1000 resultados para correlação genotípica
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With aging, naturally occurs the decline of several functions. The depression (DP), pointed to be a risk factor for cognitive decline (DC), is frequent amongst elders. Activities aimed at cognitive rehabilitation (RC) can be protective for DP and DC. Objectives: Analyze the association between DC and DP on institutionalized elders (IDI) and non-institutionalized elders (IDNI) and verify the protective function (regarding DP and DC) of RC activities. Design and Method: For the analysis were selected 48 elders, from both genders, from where 24 were institutionalized and 24 were not. The subjects were distributed in four subgroups: 1) IDI participating RC (n=12); 2) non participant IDI on RC (n=12); 3) IDNI participating UNATI (“Open College for the Elderly”) and attendees of Memory Workshop (MW) (n=12) and; 4) IDNI participating UNATI, not attending MW (n=12). The data were gathered from the instruments: Mini Mental State Exam (MEEM) to determine the degree of DC and Beck Depression Inventory (BDI) to verify the symptomatology of DP. Results: From the general sample, 8,3% of the subjects presented indicatives of DC and 52,1% traces of DP. Lesser educated elders showed more incidence of DC and DP. There was no meaningful related to the DC prevalence and DP related to gender. Among the IDI there were more incidence of DC and DP than the IDNI. There were no meaningful differences in terms of scores acquired by MEEM and BDI for the subjects participating and not participating RC activities or MW. Conclusion: Therefore, it is necessary the development and application of curative and preventive strategies for depressive disorder. Special attention must be given for INI, more vulnerable to DP and DC.
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The six-minute walking test can be affected by several variables, among them, the respiratory and peripheral muscle strength. The objective of this study was to correlate the respiratory muscle strength (maximum inspiratory pressure – MIP; and maximum expiratory pressure – MEP) and the hand grip test (HGT)with the six minute walking test distance in institutionalized elderly. It was included in this study 9 institutionalized elderly with age over 70 years old, both gender, evaluated by means of manometer, dynamometry and six minute walking test. The data were correlated by using the Pearson’s correlation test and the Spearman correlation test. From the evaluated elderly, it was four men and five women, with mean age: 78.8±7.3 years old, MIP: 75.7±33.6 cmH2O, MEP: 62.4±25.0 cmH2O, HGT: 20.4±6.2 kgf (right member) and 20.7±6.8 kgf (left member) and the distance on six minute walking test: 238.5±99.0 meters. There was correlation between expiratory strength and hand grip of both members with the distance on the six minute walking test. It is possible to conclude that there are correlation between expiratory muscle strength with the hand grip test and the functional capacity in institucionalized elderly.
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The six-minute walking test can be affected by several variables, among them, the respiratory and peripheral muscle strength. The objective of this study was to correlate the respiratory muscle strength (maximum inspiratory pressure – MIP; and maximum expiratory pressure – MEP) and the hand grip test (HGT)with the six minute walking test distance in institutionalized elderly. It was included in this study 9 institutionalized elderly with age over 70 years old, both gender, evaluated by means of manometer, dynamometry and six minute walking test. The data were correlated by using the Pearson’s correlation test and the Spearman correlation test. From the evaluated elderly, it was four men and five women, with mean age: 78.8±7.3 years old, MIP: 75.7±33.6 cmH2O, MEP: 62.4±25.0 cmH2O, HGT: 20.4±6.2 kgf (right member) and 20.7±6.8 kgf (left member) and the distance on six minute walking test: 238.5±99.0 meters. There was correlation between expiratory strength and hand grip of both members with the distance on the six minute walking test. It is possible to conclude that there are correlation between expiratory muscle strength with the hand grip test and the functional capacity in institucionalized elderly.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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INTRODUCTION: Temporomandibular disorders (TMD) have association with psychological manifestations. OBJECTIVE: The aims of this study were to correlate the severity of TMD and the level of self-esteem, and to investigate sex‑related differences. MATERIAL AND METHOD: We evaluated 57 subjects of both gender, with mean age of 20.28 ± 2.07 years, through the Fonseca Anamnesis Index (FAI) and Rosenberg Self-esteem Scale (RSS). Correlations between variables were performed using the Spearman correlation coefficient; comparisons between the genders were performed using the Mann-Whitney test. It was considered a significance level of 5%. RESULT: No differences were found for the comparisons between the gender in the FAI (p = 0.79) and the RSS (p = 0.90). RSS correlates with the FAI in women (p = 0.01), but in men this result does not occur (p = 0.07). CONCLUSION: We concluded that women are more likely to have emotional disturbances resulting from changes in the temporomandibular joint than men.
