has effects similar to E2 in BC cell lines. Despite controversy regarding the relationship between thyroid disturbances and the incidence of BC, studies show that thyroid status may influence the development of tumor, proliferation and metastasis.

Formato

503-508

Identificador

http://dx.doi.org/10.5306/wjco.v5.i3.503

World Journal Of Clinical Oncology, v. 5, n. 3, p. 503-508, 2014.

2218-4333

http://hdl.handle.net/11449/131058

10.5306/wjco.v5.i3.503

25114863

PMC4127619

Idioma(s)

eng

Publicador

Baishideng Publishing Group Inc

Relação

World Journal Of Clinical Oncology

Direitos

closedAccess

Palavras-Chave #Breast cancer #Mammary gland and metabolism #Thyroid hormone #Triiodothyronine
Tipo

info:eu-repo/semantics/article