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The fracture surfaces express the sequence of events of energy release due to crack propagation by linking the relief of the fracture to the loading stresses. This study aims to evaluate the heterogeneity of the critical zone for the advancement of the crack along its entire length in a thermoset composite carbon fiber and epoxy matrix, fractured in DCB testing (Double Cantilever Beam) and ENF (End-Notched Flexure). Investigations were made from image stacks obtained by optical reflection of extended depth from focus reconstruction. The program NIH Image J was used to obtain elevation map and fully focused images of the fracture surface, whose topographies were quantitatively analyzed. The monofractal behavior for DCB samples was assessed as being heterogeneous along the crack front and along the crack for all the conditionings. For the samples fractured in ENF test, there was a strong positive correlation to the natural condition, considering the fibers at 0° for the monofractal dimension and structural dimension (Df and Ds). For fibers at 90° to crack propagation, there was a moderate positive correlation for the textural dimension of natural condition. However, for the samples under ultraviolet condition and those subjected to thermal cycles, there was no correlation between the fractal dimension and fracture toughness in mode II
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Orchidaceae é uma das maiores famílias de Angiospermas, com distribuição cosmopolita, sendo que Bulbophyllum é o maior gênero da família, com mais de 1200 espécies. A seção Micranthae apresenta 12 espécies distribuídas na América do Sul e com grande representatividade no Brasil. A interpretação das Orchidaceae de maneira geral, é dificultada pela grande diversidade de espécies, gerando problemas taxonômicos. Visando levantar caracteres diagnósticos para as espécies e estados de caráter compartilhados entre elas, foram realizados estudos anatômicos das folhas de 11 espécies de Bulbophyllum seção Micranthae e de outras três espécies de Bulbophyllum constituindo o grupo externo. As estruturas anatômicas: epiderme unisseriada com cera epicuticular espessa; estômatos tetracíticos com câmaras supraestomáticas; presença de hipoderme e de feixes vasculares colaterais caracterizam as espécies estudadas. A forma cilíndrica da folha de Bulbophyllum insectiferum Barb. Rodr. é caráter diagnóstico da espécie, assim como a ausência de idioblastos traqueoidais de paredes espessadas em Dendrobium kingianum Bidwill ex Lindl. A morfologia das folhas, forma da lâmina foliar em secção transversal, forma das células epidérmicas em vista frontal, tipo de mesofilo, tipos de cristais e número de feixes vasculares são caracteres que permitem agrupamentos entre as espécies analisadas. Esses caracteres serão utilizados numa futura análise cladística procurando auxiliar a filogenia do grupo
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10 A diálise peritoneal (DP) é uma terapia de substituição renal utilizada em pacientes renais crônicos. A peritonite é uma das suas principais complicações; sendo o Staphylococcus aureus causador de episódios mais graves e reincidentes. Os fatores de virulência desta bactéria são responsáveis por essa alta patogenicidade. Esse estudo objetivou avaliar esses fatores e a presença do gene mecA em amostras de S.aureus obtidas de episódios de peritonites de pacientes tratados com DP. Foram estudadas 73 amostras de peritonites ocorridas entre janeiro de 1996 e setembro de 2008. O estudo dos fatores de patogenicidade consistiu na detecção da produção de biofilme, de enzimas hemolisinas α e β, lipase, lecitinase e nucleases; e das enterotoxinas A, B, C, D e da Toxina 1 da Síndrome do Choque Tóxico (TSST-1). Ainda foi verificado o perfil de sensibilidade dos isolados à oxacilina pelo Etest® e detecção do gene mecA por PCR. Dentre todos os resultados, a produção de toxina B e a resistência à oxacilina foram os dois fatores que influenciaram a evolução dos casos de nova infecção. Quanto aos casos recorrentes, características dos pacientes como idade, raça e presença de diabetes foram mais determinantes para a não resolução dos surtos de peritonite
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O trabalho de parto prematuro (TPP) é uma intercorrência obstétrica com etiologia multifatorial, que tem como principal complicação a prematuridade. A infecção da cavidade amniótica (CA) é um fator associado ao TPP e, nos últimos anos, inúmeros trabalhos têm demonstrado a presença de diferentes espécies bacterianas no líquido amniótico (LA) de pacientes em TPP. Dentre essas, destacam-se duas espécies de micoplasmas genitais, Mycoplasma hominis e Ureaplasma urealyticum, que embora sejam freqüentemente detectadas no LA ainda são pouco estudadas quanto à sua relação com essa complicação obstétrica. Avaliar a infecção na cavidade amniótica por M. hominis e U. urealyticum bem como determinar os níveis de IL-6 e IL-10 no líquido amniótico de gestantes com trabalho de parto prematuro. Foi realizado estudo prospectivo com 20 gestantes em TPP, atendidas no Serviço de Obstetrícia do Hospital das Clínicas da Faculdade de Medicina de Botucatu, UNESP. O grupo controle foi constituído de 20 gestantes com indicação para amniocentese transabdominal para avaliação da maturidade fetal. Foram obtidas amostras do líquido amniótico e das membranas corioamnióticas de todas as pacientes incluídas no estudo. A pesquisa de M.hominis e U.urealyticum no LA foi realizada empregando-se a técnica de reação em cadeia da polimerase (PCR) e os níveis de IL-6 e IL-10 quantificados por ensaio imunoenzimático (ELISA). Os dados obtidos referentes às características maternas, infecção da cavidade amniótica e concentração de citocinas no LA foram submetidos ao teste z de proporção e ao teste de Mann-Whitney e o nível de significância adotado foi de 5%. A incidência de TPP no período do estudo foi de 5,8%. No grupo TPP, a pesquisa de invasão microbiana da CA foi positiva para... (Resumo completo, clicar acesso eletrônico abaixo)
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Infertility is directly related to chromosomal abnormalities in germ cells. Among them, the aneuploidies are the most frequent chromosomal abnormalities and responsible for embryo implantation failures, miscarriages, fetal losses and newborns with congenital malformations, mental disability and neuropsychomotor developmental delay. Male patients with normal somatic karyotype may present different rates of aneuploidies in sperm, resulting in abnormal embryos. This study aimed to correlate the frequency of chromosomal aneuploidies in spermatozoa with embryo implantation rate in couples undergoing assisted reproductive techniques. The methodology has included chromosomal analysis by GTG banding and molecular cytogenetic study using Fluorescent In Situ Hybridization technique for evaluation of chromosomes 9, X and Y in germ cells of 22 patients referred to the Human Reproduction Service of the Clinical Hospital FMRP-USP. Embryo implantation rates were determined by hormonal evaluation in maternal peripheral blood and ultrasound confirmation. Two patients presented abnormal karyotype, characterized by polymorphism of the heterochromatic region of the long arm of chromosome 9 and a satellite in the short arm of chromosome 22. Both alterations, usually considered variants of normality, have been related to infertility phenotype and miscarriages. Significant differences were detected between couples who presented pregnancy (group 1) and couples with embryo implantation failure (group 2), with higher frequency of aneusomy and diploidy of chromosome 9, as well as total aneuploidy in sperm of group 2 patients. Our results suggest a correlation between aneuploidy and embryo implantation rates, since the infertile group with reproductive failure has showed higher frequency of aneuploidy. Screening for aneuploidies detection in male germ cells should be included in order to decrease embryo implantation failures, miscarriages and fetuses with chromosomal ...
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Objective - At evaluating the IL-10 production in maternal blood and placenta and correlate them with perinatal outcomes in pregnancies complicated by hyperglycemia, or with risk to developing it, differentiated by the glycemic mean (GM < or ≥ 100mg/dL). Method- 186 pregnant women were distributed into groups GM < 100 mg/dL and GM ≥ 100 mg/dL. We evaluated the GM, HbA1c levels, maternal and placental IL-10 and TNF-α and the correlation between placental cytokines and perinatal outcomes. Results - In maternal blood, the lower concentrations of IL-10 (1.01 ± 0.87 vs. 3.08 ± 5.57 pg / mL, p = 0.0019) were observed in GM ≥ 100 mg / dL group. Placental IL-10 was directly correlated with hemoglobin levels (r = 0.63, p = 0.02) and insulin (r = 0.78, p = 0.01) from umbilical cord and with Apgar scores 1 (r = 0.53, p = 0.0095) and Apgar 5 (r = 0.69, p = 0.0003). Conclusion - GM ≥ 100mg/dL was associated with decreased of maternal IL-10. Placental IL-10 was similar in both groups and correlated directly with hemoglobin and insulin and with Apgar scores of 1st. and 5th. minutes
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Este trabalho teve por objetivo desenvolver hidrogéis do ácido acrílico e correlacionar as propriedades bioadesivas e a liberação in vitro empregando metronidazol. Para tanto, inicialmente foram preparadas dispersões dos polímeros Carbopol 974 ® e Policarbofil ® nas concentrações de 0,5%, 1,0% e 1,5%, que foram submetidas a testes para avaliação das propriedades bioadesivas, mecânicas e reológicas. As amostras com maior concentração de polímeros (Carbopol 974 ® 1,5%, e Policarbofil ® 1,0% e 1,5%,) foram as que apresentaram melhores resultados nos testes de bioadesão, e portanto selecionadas para prosseguimento dos estudos, que envolveu a incorporação de metronidazol (MTZ) na concentração de 0,5% para estudo de liberação in vitro por 12 horas. O experimento foi realizado por meio do sistema automático com célula de difusão vertical de Franz e solução tampão fosfato pH 7,4 como solução receptora. A temperatura utilizada foi 32,5 o C. Os resultados demonstraram que o tipo e a concentração do polímero influenciou diretamente na liberação do fármaco. Os melhores resultados em termos de controle de liberação foram apresentados pelo polímero Policarbofil ® na concentração de 1,5%
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Pós-graduação em Medicina Veterinária - FCAV